| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.5494446 |
| Focal adhesion kinase ( FAK ) and paxillin are known to form a complex with c Src at the focal contacts and to participate in the integrin mediated signal transduction as c Src substrates . 0.5494446^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.5494446 |
| Focal adhesion kinase ( FAK ) and paxillin are known to form a complex with c Src at the focal contacts and to participate in the integrin mediated signal transduction as c Src substrates . 0.5494446^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , the levels of tyrosine phosphorylation of paxillin and pp125FAK were greatly reduced during mitosis , whereas the kinase activity of c Src was elevated . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin binds in vitro to the focal adhesion protein vinculin as well as to the SH 3 domain of c src and , when tyrosine phosphorylated , to the SH 2 domain of 5 crk . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin is tyrosine phosphorylated during interphase of the cell cycle by protein tyrosine kinases ( PTK ) such as c Src and Csk , and becomes dephosphorylated during mitosis . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We have shown that suppression of a certain fraction of c Src activity by Csk may require the binding of Csk to tyrosine phosphorylated paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Subsequent analysis of phosphotyrosine proteins revealed that bradykinin stimulated tyrosine phosphorylation of the cytoskeleton associated protein paxillin and the nonreceptor protein tyrosine kinase pp 60 ( c src ) . ^^^ Paxillin and pp 60 ( c src ) co precipitated after bradykinin treatment . ^^^ Taken together , our data suggest that pp 60 ( c src ) and paxillin are putative components of the intracellular signaling pathway of bradykinin mediated neurite retraction and provide evidence for a crosstalk between G protein and tyrosine kinase dependent pathways in these cellular events . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Here , we show that hypoxia induced tyrosine phosphorylation of p 125 ( FAK ) and paxillin and that hypoxia induced activation of p 125 ( FAK ) was accompanied by its increased association with adapter proteins Shc and GRB 2 , and non receptor type tyrosine kinase p 60 ( c src ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We show that simultaneous overexpression of FAK and pp 60 ( c src ) or p 59 ( fyn ) results in the enhancement of the tyrosine phosphorylation of a limited number of cellular substrates , including paxillin . ^^^ FAK mutants defective for Src binding or focal adhesion targeting fail to cooperate with pp 60 ( c src ) or p 59 ( fyn ) to induce paxillin phosphorylation , whereas catalytically defective FAK mutants can direct paxillin phosphorylation . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The results suggest that c Src participates in the tumorigenic phenotype induced in NIH3T3 cells by MET M1268T by signaling through focal adhesion kinase and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| A carboxy terminal fragment of CAS ( CAS CT ) , which contains the c SRC binding site , was sufficient to induce c SRC dependent protein tyrosine kinase activity , as measured by tyrosine phosphorylation of cortactin , paxillin , and , to a lesser extent , focal adhesion kinase . ^^^ A single amino acid substitution located in the binding site for the SRC SH 3 domain of CAS CT disrupted CAS CT ' s interaction with c SRC and inhibited its ability to induce tyrosine phosphorylation of cortactin and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Integrin engagement , the actin cytoskeleton , and c Src are required for the calcitonin induced tyrosine phosphorylation of paxillin and HEF 1 , but not for calcitonin induced Erk1 / 2 phosphorylation . ^^^ Overexpression of wild type c Src increased calcitonin induced paxillin and HEF 1 phosphorylation , whereas overexpression of kinase dead Src or Src lacking a functional SH 2 domain inhibited the calcitonin stimulated tyrosine phosphorylation of these proteins . ^^^ In contrast to the regulation of paxillin and HEF 1 phosphorylation , the calcitonin induced phosphorylation of Erk 1 and Erk 2 did not appear to involve c Src and was only partially dependent on cell adhesion to the extracellular matrix and an intact actin cytoskeleton . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the c Src cellular substrates paxillin , p 130 ( cas ) , and Stat 3 was also inhibited at concentrations < 1 microM . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The functions and regulation of proteins associated with `` focal adhesion complexes ' ' ( membrane associated dense plaques ) in differentiated smooth muscle , including integrins , focal adhesion kinase ( FAK ) , c Src , paxillin , and the 27 kDa small heat shock protein ( HSP 27 ) are described . ^^^ Integrins in smooth muscles are key elements of mechanotransduction pathways that communicate with and are regulated by focal adhesion proteins that include FAK , c Src , and paxillin as well as proteins known to mediate cytoskeletal remodeling . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Here we show that gelsolin coprecipitates some of the focal adhesion associated proteins such as c Src , phosphoinositide 3 kinase ( PI3K ) , p 130 ( Cas ) , focal adhesion kinase , integrin alpha ( 5 ) beta ( 3 ) , vinculin , talin , and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| ATP depletion increased the content of Tyr ( 416 ) Src , the activated form of this kinase . c Src activation was associated with an increase in the tyrosine phosphorylation state of beta catenin , paxillin , and vinculin , three c Src substrate proteins that localize to and regulate cell contact sites . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Cytosolic signaling factors such as paxillin , c Src , and c Csk were also associated with the cytoskeleton . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| While PLD activity as a lipid hydrolyzing enzyme is not affected by c Src , wild type PLDs but not catalytically inactive PLD mutants significantly increase c Src kinase activity , up regulating c Src mediated paxillin phosphorylation and extracellular signal regulated kinase activity . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Since these Shc isoforms have been implicated in the activation of protein kinase c Src , which is required for FAK tyrosine phosphorylation , the observed dephosphorylation of FAK and of the FAK substrate paxillin by OTA could be ascribed to the early down regulation of Shc isoforms . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| PP 2 inhibited the formation of lamellopodia and expression of kinase inactive c Src reduced phosphorylation of cortactin and paxillin , suggesting a model in which Src kinases are involved in organization of the actin cytoskeleton . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| MSU induced rapid tyrosine phosphorylation of Pyk 2 and FAK , their adaptor protein paxillin , and interacting kinase c Src . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the extent of both c Src dephosphorylation at Tyr 529 , FAK and paxillin phosphorylation , and the increased cell adhesion were associated with the degree of r PTPeta expression . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Among the focal adhesion proteins , paxillin and c Src decreased also . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Herein , we show that FAK expression is essential for alpha5beta1 stimulated cell motility and that exogenous expression of human alpha 4 in FAK null fibroblasts forms a functional alpha4beta1 receptor that promotes robust cell motility equal to the alpha5beta1 stimulation of wild type and FAK reconstituted fibroblasts . alpha4beta1 stimulated FAK null cell spreading and motility were dependent on the integrity of the alpha 4 cytoplasmic domain , independent of direct paxillin binding to alpha 4 , and were not affected by PRNK expression , a dominant negative inhibitor of Pyk 2 . alpha 4 cytoplasmic domain initiated signaling led to a approximately 4 fold activation of c Src which did not require paxillin binding to alpha 4 . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| An acute PMA treatment increased phosphorylations of focal adhesion ( FA ) kinase , paxillin , c Src , and cofilin , just as TGFbeta 1 did . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| To study the role of c Src in breast cancer tumorigenesis , we generated a cell line derived from MCF 7 carrying an inducible dominant negative c Src ( c SrcDN : K295M / Y527F ) under tetracycline control ( Tet On system ) . c SrcDN expression caused phenotypic changes , relocation of c Src , Fak , and paxillin , and loss of correct actin fiber assembly . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the multidomain protein paxillin , which is also a FAK ligand and a c Src substrate , has been associated with less malignant tumor behavior . ^^^ The purpose of this study was to analyze the involvement of integrin signaling molecules FAK , c Src , and paxillin in malignant transformation of the breast epithelium . ^^^ In summary , focal adhesion proteins FAK and c Src can be used as markers of malignant transformation in epithelial cells but not invasive phenotype , whereas expression and activation of paxillin may represent a good prognosticator in breast carcinoma . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Met and substrates such as phosphatidylinositol 3 kinase , Src homology and collagen like , pp60c src , focal adhesion kinase p125FAK , and paxillin were associated with tyrosine phosphorylated complexes in a hepatocyte cell line established from the transgenic liver . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin is a 68 kDa focal adhesion protein that is phosphorylated on tyrosine residues in fibroblasts in response to transformation by 5 src , treatment with platelet derived growth factor , or cross linking of integrins . ^^^ Paxillin has been shown to have binding sites for the SH 3 domain of Src and the SH 2 domain of Crk in vitro and to coprecipitate with two other focal adhesion proteins , vinculin and focal adhesion kinase ( p125fak ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of paxillin on tyrosine creates binding sites for the SH 2 domains of Crk , Csk , and Src . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The tyrosine phosphorylated sites in p130Cas and cortactin may serve as binding sites for proteins containing Src homology 2 domains , as is the case with two other integrin regulated docking proteins , focal adhesion kinase and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin has also been implicated in cell signaling by virtue of its association with the protein tyrosine kinases pp60src and Csk ( C terminal Src kinase ) as well as with the adapter / oncoprotein p47gag crk . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Regulation of cortactin and tensin hyperphosphorylation is Src dependent , whereas focal adhesion kinase and paxillin hyperphosphorylation is partly dependent on both Src and Fyn . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin physically complexes with two protein tyrosine kinases , pp60src and Csk ( COOH terminal src kinase ) , and the oncoprotein p47gag crk , each of which could function as part of a paxillin signaling complex . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In all , these results show that multiple mechanisms are involved in BK stimulated tyrosine phosphorylation of p125FAK , paxillin , Ras GAP associated p 125 , and src transformation associated p130 . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Src family tyrosine kinase Lyn binds several proteins including paxillin in rat basophilic leukemia cells . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| However , coexpression of an autophosphorylation site mutant of pp125FAK , which fails to bind the SH 2 domain of pp60c Src , or a mutant that fails to bind paxillin did not promote cell spreading . ^^^ In contrast , expression of pp41 / 43FRNK and pp60c Src reconstituted cell spreading and tyrosine phosphorylation of paxillin but did so without inducing tyrosine phosphorylation of pp125FAK . ^^^ These data provide additional support for a model whereby pp125FAK acts as a `` switchable adaptor ' ' that recruits pp60c Src to phosphorylate paxillin , promoting cell spreading . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemistry , sucrose density gradient sedimentation , co immunoprecipitation analyses and in vitro binding assays have shown that polycystin 1 associates with the focal adhesion proteins talin , vinculin , p130Cas , FAK , alpha actinin , paxillin and pp60c src in subconfluent normal human fetal collecting tubule ( HFCT ) epithelia when cell matrix interactions predominate . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Detection of Src homology 3 binding proteins , including paxillin , in normal and 5 Src transformed Balb / c 3T3 cells . ^^^ We identified paxillin , a vinculin binding protein , as one of the Src SH 3 binding proteins . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Although we have shown that the Csk Src homology 2 domain can bind to several tyrosine phosphorylated proteins , including pp125FAK and paxillin , a majority of protein which bound to Csk was IRS 1 when cells were stimulated by insulin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin is a 68 kD focal adhesion phosphoprotein that interacts with several proteins including members of the src family of tyrosine kinases , the transforming protein 5 crk , and the cytoskeletal proteins vinculin and the tyrosine kinase , focal adhesion kinase ( FAK ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| A signaling partnership is formed between FAK and Src family kinases , leading to tyrosine phosphorylation of FAK and associated ' docking ' proteins Cas and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The results show that the tyrosine phosphorylation levels of focal adhesion kinase , paxillin , and pp 60 ( src ) decreased immediately after mechanical separation of the cells . ^^^ Preincubation of cell monolayers with phenylarsine oxide , a protein tyrosine phosphatase inhibitor , blocked the decrease in tyrosine phosphorylation levels of focal adhesion kinase , paxillin and pp 60 ( src ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Here it is reported that ET 1 promotes the formation of stress fibers and focal adhesions and the tyrosine phosphorylation of focal adhesion kinase ( FAK ) and paxillin , as well as Src activation and association of phosphorylated FAK with Grb 2 . ^^^ Pretreatment of astrocytes with cytochalasin D or C 3 transferase , which inhibits actin polymerization or Rho activity , respectively , prevented the activation / phosphorylation of Src , FAK , and paxillin after ET 1 stimulation ; by contrast , the ERK pathway was not significantly affected . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin , a 65 70 kDa phosphoprotein containing high affinity binding sites common for the Src homology 2 ( SH 2 ) domains of CrkII and CrkL , was observed in both CrkII and CrkL immunoprecipitates . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| FAK / Src association activates both kinases , which act on the potential substrates tensin , paxillin and p130cas . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The activated FAK / Src complex acts on potential substrates tensin , paxillin and p130cas . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| This mutation also reduces Src dependent tyrosine phosphorylation on the mutant itself and downstream substrates , such as paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Three of these proteins were identified as Src , paxillin , and focal adhesion kinase ( FAK ) , all of which show an increase in their tyrosine phosphate levels with increasing density . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| There was a large , rapid and reversible increase in the tyrosine phosphorylation of the p 120 Src substrate in peroxynitrite treated SH SY5Y cells , a response that was potentiated by glutathione depletion ; in contrast , peroxynitrite decreased the tyrosine phosphorylation of focal adhesion kinase and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Proteins that also underwent redistribution in response to the tyrosine phosphatase inhibitor included paxillin , phospholipase C gamma 1 , mitogen activated protein kinase , and the tyrosine kinases Src and Fyn . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Using immunoprecipitation assays coupled to Western blot analysis , we demonstrate here the collagen dependent association of paxillin and Src with pp125FAK . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Furthermore , regulated association of Src SH 2 domain with FAK and paxillin during cell attachment and detachment on fibronectin was disrupted in Shp 2 mutant cells . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| When phosphorylated , Crkl binds through its Src homology 2 ( SH 2 ) domain to other tyrosine phosphoproteins such as paxillin and Cbl . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We have extended these studies by demonstrating that paxillin , another focal adhesion protein , and Src undergo tyrosine dephosphorylation in response to insulin in Chinese hamster ovary ( CHO ) and rat hepatoma ( HTC ) cells that overexpress the insulin receptor . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In addition , paxillin , a Src and / or pp 125 ( FAK ) substrate , displayed increased levels of tyrosine phosphorylation in PTPalpha expressing cells and was associated with elevated amounts of Csk . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin is a focal adhesion scaffolding protein which was originally identified as a substrate of the oncogenic tyrosine kinase , 5 src . ^^^ In addition , like paxillin , Hic 5 can bind to a negative regulator of Src PTKs , csk but does not bind to the adaptor protein Crk . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| FAK interacts with a number of signaling and cytoskeletal proteins , including Src , phosphatidylinositol 3 kinase , Grb 2 , p130Cas and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| On the other hand , overexpression of Csk DeltaK induced tyrosine phosphorylation of cellular proteins , including the paxillin and focal adhesion kinase ( FAK ) and enhanced to some extent the cytoskeletal organization and the rate of cell spreading on fibronectin , indicating that Src or its relatives was functionally activated in the cells . ^^^ These findings suggest that Csk regulates Src family tyrosine kinases that play essential roles in the regulation of cell adhesion via a FAK dependent mechanism and that the tyrosine phosphorylation of paxillin alone may not be sufficient for the regulation of the cell adhesion mechanism in astrocytes . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| These results strongly suggest that cyclic stretch induces the activation of pp 60 ( src ) and that pp 60 ( src ) is indispensable for the tyrosine phosphorylation of pp 130 ( CAS ) , pp 125 ( FAK ) and paxillin followed by the orienting response in 3Y1 fibroblasts . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| To measure the inhibition of cellular Src activity , we identified the major tyrosine phosphorylated proteins in an Src overexpressing cell line IC8 . 1 as Src , Fak , and paxillin . ^^^ CGP 77675 potently inhibited tyrosine phosphorylation of the Src substrates Fak and paxillin , but had much less effect on Src ( IC 50 values 0 . 3 , 0 . 5 , and 5 . 7 micromol / L ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Focal adhesion kinase ( FAK ) plays a prominent role in the adhesion signaling pathway through its tyrosine kinase activity and protein protein interaction with other signaling molecules , including src , paxillin , and p130CAS , and other proteins . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of p125FAK and paxillin focal adhesion proteins in src transformed cells with different metastatic capacity . ^^^ To check this hypothesis , phosphorylation of the FAK and paxillin proteins , involved in signal transduction pathways and known as src protein substrates , was tested . ^^^ In addition , our data confirm that 5 src protein plays a direct role in paxillin phosphorylation . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The mutant exhibited reduced levels of phosphotyrosine relative to wild type paxillin in subconfluent cells growing in culture , following cell adhesion to fibronectin and in src transformed fibroblasts . ^^^ These results suggest that paxillin must bind FAK for maximal phosphorylation in response to cell adhesion and that FAK may function to direct tyrosine phosphorylation of paxillin in the process of transformation by the src oncogene . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Furthermore , VEGF induction enhanced the complex formation between Src kinase and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Corroborating results showed altered localizations of src in dilated cardiomyopathy and paxillin in both cardiomyopathic phenotypes . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| These include bombesin induced assembly of focal adhesions , formation of parallel arrays of actin stress fibers , increase in the tyrosine phosphorylation of focal adhesion kinase ( FAK ) , p 130 ( Cas ) , and paxillin , and formation of a complex between FAK and Src . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Evidence that E4orf4 can associate with and modulate Src family kinase activity , inhibiting Src dependent phosphorylation of focal adhesion kinase ( FAK ) and paxillin while increasing phosphorylation of cortactin and some other cellular proteins , is presented . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In addition , negative regulators of these pathways , including CSK ( an inhibitor of SRC activity ) and PTP PEST ( a phosphatase that dephosphorylates p130Cas ) , bind directly to paxillin , thereby bringing them into close proximity with their targets . ^^^ Several of the paxillin binding proteins have oncogenic equivalents , such as 5 Src , 5 Crk and BCR ABL ( not shown ) . ^^^ Abbreviations : CAS , CRK associated substrate ; CH , calponin homology domain ; CSK , C terminal SRC kinase ; E 6 , Papillomavirus E 6 protein ; FAK , focal adhesion kinase ; GIT , GRK interacter ; GPCR , heterotrimeric G protein coupled receptor ; GRK , G protein coupled receptor kinase ; MAPK , mitogen activated protein kinase ( ERK , p 38 , JNK ) ; PAK , p 21 activated kinase ; PBS , paxillin binding subdomain ; PIX , PAK interacting exchange factor ; PKL , paxillin kinase linker ; POR 1 , partner of Rac ; PS , phosphoserine ; PT , phosphothreonine ; PY , phosphotyrosine ; RTK , growth factor receptor tyrosine kinase ; SH , SRC homology domain . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Herbimycin A promoted recovery of paxillin and phosphotyrosine into nascent focal adhesion sites , in addition to restoring normal src tyrosine kinase distribution . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Gastrin and CCK also induce rapid Rho dependent actin remodeling and coordinate tyrosine phosphorylation of cellular proteins including the non receptor tyrosine kinases p125fak and Src and the adaptor proteins p130cas and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Src deficient cells attach to but do not spread on vitronectin ( Vn ) coated surfaces and , contrary to wild type cells , their adhesion does not lead to tyrosine phosphorylation of molecules activated by adhesion , including PYK 2 , p 130 ( Cas ) , paxillin , and PLC gamma . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Interestingly , tyrosine phosphorylation of paxillin , but not p130cas , was induced by expression of Src FAT , suggesting a potential role of paxillin in mediating stimulation of cell migration by the chimeric molecule . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Integrin engagement caused the formation of phosphorylated pp 60 ( src ) / focal adhesion kinase complexes and the aggregation of focal adhesion plaques containing the beta ( 3 ) integrin subunit , the cytoskeletal proteins vinculin , cortactin , and paxillin , the tyrosine kinases focal adhesion kinase and pp 60 ( src ) , the adapter protein Grb 2 , and the mitogen activated protein kinase ERK 2 . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Consistent with a delay in tyrosine phosphorylation of paxillin , PDGF treatment caused a lag in focal complex formation , although this was not associated with any change in Src family tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The src family kinase selective inhibitor PP 1 reduced carbachol stimulated tyrosine phosphorylation of FAK , Cas , and paxillin by 50 to 75 % . ^^^ Thus , muscarinic receptors activate protein tyrosine phosphorylation in differentiated cells , and the tyrosine phosphorylation of FAK , Cas , and paxillin , but not ERK1 / 2 , is mediated by a src family tyrosine kinase activated in response to stimulation of muscarinic receptors . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In cells transformed by the src , crk or BCR Abl oncogenes , the phosphotyrosine content of paxillin is elevated . ^^^ These stimuli induce tyrosine phosphorylation of paxillin , regulating the association of Src homology 2 domain containing signalling molecules with paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| FAK regulates tyrosine phosphorylation of CAS , paxillin , and PYK 2 in cells expressing 5 Src , but is not a critical determinant of 5 Src transformation . ^^^ Our results portray FAK as a major 5 Src substrate that also plays a role in recruiting 5 Src to phosphorylate substrates CAS ( Crk associated substrate ) and paxillin . ^^^ Despite these effects , FAK does not play an essential role in targeting 5 Src to major cellular substrates including CAS and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin associates with numerous signaling molecules including adaptor molecules ( p130Cas , CRK ) , kinases ( FAK , Pyk 2 , PAK and SRC ) , tyrosine phosphatases ( PTP PEST ) , ARF GAP proteins ( p95pkl , PAG 3 ) and papillomavirus E 6 oncoproteins . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In contrast , Src mutations in the SH 2 or SH 3 domain greatly reduced binding to FAK , Cas , and paxillin but had little effect on tyrosine phosphorylation or biological assays . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Ligation of HLA class 1 molecules on endothelial cells induces phosphorylation of Src , paxillin , and focal adhesion kinase in an actin dependent manner . ^^^ In this study , we show that ligation of HLA class 1 molecules on the surface of human aortic endothelial cells stimulates phosphorylation of Src , focal adhesion kinase , and paxillin . ^^^ Inhibition of Src protein kinase activity blocked HLA class 1 stimulated tyrosine phosphorylation of paxillin and focal adhesion kinase . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Here , endothelial GM 7373 cells spread and organize focal adhesion plaques on immobilized FGF 2 , fibronectin ( FN ) , and vitronectin ( VN ) . alpha ( 5 ) beta ( 3 ) integrin , paxillin , focal adhesion kinase , vinculin and pp 60 ( src ) localize in cell substratum contact sites on FGF 2 , FN or VN . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PP 2A caused hyperphosphorylation of the paxillin serine residues and dephosphorylation of its tyrosine residues , dissolution of FAK / Src / paxillin complexes and decreased phosphorylation of the inhibitory Y 529 residue of Src , suggesting increased Src activity . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated Tyr31 / 118 was found to bind to two src homology ( SH ) 2 domains of p120RasGAP , with coprecipitation of endogenous paxillin with p120RasGAP . p190RhoGAP is known to be a major intracellular binding partner for the p120RasGAP SH 2 domains . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PP 2A also led to the dissolution of FAK / Src / paxillin focal adhesion complexes , which was also dependent on paxillin S 457 and S 481 residues . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| CalA stimulated an increase in MLCP , Src kinase activity , an increase in the tyrosine phosphorylation of paxillin and focal adhesion ( FA ) kinase ( p 125 ( FAK ) ) , and monolayer hyperpermeability . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| PP 2 , an inhibitor of Src family tyrosine kinases , prevented the TLR induced phosphorylation of paxillin and Pyk 2 without affecting TLR induced IRAK activation . ^^^ Thus , TLR regulate the function of paxillin in an Src family dependent mechanism through both MyD 88 dependent and MyD 88 independent pathways . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| This adhesion induces recruitment and activation of the focal adhesion kinase Pyk 2 , the cytoskeleton linker paxillin , and the Src kinases Lck and Fyn in the contact site . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Src family kinases recruited to the Tyr 397 site phosphorylate two FAK interacting proteins , Crk associated substrate ( CAS ) and paxillin , which results ultimately in regulation of Rho family GTPases contributing to cell motility . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Transient overexpression of FRNK in SMC attenuated autophosphorylation of FAK at Tyr 397 , reduced Src family dependent tyrosine phosphorylation of FAK at Tyr 576 , Tyr 577 , and Tyr 881 , and reduced phosphorylation of the FAK / Src substrates Cas and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| PYK 2 has ligand sequences for Src homology 2 and 3 ( SH 2 and SH 3 ) , and has binding sites for paxillin and p 130 ( cas ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We show that the overexpression of CrkII or CrkL , but not Src homology 2 or amino terminal Src homology 3 domain mutant Crk proteins , promotes the relocalization of Paxillin to focal contacts throughout the cell and within lamellipodia in a Rac dependent manner . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin , a substrate of both Abl and Src , organizes a similar regulatory complex . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| METHODS : Triton 10 insoluble ( actin cytoskeleton ) fractions from suspension phase cells and cells adherent to the beta ( 1 ) integrin ligand fibronectin were assessed for the presence of the integrin associated kinase Pyk 2 , the scaffolding protein paxillin , and the downstream Src family kinase Lyn . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| PAF exposure induced binding of p 130 ( Cas ) , Src , SHC , and paxillin to FAK . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Examples will include studies of ECM proteins , such as fibronectin , and proteins associated with focal adhesion complexes that involve fibronectin , integrins and various intracellular modular proteins , such as focal adhesion kinase , Src family kinases , talin and paxillin . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with the specific Src inhibitor PP 2 , or expression of dominant negative , kinase dead c Src abrogates EphB 1 induced tyrosine phosphorylation of paxillin . ^^^ These data suggest a model in which ligand activated EphB 1 forms a signaling complex with Nck , paxillin , and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c Src dependent manner to promote cell migration . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Activated STAT 3 coimmunoprecipitated with phosphorylated paxillin and focal adhesion kinase and required paxillin and Src for its localization to focal adhesions . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| However , Src significantly enhanced RAFTK mediated paxillin phosphorylation , suggesting a key role for Src in RAFTK activation and phosphorylation of downstream substrates . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of paxillin was reduced by HGF and was sensitive to the Src kinase inhibitor PP 2 . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Roles of Gab 1 and SHP 2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor . ^^^ Epidermal growth factor ( EGF ) induces paxillin tyrosine dephosphorylation and Src activation , but the signaling pathways that mediate these responses were largely undefined . ^^^ SHP 2 dephosphorylated paxillin and caused dissociation of Csk , a negative regulator of Src , from paxillin but had no effect on paxillin Src association . ^^^ A lower level of Src Tyr 530 phosphorylation was detected in paxillin associated Src in EGF stimulated cells . ^^^ Expression of an SHP 2 binding defective mutant of Gab 1 ( Gab1FF ) or a catalytically inactive mutant of SHP 2 ( SHP2DN ) prevented paxillin tyrosine dephosphorylation and Src activation induced by EGF . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Further analysis demonstrated that , although TSA reduced the expression of Eps 8 in a dose and time dependent manner , both the protein expression and kinase activity of 5 Src remained constant , and the abundance and phosphotyrosine levels of Src substrates , including cortactin , focal adhesion kinase , p 130 ( Cas ) , paxillin , and Shc , were not altered . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| FAK Src signalling through paxillin , ERK and MLCK regulates adhesion disassembly . ^^^ Using these assays , we show that kinases and adaptor molecules , including focal adhesion kinase ( FAK ) , Src , p130CAS , paxillin , extracellular signal regulated kinase ( ERK ) and myosin light chain kinase ( MLCK ) are critical for adhesion turnover at the cell front , a process central to migration . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Oxidative stress activates both Src kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk : caveolin 1 and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| After CD155alpha stimulation with its ligands , cell adhesion was inhibited and cell motility was enhanced , effects that were associated with the phosphorylation of ITIM by Src kinases and accompanied by dephosphorylation of focal adhesion kinase and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| CAS expression led to a substantial increase in the phosphotyrosine content of FAK and paxillin , supporting a role for CAS as a positive regulator of Src activity at integrin adhesion sites . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Cardiomyocyte apoptosis triggered by RAFTK / pyk2 via Src kinase is antagonized by paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We will identify the key players in the integrin mediated signaling pathways involved in cell motility and apoptosis , such as FAK , paxillin and p 130 ( CAS ) , and discuss how Src signaling affects the formation of focal adhesions and the extracellular matrix . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In conclusion , these results suggest that Ang 2 mediates an increase in FAK and paxillin phosphorylation and induces HUVEC migration through signal transduction pathways dependent on PI3K and Src tyrosine kinase activation and EGFR transactivation . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We observed that collagen 4 also stimulated Src dependent phosphorylation of both paxillin Tyr 31 and paxillin Tyr 118 . ^^^ Although p130cas siRNA inhibited cell spreading on collagen 4 by 33 % , three different paxillin siRNAs did not inhibit cell spreading . p130cas siRNA did not affect Src Tyr 416 or Src Tyr 527 phosphorylation , FAK Tyr 397 phosphorylation , or Src dependent phosphorylation of FAK Tyr 925 , suggesting that p130cas did not inhibit cell spreading by altering FAK or Src activity . ^^^ These results suggest that Src may regulate Caco 2 migration on collagen 4 via both p130cas and paxillin but that Src phosphorylation of p130cas is more important for this process . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Activity of Src family kinase correlated well with metastatic potential , and a Src family kinase inhibitor , PP 2 , not only abolished tyrosine phosphorylation of paxillin but also impaired the motility of high metastatic sublines . ^^^ These findings suggest that enhanced activity of Src family kinases and overexpression of paxillin synergistically contribute to the high metastatic potential of human osteosarcoma through the hyperphosphorylation of paxillin . . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| We recently reported that reexpression of CAS in CAS deficient mouse embryo fibroblasts transformed by oncogenic Src promoted an invasive phenotype associated with enhanced cell migration through Matrigel , organization of actin into large podosome ring and belt structures , activation of matrix metalloproteinase 2 , and elevated tyrosine phosphorylation of the focal adhesion proteins FAK and paxillin . ^^^ The ability of CAS to promote Matrigel invasion , formation of large podosome structures , and tyrosine phosphorylation of Src substrates , including FAK , paxillin , and cortactin , was also strictly dependent on the YxxP tyrosines . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| RESULTS : CN binding to integrins can mimic the intracellular signaling cascade evoked by FN , because the phosphorylation of the key signaling proteins focal adhesion kinase , paxillin , and p 130 Crk associated substrate and the association of Src with focal adhesion kinase are similar . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Src and FAK kinases cooperate to phosphorylate paxillin kinase linker , stimulate its focal adhesion localization , and regulate cell spreading and protrusiveness . ^^^ PKL is phosphorylated on tyrosine residues 286 / 392 / 592 by Src and / or FAK and these sites are required for PKL localization to focal adhesions and for paxillin binding . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Kit modulated phosphorylation dependent interactions with pathways controlling focal adhesion ( paxillin , leupaxin , p130CAS , FAK 1 , the Src family kinase Lyn , Wasp , Fhl 3 , G25K , Ack 1 , Nap 1 , SH3P12 / ponsin ) and septin actin complexes ( NEDD 5 , cdc 11 , actin ) . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In addition , under anoikis stress , the induction of the Y397F mutant in 5 Src transformed FAK ( / ) cells selectively led to a decrease in the level of p 130 ( Cas ) , but not other focal adhesion proteins such as talin , vinculin , and paxillin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Ang 2 induced AT1R activation via Gq / 11 stimulates phospholipases A 2 , C , and D , and activates inositol trisphosphate / Ca2+ signaling , protein kinase C isoforms , and MAPKs , as well as several tyrosine kinases ( Pyk 2 , Src , Tyk 2 , FAK ) , scaffold proteins ( G protein coupled receptor kinase interacting protein 1 , p130Cas , paxillin , vinculin ) , receptor tyrosine kinases , and the nuclear factor kappaB pathway . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The effects on migration and invasion correlated with the inhibition of Src and downstream mediators of adhesion [ e . g . , focal adhesion kinase ( FAK ) , p 130 , and paxillin ] , and the cell cycle effects and apoptosis correlated with the induction of p 27 and the dephosphorylation of Rb . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| This appears to occur through assembly of an EphB associated protein complex that includes focal adhesion kinase ( FAK ) , Src , Grb 2 , and paxillin and the subsequent activations of FAK , Src , paxillin , and RhoA . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| This results in the reduction of Src kinase activity and dephosphorylation of paxillin at Tyr 31 / 118 , the target sites for Src kinase phosphorylation and also the binding sites for the downstream effector Crk . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| The puncta co localized with focal adhesion kinase ( FAK ) and Src , and defined the distal tips of cell matrix adhesion sites identified with paxillin and vinculin . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| In addition , we observed that in response to gastrin , beta 1 integrin is tyrosine phosphorylated by Src family kinases and associates with paxillin , a scaffold protein involved in focal adhesion and integrin signalling . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of phosphatidylinositide 3 kinase , extracellular signal regulated kinase ( ERK ) , and Src kinase reduced the adhesion and migration of VSMCs on betaig h 3 . betaig h 3 triggered phosphorylation and activation of AKT , ERK , focal adhesion kinase , and paxillin mediating the adhesion and migration of VSMCs . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| Paxillin is a substrate of the Src tyrosine onco kinase and is involved in cell transformation , cell spreading , migration , and cancer development mediated through the mitogen activated protein kinase signaling cascades . ^^^ |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|