| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| This effect may be mediated by pp 60 ( c src ) , because in beta adrenergic receptor kinase 1 overexpressing cells , pp 60 ( c src ) activation was inhibited , and in normal cells anti pp 60 ( c src ) antibody inhibited Ang 2 stimulated PLD activity . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Agonist dependent phosphorylation of the G protein coupled receptor kinase 2 ( GRK 2 ) by Src tyrosine kinase . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Beta arrestin and c Src dependent degradation of G protein coupled receptor kinase 2 . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c Src and G protein coupled receptor kinase 2 in a signaling unit that regulates p42 / p44 mitogen activated protein kinase by epidermal growth factor . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Downstream of binding to the receptor , Src phosphorylates and activates G protein linked receptor kinase 2 ( GRK 2 ) , a response obligate for agonist induced desensitization . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , binding by G ( betagamma ) or phosphorylation by PKC or c Src [ corrected ] has been shown to activate or enhance GRK 2 activity , respectively . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| The compounds are inactive or weakly active toward a number of other tyrosine kinases , including the FGF receptor 1 , EGF receptor , and c Src kinase , as well as toward serine threonine kinases , including different PKC isoforms and GRK 2 , and appear therefore selective for PDGF receptor inhibition . . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Interestingly , MAPK mediated modulation of wild type GRK 2 stability requires beta arrestin function and is facilitated by previous phosphorylation of GRK 2 on tyrosine residues by c Src . ^^^ Our data suggest that both c Src and MAPK mediated phosphorylation would contribute to modulate GRK 2 degradation , and put forward the existence of new feedback mechanisms connecting MAPK cascades and GPCR signaling . . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Namely , GRK 2 has been shown to be rapidly degraded by the proteasome pathway in a process dependent on beta arrestin and c Src function , and also to be proteolyzed by m calpain . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Indeed , the PDGF dependent activation of p42 / p44 MAPK was reduced by over expression of the C terminal domain of GRK 2 ( sequesters Gbetagamma subunits ) , the clathrin binding domain of beta arrestin and by inhibitors of c Src and clathrin mediated endocytosis . ^^^ |
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| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| The EGF induced GRK 2 EGFR complex formation was greatly reduced by perturbation of EGFR and Src tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Moreover , TARC was able to induce Src dependent serine phosphorylation of the beta ( 2 ) AR as well as its association with GRK 2 and beta arrestin . ^^^ Our data suggest that this is mediated by Src dependent activation of GRK 2 , resulting in receptor phosphorylation , binding to beta arrestin , and a switch from cAMP dependent signaling to activation of the MAPK pathway . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| Because activation of GRK 2 may involve phosphorylation of its N terminal tyrosines by c Src , we tested whether the PDGFRbeta itself could tyrosine phosphorylate and activate GRK 2 . ^^^ |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25098 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|