| We report here that PDEgamma is in a pre formed complex with c Src and that stimulation of cells with epidermal growth factor promotes the association of GRK 2 with this complex . c Src has a critical role in the stimulation of the p42 / p44 mitogen activated protein kinase cascade by epidermal growth factor , because c Src inhibitors block the activation of this kinase by the growth factor . ^^^ |