Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Analyses of various signaling molecules by transient cotransfection assays and in vitro kinase assays established that a signaling pathway involving c Src , SOS , Ras , Raf 1 and ERK is activated by middle T in NIH3T3 cells , resulting in the activation of the uPA gene promoter via PEA3 / AP1 elements . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We have expressed the mitogenic signaling proteins Src , Ras , Raf 1 , Mek ( MAP kinase kinase ) , and Erk ( MAP kinase ) in baculovirus infected Sf 9 insect cells in order to study a potential role for the chaperone hsp 90 in formation of multiprotein complexes . ^^^ Src , but no complex containing Erk was obtained by mixing cytosols . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of ERK 1 and 2 may involve the Src homology 2 containing proteins Shc and Grb 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Pretreatment of astrocytes with cytochalasin D or C 3 transferase , which inhibits actin polymerization or Rho activity , respectively , prevented the activation / phosphorylation of Src , FAK , and paxillin after ET 1 stimulation ; by contrast , the ERK pathway was not significantly affected . ^^^ This differential activation of FAK / Src and ERK pathways was also observed with astrocytes 10 and 60 min after replating on poly L ornithine precoated dishes . ^^^ Collectively , these findings indicate that activation of FAK and Src is dependent on actin cytoskeleton integrity , Rho activation , and adhesion to extracellular matrix , whereas ERK activation is independent of these intracellular events and seems to correlate with activation of the newly identified protein tyrosine kinase PYK 2 . ^^^ This study provides a demonstration of Rho and adhesion dependent activation of FAK / Src , which collaborates with adhesion independent activation of PYK2 / ERK for DNA synthesis in ET 1 stimulated astrocytes . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Our findings are consistent with a specific regulation of mitogenesis by LMW PTP through a pathway involving c Src kinase but independent by both PI3K and ERK . ^^^ Moreover , we studied the insulin mediated signal transduction pathways starting from insulin receptor , such as the Src kinase , the p21Ras / ERK , and the PI3K routes . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
When CSK , a negative regulator of Src family tyrosine kinases , or dominant negative mutant of Ras or of Raf 1 kinase was overexpressed , activation of transfected ERK 2 by H2O2 was abolished . ^^^ These results suggest that Src family tyrosine kinases , Ras and Raf 1 are critical for ERK activation by hydroxyl radicals and that activation of ERKs may play an important role in protecting cardiac myocytes from apoptotic death following oxidative stress . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The importance of Src kinases in the mediation of the colchicine effect is underscored by the fact that CP 118556 , a specific inhibitor of Src like kinase , abrogates both the colchicine induced ERK activation and IL 1 production . ^^^ Altogether , our data lend support to a model where the status of microtubule integrity controls the level of Src activities that subsequently activate the ERK kinase cascade , thus leading to IL 1 production . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In contrast , Src or related kinases appear to be required to activate ERK , but not NHE . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Overexpression of C terminal Src kinase ( Csk ) , which inactivates Src family tyrosine kinases , suppressed the activation of transfected ERK in cardiac fibroblasts . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
It has been reported previously that estrogens activate the signal transducing Src / p21 ( ras ) / Erk pathway in human breast cancer cells via an interaction of estrogen receptor ( ER ) with c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
A mutant PDGFR chimera that was not able to detectably associate with or activate Src was compromised in its ability to mediate tyrosine phosphorylation of receptor associated signaling molecules and initiated a submaximal activation of Erk . ^^^ We conclude that the initial burst of Src activity is required for efficient tyrosine phosphorylation of receptor associated proteins such as PLCgamma , RasGAP , Shc , and SHP 2 and for maximal activation of Erk . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moderate increases in ERK and JNK activities , in addition to up regulation of c Src , p125FAK , and tyrosine phosphorylated proteins , were observed in a subset of the colorectal carcinomas . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Cholesterol depleted caveolae had a reduced amount of several key protein components of the MAP kinase complex , including Ras , Grb 2 , Erk 2 , and Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Some of these proteins were identified as the Src Homology Collagen ( SHC ) protein , Janus kinase ( JAK 2 ) and the Mitogen Activated Protein Kinase isoforms ERK 1 and ERK 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Collectively , these findings indicate that PACAP 38 stimulated neuritogenesis requires PKC and Erk activation but is independent of cAMP dependent protein kinase , nerve growth factor receptor tyrosine kinase , p 21 ( ras ) G protein , and pp 60 ( c src ) cytoplasmic tyrosine kinase . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Biochemical analyses indicated that FAK mutant DeltaC 14 was mislocalized and functioned as a dominant negative mutant by competing with endogenous FAK in focal contacts for binding signaling molecules such as Src and Fyn , resulting in a decreases of Erk activation in cell adhesion . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Here , we report that ERK 2 activated by its upstream kinase , MEK 1 , represses Stat 3 transcriptional activity induced by Src or Jak 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We have reported that angiotensin 2 ( Ang 2 ) induces Ca2+ dependent transactivation of the epidermal growth factor receptor ( EGFR ) which serves as a scaffold for preactivated c Src and downstream adaptors ( Shc / Grb2 ) , leading to ERK activation in cultured rat vascular smooth muscle cells ( VSMC ) . ^^^ Although a selective EGFR kinase inhibitor completely abolished Ang 2 induced recruitment of Grb 2 to EGFR and markedly attenuated Ang 2 induced ERK activation , it had no effect on Ang 2 induced PYK 2 tyrosine phosphorylation or its association with c Src and Grb 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Overexpression of C terminal Src kinase , which inhibits functions of the Src family of tyrosine kinases , or overexpression of DNRas had no effect on stretch induced activation of transfected ERK 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Overexpression of the Gbetagamma subunit binding domain of the beta adrenoreceptor kinase 1 and of COOH terminal Src kinase , which inhibit functions of Gbetagamma and the Src family tyrosine kinases , respectively , also inhibited isoproterenol induced ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Incubation of Raji with Fg resulted in the increased tyrosine phosphorylation of the receptor associated tyrosine kinase , pp 60 ( Src ) and extracellular signal regulated kinase 1 ( ERK ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In all three cell types , GPCR stimulated Erk 1 / 2 activation is significantly inhibited by the Src kinase inhibitors , herbimycin A and 4 amino 5 ( 4 methylphenyl ) 7 ( t butyl ) pyrazolo D 3 , 4 pyrimidine ( PP 1 ) , suggesting that Src family nonreceptor tyrosine kinases represent a point of convergence for signals originating from either scaffold . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In this report , we provide evidence that the protein tyrosine kinase Src and adaptor proteins Grb 2 , Crk , and p130Cas act as downstream mediators of Pyk 2 leading to the activation of extracellular signal regulated kinase ( ERK ) and c Jun amino terminal kinase ( JNK ) . ^^^ Pyk 2 induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb 2 and Crk , respectively , and for the activation of ERK and JNK cascades . ^^^ Expression of a Grb 2 mutant with a deletion of the amino terminal Src homology 3 domain or the carboxyl terminal tail of Sos strongly reduced Pyk 2 induced ERK activation , with no apparent effect on JNK activity . ^^^ Grb 2 with a deleted carboxyl terminal Src homology 3 domain partially blocked Pyk 2 induced ERK and JNK pathways , whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In response to adhesion on a fibronectin substrate , RPTPalpha / fibroblasts also exhibited characteristic deficiencies in integrin mediated signalling responses , such as decreased tyrosine phosphorylation of the c Src substrates Fak and p 130 ( cas ) , and reduced activation of extracellular signal regulated ( Erk ) MAP kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
This compound also inhibited CDK2 / cyclin A ( IC 50 , 0 . 68 microM ) , CDK2 / cyclin E ( IC 50 , 7 . 5 microM ) , and CDK5 / p25 ( IC 50 , 0 . 85 microM ) but had much less effect on other kinases ; only c src ( IC 50 , 15 microM ) , casein kinase 2 ( IC 50 , 20 microM ) , erk 1 ( IC 50 , 20 microM ) , and erk 2 ( IC 50 , 9 microM ) were inhibited with IC50s less than 35 microM . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , fMLP induced p21rac activation was not inhibited by broad tyrosine kinase inhibitors or specific inhibitors of ERK , p 38 mitogen activated protein kinase , Src , or phosphatidylinositol 3 kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We conclude that ERK activation by G ( i / o ) coupled sst ( 4 ) receptors involves a Src and Ras dependent acute phase , but the proliferative response is dependent upon the prolonged ERK induced activity , mediated by protein kinase C . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Also , co transfection of the dominant negative mutant of Ras or active mutant of C terminal Src kinase , a tyrosine kinase which inhibits Src family tyrosine kinases , with hemagglutinin tagged ERK 2 had no effects on ET 1 induced ERK 2 activation . ^^^ These results suggest that protein kinase C and Raf 1 kinase , but not Src or Ras , are critical to ET 1 induced ERK activation in cardiac myocytes . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
ERK activation was blocked by CP 118556 , indicating it is regulated by a Src like kinase , while JNK 1 was inhibited by piceatannol , revealing an upstream regulation by Syk . ^^^ Our data support a model where the status of microtubule polymerization influences the activity of Go or Gi proteins that control , in turn , two independent Src / ERK and Syk / JNK1 cascades that are both necessary to sustain IL 1 synthesis . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
G protein coupled receptors can activate Erk MAPK pathways through a variety of mechanisms , including stimulation of Src , phosphoinositide 3 kinase ( PI 3 K ) , protein kinase C ( PKC ) , or the epidermal growth factor ( EGF ) receptor tyrosine kinase . ^^^ In isolated strips of rat aorta , the MAPK / Erk kinase inhibitor U 0126 ( 50 microM ) , Src inhibitor PP 1 ( 0 . 5 microM ) , PKC inhibitors calphostin C ( 1 microM ) and chelerythrine ( 10 microM ) , and the PI 3 K inhibitor LY 294002 ( 1 20 microM ) reduced 5 HT induced contraction . ^^^ These data suggest that the rat aortic 5 HT ( 2A ) receptor uses Src but not PKC , PI 3 K , or the EGF receptor tyrosine kinase in stimulating Erk MAPK activation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
By negatively regulating GRK mediated receptor phosphorylation , beta arrestin mediated processes such as Src recruitment and clathrin mediated internalization , which are required for GPCR mediated ERK activation , are inhibited , thus dampening further ERK activation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Also , c Src activated by EGF treatment or expression of constitutively activated Ral GTPase led to tyrosine phosphorylation of Stat 3 and cortactin , but not Shc or subsequent Erk activation . ^^^ In contrast , c Src activated by isoproterenol led to tyrosine phosphorylation of Shc and subsequent Erk activation , but not tyrosine phosphorylation of cortactin or Stat 3 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We propose that NAD ( P ) H oxidase is located in the ERK activation pathway stimulated by the transfected 5 HT ( 1A ) receptor in Chinese hamster ovary ( CHO ) cells downstream of G ( 1 ) betagamma subunits and upstream of or at the level of the non receptor tyrosine kinase , Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Coincident with EGFR transactivation , isoproterenol exposure induces the formation of a multireceptor complex containing both the beta ( 2 ) AR and the `` transactivated ' ' EGFR . beta ( 2 ) AR mediated EGFR phosphorylation and subsequent beta ( 2 ) AR stimulation of extracellular signal regulated kinase ( ERK ) 1 / 2 are sensitive to selective inhibitors of both EGFR and Src kinases , indicating that both kinases are required for EGFR transactivation . beta ( 2 ) AR dependent signaling to ERK1 / 2 , like direct EGF stimulation of ERK1 / 2 activity , is sensitive to inhibitors of clathrin mediated endocytosis , suggesting that signaling downstream of both the EGF activated and the GPCR transactivated EGFRs requires a productive engagement of the complex with the cellular endocytic machinery . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In cardiac fibroblasts , angiotensin 2 activated ERK via the G ( beta ) gamma subunit of Gi , Src , Shc , Grb 2 , and Ras , whereas Gq and protein kinase C were critical in cardiomyocytes . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Most notably , G ( q / 11 ) induced ERK activation was sensitive to N 17 Ras and to expression of the C terminal Src kinase but also to other dominant negative mutants of signaling components localized upstream of Ras , like Shc and the EGFR . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator stimulates the Ras / Extracellular signal regulated kinase ( ERK ) signaling pathway and MCF 7 cell migration by a mechanism that requires focal adhesion kinase , Src , and Shc . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The Src family kinase inhibitor , PP 2 ( 20 nM 20 microM ) attenuated CCh stimulated EGFR and ERK phosphorylation and potentiated chloride secretory responses to CCh . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of pp 60 ( c Src ) kinase and phosphorylation of ERK were observed in response to glutamate treatment . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibition of c Src tyrosine kinase ( 4 amino 5 [ 4 chlorophenyl ] 7 [ t butyl ] pyrazolo [ 3 , 4 d ] pyrimidine ; PP 2 ) or MEK 1 ( mitogen activated protein kinase [ MAP ] / extracellular signal regulated kinase [ ERK ] 1 ) ( PD 98059 , blocking ERK1 / 2 ) blocked or reversed the pulsatile flow pH ( 1 ) change to acidification . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We demonstrate that stimulation of Src family kinase within membrane rafts initiates a pathway implicating ERK activation , which leads to interleukin ( IL ) 1alpha / beta and IL 1Ra mRNA production and contributes to p 38 dependent IL 12 mRNA production . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Transfection with dominant negative mutants of Ras , Raf , and MKK 1 also inhibited the increase in ERK activity in response to calcium , as did treatment with herbimycin , a selective inhibitor for Src family kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We conclude that 1 ) all three members of the MAPK family ( ERK , JNK 2 , and p 38 ) as well as Src kinases are required for tonicity stimulated COX 2 expression in mouse collecting duct cells and that 2 ) COX 2 may play a role in cell survival of medullary cells under hypertonic conditions . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
This suggested that they may inhibit Erk activation in an analogous manner as the mislocalized FAK mutant ( & Dgr ; ) C 14 described previously by competing with endogenous FAK for binding signaling molecules such as Src and Fyn . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Overexpression of gene 33 protein in mouse fibroblasts inhibited ( 1 ) cell proliferation driven by ErbB 2 but not by serum , ( 2 ) cell transformation induced by ErbB 2 but not by Ras or Src , and ( 3 ) sustained activation of ERK 1 and 2 by ErbB 2 but not by serum . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We previously showed that c Src is required for ERK activation by beta ( 2 ) AR and that it is recruited to activated beta ( 2 ) AR through binding of the Src homology 3 ( SH 3 ) domain to proline rich regions of the adapter protein beta arrestin 1 . ^^^ Despite the absence of sites for phosphorylation and beta arrestin binding , ERK activation by beta ( 3 ) AR still requires c Src . ^^^ Together , these data describe a novel mechanism of ERK activation by a G protein coupled receptor in which the intracellular domains directly recruit c Src . . ^^^ ERK activation and Src co precipitation with beta ( 3 ) AR also occurred in adipocytes in an agonist dependent and pertussis toxin sensitive manner . ^^^ ERK activation and Src co precipitation were abolished in cells expressing point mutations in these PXXP motifs . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Finally , we showed that activation of the Erk 1 / 2 pathway in the prostate cancer cells by lysophosphatidic acid and serum is dependent on the EGF receptor and c Src protein tyrosine kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Abbreviations : CAS , CRK associated substrate ; CH , calponin homology domain ; CSK , C terminal SRC kinase ; E 6 , Papillomavirus E 6 protein ; FAK , focal adhesion kinase ; GIT , GRK interacter ; GPCR , heterotrimeric G protein coupled receptor ; GRK , G protein coupled receptor kinase ; MAPK , mitogen activated protein kinase ( ERK , p 38 , JNK ) ; PAK , p 21 activated kinase ; PBS , paxillin binding subdomain ; PIX , PAK interacting exchange factor ; PKL , paxillin kinase linker ; POR 1 , partner of Rac ; PS , phosphoserine ; PT , phosphothreonine ; PY , phosphotyrosine ; RTK , growth factor receptor tyrosine kinase ; SH , SRC homology domain . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We report that at least three parallel pathways , the Src pathway , the MAPK / ERK kinase ( MEK ) / extracellular signal regulated kinase ( ERK ) pathway , and the c myc pathway , are involved . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Role of dynamin , Src , and Ras in the protein kinase C mediated activation of ERK by gonadotropin releasing hormone . ^^^ We show that extracellular signal regulated kinase ( ERK ) activation is fully dependent on protein kinase C ( PKC ) , but only partially dependent on Src , dynamin , and Ras . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moreover the phosphatidyl inositol 3kinase and the cytosolic tyrosine kinase c src participate in the signal transduction regulated by SSTRI to activate ERK , as well as it is involved the protein tyrosine phosphatase ( PTP ) SHP 2 . ^^^ SHP 2 may . in turn , regulate the activity of kinases upstream of ERK that require tyrosine dephosphorylation to be activated , such as c src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The G betagamma responsive ERK activation induced by H2O2 is independent of ligands binding to Gi coupled receptors , but requires phosphatidylinositol 3 kinase and Src activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Pretreatment of cells with Src kinase and MAPK kinase inhibitors blocked ERK activation by 50 80 % ( P < 0 . 05 ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Signal transduction by the chemokine receptor CXCR 3 : activation of Ras / ERK , Src , and phosphatidylinositol 3 kinase / Akt controls cell migration and proliferation in human vascular pericytes . ^^^ The increase in ERK activity was inhibited by genistein and PP 1 , but not by wortmannin , indicating that Src activation is necessary for the activation of the Ras / ERK pathway by CXCR 3 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
This effect of Src is mediated partly through a Raf / mitogen activated ERK kinase / extracellular signal regulated kinase ( Raf / MEK / ERK ) signaling cascade and partly through a MEKK / JNKK / JNK cascade . ^^^ Although , as previously shown , Src action through activated ERK stimulates AF 1 by phosphorylation at S 118 , Src action through activated JNK neither leads to phosphorylation of S 118 nor requires S 118 for its action . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In this study , activation of the Gq / G11 coupled thromboxane A 2 ( TxA 2 ) receptor ( TP ) by the TxA 2 mimetic IBOP in ECV 304 cells was found to induce extracellular regulated kinase ( ERK ) phosphorylation and tyrosine phosphorylation of the epidermal growth factor receptor ( EGFR ) , which were inhibited by the TP antagonist SQ 29548 , the EGFR kinase inhibitor AG 1478 , the Src family kinase inhibitor PP 1 , the Gi / o protein inhibitor pertussis toxin ( PTX ) , or the protein kinase C ( PKC ) inhibitor calphostin C . ^^^ In conclusion , TPalpha is directly coupled to the Gi protein by a PKC regulated mechanism ; Gi coupling causes Src dependent transactivation of the EGFR , which is the dominant pathway in TP mediated ERK activation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Analysis of signaling molecules showed evidence that PLCgamma PKC , Src , Erk 1 / 2 and p 38 MAPK pathways are activated by rhFGF 2 in IHNC cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of Src homologous and collagen ( Shc ) , extracellular signal regulated kinase ( ERK ) 1 and ERK 2 , and phospholipase C gamma 1 ( PLC gamma 1 ) was increased by the three neurotrophins and the increase was inhibited in the presence of K252a . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The signalling mechanisms involved in this phenomenon depend on activation of VEGFR 2 , impinge on a tyrosine kinase of the Src family and activate the Erk family of MAP kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Ang 2 directed migration was also blocked by the Src kinase inhibitor PP 2 ( 10 micromol / L ) , by the extracellular regulated protein kinase ( ERK 1 / 2 ) inhibitor PD 98059 ( 30 micromol / L ) , and by the p 38 MAPK inhibitor SB 203580 ( 10 micromol / L ) , indicating that Src , ERK 1 / 2 , and p 38 are all involved in Ang 2 induced migration of HPBM and human THP 1 monocytes . ^^^ This study demonstrates a novel proatherogenic action of Ang 2 on human monocytes by stimulating their migration , through an AT 1 R dependent process , involving signaling through Src , ERK 1 / 2 , and p 38 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The purpose of this study was to further unravel the underlying signal transduction mechanisms , and we particularly tested the involvement of src tyrosine kinases and extracellular signal regulated kinase ( ERK ) . ^^^ The involvement of src and ERK was tested with the inhibitors herbimycin A ( 1 micromol / L ) , PP 1 ( 10 micromol / L ) , PP 2 ( 10 micromol / L ) , and PD 98059 ( 30 micromol / L ) . ^^^ The results suggest that pressure induced c fos expression in intact cannulated rat mesenteric small arteries may be mediated , at least in part , by src tyrosine kinases and ERK . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Second , interaction with molecules such as Src , Raf , Erk , ASK 1 and JNK 3 appears to regulate several pathways that result in the activation of MAP kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The use of specific tyrosine kinase inhibitors revealed that the ERK pathway is strictly controlled by Syk , whereas c Src up regulated the downstream SAPK2 / p38 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition , the Src inhibitor , PP 1 , or expression of dominant negative Ras also attenuated the transient phase of ERK phosphorylation . ^^^ In contrast , inhibition of Ras or Src had no effect on the sustained ERK activity , which was critically dependent on phosphatidylinositol 3 kinase . ^^^ In conclusion , adenosine di and triphosphate stimulation of the human P2Y ( 1 ) receptor can transiently activate the Ras ERK cascade via the cooperative effects of phosphatidylinositol 3 kinase , Src and PKC . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
There was little evidence for the involvement of either Gbetagamma subunits , Ras GTPases , Raf 1 , p 60 ( src ) , or phosphatidylinositol 3 ' kinases in PTX mediated ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Experiments with various chemical inhibitors and dominant inhibitory mutants demonstrate that EGFR dependent activation of the ERK cascade after alpha ( 2A ) AR stimulation requires Gbetagamma subunits upstream and dynamin dependent endocytosis downstream of HB EGF shedding and EGFR activation , whereas Src kinase activity is required both for the release of HB EGF and for HB EGF mediated ERK 2 phosphorylation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Adhesion of A1N4 cells results in the activation both of c Src and of the Erk 1 / 2 mitogen activated protein kinase ( MAPK ) , each of which precedes the induction of c Myc . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We are the first to establish two fucoidan mediated signaling pathways : PTK ( Src ) / Rac1 / PAK / JNK and PTK ( Src ) / Rac1 / PAK / p38 , but not PTK / phospholipase C gamma 1 / PKC / MEK1 / ERK , playing critical roles in proIL 1 / IL 1 regulation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These data demonstrate that alpha ( 2 ) adrenoceptor mediated vasoconstriction in the porcine palmar lateral vein is dependent upon activation of the Erk signal transduction cascade , which is downstream of an influx of extracellular calcium , and activation of Src tyrosine kinases . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The Src family of nonreceptor tyrosine kinases has been shown to mediate the mitogenic effects of other growth factors that also activate Shc and the ERK 1 and 2 MAPKs . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
To elucidate the signal transduction pathway by which LDL phosphorylate ERK , we examined the roles of the Ca ( 2+ ) / calmodulin pathway , protein kinase C ( PKC ) , src kinase , and mitogen activated protein kinase kinase ( MEK ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Extracellular signal regulated protein kinase ( ERK ) 1 / 2 , p 38 , and Src were activated by chronic pressure overload and their activity was sustained for 8 weeks after aortic banding . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moreover , PP 2 ( 20 nM ) , an inhibitor of Src , blocked D ( 4 ) receptor mediated SHC phosphorylation and ERK activation . ^^^ We also demonstrated that D ( 4 ) receptor stimulated cell proliferation is mediated by the Src / SHC / Ras / ERK pathway . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Complex formation of Ca2+ or inhibition of Src family tyrosine kinases prevented ET 1 induced ERK 2 activation in C 6 cells . ^^^ Our results indicate that endothelin promoted ERK / MAPK activation criticially depends on palmitoylation but not on phosphorylation of ET receptors , and that the G ( alpha ) q / phospholipase C beta / Ca2+ / Src signaling cascade is necessary for efficient coupling of ET receptors to the ERK / MAPK pathway . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Overexpression of Csk that inactivates Src family tyrosine kinases also inhibited ERK activation evoked by GH . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
UV induced ERK activation was accompanied with the Tyr phosphorylation of EGF receptors , and both responses were completely abolished in the presence of a selective EGF receptor inhibitor ( AG 1478 ) or the Src inhibitor PP 2 and by the expression of a kinase dead Src mutant . ^^^ UV stimulated Src activity in a manner similar to the ERK activation , but the Src activation was insensitive to AG 1478 . ^^^ These results indicate that UV induced ERK activation , which provides a survival signal against stress induced apoptosis , is mediated through Src dependent Tyr phosphorylation of EGF receptors . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibition of Src family tyrosine kinases or PI 3 kinase also inhibited ET 1 induced activation of the mitogen activated protein kinase family member , extracellular signal regulated kinase ( ERK ) 1 . ^^^ Structure function analyses of Gab 1 indicated that mutant forms of Gab 1 that do not bind the Src homology ( SH ) 2 domains of the p 85 adapter subunit of PI 3 kinase or the SH 2 domain containing protein tyrosine phosphatase 2 ( SHP 2 ) were impaired in their ability to potentiate ET 1 induced ERK 1 activation . ^^^ Taken together , our data indicate that PI 3 kinase and Src family tyrosine kinases regulate ET 1 induced Gab 1 tyrosine phosphorylation , which , in turn , induces ERK 1 activation via PI 3 kinase and SHP 2 dependent pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
PP 2 , a Src family kinase inhibitor , suppressed not only E 2 induced phosphorylation of c Src , but ERK phosphorylation as well , suggesting that c Src may be an upstream regulator of E 2 signaling . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The EGFR phosphorylation by arsenic is ligand independent and does not involve the major autophosphorylation site Tyr ( 1173 ) . c Src activity is also induced by arsenic and is a prerequisite for the EGFR and ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The signal transducing property of Cx 43 requires the pore forming as well as the C terminal domains of the protein , the activation of both Src and ERK kinases , and the SH 2 and SH 3 domains of Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
METHODS : In addition to the three classical MAP kinases ( ERK , p 38 kinase , and c Jun NH ( 2 ) terminal kinase ( JNK ) ) , we examined the protein expression and activity of Src , BMK 1 , and p90RSK in explanted hearts from patients with dilated cardiomyopathy ( n=9 ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of ERK one of the MAPK cascades by GnRH in these cells depends mainly on the phosphorylation of Raf 1 by PKC , supported by a pathway involving c Src , dynamin , and Ras . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether Src tyrosine kinases are one of the signaling intermediaries linking M ( 2 ) receptor stimulation to extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase ( MAPK ) in cultures of canine colonic smooth muscle cells ( CSMC ) . ^^^ Treatment with the pyrazolopyrimidine Src inhibitor PP 1 ( 10 microM ) or AF DX 116 ( 10 microM ) blocks ACh stimulated ERK phosphorylation . ^^^ Together these results indicate that M ( 2 ) receptors are coupled to Src tyrosine kinase and subsequent activation of ERK in cultured CSMC . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Consistent with these results , MIF stimulated phosphorylation of tyrosine , autophosphorylation of Src , activation of Ras , activation of extracellular signal regulated kinases ( ERK ) 1 / 2 , a MAPK , but not c Jun N terminal kinase or p 38 , and phosphorylation of c Jun . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Our data support the hypothesis that in BACC , AII upregulates CREB functionality through a mechanism that requires Src mediated activation of ERK 1 / 2 and ( p 90 ) RSK . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These effects , and the similar actions of the Src kinase inhibitor PP 2 indicate the involvement of PKCdelta and Src kinase in ERK activation . ^^^ Ang 2 induced activation of ERK , but not Pyk 2 , was prevented by inhibition of EGF receptor phosphorylation by AG 1478 and of Src kinase by PP 1 . ^^^ These findings indicate that Src and Pyk 2 act upstream of the EGF R and that the majority of Ang 2 induced ERK phosphorylation is dependent on trans activation of the EGF R . ^^^ Ang 2 induced ERK activation in C 9 cells is initiated by a PKCdelta dependent but Ca ( 2+ ) independent mechanism and is mediated by the Src / Pyk2 complex through trans activation of the EGF R . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
To investigate the specific role of A Raf in this process we generated A Raf deficient mouse embryonic fibroblasts ( MEFs ) and embryonic stem ( ES ) cells by gene targeting and characterized their ability to undergo proliferation , differentiation , apoptosis , ERK activation , and transformation by oncogenic Ras and Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
H ( 2 ) O ( 2 ) induced ERK activation was inhibited not only by PD 98059 ( 10 microM ) , but also by the non selective tyrosine kinase inhibitor genistein ( 3 100 microM ) , the EGF receptor kinase inhibitor AG 1478 ( 3 300 nM ) and the Src family kinase inhibitor PP 2 ( 0 . 1 10 microM ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
AVP induces extracellular signal related kinase ( ERK ) 1 ( p 44 ( mapk ) ) and ERK 2 ( p 42 ( mapk ) ) activation , a response prevented by treatment with mitogen activated protein kinase kinase ( MEK ) inhibitors ( PD 98059 and U 0126 ) , specific PKC inhibitors ( GF 1 and Ro 31 8220 ) , depletion of Ca ( 2+ ) ( EGTA and thapsigargin ) , selective epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors ( tyrphostin AG 1478 , compound 56 ) , or the selective Src family kinase inhibitor PP 2 . ^^^ Furthermore , AVP acts as a potent growth factor for IEC 18 cells , inducing DNA synthesis and cell proliferation through ERK , Ca ( 2+ ) , PKC , EGFR tyrosine kinase , and Src dependent pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The Gbetagamma dependent activation of ERK requires tyrosine kinases , including epidermal growth factor receptor and c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
EGFR was Ca ( 2+ ) independently activated and predominantly contributed to Shc / ERK / c fos activation , while Pyk 2 or c Src contributed less to it . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These results demonstrated that the activation of Src by pervanadate is involved in PLC gamma1 / InsPs signalling but does not play a major role in ERK activation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We conclude that ERK and JNK are involved in basal and GnRH A stimulation of LHbeta CAT activity . c Src participates also in LHbeta promoter activation by a mechanism which might be linked to ERK and JNK activation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Further evidence for differential regulation of RAS and ERK is provided by the observations that TPO , which activates RAS but not protein kinase C , does not activate ERK , and that the inhibitor of SRC kinases PP 1 inhibits activation of RAS but not ERK 2 in response to thrombin . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibiting ERK activation with the MEK inhibitor U 0126 increased the EGF stimulated association of Gab 1 with either full length glutathione S transferase p 85 or the p 85 C terminal Src homology 2 ( SH 2 ) domain , a result reproduced by co immunoprecipitation of the native proteins from intact cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Ca2+ mediated activation of ERK in hepatocytes by norepinephrine and prostaglandin F 2 alpha : role of calmodulin and Src kinases . ^^^ The Src kinase inhibitors PP 1 and PP 2 partially diminished the ERK responses elicited by both norepinephrine and PGF2alpha . ^^^ CONCLUSION : The present data indicate that Ca2+ is involved in ERK activation induced by hormones acting on G protein coupled receptors in hepatocytes , and suggest that calmodulin and Src kinases might play a role in these signaling pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , whereas src inhibition resulted in inhibition of Raf / Mek / Erk phosphorylations , syk inhibition could only inhibit Mek and Erk phosphorylations but not the phosphorylation of Raf . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The MK induced migration was inhibited by PP 1 , wortomanin , PD 98059 and vanadate , indicating that the downstream signaling system , which includes Src , PI 3 kinase and ERK as important components , is shared with other MK signaling systems in which PTP zeta is involved . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Pretreatment of AEC with Src homology 3 binding peptide , which blocks the interaction between Grb 2 and Sos , did not prevent DA activation of ERK . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These cells overexpress urokinase receptor ( uPAR ) which , by activating alpha5beta1 integrin , initiates an intracellular signal through FAK and Src leading to ERK activation and tumorigenicity in vivo . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
AII directly activated Src , as well as the proximal ( Raf ) and distal ( ERK ) elements of the classic MAPK module , and the activation of Src was prevented by AT 1 receptor antagonism . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moreover , pretreatment with PP 2 , a selective inhibitor of the Src tyrosine kinase , attenuated both ISO mediated EGFR phosphorylation and ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibition of ERK activation with the MEK inhibitors PD 98059 and U 0126 as well as the Src family kinase inhibitor PP 2 completely blocked the effect of DABK to increase p27Kip1 and partially reversed the DABK mediated inhibition of PDGF stimulated proliferation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
ET 1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells . ^^^ Inhibition of Src kinases by PP 1 abrogated phorbol ester and ET 1 induced ERK activation . ^^^ Altogether , our results indicate that ET 1 induces ERK activation in rat myometrial cells through the sequential stimulation of PKC , Src , and Ras . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The spin trapping agent PBN stimulates H 2 O2 induced Erk and Src kinase activity in human neuroblastoma cells . ^^^ In the present study , we examined the effects of PBN on the regulation of the mitogen activated kinase Erk and as well as Src family tyrosine kinases , enzymes known to be activated by oxygen species such as H2O2 . ^^^ In SH SY5Y human neuroblastoma cells , H2O2 induced activation of Erk and Src kinases was markedly potentiated by treatment with PBN . ^^^ The potentiation by PBN of the Erk and Src kinase activation by H2O2 required extracellular Ca2+ and appeared dependent on voltage sensitive Ca2+ channels . ^^^ In contrast , PBN did not affect depolarization dependent or growth factor dependent Erk and Src kinase phosphorylation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Bisphosphonate induced , hemichannel mediated , anti apoptosis through the Src / ERK pathway : a gap junction independent action of connexin 43 . ^^^ The signal transducing property of connexin 43 requires the pore forming , as well as the C terminal domains of the protein , the interaction of connexin 43 with Src . and the activation of both Src and ERK kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Pertussis toxin , as well as Src protein tyrosine kinase and protein kinase C inhibitors , did not prevent the GM 1 induced activation of Erk 2 , apparently excluding the participation of Gi and Gq / 11 protein coupled receptors . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Induction of ERK by LPA proceeds via Gbetagamma dependent activation of tyrosine kinases , including the epidermal growth factor ( EGF ) receptor and c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Role of c SRC and ERK in acid induced activation of NHE 3 . ^^^ METHODS : OKP cells were incubated in control ( pH 7 . 4 ) or acid ( 7 . 0 ) media , and NHE 3 activity measured as cytoplasmic pH ( pHi ) recovery from an acid load using BCECF . c Src , ERK , and JNK kinase activities were measured by immune complex kinase assays with enolase , MBP , and GST c Jun , respectively , as substrates in the in vitro assays . ^^^ Acidosis in vivo also activated renal cortical c Src and ERK kinases , whereas incubation of 3T3 cells in acid media activated c Src but not ERK kinase . ^^^ CONCLUSIONS : These studies suggest that acidosis activates c Src and MEK / ERK / c fos . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
IL 18 induced a time dependent activation of c Src , Ras , and Raf 1 , suggesting this signaling cascade plays a role in ERK activation . ^^^ Electrophoretic mobility shift assay showed that activator protein 1 ( AP 1 ) is activated by IL 18 through ERK and Src but not through PI 3 kinase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Upon stimulation of the bombesin receptors , KUZ increases the docking and activation of adaptors Src homology 2 domain containing protein and Gab 1 on the EGFR , and activation of Ras and Erk . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We investigated the tyrosine kinase receptor pathway by evaluating the protein expression of total and phosphorylated mitogen activated protein kinase ( MAPK ) isoform p44 / p42 ( e . g . , extracellular signal regulated kinase [ ERK ] 1 / 2 ) , the steroid receptor coactivator Src and Shc ( Src homology / collagen protein ) . ^^^ Proliferation was also evaluated in normal purified cholangiocytes treated with 17 beta estradiol in the presence or absence of tamoxifen , Ici 182 , 780 , ERK , or Src inhibitors . ^^^ Specific inhibitors of ER ( Ici 182 , 780 ) , ERK ( U 0125 ) , and Src ( PP 2 ) inhibited in vitro 17 beta estradiol induced cholangiocyte proliferation . ^^^ In conclusion , this study showed that estrogens induced cholangiocyte proliferation by activating the Src / Shc / ERK pathway . ^^^ This might suggest that pharmacologic modulation of ER , ERK , and / or Src could be proposed for the treatment of human pathology characterized by dysregulation of cholangiocyte proliferation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Co incubation with the Src kinase inhibitor PP 2 and anti EGFr had an additive inhibitory effect on CCh induced ERK phosphorylation greater than either inhibitor alone . ^^^ We conclude that CCh stimulated EGFr transactivation and subsequent ERK activation , a pathway that limits CCh induced chloride secretion , is mediated by metalloproteinase dependent extracellular release of TGF alpha and intracellular Src activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We report here that VPF significantly enhances permeability in aortic endothelial cells via a linked signaling pathway , sequentially involving Src , ERK , JNK , and phosphatidylinositol 3 kinase / AKT . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , a Src mutant ( SrcS17D ) , which mimics PKA phosphorylation at serine 17 , stimulates Rap 1 activation , Rap1 / B Raf association , and ERK activation but does not stimulate Ras or AKT . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We demonstrate that pharmacological ablation of extracellular signal regulated kinase ( ERK ) activation leads to blockade of RALT expression , unlike genetic and / or pharmacological interference with the activities of PKC , Src family kinases , p 38 SAPK and PI 3K . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of Akt and ERK occurs through an MLK independent pathway that may involve c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Additionally , the general tyrosine kinase inhibitor genistein , as well as the Src inhibitor PP 1 and the epidermal growth factor receptor kinase inhibitor 4 ( 3 chloroanilino ) 6 , 7 dimethoxyquinazoline ( AG 1478 ) , inhibited receptor mediated activation of ERK , suggesting a role for tyrosine kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moreover , FAK overexpression was able to enhance HGF elicited signals , leading to sustained activation of ERK , JNK , and AKT , which could be prevented by the expression of the Src homology 3 domain of p 130 ( cas ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
HU 210 induced ERK activation was inhibited by tyrphostin AG 1478 and PP 2 , widely employed inhibitors of the epidermal growth factor receptor ( EGF ( R ) ) and the Src family of cytosolic tyrosine kinases , respectively . ^^^ In addition , dominant negative forms of both proteins were unable to prevent cannabinoid induced ERK activation , thus excluding the existence of CB ( 1 ) mediated EGF ( R ) transactivation or Src activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Further , inhibition of Src non receptor tyrosine kinase activity by PP 1 attenuated the ERK response generated by both receptor subtypes , but only mGlu1a receptor ERK activation was attenuated by PDGF receptor tyrosine kinase inhibitor AG 1296 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Bcr Abl constitutively activates several signaling proteins important for the proliferation and survival of myeloid progenitors , including the Src family kinases Hck and Lyn , the Stat 5 transcription factor and upstream components of the Ras / Erk pathway . ^^^ These data implicate the Src kinase family in Stat 5 and Erk activation downstream of Bcr Abl , and identify myeloid specific Src kinases as potential drug targets in CML . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Finally , the actions of GDNF are inhibited by PP 2 , an inhibitor of Src family tyrosine kinases , and by LY 29003 , an inhibitor of phosphatidylinositol 3 kinases , but not by PD 98059 , an inhibitor of the Erk signaling cascade . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
FRNK expression disrupted the formation of a 5 Src FAK signaling complex , inhibited p130Cas tyrosine phosphorylation , and attenuated 5 Src stimulated ERK and JNK kinase activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Src / ERK but not phospholipase D is involved in keratinocyte growth factor stimulated secretion of matrix metalloprotease 9 and urokinase type plasminogen activator in SNU 16 human stomach cancer cell . ^^^ METHODS : Alterations in the activities of Src , extracellular signal regulated kinase ( ERK ) , and phospholipase D ( PLD ) were measured using [ gamma ( 32 ) P ] ATP for autophosphorylation of Src , phospho specific ERK antibody , and [ 9 , 10 ( 3 ) H ] myristic acid , respectively , while herbimycin A , PD 98059 and butan 1 ol were used to inhibit their activities . ^^^ RESULTS : Src , ERK , and PLD were activated in response to KGF treatment , and inhibition of these enzymes by their specific inhibitors decreased KGF induced invasion in a dose dependent manner . ^^^ However , only inhibition of Src and ERK could block KGF stimulated secretion of uPA and MMP 9 . ^^^ CONCLUSION : Src , ERK , and PLD are suggested as mediators of KGF induced invasion in SNU 16 . uPA and MMP 9 are considered as downstream targets of Src and ERK whereas PLD is thought to utilize different pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We analyzed the signal transduction pathways regulating bud development using inhibitors of protein kinase C , Src , PI3K and ERK . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Both a protein kinase C inhibitor , GF109203X , and a Src inhibitor , PP 1 , attenuated 5 HT stimulated Erk 1 / 2 activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In contrast , an inhibitor of the Src family tyrosine kinase prevented the nicotine induced Akt phosphorylation but not ERK phosphorylation . ^^^ These results suggested that nicotine induces the activation of both PI 3 kinase / Akt and ERK pathways via common pathways including non alpha 7 nAChRs , L type VSCC , CaM kinase 2 and EGFR in PC12h cells , but Src family tyrosine kinases only participate in the pathway to activate Akt . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Results show that the ERK kinase MEK and upstream intermediates Raf 1 , Ras , Src , and L type Ca ( 2+ ) channels are already partially activated in vehicle treated cells and that FSH does not further activate them . ^^^ Consistent with this premise , FSH stimulated ERK activation is inhibited by the cell permeable protein kinase A specific inhibitor peptide Myr PKI as well as by inhibitors of MEK , Src , a Ca ( 2+ ) channel blocker , and chelation of extracellular Ca ( 2+ ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Bikunin showed no additive effect on SK & F 96365 mediated suppression of TGF beta 1 expression . 6 ) The ability of TGF beta 1 to elevate free intracellular Ca ( 2+ ) , followed by activation of Src and ERK , was reduced by preincubation of the cells with bikunin . ^^^ In conclusion , bikunin could inhibit the constitutive expression of TGF beta 1 and TGF beta 1 mediated , Src and ERK dependent , PA system signaling cascade , at least in part , through inhibition of a non voltage sensitive calcium channel . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Alpha 2 adrenoceptor mediated vasoconstriction in porcine palmar lateral vein : role of phosphatidylinositol 3 kinase and EGF receptor transactivation . 1 Alpha ( 2 ) adrenoceptors cause vasoconstriction in the porcine palmar lateral vein through a mechanism involving the ERK signal transduction cascade , calcium influx , and a Src tyrosine kinase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Additionally , stretch induced increases in both ERK phosphorylation and force generation were attenuated by inhibition of tyrosine kinases ( genistein ) , src ( PP 2 ) , and specific sites on the epidermal growth factor receptor ( EGFR ) ( AG 1478 ) . ^^^ In summary , stretch seems to enhance force generation via ERK signaling through an EGFR / src dependent mechanism activated by peroxide derived from a stretch mediated activation of the NAD ( P ) H oxidase , a response that may contribute to hypertensive alterations in vascular reactivity . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moreover , we showed that both isoforms activate ERK phosphorylation in an Src kinase dependent manner , whereas PKC was mainly implicated in ERK activation and EGFR phosphorylation by TP beta . ^^^ We demonstrated further that EGFRs , PKC , Src kinase and MMPs are involved in ERK activation by TX . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We used the human alpha subunit promoter linked to chloramphenicol acetyl transferase ( alphaCAT ) to examine the role of ERK , JNK , and c Src , which is implicated in MAPK activation , in basal and GnRH stimulated alphaCAT . ^^^ Surprisingly , although c Src is involved in GnRH A stimulated ERK , its involvement is mapped to another region ( 280 / 180 ) containing the glycoprotein specific element . ^^^ Thus , ERK and c Src but not JNK are involved in basal and GnRH A stimulated alphaCAT , whereas c Src contribution is independent of ERK activation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Src kinase was phosphorylated and mitogen activated protein kinase / extracellular signal regulated kinase ( MAPK / ERK ) activated in a time related fashion after SDF 1 stimulation . ^^^ CaM1 . 6 cells respond as well as the parental cells to SDF 1 in terms of ERK activation and tyrosine phosphorylation of WASP after SDF 1 stimulation , it appears that src kinase , but not the src kinase family member lck , mediates chemotaxis of Jurkat cells in response to SDF 1 induction and that src kinase may link with WASP in this effect . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , both thrombin induced Pyk 2 phosphorylation and extracellular signal regulated kinase ( ERK ) 1 / 2 phosphorylation can be attenuated by Src kinase inhibitor 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Antisense transfection of HCT 116 cells had no effect on proliferation but the following effects were observed : ( 1 ) a 1 . 3 fold decreased adhesion ; ( 2 ) a two fold decreased Erk MAP kinase activity ; ( 3 ) a 2 . 7 fold decrease in Src kinase activity ; ( 4 ) a 1 . 5 and two fold decrease in uPA cell surface expression and secretion ; ( 5 ) abrogation of promatrix metalloproteinase 9 secretion ; and ( 6 ) a complete suppression of plasminogen dependent matrix degradation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Langendorff rat heart preparations were exposed to 50 microM ouabain to produce positive inotropy without toxicity , and assayed for Src kinase , protein kinase C , and extracellular signal regulated kinases 1 and 2 ( ERK ( 1 / 2 ) ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition to PKC , active Src kinase was also shown to be involved in the maintenance of Raf independent ERK activation in HCs . ^^^ Taken together , these results suggest that active p38 / JNK make HCs susceptible to apoptosis , but the cells are effectively rescued by ERK activation involving constitutively active PKC and Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Such inhibitor sensitivity profiles suggested that src family members , likely pp 60 ( c src ) , were important upstream elements in deformation related ERK activation . pp 60 ( c src ) kinase activity was elevated fourfold within 15 min after CD addition to quiescent R 22 smooth muscle cells and declined quickly thereafter . ^^^ These data indicate that pp 60 ( c src ) is a critical upstream activator of the ERK cascade leading to PAI 1 transcription in response to cellular deformation stimuli . . ^^^ Pp60c src mediates ERK activation / nuclear localization and PAI 1 gene expression in response to cellular deformation . ^^^ Pp60c src mediates ERK activation / nuclear localization and PAI 1 gene expression in response to cellular deformation . ^^^ ERK activation in response to microfilament disruption was inhibited completely by the broad spectrum tyrosine kinase inhibitor genistein and the relatively src kinase selective compound PP 1 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In this report , we investigated the activation and regulation of p130Cas , Crk , Pyk 2 , and c Src by a well known hypertrophic agonist , endothelin 1 ( ET ) , and determined their contributions to the activation of c Jun NH 2 terminal kinase ( JNK ) and extracellular signal regulated kinase ( ERK ) in cardiomyocytes . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibition of C SRC tyrosine kinase activity also blocks PGE ( 2 ) induced HIF 1alpha protein and VEGF mRNA expression without blocking ERK phosphorylation . ^^^ In contrast , phosphorylation of AKT is dependent on ERK and C SRC activity . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
An integrin inhibitory peptide with an RGD motif blocked TUDC induced FAK , Src , ERK , and p 38 ( MAPK ) activation , suggesting that integrin signaling toward FAK / Src is required for TUDC induced MAPK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The RANK signaling mechanisms involved in these responses include the recruitment of TNF receptor associated factor proteins , the activation of transcription factors ( NF kappaB , AP 1 , and NFAT 2 ) , the cascades of mitogen activated protein kinases ( ERK , JNK , and p 38 ) , and the induction of Src and phosphatidylinositol 3 kinase dependent Akt activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Interestingly , NT did not stimulate epidermal growth factor receptor transactivation , and epidermal growth factor receptor tyrosine kinase or Src inhibitors did not affect NT induced ERK activation in PANC 1 cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
ERK activation by GnRHR is mediated by the EGF receptor , which activates Ras either directly or via c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These studies demonstrate that CRs on chicken heterophils lack intrinsic tyrosine kinase activity , but that binding of serum opsonized bacteria activates both proximal tyrosine kinases ( src and Syk kinases ) , but differentially activates downstream tyrosine kinases ( JNK , but not p 38 nor ERK ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Western blot analysis revealed tyrosine phosphorylation of the functionally related kinases c Src and extracellular signal regulated kinase ( ERK ) 1 / 2 in corneal fibroblasts within 15 min after infection . ^^^ Application of inhibitors to Src and ERK kinase assays suggested an upstream relationship of c Src to ERK . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In this study we show that SDF 1alpha stimulation of prolonged ERK activation in Jurkat T cells requires both the ZAP 70 tyrosine kinase and the Src homology 2 domain containing leukocyte protein of 76 kDa ( SLP 76 ) scaffold protein . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
RESULTS : The majority of cytoskeletal proteins , Src substrates , Src kinases and members of the ERK and JNK signaling molecule families require actin cytoskeletal organization and tyrosine kinase mediated phosphorylation to accumulate . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , non receptor tyrosine kinase Src and cellular Ca2+ were shown to be involved in bombesin induced EGF receptor transactivation and ERK phosphorylation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition , using dominant negative mutants , we show that sst 2 mediated ERK 2 stimulation is dependent on the pertussis toxin sensitive Gi / o protein , the tyrosine kinase Src , both small G proteins Ras and Rap 1 , and the MEK kinase B Raf but is independent of Raf 1 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
EphB 1 recruits c Src and p52Shc to activate MAPK / ERK and promote chemotaxis . ^^^ Here we demonstrate that activated EphB 1 recruits the adaptor proteins Grb 2 and p52Shc and promotes p52Shc and c Src tyrosine phosphorylation as well as MAPK / extracellular signal regulated kinase ( ERK ) activation . ^^^ Together these findings highlight a new aspect of EphB 1 signaling , whereby the concerted action of c Src and p52Shc activates MAPK / ERK and regulates events involved in cell motility . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Effects of estrogen , age , and calpain on MAP kinase and NMDA receptors in female rat brain . 17 beta Estradiol ( E 2 ) , by activating Src and ERK / MAP kinases , enhances NMDA receptor phosphorylation and function . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
A novel role for FAK as a protease targeting adaptor protein : regulation by p 42 ERK and Src . ^^^ ERK / MAP kinase mediated activation of the protease Calpain 2 also promotes focal adhesion turnover ; however , it is not known if this is linked to the activities of Src and FAK . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Finally , the increased phosphorylation of Gab 1 by Src selectively potentiated HGF induced activation of ERK and AKT . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We found that GnRH induced Src , Ras , and ERK activation were also gelatinase dependent . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The phosphatidylinositol ( PI ) 3 kinase inhibitor LY 294002 and the Src kinase inhibitor PP 2 partially occluded the response but also decreased basal levels of phospho ERK . ^^^ PI 3 kinase and Src appear to contribute to ERK activation by maintaining activation of kinases , which prime the pathway and maintain cellular viability . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Compared with GEC on plastic substratum , adhesion to collagen increased activation of focal adhesion kinase ( FAK ) , c Src , and ERK and facilitated survival ( prevented apoptosis ) . ^^^ Glomeruli isolated from rats with PAN revealed increased beta 1 integrin expression , along with increased activation of FAK , c Src , and ERK , compared with controls . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of ERK was dependent on its protein protein assembly with FAK and c Src at focal adhesion complexes . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In a quest for molecules upstream of ShcA in this signaling , we found that CSR induced ShcA tyrosine phosphorylation , its association with Grb 2 , Erk activation , and uPA gene expression were all dependent on Rho kinase , p 38 mitogen activated protein kinase , and Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Collagen 4 regulates Caco 2 migration and ERK activation via alpha1beta1 and alpha2beta1 integrin dependent Src kinase activation . ^^^ Both dominant negative Src and Src inhibitor PP 2 strongly inhibited collagen 4 ERK activation in Caco 2 intestinal epithelial cells . ^^^ Additionally , FAK Y925F expression blocked collagen 4 ERK activation . alpha ( 1 ) beta ( 1 ) Or alpha ( 2 ) beta ( 1 ) integrin blockade with alpha ( 1 ) or alpha ( 2 ) integrin subunit antibodies indicated that either integrin can mediate adhesion , cell spreading , and FAK , Src , and ERK activation on collagen 4 . ^^^ These results suggest a pathway for collagen 4 ERK activation requiring Src phosphorylation of FAK Y 925 not previously described for this matrix protein and suggest either alpha ( 1 ) beta ( 1 ) or alpha ( 2 ) beta ( 1 ) integrins can regulate Caco 2 spreading and ERK activation on collagen 4 via Src . ^^^ Additionally , these results suggest Src regulates Caco 2 migration on collagen 4 primarily through ERK independent pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Finally , IL 1beta induced proliferation of Balb 3T3 cells and inhibition of Erk and Akt signalings or their upstream signaling molecules , Src kinase and PKC by their inhibitors strongly inhibited IL 1beta dependent cell proliferation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Consistent with the abrogation of Src activity was the reduction of Src Tyr 416 phosphorylation , Src mediated Shc Tyr 317 phosphorylation , decreased ERK activation , and cell proliferation in 5 Src transformed cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of phospholipase C gamma , protein kinase C , Ca ( 2+ ) , ERK ( extracellular signal regulated protein kinase ) , Akt , Src , focal adhesion kinase and calcineurin pathways has been implicated in mediating multiple VEGF functions , including survival , proliferation , migration , vascular permeability , tubulogenesis , NO and prostanoid synthesis , and gene expression . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Regulation of phospho Akt was found to be under the control of various factors , namely VE cadherin activation , Src kinase , tyrosine kinase , extracellular signal regulated kinase ( ERK ) , and c Jun N terminal kinase ( JNK ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Importantly , Gab1FF blocked paxillin SHP 2 complex formation , Src Tyr 530 dephosphorylation , Erk activation , and cell migration induced by EGF . ^^^ Inhibition of Src tyrosine kinase activity abrogated EGF stimulated Erk activation and cell migration . ^^^ Together , these results reveal that Gab 1 recruits SHP 2 to dephosphorylate paxillin , leading to dissociation of Csk from the paxillin Src complex and Src activation and that Src is an SHP 2 effector involved in EGF stimulated Erk activation and cell migration . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We assessed binding affinity by detachment assay ; integrin surface expression by flow cytometry ; and focal adhesion kinase ( FAK ) , Src , and extracellular signal regulated kinase ( ERK ) activation by Western analysis and Src in vitro kinase assay . ^^^ Pressure activated SW 620 FAK and Src , but not ERK . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibition of ERK , Src , or Akt suppressed telomerase activity in HSC 1 cells , but to a lesser extent than did treatment with AG 1478 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Assays with inhibitors and antibodies against proteins involved in signal transduction demonstrated that NAPS and TAPS elevated COX 2 expression via tyrosine kinase , src , PI 3 kinase and PKC , followed by ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The ATP provoked activation of JNK and p 38 [ but not extracellular signal regulated kinase ( ERK ) ] could be inhibited by brilliant blue G , a P2X7 receptor blocker , and by genistein and 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine , which are general and src family specific tyrosine kinase inhibitors , respectively . ^^^ Together , these findings indicate that both ERK and JNK are involved in the regulation of TNF mRNA expression , that p 38 is involved in the nucleocytoplasmic transport of TNF mRNA , and that a PTK ( protein tyrosine kinase ) , possibly a member of the src family , acts downstream of the P2X7 receptor to activate JNK and p 38 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition , the c Src inhibitor PP 2 and selective EGF receptor kinase inhibitor AG 1478 attenuated both ERK 1 / 2 and EGF receptor phosphorylation by cyclic stretch . ^^^ In addition , these findings indicate cyclic stretch increased the tyrosine phosphorylation of the EGF receptor and c Src and that c Src acts upstream of the EGF receptor to mediate its phosphorylation , whereby both are critical for stretch induced ERK 1 / 2 activation in rabbit proximal tubular cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Biochemical analysis revealed that the Cas SH 3 domain selectively inhibited 5 Src stimulated activations of AKT and JNK , but not ERK and STAT 3 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
FAK Src signalling through paxillin , ERK and MLCK regulates adhesion disassembly . ^^^ Using these assays , we show that kinases and adaptor molecules , including focal adhesion kinase ( FAK ) , Src , p130CAS , paxillin , extracellular signal regulated kinase ( ERK ) and myosin light chain kinase ( MLCK ) are critical for adhesion turnover at the cell front , a process central to migration . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
THP 1 macrophages constitutively expressed activated FAK , ERK , and Src . ^^^ Exposure of macrophages to pressure decreased ERK and FAK Y 397 phosphorylation ( 77 . 6 + / 7 . 9 % , n = 7 , P < 0 . 05 ) but did not alter FAK Y 576 or Src phosphorylation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition , we found that NO produces c Src / PI3K and PKG dependent activation of ERK 1 / 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Shp 2 regulates SRC family kinase activity and Ras / Erk activation by controlling Csk recruitment . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
This data driven , multivariate ( 16 conditions 10 31 components 10 3 time points = approximately 1 , 500 values ) proteomic approach identified a set of signaling network components most critically associated ( positively or negatively ) with differentiation ( Stat 3 , Raf 1 , MEK , and ERK ) , proliferation of undifferentiated cells ( MEK and ERK ) , and proliferation of differentiated cells ( PKB alpha , Stat 3 , Src , and PKC epsilon ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We found that Src inhibitor PP 2 and Syk inhibitor piceatannol inhibited phagocytosis , macrophage inflammatory protein 1alpha ( MIP 1alpha ) release , as well as phosphorylation of extracellular regulated kinase ( ERK ) and Akt , consistent with Src / Syk involvement early in FcgammaR signaling . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of TrkA and extracellular signal regulated kinase ( ERK ) by nerve growth factor ( NGF ) was inhibited by pretreatment with PP 2 , an inhibitor of Src family kinases . ^^^ Moreover , NGF induced phosphorylation of TrkA and ERK was also attenuated by the transfection with a dominant negative src construct . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The upregulation of IL 8 expression by IGF 2 was reduced by pretreatment with inhibitors of tyrosine kinase , Src , PI 3 kinase , and ERK , but not by p 38 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibitors were employed to determine pathway ( ER , EGFR , membrane organization , PI 3 kinase , Src kinase , Ca2+ ) involvement and timing of pathway activations ; all affected ERK activation as early as 3 6 min , suggesting simultaneous , not sequential , activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Our results show that Src , phosphatidylinositol 3 kinase , and atypical protein kinase C were commonly involved in D ( 2 ) R / D ( 3 ) R mediated ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In this paper , we reported that GST sHLA G1a chain could bind to its receptor ILT 2 on NK 92 cells and then the latter recruited Src homology 2 domain containing tyrosine phosphatase 1 ( SHP 1 ) , which consequently dephosphorylated some important protein tyrosine kinases and blocked the activation of downstream molecules such as MEK and ERK so that the cytotoxicity of natural killer ( NK ) cells was inhibited . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NHERF 2 increases platelet derived growth factor induced proliferation through PI 3 kinase / Akt , ERK , and Src family kinase dependent pathway . ^^^ Pretreatment with PP 2 , a specific inhibitor of Src family tyrosine kinase , completely blocked the NHERF 2 dependent increase of the phosphorylation of ERK and Akt , suggesting that NHERF 2 up regulates Erk phosphorylation through a Src family kinase dependent pathway . ^^^ These results suggest that NHERF 2 stimulates PDGF induced proliferation by increasing PI 3 kinase / Akt , MEKindependent ERK , and Src family kinase mediated signaling pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Expression of a PTPD 1 mutant lacking catalytic activity inhibits src and downregulates ERK 1 / 2 but does not affect the activity of c Jun N terminal kinase 1 / 2 and p38alpha mitogen activated protein kinase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We also determined that cisplatin induced ERK as well as caspase 3 activation are epidermal growth factor receptor ( EGFR ) and c src dependent because inhibition of these genes inhibited ERK and caspase 3 activation and attenuated apoptotic death . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Nicotine induces the activation of both PI 3 kinase / Act and ERK / CREB pathways via common pathways including non alpha 7 nAChRs , L type VSCC , CaM kinase and EGFR in PC12h cells , but Src family tyrosine kinases only participate in the pathway to activate Akt . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The Src tyrosine kinase inhibitor 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolol [ 3 , 4 d ] pyrimidine had no effect on Tau Cl induced EGF receptor or ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Here we investigated the ability of cAMP to modulate the endotoxin signaling by exposing DCs to exogenous 8 bromium cyclic AMP in the presence or absence of H 89 , a selective inhibitor of the protein kinase A , one of the major molecular targets of the cyclic nucleoside . cAMP affects the early lipopolysaccharide induced signaling cascade dissociating the activation of NF kappa B , p 38 , and ERK pathways from the stimulation of c Src and Lyn kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Erk / Src phosphorylation of cortactin acts as a switch on switch off mechanism that controls its ability to activate N WASP . ^^^ Cortactin is a target for phosphorylation by Src tyrosine kinases and by serine / threonine kinases that include Erk . ^^^ In contrast , Src phosphorylation inhibited the ability of cortactin previously phosphorylated by Erk , and that of S 405 , 418D double mutant cortactin , to bind and activate N WASP . ^^^ We propose that Erk phosphorylation liberates the SH 3 domain of cortactin from intramolecular interactions with proline rich regions , causing it to synergize with WASP and N WASP in activating the Arp2 / 3 complex , and that Src phosphorylation terminates cortactin activation of N WASP and WASP . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The expression of beta ( 1 ) integrin receptor , as well as Src , son of sevenless protein ( SOS ) and phosphorylated mitogen activated protein ( MAP ) kinases ( MAPK ) , extracellular signal regulated kinase 1 ( ERK ( 1 ) ) and kinase 2 ( ERK ( 2 ) ) but not focal adhesion kinase pp 125 ( FAK ) ( FAK ) , Shc , and Grb 2 was significantly decreased in cells incubated for 24 h with 10 microM AB ( 1 ) compared to the control , whereas in the same conditions chlorambucil did not evoke any changes in expression of all these signaling proteins , as shown by Western immunoblot analysis . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
GDNF mediated CRMP 2 expression was regulated mainly by the extracellular regulated kinase ( ERK ) pathway , but was independent of activation of phosphatidylinositol 3 kinase and Src family kinases . ^^^ However , neuritogenesis of TGW cells was mostly dependent on Src family kinase activity and not ERK activity , indicating that the increased expression of CRMP 2 alone was not sufficient for neuritogenesis . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The activation state of Src kinases and the MAP kinases extracellular signal regulated protein kinase ( ERK ) , c jun N terminal kinase ( JNK ) , and p 38 in the lens epithelium was determined over a time course from 10 minutes to 10 days in culture by immunoblot analysis . ^^^ Although the inhibitors of ERK and JNK did not interfere with the formation of cataract , p 38 inhibitors blocked the development of lens opacities with an efficacy similar to that of the Src kinase inhibitor PP 1 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The non receptor tyrosine kinase Src is involved in the pathway leading to activation of ERK 1 / 2 by serum . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These results suggest that IGF 2 induces COX 2 expression through the tyrosine kinase Src ERK and tyrosine kinase PI 3 kinase pathways , but not via p 38 MAPK pathway , and that the basal JNK activity is required for the upregulation of COX 2 by IGF 2 , as well . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The tyrosine kinase Src is involved in the pathway leading to activation of ERK 1 / 2 by serum . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These data suggest that 15 d PGJ 2 and TZDs activate PI 3 K / ERK pathway through Src family kinase and matrix metalloproteinase dependent transactivation of EGF R and PDGF R . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The gastric mucosal phospholipid secretory responses to isoproterenol , furthermore , were inhibited by PP 2 , a selective inhibitor of tyrosine kinase Src responsible for ligand independent EGFR phosphorylation , but not by ERK inhibitor , PD 98059 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Ionotropic and metabotropic receptors , protein kinase A , protein kinase C , and Src contribute to C fiber induced ERK activation and cAMP response element binding protein phosphorylation in dorsal horn neurons , leading to central sensitization . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In AD LNCaP ( nan ) cells , dihydrotestosterone ( DHT ) stimulated in an androgen receptor ( AR ) dependent way a phosphorylation signaling pathway involving steroid receptor coactivator ( Src ) mitogen activated protein / extracellular signal regulated kinase ( ERK ) kinase ( MEK ) 1 / 2 ERK 1 / 2 cAMP response element binding protein ( CREB ) . ^^^ In contrast , in AI LNCaP HP cells , the Src MEK 1 / 2 ERK 1 / 2 CREB pathway was constitutively active . ^^^ Additional experiments showed that Src and the scaffold protein MNAR coimmunoprecipitated with AR , indicating a role for Src as an apical molecule in the Src MEK 1 / 2 ERK 1 / 2 CREB pathway . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
G 16 mediated activation of nuclear factor kappaB by the adenosine A 1 receptor involves c Src , protein kinase C , and ERK signaling . ^^^ Inhibition of c Src and numerous intermediates along the extracellular signal regulated ( ERK ) kinase cascade including Ras , Raf 1 kinase , and MEK1 / 2 abolished the CHA induced IKK / NFkappaB activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In conclusion , our data demonstrate for the first time that US promotes cell proliferation via activation of integrin receptors and a Rho / ROCK / Src / ERK signaling pathway . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The process requires Src and erk signaling and eNOS phosphorylation by phosphoinositide 3 kinase ( PI 3 kinase ) Akt kinase , with Src and PI 3 kinase associating with ERalpha upon ligand activation . ^^^ The loss of NLS2 / NLS3 prevented Src and erk activation , and it altered ligand induced PI 3 kinase ERalpha interaction and prevented eNOS phosphorylation . ^^^ Loss of the DNA binding domain did not change E 2 activation of Src or erk , but ligand induced PI 3 kinase ERalpha binding and eNOS phosphorylation did not occur . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Pyk 2 , rather than PI 3K / Akt or Erk , appears to be the key downstream effecter of Src in mediating the cell survival signals . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
PDGF BB induced Egr 1 activation was suppressed by inhibitors of 2 upstream activators of Egr 1 , extracellular signal regulated kinase ( ERK ) and Src family kinases , whereas antioxidants , phosphatidylinositol 3 phosphate kinase , and p 38 MAPK inhibitors had no effect . ^^^ Taken together , the results suggest that PDGF BB induces TF expression and activity in SMC by a Src family kinases / ERK / Egr 1 signaling pathway and may therefore contribute to thrombus formation in advanced atherosclerosis and restenosis . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of both PKB and Erk as well as survival in low serum containing media are all rescued by reexpression of Grb 2 containing mutations within the N terminal Src homology 3 ( SH 3 ) domain , but not by C terminal SH 3 domain mutants . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
To identify signaling pathways involved in ERK activation , we used specific inhibitors of ERs , epidermal growth factor receptors , Ca2+ signaling , Src and phosphoinositide 3 kinases , and a membrane structure disruption agent . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
ERK , p 38 , c Src and Akt phosphorylation and PKCalpha redistribution were assessed by western blot after 30 min and PKC activation by ELISA . ^^^ Pressure activated p 38 , ERK , and c Src ( P < 0 . 05 each ) but not Akt / PKB . ^^^ Blockade of p 38 , ERK , c Src or PI 3 K or actin depolymerization did not inhibit pressure stimulated proliferation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Because the non receptor tyrosine phosphatase Src homology 2 domain containing protein tyrosine phosphatase 2 ( SHP 2 ) is enriched in focal adhesions and IL 1 induced ERK activation requires increased Ca ( 2+ ) , we determined whether SHP 2 modulates IL 1 induced Ca ( 2+ ) signaling . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
FRS 2 dependent SRC activation is required for fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of ERK activity . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In contrast , phosphorylation of the extracellular signal regulated kinase ERK 2 , the ERK kinase MEK , proline rich tyrosine kinase 2 ( Pyk 2 ) , and Src family kinases was significantly , but transiently , increased . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition to its role in conferring cell adhesion formation , the p FAK / c Src protein complex apparently also regulates apical ES disruption via the ERK signaling pathway . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Evaluation of the role of c Src and ERK in TCDD dependent release from contact inhibition in WB F 344 cells . ^^^ Our data show that neither c Src activation , nor ERK activation are required for TCDD dependent release from contact inhibition arguing against a functional role of EGF receptor activation in response to TCDD in WB F 344 cells . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Moreover , the effect of Src family kinase inhibitors on EGF stimulated ERK phosphorylation was transient , prompting a search for other targets of Src family kinase action . ^^^ Together , these observations demonstrate that one or more Src family kinases act upstream as well as downstream of ErbB 1 to promote amphiregulin dependent autocrine stimulation of NHKs and suggest that autocrine NHK proliferation is more dependent upon ERK activation than upon Tyr 845 phosphorylation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands . ^^^ Src inhibitor PP 2 also prolonged ERK stimulation by DPDPE . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , the PDGF dependent anti apoptotic effect in non transfected cells was completely abolished by the PI3K inhibitor wortmannin , whereas inhibitors of Src , PLCgamma , ERK , or p 38 MAP kinase had no effect . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Prolidase activity and collagen biosynthesis are supposed to be regulated by beta ( 1 ) integrins , which initiate a signaling pathway in which several kinases and intracellular proteins are involved , including focal adhesion kinase pp 125 ( FAK ) ( FAK ) , Src , Shc , growth factor receptor bound protein 2 ( Grb 2 ) , son of sevenless protein ( SOS ) , Ras , Raf and mitogen activated protein kinases ( MAPK ) , extracellular signal regulated kinase 1 ( ERK ( 1 ) ) and kinase 2 ( ERK ( 2 ) ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
When angiotensin 2 was used as the trophic stimulus , treatment with a Src tyrosine kinase inhibitor ( PP 2 , 0 . 5 mg / kg , starting at 21 h of the 26 h stimulation ) produced a significant attenuation of extracellular regulated kinase 1 ( ERK 1 ) phosphorylation and of protein synthesis . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Signal transduction molecules activated by these neuropeptides include Src , focal adhesion kinase ( FAK ) , ERK , and PI3K / Akt , with subsequent activation of Elk 1 , NF kappaB , and c myc transcription factors . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
TCDD causes suppression of growth and differentiation of MCF10A , human mammary epithelial cells by interfering with their insulin receptor signaling through c Src kinase and ERK activation . ^^^ Together , these results indicate that the mechanism of the antagonistic action of TCDD on insulin signaling is mainly mediated through c Src signaling through activation of ERK . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The stimulatory effects of isoproterenol and cAMP on ERK phosphorylation were not reduced by the PKA inhibitor H 89 , whereas the Src family inhibitor 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidase ( PP 2 ) and transfection of a dominant negative Src construct diminished isoproterenol induced ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Selective regulation of tumor necrosis factor induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
GM CSF induced phosphorylation of Jak 2 , Stat 5 , Hck ( the myeloid restricted Src kinase ) , Akt , Stat 3 , and Erk MAPKs in microglia . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Cuc Q inhibits selectively the activation of STAT 3 and induces apoptosis without inhibition of JAK 2 , Src , Akt , Erk , or JNK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The Src / PLC / PKC / MEK / ERK signaling pathway is involved in aortic smooth muscle cell proliferation induced by glycated LDL . ^^^ ERK phosphorylation was not affected by exposure to the Ca2+ chelator BAPTA AM but inhibition of protein kinase C ( PKC ) with GF109203X , inhibition of Src kinase with PP 1 ( 5 microM ) and inhibition of phospholipase C ( PLC ) with U73122 / U73343 ( 5 microM ) all reduced ERK phosphorylation in response to glycated LDL . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These analyses revealed an up regulation of Src tyrosine kinase and related signaling pathways [ phosphatidyl inositol 3 ' kinase ( PI3K ) / Akt , Janus activated kinase ( JAK ) 2 , signal transducer and activator of transcription ( STAT ) 3 , and extracellular signal regulated kinases ( ERK ) ] in both MTI / G Gly and hGAS mice compared with the wild type control animals as well as an overexpression of transforming growth factor alpha ( TGF alpha ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Src activation also leads to activation of ERK and p 38 MAPKs . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of STAT 3 , p 38 , extracellular signal regulated kinase ( ERK ) 1 / 2 and Src was assessed by immunoblotting using phosphospecific antibodies . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Down regulation of endogenously expressed CNK 1 by small inhibitory RNA interferes with Src dependent activation of ERK . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The repression in ERbeta response to hormone was dependent upon its AF 1 domain which includes serines 106 and 124 , two phosphorylation target sites for Erk that we previously showed to be involved in SRC 1 recruitment to ERbeta . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These kinases were shown to associate with ES associated proteins such as beta 1 integrin , phosphorylated focal adhesion kinase , and c Src by co immunoprecipitation , suggesting that the integrin . laminin protein complex at the apical ES likely utilizes these protein kinases as regulatory proteins to modulate Sertoli germ cell adherens junction dynamics via the ERK signaling pathway . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
An inhibitor of p 38 MAP kinase ( SB 202190 ) , but not the ERK kinase inhibitor PD 98059 , was found to diminish localization of alphaB crystallin to the lamellipodia , and this effect was found to be associated with reduced levels of Serine 59 phosphorylated alphaB crystallin in SB 202190 treated migrating lens epithelial cells . alphaB crystallin localization to the lamellipodia was also altered by the treatment with RGD ( Arg Ala Asp ) peptide , dominant negative N 17 Rac1 GTPase , cytochalasin D and Src kinase inhibitor ( PP 2 ) , but not by the Rho kinase inhibitor Y 27632 or the myosin 2 inhibitor , blebbistatin . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The increased mRNA of these two integrin genes was associated with the increased expression of laminin ( a ligand for integrin alpha ( 6 ) beta ( 1 ) and alpha ( 6 ) beta ( 4 ) ) , Icam 1 ( a ligand of alphaLbeta 2 ) , Src , MEKK 1 , and ERK 1 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
All these effects could be inhibited by the Src kinase inhibitor PP 1 but not by the Erk inhibitor U 0126 , the Rho kinase inhibitor Y 27632 , or the calcium channel blocker verapamil . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
PMP exerted their effect via PI 3 kinase , Src kinase , and ERK , whereas protein kinase C and p 38 were not involved . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
These effects were explained in part by our observation in endothelial cells that Sema ECD inhibited VEGF mediated Src , FAK and ERK phosphorylation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
VEGF induced Erk activation was not dependent on phosphoinositide ( PI ) 3 kinase activation but required sequential phosphorylation of type 2 VEGF receptor , PLCgamma and c Src , as demonstrated by inhibitors SU 1498 , U 73122 , and PP 1 , respectively . c Src phosphorylation was inhibited by U 73122 , indicating it was downstream of phospholipase ( PL ) Cgamma . ^^^ Studies with PP1 / 2 showed that phosphorylation of c Src was required for tyrosine phosphorylation of Raf 1 , an upstream regulator of Erk . ^^^ VEGF induced phosphorylation of Mnk 1 and eIF4E required phosphorylation of PLCgamma , c Src , and Erk . ^^^ Our data demonstrate that VEGF stimulated protein synthesis is Erk dependent and requires the activation of VEGF receptor 2 , PLCgamma , c Src , Raf , and Erk pathway . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In DDC primed hepatocytes , NF kappaBi 0 . 1 muM treatment for 6 days significantly decreased mRNA expression of Src , p105 / NF kappaB 1 , ERK 1 , MEKK 1 , and JNK1 / 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The tyrosine phosphorylation inhibitor suramin and src kinase inhibitor PP 2 inhibited both ERK 1 / 2 phosphorylation and VDR expression . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Hyposmolarity also activated the non receptor tyrosine kinases , Src , focal adhesion kinase ( FAK ) , extracellular signal regulated protein kinase ( ERK ) 1 / 2 , and the tyrosine kinase target phosphatidyl inositol 3 kinase ( PI3K ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
They stimulate various signal transduction pathways involving phosphorylation of kinases such as focal adhesion kinase , c Src , Akt kinase , phosphatidylinositol 3 kinase , myosin light chain kinase and mitogen activated protein kinases ( MAPK ) such as extracellular signal regulated kinase ( ERK ) . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of Src , JAK 2 , STAT 1 , STAT 3 , and ERK was determined by Western blotting using anti phospho specific antibodies . ^^^ RESULTS : PDGF BB induced STAT specific binding activity , and activation of Src , JAK 2 , STAT 1 , STAT 3 , and ERK . ^^^ PDGF induced activation of STAT 1 and STAT 3 was inhibited by a Src inhibitor PP 1 and a JAK 2 inhibitor AG 490 , whereas PDGF induced activation of ERK was inhibited by PP 1 , and not by AG 490 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The gastric mucin secretory responses to isoproterenol , furthermore , were inhibited by PP 2 , a selective inhibitor of tyrosine kinase Src responsible for ligand independent EGFR autophosphorylation , but not by ERK inhibitor , PD 98059 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The Gi mediated ERK activation was completely suppressed upon inhibition of Src tyrosine kinases by PP 1 , while the Gq induced response was suppressed by both PP 1 and the Ca2+ chelator , BAPTA AM . ^^^ The Gi / Gq induced synergistic ERK activation was PTX sensitive , and appeared to be a co operative effect between Ca2+ and Src family tyrosine kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We show that PDGF BB induces TSP 1 and TGF beta 1 via the src kinase pathway whereas TNF a utilizes the MAPK / Erk pathway . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Src family kinase mediated and Erk mediated thromboxane A 2 generation are essential for VWF / GPIb induced fibrinogen receptor activation in human platelets . ^^^ VWF induced Erk 2 phosphorylation and thromboxane A 2 ( TXA 2 ) release were completely blocked by PP 2 , an Src family kinase inhibitor , suggesting that Erk is downstream of Src family kinases . ^^^ Thus , we conclude that VWF stimulation of platelets results in phospholipase A 2 activation through Erk stimulation and that Src family kinases and phospholipase C play essential roles in this event . ^^^ We further conclude that VWF induced platelet aggregation does not directly depend on Erk activation but has an absolute requirement for Src / Erk mediated TXA 2 generation . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of the Erk pathway by PGE 2 was also resistant to src kinase inhibitors but sensitive to the protein kinase C inhibition . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Our data also indicated that ERK activation and the potentiation of ATP calcium responses were sensitive to the src like kinase inhibitor herbimycin A , p 21 ( ras ) farnesyltransferase inhibitor peptide , and some PKC inhibitors . ^^^ Taken together , our findings reveal that Ap ( 5 ) A triggers the potentiation of ATP calcium responses through an intracellular mechanism that is insensitive to pertussis toxin and that this potentiation requires src protein mediated ERK activation and the participation of an atypical protein kinase C isoform activated downstream from ERK . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibition of c Src activity resulted in decreased phosphorylation of Akt , p 38 , and extracellular signal regulated kinase ( Erk ) 1 / 2 . ^^^ Significant ( P < 0 . 005 ) dose dependent decreases were observed in IL 8 expression by inhibiting Src dependent signaling molecules Erk 1 / 2 and p 38 but not phosphatidylinositol 3 kinase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The ability of mRon to activate the MAP kinase pathway is dependent on c Src activity , and we have shown that c Src co immunoprecipitates with mRon . c Src fails to interact with mRon when the three tyrosines required for MAP kinase activation are mutated , whereas the presence of any one of these tyrosines alone restores Erk phosphorylation and recruitment of c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of nuclear factor { kappa } B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G { alpha } 14 and multiple signaling components : a mechanism requiring protein kinase C , calmodulin dependent kinase 2 , ERK , and c Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The PAR ( 2 ) triggered PGE ( 2 ) formation was attenuated by inhibition of the following signal pathway enzymes : cyclooxygenases 1 and 2 ( COX 1 and COX 2 , respectively ) , cytosolic Ca ( 2+ ) dependent phospholipase A ( 2 ) ( cPLA ( 2 ) ) , the mitogen activated protein kinases ( MAPKs ) , mitogen activated protein kinase / extracellular signal regulated kinase kinase ( MEK ) extracellular signal regulated kinase ( ERK ) and p 38 MAPK , Src family tyrosine kinase , epidermal growth factor ( EGF ) receptor tyrosine kinase ( EGFRK ) , and protein kinase C ( PKC ) , but not by inhibition of matrix metalloproteinases . ^^^ SLIGRL NH ( 2 ) up regulated COX 2 protein and / or mRNA levels that were blocked by inhibition of p 38 MAPK , EGFRK , Src , and COX 2 but not MEK ERK . ^^^ We conclude that PAR ( 2 ) triggered PGE ( 2 ) formation in A 549 cells involves a coordinated up regulation of COX 2 and mPGES 1 involving cPLA ( 2 ) , increased cytosolic Ca ( 2+ ) , PKC , Src , MEK ERK , p 38 MAPK , Src mediated EGF receptor trans activation , and also metabolic products of both COX 1 and COX 2 . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor ( MIF ) and dependence on JAB1 / CSN5 and Src kinase activity . ^^^ A role for an upstream Src kinase was proven by applying Src deficient cells which did not exhibit transient ERK activation upon treatment with MIF , but in which MIF induced ERK signalling could be restored by re expressing Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
However , the expression of the Y397F mutant rendered 5 Src transformed FAK ( / ) cells susceptible to anoikis , correlated with suppression on 5 Src stimulated activation of ERK and AKT . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Dissection of the signal pathways to ERK using multiple inhibitors and dominant negative constructs indicated involvement of Ras , protein kinase C , phosphoinositide 3 kinase , and Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We have previously shown that RET signals through focal adhesion kinase ( FAK ) in medullary thyroid cancer cells and that extracellular signal regulated kinase ( ERK ) activity can be blocked by pp 2 , an inhibitor of both Src and RET . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Following M CSF treatment , FAK and the active forms of M CSFR and Src were redistributed to the cytoskeleton , where active ERK , JNK and PI3K were detectable . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Furthermore , the activation of c Src on Ad 19 infection appears to regulate both the ERK and the JNK pathways . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In accordance , neither nuclear ERK phosphorylation nor Elk phosphorylation were observed in SYF cells stimulated with SDF 1 but were reconstituted in Src ( ++ ) cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Antagonists of TCDD which were found to be effective in this way were ( a ) inhibitors of c Src kinase , such as PP 2 and CGP 77675 , ( b ) those known to block the action of TGF alpha , such as anti TGF alpha antibody , and alpha ( 1 ) antitrypsin , ( c ) PD 98059 , a specific inhibitor of ERK activation , but not SB 202190 ( an inhibitor of p 38 MAPK activation ) or SP 600125 ( a JNK inhibitor ) and ( d ) Ah receptor antagonists , alpha naphthoflavone and 1 , 10 phenanthroline . ^^^ These results support the notion that TCDD acts as an anti apoptotic agent by mimicking the action of EGF through activation of the c Src / ERK signaling pathway . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of phospholipase D by 8 Br cAMP occurs through novel pathway involving Src , Ras , and ERK in human endometrial stromal cells . ^^^ In addition , transfection of ES cells with DN Src , or DN Ras partially inhibited 8 Br cAMP induced ERK1 / 2 and consequently PLD activation , whereas cotransfection of DN Src and DN Ras completely inhibited ERK1 / 2 and PLD activation , suggesting that Src and Ras independently regulate ERK / PLD activation . ^^^ Taken together , these results demonstrate a novel pathway in ES cells that 8 Br cAMP activate PLD through PKA and ERK1 / 2 and this ERK / PLD activation by 8 Br cAMP is mediated by Src and Ras , separately . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta catenin dependent and independent signaling cascades involving Src / ERK and phosphatidylinositol 3 kinase / AKT . ^^^ These results demonstrate for the first time that Wnt proteins , irrespective of their ability to stimulate canonical Wnt signaling , prolong the survival of osteoblasts and uncommitted osteoblast progenitors via activation of the Src / ERK and PI3K / Akt signaling cascades . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
L 59 activated Src ( a known substrate of LAR ) , FAK and TrkB and also activated downstream signalling intermediates including PKC , ERK , AKT and CREB . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In washed platelets , coincubation with neutrophils resulted in reduced formation of large aggregates when stimulated with collagen or thrombin and repressed agonist induced activation of tyrosine protein kinases ( Syk , Lyn , Src , and Pyk 2 ) , but not thrombin induced ERK and p 38 MAP kinase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
They stimulate ERK , Shc , and Src phosphorylation in MCF 7 breast cancer cells at low concentrations , yet they are very ineffective in stimulating transcription of endogenous estrogen target genes , being approximately 10 , 000 fold less potent than estradiol in genomic actions . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition , inhibition of extracelluar signal regulated kinase ( ERK ) , Src tyrosine kinase and protein kinase C prevented both neuronal injury in the cortex and shrinkage of the striatum , whereas inhibition of p 38 mitogen activated protein kinase and c Jun N terminal kinase prevented shrinkage of the striatum only . ^^^ Thrombin treatment promptly induced phosphorylation of ERK , which was not prevented by inhibition of Src and protein kinase C . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
H2O2 induced ERK activation was inhibited by the Src family selective inhibitor PP 2 and the epidermal growth factor receptor inhibitor AG 1478 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Recently , it has been shown that 17beta estradiol ( E 2 ) induces a rapid and transient activation of the Src ERK phosphorylation cascade : a clear indication that the alpha oestrogen receptor ( ERalpha ) is able to associate with the plasma membrane . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
The E76K mutation in the N terminal Src homology 2 domain increased interactions of mutant SHP 2 with Grb 2 , Gab 2 , and p 85 , leading to hyperactivation of IL 3 induced Erk and phosphatidylinositol 3 kinase ( PI3K ) pathways . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Our findings suggest that mER is associated to G proteins , and its activation with non permeable E ( 2 ) BSA results in the activation of the following downstream pro survival kinases pathways : ( 1 ) the PKB / Akt pathway , ( 2 ) the Src > MEK > ERK kinases and finally ( 3 ) the MAPK > ERK kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
MVP overexpression downregulates EGF dependent ERK activation in Src overexpressing cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Absolutely required for migration are protein tyrosine kinase Src , Ras , protein kinase C ( PKC ) , phosphatidylinositol 3 kinase , ERK , and JNK ; partial requirements were exhibited by cAMP activated protein kinase and p 38 kinase . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Src oncogene activates MMP 2 expression via the ERK / Sp1 pathway . ^^^ Our data showed that extracellular signal regulated kinase ( ERK ) pathway inhibitor PD 98059 , but not the c Jun N terminal kinase ( JNK ) inhibitor SP 600125 , p 38 kinase inhibitor SB 203580 , and PI3K inhibitor wortmannin , attenuated Src induced MMP 2 promoter activity . ^^^ In addition , the dominant negative mutant of ERK 2 suppressed the activation of MMP 2 by Src . ^^^ Taken together , our results strongly suggest that Src induces MMP 2 expression via transcription activation and the ERK / Sp1 signaling pathway is involved in this process . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
METHODS : Using parental and 5 src or c H ras transfected HAG 1 human gallbladder adenocarcinoma cell lines , effects of gefitinib on cytotoxicity , cell cycle purtubation and apoptosis , and tyrosine phosphorylation of EGFR , Akt , and Erk were determined by WST 1 assay , flow cytometry , and Western blots , respectively . ^^^ By contrast , gefinitib failed to inhibit the activation of both Akt and Erk in 5 src transfected cells and Erk , but not Akt in c H ras transfected cells , despite the blockade of EGFR activation in these respective cell lines . ^^^ Treatment of 5 src transfected cells with herbimycin A , a Src tyrosine kinase inhibitor , partially reversed the gefitinib resistance , with concomitant inhibition of Akt and Erk . ^^^ CONCLUSION : Our results suggest that activated Ras and Src could induce gefitinib resistance by activating either or both of Akt and Erk signaling pathways , thus providing a strategic rationale for assessment of these specific signaling molecules downstream of EGFR to customize treatment . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
As assessed by employing specific inhibitors , the survival pathways mediated by the EGF receptor , ERK , PI 3K or Src kinase , or basal transcriptional activity are important for unstressed cell survival . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Hypoxia produced a significant increase in KC Src and MAPK ( p 38 , ERK , JNK ) activity compared with normoxic controls . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
This protection occurs independently of neurophin signaling but requires Src activation of ERK ( extracellular signal regulated kinase ) and Akt . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Angiotensin 2 induced extracellular signal regulated kinase ( ERK ) activation in primary cultures of rabbit proximal tubule cells via the activation of c Src and association of the EGFR with the c Src SH 2 domain , effects that were mimicked by arachidonic acid and its inactive analogue eicosatetraynoic acid . ^^^ Arachidonic acid induces ERK activation via Src SH 2 domain association with the epidermal growth factor receptor . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Involvement of growth factor receptor transactivation in the signaling towards ERK phosphorylation could be ruled out by the lack of an effect of PP 2 , AG 1024 , AG 1296 or SU 1498 , inhibitors of Src , insulin like growth factor receptor , platelet derived growth factor receptor and vascular endothelial growth factor receptor kinase activity , respectively . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
We found that L AP 4 induced a rapid and transient activation of the MAP kinase extracellular signal regulated kinase ( ERK ) through a pathway mediated by dynamin , beta arrestin 2 , and Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Inhibitors of phosphatidylinositide 3 kinase , extracellular signal regulated kinase ( ERK ) , and Src kinase reduced the adhesion and migration of VSMCs on betaig h 3 . betaig h 3 triggered phosphorylation and activation of AKT , ERK , focal adhesion kinase , and paxillin mediating the adhesion and migration of VSMCs . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Activation of the Erk pathway was necessary , but not sufficient for full induction of EphA 2 upreglation by Src kinases . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Phosphorylation of extracellular signal regulated kinase ( ERK ) , AKT ( a major substrate of phosphatidylinositol 3 ' kinase [ PI3K ] ) , Src at tyrosine Y 416 , and EGFR at Y 845 was analyzed by Western blotting with antibodies specific to phosphorylated proteins . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
BCR cross linking resulted in decreased Src and Syk activation but paradoxically enhanced and prolonged BCR signaling , as measured by cellular tyrosine phosphorylation , Ca ( ++ ) flux , AKT , and ERK activation . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Hsp 90 inhibition transiently activates Src kinase and promotes Src dependent Akt and Erk activation . ^^^ Here , we show that the prototypical Hsp 90 inhibitor geldanamycin induces Akt and Erk activation that is independent of PTEN status and is mediated by transient activation of Src kinase . ^^^ Activated Src phosphorylates Cbl , which recruits the p 85 subunit of phosphatidylinositol 3 kinase , resulting in phosphatidylinositol 3 kinase activation and eventually the activation of Akt and Erk . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Indeed , p 38 mitogen activated protein kinase ( MAPK ) and Src kinase , but not extracellular regulated kinase ( ERK ) , were activated by short term incubation with leptin . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Additionally , suppression of beta arrestin also blocked activation of Src , suppressed levels of phosphorylated ERK , and abrogated Rb Raf 1 binding in response to nicotine . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
METHODS : The expression and activation of Src and ERK were studied in vivo using immuno fluorescence and western blot techniques . ^^^ Src activation was measured by in vitro kinase assays , ERK activation by western blot using anti phospho ERK antibodies and the involvement of Src in gastrin induced cell proliferation by MTT test . ^^^ RESULTS : We showed in vivo that the targeted CCK2R expression in the pancreas of Elas CCK 2 mice , led to the activation of Src and the ERK pathway . ^^^ Src was activated upstream of the ERK pathway by the CCK2R in pancreatic tumoral cells and contributed to the proliferative effects mediated by this receptor . ^^^ In vitro results demonstrated that activation of the Src / ERK pathway by the CCK2R required the NPXXY motif , located within the CCK2R sequence at the end of the 7th transmembrane domain , and suggested the putative role of Gq in this mechanism . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
RESULTS : We found that diarylpropionitrile and estrogen triggered rapid activation of the extracellular signal regulated kinase 1 / 2 ( ERK ) , Src , and focal adhesion kinase signaling pathways . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Complex formation between EphB 2 and Src requires phosphorylation of tyrosine 611 in the EphB 2 juxtamembrane region . ^^^ Here we show that in vivo tyrosine phosphorylation sites of the Eph receptors EphA 3 , EphA 4 , and EphB 2 in embryonic retina serve as binding sites for the Src homology 2 ( SH 2 ) domain of Src kinase . ^^^ Furthermore , tyrosine phosphorylated EphB 2 was detected in Src immunoprecipitates from transfected Cos cells , indicating that EphB 2 and Src can physically associate . ^^^ Interestingly , a form of Src with reduced electrophoretic mobility and increased tyrosine phosphorylation was detected in Cos cells expressing tyrosine phosphorylated EphB 2 , suggesting a functional interaction between EphB 2 and Src . ^^^ Yeast two hybrid analysis in conjunction with site directed mutagenesis demonstrated that phosphorylated tyrosine 611 in the juxtamembrane region of EphB 2 is crucial for the interaction with the SH 2 domain of Src . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
SHEP 1 contains an Src homology 2 domain that binds to a conserved tyrosine phosphorylated motif in the juxtamembrane region of the EphB 2 receptor and may itself be a target of EphB 2 kinase activity , since it becomes heavily tyrosine phosphorylated in cells expressing activated EphB 2 . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
In addition , we show that MALDI mass spectrometry can be used to determine the binding sites for Src homology 2 ( SH 2 ) domains by identifying the EphB 2 phosphopeptides that bind to the SH 2 domain of the Src kinase . . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
Therapeutic maneuvers may target receptor tyrosine kinases ( EGFR , VEGFR , FGFR ) , chemokines or G protein coupled receptors ( CXCR 4 , CXCR 2 , EphB 2 ) , hypoxia inducible factor ( HIF ) , and signaling pathways ( c Src , PI3K , Akt , chaperon complexes ) in tumor cells . ^^^
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA
Interacting proteins: P29323 and P12931	Pubmed	SVM Score :0.0
NA