| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest that the I4R motif encodes binding sites for several protein tyrosine binding ( PTB ) domain containing proteins such as IRS 1 and Shc and potentially for the Src homology 2 domain of signal transducer and activator of transcription 6 ( STAT 6 ) . ^^^ |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that the structural homology between the SH 2 domain of Stat 6 and that of the distantly related Src protein may be higher than predicted on the basis of primary amino acid sequence comparisons . ^^^ |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we found that an Src kinase was involved in STAT 6 activation because 1 ) Src kinase activity was induced by IL 4 , 2 ) Src kinase activity , but not Janus kinase , was inhibited by salicylates in vitro , 3 ) cells expressing viral Src had constitutive STAT 6 phosphorylation , and 4 ) cells lacking Src showed low STAT 6 phosphorylation in response to IL 4 . ^^^ |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| IL 4 enhancement of HGF signaling was partially blocked in 32D / c Met cells treated with inhibitors of MEK 1 or c Src kinases , completely blocked by expression of a catalytically inactive mutant of Janus kinase 3 ( Jak 3 ) , and increased in 32D / c Met cells overexpressing STAT 6 . ^^^ |
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| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the absence of functional Src homology containing phosphatase 1 ( SHP 1 ) , the early loss of tyrosine phosphorylated Stat 6 was substantially reduced . ^^^ |
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| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrphostin AG 490 , a JAK 2 inhibitor , or 4 amino 5 ( 4 methylphenyl ) 7 ( t butyl ) pyrazolo 3 , 4 d pyrimidine ( PPI ) , a Src kinase blocker , blocked STAT5A phosphorylation , whereas STAT 6 phosphorylation was blocked only with tyrphostin . ^^^ For the first time , the results also indicated a role of Src kinase pathway in STAT5A PC and PI 3 kinase Akt pathways appear to be the downstream regulator for STAT5A STAT 6 signaling pathway . . ^^^ |
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| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| The p 160 coactivator nuclear coactivator 1 ( Src 1 ) was specifically recruited by and coactivated Stat 6 but not the chimeric Stat 6 molecules . ^^^ |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , down regulation of this pathway during DC differentiation is accompanied by dramatic induction of suppressors of cytokine signaling 1 ( SOCS 1 ) , SOCS 2 , SOCS 3 , and cytokine induced Src homology 2 containing protein expression , suggesting that inhibition of STAT 6 signaling may be required for DC maturation . ^^^ |
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| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| Crystallization and preliminary crystallographic studies of the NCoA 1 / SRC 1 PAS B domain bound to the LXXLL motif of the STAT 6 transactivation domain . ^^^ Among them , NCoA 1 , a member of the p160 / steroid receptor coactivator ( SRC ) family , has been found to bind to STAT 6 with the region B of its putative Per Arnt Sim ( PAS ) domain . ^^^ |
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| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , Src homology 2 containing phosphatase mutation did not affect IL 4 induced STAT 6 phosphorylation in differentiated Th 1 cells derived from viable motheaten ( me ( 5 ) / me ( 5 ) ) mice . ^^^ |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| The staphylococcal nuclease like ( SN ) domains of p 100 directly interacted with amino acids 1099 1758 of CBP , while p 100 did not associate with SRC 1 , another coactivator of STAT 6 . p 100 was found to recruit histone acetyltransferase ( HAT ) activity to STAT 6 in vivo . ^^^ |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42226 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|