| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.53099062 |
| Physical association between Flk 1 , Src , and VE cadherin may thus provide an efficient mechanism for amplification and perpetuation of VEGF stimulated angiogenic processes . . 0.53099062^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor receptor 2 inhibition also reversed VEGF stimulated phosphorylation of CrkII and its Src homology 2 ( SH 2 ) binding protein p130Cas , which are known to play a pivotal role in regulating endothelial cell migration . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| We showed previously that flow activated the phosphatidylinositol 3 kinase ( PI3K ) , Akt , and endothelial nitric oxide synthase ( eNOS ) via Src kinase dependent transactivation of vascular endothelial growth factor receptor 2 ( VEGFR 2 ) . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| One such inhibitor , 4 ( 4 ' phenoxyanilino ) 6 , 7 dimethoxyquinazoline , had a 15 nM potency against Src TK and was selective over receptor tyrosine kinases VEGFR 2 by 88 fold and C fms by 190 fold . . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| When compared with normal lungs , SPH lungs showed decreased expression of the kinases PI 3 kinase and src , which , together with Akt , relay the signal transduction downstream of VEGFR 2 . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Mutation of tyrosine 1212 on VEGFR 2 to phenylalanine severely impaired the ligand dependent autophosphorylation of VEGFR 2 and its ability to associate with and activate Src . ^^^ Unlike mutation of tyrosine 1212 to phenylalanine , replacement of tyrosine 1212 with glutamic acid preserved the ligand dependent activation of VEGFR 2 and activation of VEGFR 2 associated signaling proteins including Src , phospholipase Cgamma 1 , and MAPK . ^^^ Further analysis showed that Src activation is not required for activation of VEGFR 2 , since cells co expressing wild type receptor with kinase dead Src or wild type Src displayed no apparent effect in the ligand dependent autophosphorylation of VEGFR 2 . ^^^ Similarly , expression of wild type VEGFR 2 in fibroblast ( SYF ) cells obtained from the triple knockout Src family kinases showed normal ligand dependent autophosphorylation . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Dissociation of the VEGFR 2 / caveolin 1 complex by VEGF or cyclodextrin led to a PP 2 sensitive phosphorylation of caveolin 1 on tyrosine 14 , suggesting the participation of Src family kinases in this process . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , VEGFR 2 , insulin receptor substrate 1 , and c Src were also involved in VEGF A induced activation of PI 3 kinase , resulting in the compensation in cells expressing kinase inactive c Fes . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Src kinases are involved in flow stimulated VEGFR 2 because inhibiting Src kinases by PP 2 , a selective inhibitor for Src kinases , abolishes flow induced VEGFR 2 tyrosine phosphorylation and downstream signaling . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Deletion or mutation of two Src homology 3 binding sites in the C terminal tail of the P2Y ( 2 ) R or inhibition of Src kinase activity abolished the P2Y ( 2 ) R mediated transactivation of VEGFR 2 and subsequently inhibited UTP induced VCAM 1 expression . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that stimulation of endothelial cells with vascular endothelial growth factor ( VEGF ) induces dissociation of caveolin 1 from the VEGFR 2 receptor , followed by Src family kinase dependent tyrosine phosphorylation of the protein ( Labrecque , L . , Royal , I . , Surprenant , D . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Pharmacological blockade of VEGF , VEGFR 2 , or Src stabilizes endothelial barrier function and suppresses tumor cell extravasation in vivo . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| This unorthodox antiangiogenic effect was mediated via VEGFR 1 activation and VEGFR 2 deactivation , the latter via Src homology domain 2 containing ( SH 2 containing ) tyrosine phosphatase 1 ( SHP 1 ) . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both the VEGF 165 mediated rise in cytosolic calcium and membrane depolarization are eliminated by inhibitors of VEGFR 2 , tyrosine kinase , src kinase and inositol 1 , 4 , 5 triphosphate operated calcium channels . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we report that S1P induces membrane ruffling of human umbilical vein endothelial cells ( HUVECs ) via the vascular endothelial growth factor receptor ( VEGFR ) , Src family tyrosine kinase ( s ) , and the CrkII adaptor protein . ^^^ Notably , the S1P induced CrkII phosphorylation was also abolished by inhibitors of VEGFR or Src family tyrosine kinases . ^^^ These results delineated a novel S1P signaling pathway that involves sequential activation of G ( 1 ) coupled receptor ( s ) , VEGFR , Src family tyrosine kinase ( s ) , and the CrkII adaptor protein , and which is responsible for both the induction of membrane ruffling and the increase in cell motility . . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src kinase becomes preferentially associated with the VEGFR , KDR / Flk 1 , following VEGF stimulation of vascular endothelial cells . ^^^ However , to date , it has not been determined which VEGF receptor ( VEGFR ) is involved in binding to and activating Src kinase following VEGF stimulation of the receptors . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| In biochemical assays , SU 10944 exhibits potent inhibitory activity against VEGFR 1 ; weak activity against other related subgroup members , including stem cell factor receptor ( SCFR ) , platelet derived growth factor receptor beta ( PDGFRbeta ) , and fibroblast growth factor receptor 1 ( FGFR 1 ) ; and no detectable activity against other protein tyrosine kinases such as epidermal growth factor receptor ( EGFR ) , Src , and hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Other promising new drugs currently under preclinical and clinical evaluation , are VEGFR 2 inhibitor PTK787 / ZK 222584 , thalidomide , farnesyl transferase inhibitor R 115777 ( tipifarnib , Zarnestra ( TM ) ) , matrix metalloproteinase inhibitors , proteasome inhibitor bortezomib ( Velcade ( TM ) ) , mammalian target of rapamycin ( mTOR ) inhibitors , cyclooxygenase 2 ( COX 2 ) inhibitors , platelet derived growth factor receptor ( PDGF R ) inhibitors , protein kinase C ( PKC ) inhibitors , mitogen activated protein kinase kinase ( MEK ) 1 / 2 inhibitors , Rous sarcoma virus transforming oncogene ( SRC ) kinase inhibitors , histondeacetylase ( HDAC ) inhibitors , small hypoxia inducible factor ( HIF ) inhibitors , aurora kinase inhibitors , hedgehog inhibitors , and TGF beta signalling inhibitors . . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| VEGFR 2 activation was shown to be calcium and Src family kinase dependent by use of specific drug inhibitors and dominant negative kinase transfection . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| These compounds were evaluated for their inhibitory properties toward VEGF R 2 ( Flk 1 / KDR ) , FGF R 1 , PDGF Rbeta , p 60 ( c ) ( ) ( ) ( ) ( Src ) ( ) , and EGF R tyrosine kinases and their ability to inhibit growth factor dependent cell proliferation . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| VEGF mediated decreased TER was also significantly attenuated by inhibition of ERK1 / 2 MAPK but not by inhibition of fetal liver kinase 1 ( flk 1 ) or Src kinase . ^^^ In contrast , VEGF mediated endothelial migration was not attenuated by ERK1 / 2 inhibition but was abolished by inhibition of either flk 1 or Src kinase . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| M 475271 inhibited VEGF induced Flk 1 and Src phosphorylation and their association . ^^^ Confocal laser microscopic examination confirmed the inhibitory effect of M 475271 on VEGF induced Flk 1 / Src association . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Members of the Src family such as Fyn and Yes showed an increased level of phosphorylation upon VEGF stimulation of cells expressing Flt 1 but not in cells expressing KDR . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibition of tyrosine kinase , Src tyrosine kinase , protein kinase C , and mitogen activated protein kinase activities all blocked VEGF induced KDR up regulation . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| The 3 ( 3 , 5 dimethoxyphenyl ) derivatives were low nanomolar inhibitors of both FGFR and VEGFR and were highly selective ( > 100 fold ) over PDGFR and c Src . ^^^ The 3 ( 2 , 6 dichlorophenyl ) 2 urea derivatives were slightly less active against VEGFR and less selective , being more effective against PDGFR ( ca . 10 fold ) and c Src ( ca . 500 fold ) . ^^^ The 3 ( 3 , 5 dimethoxyphenyl ) 1 , 6 naphthyridines were generally more potent than the corresponding pyrido [ 2 , 3 d ] pyrimidines against both VEGFR and FGFR ( 2 to 20 fold ) , with only slightly increased PDGFR and c Src activity . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Therapeutic maneuvers may target receptor tyrosine kinases ( EGFR , VEGFR , FGFR ) , chemokines or G protein coupled receptors ( CXCR 4 , CXCR 2 , EphB 2 ) , hypoxia inducible factor ( HIF ) , and signaling pathways ( c Src , PI3K , Akt , chaperon complexes ) in tumor cells . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Angiogenic growth factors and their receptors , such as basic fibroblast growth factor ( bFGF ) and Flg , vascular endothelial growth factor ( VEGF ) and Flk 1 , platelet derived growth factor ( PDGF ) B chain and PDGF beta receptor , and five intracellular signal proteins ( phosphatidylinositol 3 kinase [ PI3K ] , phospholipase C gamma [ PLC gamma ] , C Src , SHC , and mitogen activated protein kinase [ MAPK ] ) were examined by Western blot analysis . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| This review covers the literature on significant studies of small molecule inhibitors of the epidermal growth factor receptor ( EGFR ) , platelet derived growth factor receptor ( PDGFR ) , fibroblast growth factor receptor ( FGFR ) , Flk 1 , and src family tyrosine kinases from 1996 through mid 1997 . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| KDR recycling appears to be distinct from the previously characterized Rab 4 and Rab 11 dependent pathways , but , instead , KDR ( + ) recycling vesicles contain Src tyrosine kinase and VEGF stimulated recycling requires Src activation . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk 1 / KDR activation of c Src . ^^^ The data showed that VEGF stimulates complex formation of the flk 1 / kinase insert domain containing receptor ( KDR ) VEGF receptor with c Src and that Src activation is required for VEGF induction of phospholipase C gamma 1 activation and inositol 1 , 4 , 5 trisphosphate formation . ^^^ This effect is mediated by a signaling cascade initiated by flk 1 / KDR activation of c Src , leading to phospholipase C gamma 1 activation , inositol 1 , 4 , 5 trisphosphate formation , release of [ Ca ( 2+ ) ] ( 1 ) and nitric oxide synthase activation . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| The nature of the substitution affected enzyme selectivity and potency for lck , src , kdr , and tie 2 . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Special attention was directed toward finding inhibitors selective against KDR tyrosine kinase in order to ensure that the in vivo profile of a specific Src inhibitor could be determined . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that Shb is phosphorylated in an Src dependent manner upon vascular endothelial growth factor ( VEGF ) stimulation using porcine aortic endothelial cells expressing the human VEGF receptor 2 ( VEGFR 2 ) ( KDR ) . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| Biochemical studies revealed that TKI 28 potently inhibited the activities of tyrosine kinases such as ErbB 2 , EGFR , KDR , PDGFRbeta , c kit and c Src , but had little effect on Flt 1 in cell free system . ^^^ |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|