| Interacting proteins: P43146 and P12931 |
Pubmed |
SVM Score :0.99690856 |
| Here we show that different regions of the intracellular domain of DCC directly interacted with the tyrosine kinases Src and focal adhesion kinase ( FAK ) . 0.99690856^^^ |
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| Interacting proteins: P43146 and P12931 |
Pubmed |
SVM Score :0.0 |
| Reported molecular genetic abnormalities involve tumor suppressor genes that undergo inactivation ( e . g . , apc , mcc , dcc , p 53 , and possibly genes on chromosomes 8p , 1p , and 22q ) and dominant acting oncogenes ( e . g . , ras , src , and myc ) . ^^^ |
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| Interacting proteins: P43146 and P12931 |
Pubmed |
SVM Score :0.0 |
| Identified abnormalities include both dominant acting oncogenes ( ras , myc , src ) and suppressor genes which undergo inactivation or deletion ( deleted in colorectal carcinoma gene [ DCC ] , p 53 , adenomatous polyposis coli gene [ APC ] , and probably loci on chromosomes 1p and 22q ) . ^^^ |
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| Interacting proteins: P43146 and P12931 |
Pubmed |
SVM Score :0.0 |
| The genetic abnormalities include both dominant acting oncogenes ( Ki ras , c src ) and tumor suppressor genes which undergo inactivation or loss ( APC , DCC , p 53 ) . ^^^ |
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| Interacting proteins: P43146 and P12931 |
Pubmed |
SVM Score :0.0 |
| Kornblum ' s ( 1992 ) Type 5 ensembles , irrelevant stimulus response compatibility ( SRC ) , logical recoding , display control arrangement correspondence ( DCC ) , and stimulus congruity are confounded . ^^^ By using 3 response alternatives and both compatible and incompatible stimulus response mappings , irrelevant SRC was pitted against logical recoding and both of them were disentangled from DCC and stimulus congruity . ^^^ |
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| Interacting proteins: P43146 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we show that DCC is phosphorylated in vivo on tyrosine residues in response to Netrin 1 stimulation of CN and that the Src family kinase inhibitors PP 2 and SU 6656 block both Netrin 1 dependent phosphorylation of DCC and axon outgrowth . ^^^ Fyn , but not Src , is able to phosphorylate the intracellular domain of DCC in vitro , and we demonstrate that Y 1418 is crucial for DCC axon outgrowth function . ^^^ |
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