| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.65360121 |
| An association between c Src and STAT 1 was increased by IFN gamma and TPA , indicating the direct phosphorylation of STAT 1 by PKC dependent c Src activation . 0.65360121^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.77554285 |
| The rapid estrogenic effect involving the phosphorylation and activation of Stat 1 was blocked in the presence of Src family kinase inhibitor PP 2 ; activated Stat 1 was associated with Src protein in estrogen treated cells . 0.77554285^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results show that Src can tyrosine phosphorylate Stat 1 and Stat 3 but not Stat 5 in this system . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Src kinase inhibitor SU 6656 suppressed IFN gamma activation of Stat 3 in both wild type and Stat 1 / fibroblasts . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL 2 leads to the phosphorylation of Stat 1 alpha , Stat 1 beta , and Stat 3 , as well as of two Stat related proteins , p 94 and p 95 . p 94 and p 95 share homology with Stat 1 at the phosphorylation site and in the Src homology 2 ( SH 2 ) domain , but otherwise are immunologically distinct from Stat 1 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Southern blot analysis of genomic DNA using the src homology domain 2 ( SH 2 ) of Stat 1 alpha confirms the presence of a related gene in the Drosophila genome . . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Only the Src homology 2 ( SH 2 ) domains of Stat 1 and Stat 2 are critical for the ligand specific activation of interferon signaling . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results show that STAT 1 , STAT 3 , and STAT 5 exist in a constitutively phosphorylated state in 5 src transformed 32Dcl3 cells , while such constitutive phosphorylation is not seen in 5 fgr transformed cell lines . ^^^ However , STAT 1 and STAT 5 , which also exist in a constitutively phosphorylated state in 5 src transformed 32Dcl3 cells , do not coimmunoprecipitate with 5 Src , suggesting that these proteins either interact weakly with 5 Src or are phosphorylated by a mechanism distinctive from that of STAT3 . . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although 5 src is a more potent inducer of tyrosine phosphorylation than c src 527 , the extent of phosphorylation of either insulin receptor substrate 1 or Shc , two of the major substrates of the IGF 1 receptor , does not seem sufficiently different to explain the qualitative difference in soft agar growth . 5 src , however , is considerably more efficient than c src 527 in its ability to tyrosyl phosphorylate , in R cells , the focal adhesion kinase , Stat 1 , and p130cas . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both tyrosine phosphorylation and DNA binding activity of STAT 1 and STAT 3 are up regulated in c Src overexpressing cells , while we observe the opposite phenomenon in cells overexpressing the dominant negative Src . ^^^ Furthermore , our results show that STAT 1 co immunoprecipitates with c Src , suggesting that the activation of STATs by Src occurs via a direct interaction . ^^^ Taken together , these data suggest that c Src is involved in activation of both STAT 1 and 3 in PDGF signal transduction . . ^^^ Src activates both STAT 1 and STAT 3 in PDGF stimulated NIH3T3 cells . ^^^ Recently it has been shown that 5 Src modulates the tyrosine phosphorylation of STAT 3 but not of STAT 1 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| The important players in the signalling pathway , namely the cytokines and the receptor components , the Janus kinases Jak 1 , Jak 2 and Tyk 2 , the signal transducers and activators of transcription STAT 1 and STAT 3 and the tyrosine phosphatase SHP 2 [ SH 2 ( Src homology 2 ) domain containing tyrosine phosphatase ] are introduced and their structural / functional properties are discussed . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases ( Jak ) , phosphorylation of the signal transducing subunit gp 130 , followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT 3 and STAT 1 and the src homology domain ( SH 2 ) containing protein tyrosine phosphatase ( SHP 2 ) . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| In epithelial and fibroblast cells , PDGF activated STAT 1 , 3 and 6 in the absence of detectable binding and activation of Src . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have shown previously that the JAK 2 tyrosine kinase and the Src family p 59 Fyn tyrosine kinase are required for Ang 2 induced STAT 1 tyrosine phosphorylation in VSMCs . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Interestingly , pretreatment of T cells with the Src kinase inhibitor PP 1 completely abrogated CD 3 mediated serine phosphorylation of Stat 1 , whereas inhibitors to MEK 1 and phosphatidylinositol 3 kinase had no effect . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Last , the IFNalpha induced serine phosphorylation of STAT 1 and STAT 3 is not inhibited by piceatannol but is sensitive to the Src kinase specific inhibitor PP 2 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| This is associated with enhanced phosphorylation of STAT 1 , STAT 3 , and Fyn , a Src homology tyrosine kinase , which interacts with both TCR and IFN alpha signal components . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| The ICAM 1 promoter activity was stimulated by cotransfection with wild type PLC gamma 2 , PKCalpha , c Src , JAK 1 , or STAT 1 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using a pharmacological inhibitor of Src kinases CGP 77675 and cells with knockout c src , it was shown that Src activated STAT 1 upon stimulation by both epidermal growth factor and hypersomatic shock . ^^^ The role of SRC kinase in activation of transcription factor STAT 1 ] . ^^^ In this paper , the role of tyrosinkinases Src and JAK 2 was estimated in activation of STAT 1 by epidermal growth factor ( EGF ) and hyperosmotic shock . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| SOCS1R105K , carrying a mutation within the phosphotyrosine binding pocket of the Src homology 2 domain , did not inhibit STAT 1 phosphorylation , yet considerably inhibited IFN gamma mediated growth arrest . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Therefore , the C terminal region ( transcriptional activation and Src homology 2 domains ) of STAT 1 is not necessary for its degradation caused by MuV 5 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Upon JAK 2 activation , tyrosine phosphorylation of signal transducer and activator of transcription 1 ( STAT 1 ) , STAT 5b , insulin receptor substrate 1 ( IRS 1 ) , and Src homology and collagen homology ( Shc ) were detected . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 ( STAT 1 ) and STAT 3 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| STAT 1 and STAT 3 activation by oxidative stress in A 431 cells involves Src dependent EGF receptor transactivation ] . ^^^ Src kinase family inhibitor CGP 77675 blocked STAT 3 and STAT 1 activation by H2O2 in a concentration dependent manner . 2 . ^^^ In Src / fibroblasts , activation of both STAT 3 and STAT 1 by H2O2 was significantly attenuated . 3 . ^^^ In contrast , H2O2 mediated activation of STAT 1 requires only Src kinase activity . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : The expression of 16 AR coactivators and corepressors ( SRC 1 , beta catenin , TIF 2 , PIAS 1 , PIASx , ARIP 4 , BRCA 1 , AIB 1 , AIB 3 , CBP , STAT 1 , NCoR 1 , AES , cyclin D 1 , p 300 , and ARA 24 ) was measured in prostate cancer cell lines , xenografts , and clinical prostate tumor specimens by using real time quantitative reverse transcription PCR . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| In control , unprimed cells , IL 10 activation of STAT 1 was suppressed by constitutive activity of protein kinase C and Src homology 2 domain containing phosphatase 1 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| RET / PTC mediated signal transducer and activator of transcription 1 ( STAT 1 ) phosphorylation requires RET / PTC kinase activity to be intact but other tyrosine kinases , such as Janus kinases or c Src , are not involved . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Tip contains a putative consensus YXPQ binding motif for the SH 2 ( src homology 2 ) domains of STAT 1 and STAT 3 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| Activation of Src , JAK 2 , STAT 1 , STAT 3 , and ERK was determined by Western blotting using anti phospho specific antibodies . ^^^ RESULTS : PDGF BB induced STAT specific binding activity , and activation of Src , JAK 2 , STAT 1 , STAT 3 , and ERK . ^^^ PDGF induced activation of STAT 1 and STAT 3 was inhibited by a Src inhibitor PP 1 and a JAK 2 inhibitor AG 490 , whereas PDGF induced activation of ERK was inhibited by PP 1 , and not by AG 490 . ^^^ |
|
| Interacting proteins: P42224 and P12931 |
Pubmed |
SVM Score :0.0 |
| To enable disulfide dependent and spontaneous formation of active Stat 1 homodimer ( as was done previously for Stat 3 ) , we engineered Stat 1 CC with double cysteine substitutions in the Src homology 2 ( SH 2 ) homodimerization domain ( at Ala 656 and Asn 658 ) . ^^^ |
|