| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Nitric oxide ( NO ) , generated by the endothelial NO synthase ( NOS ) and acting via the formation of reactive oxygen species , activates the epsilon isoform of protein kinase C ( PKC ) , which activates the Src family of protein tyrosine kinases ( Src and Lck ) and transcription factors ( nuclear factor kappaB , and possibly others ) , with resultant upregulation of the inducible NOS ( iNOS ) gene and protein expression . iNOS , and other cardioprotective proteins , including cyclooxygenase 2 and aldose reductase , confer resistance to subsequent ischemic stress . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Genistein ( broad spectrum protein tyrosine kinase inhibitor , 10 microg / ml ) , PP 1 ( src family kinase inhibitor , 5 microg / ml ) , polymyxin B ( protein kinase C ( PKC ) inhibitor , 100 microg / ml ) , and Ro 31 8220 ( PKC inhibitor , 1 microM ) significantly inhibited anti CD8alpha and anti CD8beta stimulated NO production and inducible NO synthase up regulation , suggesting that tyrosine kinase ( s ) ( src family ) and PKC are involved in CD 8 signaling . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Chemical signals released by a sublethal ischemic stress ( such as NO , reactive oxygen species , and adenosine ) trigger a complex cascade of signaling events that includes the activation of protein kinase C , Src protein tyrosine kinases , and nuclear factor kappaB and culminates in increased synthesis of inducible NO synthase , cyclooxygenase 2 , aldose reductase , Mn superoxide dismutase , and probably other cardioprotective proteins . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Sublethal ischemic insults release chemical signals ( nitric oxide [ NO ] , adenosine , and reactive oxygen species ) that trigger a series of signaling events ( eg , activation of protein kinase C , Src protein tyrosine kinases , Janus kinases 1 / 2 , and nuclear factor kappaB ) and culminates in increased synthesis of inducible NO synthase , cyclooxygenase 2 , heme oxygenase 1 , aldose reductase , Mn superoxide dismutase , and probably other cardioprotective proteins . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| In an attempt to identify this protein , immunoblotting was carried out with antibodies to the signal transducing proteins rasGAP , JAK 2 iNOS , p125FAK , and the Src substrate , pp 120 , but all proved negative . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| As expected , herbimycin A can block Src kinase activity under circumstances in which iNOS expression is also inhibited . ^^^ The study results suggest that Src tyrosine kinase plays a prominent role in transducing the signal to induce iNOS expression in hepatocytes treated with TNF alpha / LPS / ethanol . . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| PKC epsilon activation triggers a complex signaling cascade that involves tyrosine kinases ( among which Src and Lck appear to be involved ) and probably other kinases , the transcription factor NF kappa B , and most likely other as yet unknown components , resulting in increased transcription of the iNOS gene and increased iNOS activity on day 2 , which is responsible for the protection during the second ischemic challenge . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Inhibitor of src family kinases ( PP 1 ) significantly ( p < 0 . 05 ) inhibited CD8alpha ( OX 8 antibody ) induced iNOS upregulation , NO , TNF alpha and IL 1beta production in rat AM . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| The src family selective tyrosine kinase inhibitor PP 1 blocks LPS and IFN gamma mediated TNF and iNOS production in murine macrophages . ^^^ We report that the pyrazolopyrimidine PP 1 , a src family selective tyrosine kinase inhibitor , potently inhibits the production of TNF and inducible nitric oxide synthase ( iNOS ) in RAW 264 . 7 murine macrophages stimulated with LPS , rlFN gamma , or LPS + rIFN gamma . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| We here provide evidence that PPARgamma ' s ability to repress iNOS transcription requires the ligand dependent charge clamp that mediates interactions with CBP and SRC 1 . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| The sarcoma virus tyrosine kinase ( Src ) family selective inhibitor 4 amino 5 ( 4 methylphenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine ( PP 1 ) blocked the upregulation of IL 1beta mRNA and the subsequent induction of iNOS but not the induction of iNOS stimulated by exogenously added IL 1beta . ^^^ In contrast , the non Src inhibitors TP 47 / AG 213 and genistein and the tyrosine phosphatase inhibitor vanadate did not affect the spontaneous upregulation of IL 1beta mRNA but blocked both the IL 1beta mediated and spontaneous induction of iNOS . ^^^ We conclude that 1 ) the upregulation of tissue IL 1beta , via a signaling pathway involving a Src family kinase , plays a key role in rat vascular iNOS induction and 2 ) non Src tyrosine kinases play roles downstream from IL 1beta for iNOS induction . . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Treatment of EMC D virus infected mice with the Src kinase inhibitor , PP 2 , resulted in the inhibition of p59 / p56 ( Hck ) activity and almost complete inhibition of the production of TNF alpha and iNOS in macrophages and the subsequent prevention of diabetes in mice . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that ( 1 ) ischemic PC upregulates cardiac COX 2 via PKC , Src PTK , and NF kappaB dependent signaling pathways , whereas generation of NO and ROS is not necessary , and ( 2 ) the activity of newly synthesized COX 2 following PC requires iNOS derived NO whereas iNOS activity is independent of COX 2 derived prostanoids , indicating that COX 2 is located downstream of iNOS in the protective pathway of late PC . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| HGF induced iNOS expression was partially abrogated in the presence of the phosphatidylinositol 3 kinase ( PI 3 kinase ) inhibitor LY 294002 , but not the Src kinase inhibitor , PP 1 . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| In a human intestinal epithelial cell line stimulated with cytokines , tyrosine phosphorylation of human iNOS protein was observed after 30 min exposure to pervanadate ( PV ) , an inhibitor of protein tyrosine phosphatases . 4 Amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine , a specific inhibitor of Src tyrosine kinases , abolished the PV induced iNOS tyrosine phosphorylation . ^^^ Cotransfection of Src with iNOS cDNA in human embryonic kidney ( HEK ) 293 cells resulted in a threefold ( P < 0 . 001 ) increase of iNOS protein levels and tyrosine phosphorylation of iNOS . ^^^ In the presence of Src , 76 % of wild type ( wt ) iNOS was redistributed to detergent insoluble domains and iNOS activity was decreased by 28 % ( P < 0 . 05 ) despite increased iNOS protein levels . ^^^ Analysis of iNOS tyrosine mutants revealed decreased Src induced effects in Y151F iNOS mutant . ^^^ These findings indicate a role for iNOS tyrosine phosphorylation in the regulation of iNOS activity and the implication of Src tyrosine kinases in this pathway . . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Upregulated expression of the mineralocorticoid receptor aldosterone synthase ( CYP11B2 ) ; NAD ( P ) H oxidase p22phox , p47phox , gp91phox , iNOS , and LOX 1 ; and activated p 65 NF kappaB , protein kinase CbetaII , c Src , p44 / p42 extracellular signal regulated kinase , and p70S6 kinase phosphorylation were inhibited by eplerenone . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Three cloned cells inducing nos . 4 and 9 had an ability of inducing osteoclasts ( multinucleated giant cells , TRAP , calcitonin receptor and c src mRNAs , osteoresorbing activity ) , and three cells , including nos . 1 and 5 , did not show the ability . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Part of these events is mediated by mitogen activated protein kinases ( MAPKs ) and tyrosine kinases ( e . g . , Src ) and leads to the modulation of survival and apoptotic factors [ e . g . , Bcl 2 family members , inhibitors of apoptosis ( IAPs ) , ceramide ] as well as enzymes involved in carcinogenesis [ cyclooxygenases ( COXs ) , nitric oxide synthase ( NOS ) , phase 1 and 2 enzymes ] . ^^^ |
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| Interacting proteins: P35228 and P12931 |
Pubmed |
SVM Score :0.0 |
| Preincubation of platelets with the Src kinase inhibitor PP 2 ( 20 microM ) blocked VO 4 induced tyrosine phosphorylation of NOS and abolished the effects of VO 4 on cGMP formation . ^^^ Furthermore , VO 4 induces a Src dependent , and to a lesser degree PKC dependent , inhibition of platelet NOS . . ^^^ |
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