| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.62186437 |
| CN also increased the association of c Src with beta catenin and p 120 and induced a substantial increase in tyrosine phosphorylation of both catenins . 0.62186437^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.73447411 |
| Recombinant pp 60 ( c src ) efficiently phosphorylated both catenins in vitro , with stoichiometries of 1 . 5 and 2 . 0 mol of phosphate / mol of protein for beta catenin and p 120 catenin , respectively . pp 60 ( c src ) phosphorylation had opposing effects on the affinities of beta catenin and p 120 for the cytosolic domain of E cadherin ; it decreased ( in the case of beta catenin ) or increased ( for p 120 ) catenin / E cadherin binding . 0.73447411^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.65973767 |
| Furthermore , neutrophil stimulation resulted in association of Src with the endothelial junction protein beta catenin and beta catenin tyrosine phosphorylation . 0.65973767^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In Src transformed MDCK cells , p 120 , beta catenin , and plakoglobin were heavily phosphorylated on tyrosine , but the physical associations between these proteins were not disrupted . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Beta catenin : a common target for the regulation of cell adhesion by Wnt 1 and Src signaling pathways . ^^^ Furthermore , beta catenin is the target of two signal transduction pathways mediated by the proto oncogenes src and wnt 1 . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Whereas skin of fyn / mice appears normal , skin of mice with a disruption in both the fyn and src genes shows intrinsically reduced tyrosine phosphorylation of beta catenin , strongly decreased p 120 Cas levels , and important structural changes consistent with impaired keratinocyte cell adhesion . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Clear evidence was found for the presence of N cadherin and its associated intracellular proteins : beta catenin , pp 120 , desmoglein , pp 60 ( src ) , and Csk . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In a 5 src transformed MDCK cell line , following 15min of src activation , beta catenin began to detach from the cell membrane and localize to the cytoplasm , while fodrin and E cadherin remained unchanged . ^^^ After 60min of src activation , fodrin localized completely in the cell cytoplasm , while E cadherin and beta catenin were partly cytoplasmic with fragmented and spiky membranous staining . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of beta catenin and pp 120 src substrate proteins , which associate with E cadherin , was unaffected . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , tyrosine phosphorylation of beta catenin by transfection of constitutively active c src was suppressed in GnT 3 transfectants as well as in the case of epidermal growth factor stimulation . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor regulates interaction of the human DF3 / MUC1 carcinoma antigen with c Src and beta catenin . ^^^ The MUC 1 cytoplasmic domain interacts with the c Src tyrosine kinase and thereby increases binding of MUC 1 and beta catenin . ^^^ These findings support a novel role for EGF R in regulating interactions of MUC 1 with c Src and beta catenin . . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| ATP depletion increased the content of Tyr ( 416 ) Src , the activated form of this kinase . c Src activation was associated with an increase in the tyrosine phosphorylation state of beta catenin , paxillin , and vinculin , three c Src substrate proteins that localize to and regulate cell contact sites . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In collagen 1 , E cadherin and beta catenin were seen partially along the lateral walls and partially in the cytoplasm of src transformed MDCK cells ; fodrin was released into the cytoplasm and ZO 1 was not visualized . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence shows that H ( 2 ) O ( 2 ) exposure caused a loss of pan reactive cadherin and beta catenin from cell junctions that was not blocked by the src kinase inhibitor PP 1 . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| We also show that the interaction of p 85 and beta catenin is direct , involves the N terminal Src homology domain 2 of p 85 and is regulated by tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Unlike the steroid hormone receptor coactivator 1 ( SRC 1 ) , beta catenin showed a strong interaction with AR but not with other steroid hormone receptors such as estrogen receptor alpha , progesterone receptor beta , and glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To explore the possible mechanism of injury by smoking and its repairing , the effects of cigarette smoke extract on the expression of beta catenin ( beta cat ) , c Src and level of phosphoric tyrosine in airway epithelial cells ( AEC ) . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src protein kinase activity , peroxide production , E cadherin expression levels , and the phosphorylation status of beta catenin and E cadherin were determined . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| The rates of oxidative stress induced activation of c Src , tyrosine phosphorylation of ZO 1 and beta catenin , decrease in resistance , increase in permeability to inulin , and redistribution of occludin and ZO 1 were significantly greater in cells transfected with wild type c Src , whereas it was low in cells transfected with kinase inactive c SrcK297R mutant , when compared with those in empty vector transfected cells . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recently , studies have shown that MUC 1 interacts with beta catenin , erbB receptors , src , GSK 3beta and protein kinase Cdelta , possibly in a complex that promotes the disassembly of adherens junctions and the invasion of cells . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using biochemical and immunohistochemical techniques , we have investigated P cadherin , beta catenin , c src and c met protein expression , and phosphorylation of beta catenin in a rat model of tongue cancer induced with 4 nitroquinoline 1 oxide . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src activity was increased in QLalpha 12 expressing MDCK cells as assessed by Src autophosphorylation , and beta catenin tyrosine phosphorylation was also increased , although there was no detectable increase in Rho activity . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our studies show that TNF alpha increases intracellular radical production , degradates E cadherin / beta catenin complex and promotes dispersion and migration in epithelial cells transformed with an activated src oncogene ( 5 src ) . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present work , we investigated the possible relationships between the activity of the mouse and human matrilysin promoters ( Mp ) , endogenous matrilysin protein expression , and two early oncogenetic defects frequently observed in human colonic cancers , namely activation of the src oncogene and impairment of the Wnt / APC / beta catenin pathway . ^^^ Using transient transfection assays , we report here that src signaling and the HMG box transcription factor LEF 1 act synergistically with the proximal ( 61 to 67 ) AP 1 binding site to transactivate the Mp in premalignant and tumorigenic kidney and colonic epithelial cells , through beta catenin and axin independent signaling pathways . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| For instance , Src , which mainly phosphorylates Tyr 86 in beta catenin , modifies Tyr 643 in plakoglobin , decreasing the interaction with E cadherin and alpha catenin and increasing the interaction with the alpha catenin equivalent protein in desmosomes , desmoplakin . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : The expression of 16 AR coactivators and corepressors ( SRC 1 , beta catenin , TIF 2 , PIAS 1 , PIASx , ARIP 4 , BRCA 1 , AIB 1 , AIB 3 , CBP , STAT 1 , NCoR 1 , AES , cyclin D 1 , p 300 , and ARA 24 ) was measured in prostate cancer cell lines , xenografts , and clinical prostate tumor specimens by using real time quantitative reverse transcription PCR . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Numerous studies have demonstrated an interaction between MUC 1 and other oncogenic proteins such as beta catenin , erbB receptors and c Src , but a functional role for MUC 1 in transformation has not been identified . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| The CPA liganded AR was coactivated by steroid receptor coactivator 1 ( SRC 1 ) but did not mediate N C terminal interactions or recruit beta catenin , indicating a nonagonist conformation . ^^^ The HF and CPA liganded T877A ARs were coactivated by SRC 1 , but only the HF liganded T877A AR was coactivated by beta catenin . ^^^ L 39 , a novel AR antagonist that transcriptionally activates the T877A AR , but still inhibits LNCaP growth , similarly mediated recruitment of SRC 1 and not beta catenin . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| The MUC 1 cytoplasmic tail ( CT ) is postulated to function in morphogenetic signal transduction via interactions with Grb2 / Sos , c Src , and beta catenin . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src42A , which is functionally redundant to Src 64 , was found to interact genetically with shotgun , a gene encoding E cadherin , and armadillo , a Drosophila beta catenin . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Examination of MMTV PyV MT glands on a wild type or Muc 1 null background demonstrates that Muc 1 expression promotes c Src signaling by influencing its association with known substrates such as the p 85 subunit of phosphatidylinositol 3 kinase and beta catenin . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of phosphorylated ( P ) c Src , P focal adhesion kinase ( FAK ) , P Akt , P glycogen synthease kinase 3beta ( GSK 3beta ) , dephosphorylated ( DP ) beta catenin , and various integrins such as , alpha 3 , alpha 5 , beta 1 , beta 3 , and beta 4 was also increased in MMTV CR 1 tumors . ^^^ HC 11 / CR 1 cells treated with the c Src inhibitor PP 2 reduced the expression of P c Src and of P FAK , P Akt , P GSK 3beta , DP beta catenin all known to be activated by c Src . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| This event was also associated with a loss of protein protein association of N cadherin and beta catenin from the cadherin / catenin / c Src / Csk / CK2 protein complex . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Regulation of Sertoli germ cell adherens junction dynamics via changes in protein protein interactions of the N cadherin beta catenin protein complex which are possibly mediated by c Src and myotubularin related protein 2 : an in vivo study using an androgen suppression model . ^^^ First , the loss of germ cells from the seminiferous epithelium during androgen suppression was associated with a surge in myotubularin related protein 2 ( MTMR 2 , a lipid phosphatase , in which adult MTMR 2 / mice were recently shown to be azoospermic because of the loss of cell adhesion function between germ and Sertoli cells ) ; kinases : phosphatidylinositol 3 kinase , c Src , and C terminal Src kinase ; adaptors : alpha actinin , vinculin , afadin , and p 130 Crk associated protein ; and AJ integral membrane proteins at the ectoplasmic specialization ( ES , a testis specific cell cell actin based AJ type ) site : N cadherin , beta catenin , integrin beta 1 , and nectin 3 . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| This MTMR 2 c Src beta catenin complex apparently regulates the phosphorylation status of beta catenin , which determines cell adhesive function conferred by the cadherin catenin protein complex in the seminiferous epithelium . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| We report that tissue type plasminogen activator ( tPA ) elicited tyrosine phosphorylation and cytosolic accumulation of an active ( non serine threonin phosphorylated , nonubiquitinated ) form of beta catenin in ECV 304 carcinoma cells . tPA dependent beta catenin activation is mediated through epidermal growth factor receptor ( EGFR ) transactivation ( via Src ) , suggested by the inhibitory effects of AG 1478 and PP 2 ( specific inhibitors of EGFR and Src , respectively ) and by the lack of beta catenin activation in EGFR negative B 82 fibroblasts . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , inactivation of Src , MKK 3 , p 38 , or the EGF receptor blocked tyrosine phosphorylation of beta catenin , a key signaling intermediate that is involved in the epithelial mesenchymal transition and vimentin expression . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Hyperosmotic mannitol induces Src kinase dependent phosphorylation of beta catenin in cerebral endothelial cells . ^^^ Because beta catenin is a key component of the junctional complex , its Src mediated phpsphorylation may play an important role in the mannitol induced reversible opening of the BBB . . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| In human normal primary keratinocytes and in colon and ovary carcinoma cells we obtained evidences for : ( 1 ) a dose dependent inhibition of proliferation without toxicity or apoptosis ; ( 2 ) a transition from a proliferative mesenchymal morphology to cell specific differentiated structures ; ( 3 ) a noticeable increase in cell cell and cell substratum junctions ; ( 4 ) a relocation of the oncogenic beta catenin at the cell cell junctions ; ( 5 ) inhibition of microtubules aggregation ; ( 6 ) upregulation of differentiation related genes including p 53 , heat shock protein 27 gene , N myc downstream regulated gene 1 , E cadherin , and downregulation of cyclooxygenase 2 ; ( 7 ) inhibition of c Src tyrosine kinase . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Active Src elevates the expression of beta catenin by enhancement of cap dependent translation . ^^^ Here we report that active Src elevates the levels of beta catenin by enhancing cap dependent translation . ^^^ Activated Src enhances the accumulation of nuclear beta catenin and enhances its transcriptional activity , elevating target genes such as cyclin D 1 . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Involvement of Src family kinases in N cadherin phosphorylation and beta catenin dissociation during transendothelial migration of melanoma cells . ^^^ Expression of a dominant negative Src in melanoma cells blocks N cadherin phosphorylation , beta catenin dissociation , and nuclear translocation in transmigrating cells , consistent with the involvement of Src family kinases . ^^^ In in vitro binding assays , Src mediated phosphorylation of the N cadherin cytoplasmic domain results in a significant reduction in beta catenin binding . ^^^ Together , the data suggest a novel role for tyrosine phosphorylation of N cadherin by Src family kinases in the regulation of beta catenin association during transendothelial migration of melanoma cells . . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| SKI 606 decreases growth and motility of colorectal cancer cells by preventing pp 60 ( c Src ) dependent tyrosine phosphorylation of beta catenin and its nuclear signaling . ^^^ In this report , pp 60 ( c Src ) kinase and beta catenin were found physically associated and constitutively activated on tyrosine residues in human colorectal cancer cells . ^^^ The use of specific small interfering RNAs ( siRNA ) validated pp 60 ( c Src ) as the major kinase responsible for beta catenin tyrosine phosphorylation in colorectal cancer . ^^^ Thus , our results show that SKI 606 operates a switch between the transcriptional and adhesive function of beta catenin by inhibiting its pp 60 ( c Src ) dependent tyrosine phosphorylation ; this could constitute a new therapeutic target in colorectal cancer . . ^^^ Src dependent activation of beta catenin was prevented by SKI 606 , a novel Src family kinase inhibitor , which also abrogated beta catenin nuclear function by impairing its binding to the TCF 4 transcription factor and its trans activating ability in colorectal cancer cells . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Following RAW / AMCM treatment , enhanced activation of c Src was seen prior to increased tyrosine phosphorylation of beta catenin , and this led to the destabilization of adherens junctions . ^^^ Pretreatment of HepG 2 cells with the Src kinase inhibitor , PP 2 , completely abolished the effects of RAW / AMCM on the EMT , migration , invasion , and expression and association of E cadherin and beta catenin . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src homology 2 domain containing phosphatase 2 ( SHP 2 ) association with beta catenin was diminished in PECAM 1 null ECs , suggesting that lack of PECAM 1 inhibits the ability of this adherens junction component to become dephosphorylated , promoting a sustained increase in permeability . beta Catenin / Glycogen synthase kinase 3 ( GSK 3beta ) association and beta catenin serine phosphorylation levels were increased and beta catenin expression levels were reduced in PECAM 1 null ECs . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| The novel Src kinase inhibitor M 475271 inhibits VEGF induced vascular endothelial cadherin and beta catenin phosphorylation but increases their association . ^^^ |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|