| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| SH 2 domains from Src like tyrosine kinases bound predominantly to the HS 1 phosphoprotein . ^^^ |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| IL 5 stimulation results in rapid tyrosine phosphorylation of beta c and proteins containing Src homology 2 ( SH 2 ) and / or SH 3 domains such as phosphatidyl inositol 3 kinase , Shc , Vav , and HS 1 , suggesting their involvement in IL 5 mediated signal transduction . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| The HS 1 gene is expressed specifically in hematopoietic cells and encodes p75HS1 , which carries both helix turn helix and Src homology 3 motifs . p75HS1 showed rapid tyrosine phosphorylation and association with a Src like kinase , Lyn , after crosslinking of membrane bound IgM . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| We also show that the HS 1 peptide can be used for the specific monitoring of p72syk since neither the two Src related c Fgr and Lyn kinases ( needing a hydrophobic instead of acidic residue at position 1 ) nor CSK appreciably phosphorylate it . . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| SH 2 domains mediate the sequential phosphorylation of HS 1 protein by p72syk and Src related protein tyrosine kinases . ^^^ The sequential phosphorylation of p50 / HS1 as well as its specific blockage by the HS 1 phosphopeptide is also observable if c Fgr is replaced by two other Src related kinases , namely , Lyn and Fyn , as secondary phosphorylating agents . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| Distinct binding patterns of HS 1 to the Src SH 2 and SH 3 domains reflect possible mechanisms of recruitment and activation of downstream molecules . ^^^ In the present report , we analyzed the binding pattern of several src kinases and HS 1 in greater detail . ^^^ Such distinct binding patterns of the src kinase SH 2 and SH 3 domains to HS 1 may represent a mechanism by which src family kinases select substrates and activate particular downstream signaling pathways . . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| HAX 1 , a novel intracellular protein , localized on mitochondria , directly associates with HS 1 , a substrate of Src family tyrosine kinases . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| The dephosphorylated HS 1 ( 320 329 ) peptide is totally ineffective , while the stimulatory efficacy of other phosphopeptides derived from the polyoma virus middle T antigen ( 393 402 ) sequence , c Src , and c Fgr autophosphorylation sites , and the C terminal c Src site ( Tyr 527 ) is variable and correlates reasonably well with the predicted affinity for the c Fgr SH 2 domain . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| The results suggest that PDT rapidly activates a membrane associated src family kinase ( s ) in L5178Y R cells , one substrate of which is HS 1 , and that protein tyrosine phosphorylation is part of a stress response , protecting a portion of the cells from the lethal effects of PDT but not altering the mechanism by which they die . . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| In vivo studies indicated that CD 3 induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD 45 , did not require MEK 1 kinase activity , and was regulated by protein kinase C activation . ^^^ |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| The hematopoietic lineage cell specific protein HS 1 was shown to undergo a process of sequential phosphorylation both in vitro and in vivo , which is synergistically mediated by Syk and Src family protein tyrosine kinases and essential for B cell antigen receptor mediated apoptosis . ^^^ We have now identified tyrosine 222 as the HS 1 residue phosphorylated by the Src family protein kinases c Fgr and Lyn , and we show that a truncated form of HS 1 ( HS 1 208 401 ) lacking the N terminal putative DNA binding region and the C terminal Src homology 3 ( SH 3 ) domain is still able to undergo all the steps of sequential phosphorylation as efficiently as full length HS 1 . ^^^ Kinetic studies with HS 1 and its truncated forms previously phosphorylated by Syk and with a peptide substrate reproducing the sequence around tyrosine 222 support the view that efficient phosphorylation of HS 1 by Src family protein kinases entirely relies on TyrP SH 2 domain interaction with negligible , if any , contribution of local specificity determinants . ^^^ Our data indicate that the proline rich region of HS 1 bordered by tyrosyl residues affected by Syk and Src family kinases represents a functional domain designed to undergo a process of sequential phosphorylation . . ^^^ |
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| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found that actin binding and Src homology 3 ( SH 3 ) domain containing proteins cortactin , hematopoietic specific protein 1 ( HS 1 ) , and hematopoietic progenitor kinase 1 interacting protein of 55 kDa ( HIP 55 , also called SH3P7 and Abp 1 ) were degraded in a caspase dependent manner during apoptosis . ^^^ |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although HS 1 contains a 37 amino acid tandem repeat motif and a C terminal Src homology 3 domain and is closely related to the cortical actin associated protein cortactin , it lacks the fourth repeat that has been shown to be essential for cortactin binding to filamentous actin ( F actin ) . ^^^ |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| We find that the Src homology 3 domains of Grb 2 directly associate , in vitro and in vivo , with murine hemopoietic specific protein 1 ( HS 1 ) , a protein identical to Lck binding protein 1 . ^^^ |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31946 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|