| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.79959862 |
| The activation of PTPalpha , combined with the effects of mitotic Cdc 2 mediated phosphorylations of Src , quantitatively accounts for the mitotic activation of Src , indicating that PTPalpha is the membrane bound , serine phosphorylation activated , protein tyrosine phosphatase that activates Src during mitosis . . 0.79959862^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Receptor protein tyrosine phosphatase alpha activates pp60c src and is involved in neuronal differentiation . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase alpha regulates Src family kinases and alters cell substratum adhesion . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Brain and embryo derived fibroblast src and fyn activity is reduced to < 50 % in PTPalpha ( / ) mice . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| PTP1C , a protein tyrosine phosphatase ( protein tyrosine phosphate phosphohydrolase , EC 3 . 1 . 3 . 48 ) containing two src homology 2 domains , is poorly active when assayed with various protein substrates in vitro . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| A protein tyrosine phosphatase ( PTPase ; EC 3 . 1 . 3 . 48 ) containing two Src homology 2 ( SH 2 ) domains , SHPTP 1 , was previously identified in hematopoietic and epithelial cells . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| We discovered a phosphotyrosine phosphatase ( PTPase ; EC 3 . 1 . 3 . 48 ) activity which associates with specific subcellular pools of c Src in vivo and which preferentially binds the SH 2 ( Src homology 2 ) domain of c Src in vitro . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Anti c Src and anti phosphotyrosine immunoprecipitates from receptor like protein tyrosine phosphatase alpha ( PTP alpha ) transfected and control rat embryo fibroblasts contain a 39 kDa phosphoprotein ( p 39 ) whose phosphorylation is enhanced by PTP alpha expression . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have examined the in vivo activity of receptor like protein tyrosine phosphatase alpha ( PTPalpha ) toward p 59 ( fyn ) , a widely expressed Src family kinase . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| A role for the receptor like protein tyrosine phosphatase alpha ( PTPalpha ) in regulating the kinase activity of Src family members has been proposed because ectopic expression of PTPalpha enhances the dephosphorylation and activation of Src and Fyn [ 1 ] [ 2 ] [ 3 ] . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| The receptor protein tyrosine phosphatase alpha ( PTPalpha ) is involved in the activation of c Src kinase as well as in down regulation of the insulin signal . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase alpha ( PTPalpha ) is believed to dephosphorylate physiologically the Src proto oncogene at phosphotyrosine ( pTyr ) 527 , a critical negative regulatory residue . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Mitotic activation of protein tyrosine phosphatase alpha and regulation of its Src mediated transforming activity by its sites of protein kinase C phosphorylation . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| The differentiation of skeletal muscle cells involves a protein tyrosine phosphatase alpha mediated C Src signaling pathway . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase alpha ( PTPalpha ) : a Src family kinase activator and mediator of multiple biological effects . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have indicated that receptor protein tyrosine phosphatase alpha ( RPTPalpha ) regulates SRC family kinases , potassium channels and NMDA receptors . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Integrin activates receptor like protein tyrosine phosphatase alpha , Src , and Rho to increase prolactin gene expression through a final phosphatidylinositol 3 kinase / cytoskeletal pathway that is additive with insulin . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Notably , alpha 4 stimulated cell motility was inhibited by catalytically inactive receptor protein tyrosine phosphatase alpha overexpression and blocked by the p50Csk phosphorylation of c Src at Tyr 529 . alpha4beta1 stimulated cell motility of triple null Src ( / ) , c Yes ( / ) , and Fyn ( / ) fibroblasts was dependent on c Src reexpression that resulted in p130Cas tyrosine phosphorylation and Rac GTPase loading . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| A role for the receptor protein tyrosine phosphatase alpha ( PTPalpha ) in immune cell function and regulation of Src family kinases was investigated using thymocytes from PTPalpha deficient mice . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase alpha ( PTPalpha ) activates Src family kinases ( SFKs ) to promote the integrin stimulated early autophosphorylation of focal adhesion kinase ( FAK ) . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| The model offers explanations for the existence of the positive and negative feedback loops involving protein tyrosine phosphatase alpha ( PTPalpha ) and translocation of CSK and predicts a specific relationship between Src phosphorylation and activity . . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results show that platelet derived growth factor ( PDGF ) BB induces a transient tyrosine phosphorylation of the LRP cytoplasmic domain in a process dependent on PDGF receptor activation and c Src family kinase activity . ^^^ The use of LRP mini receptor mutants as well as in vitro phosphorylation studies demonstrated that the tyrosine located within the second NPXY motif found in the LRP cytoplasmic domain is the primary site of tyrosine phosphorylation by Src and Src family kinases . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the cytoplasmic domain of the LDL receptor related protein ( LRP ) was found to be a substrate for the non receptor tyrosine kinase Src , but the physiological significance of this phosphorylation event remained unknown . ^^^ Chem . 277 , 15499 15506 ) Loukinova et al . further demonstrate that one form of PDGF , PDGF BB , binds specifically to LRP and that phosphorylation of LRP requires the activation of Src family kinases . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using a panel of cytoplasmic domain mutants of the chimeric M CSF / PDGFR beta , we confirmed that the kinase domain of PDGFR beta is absolutely required for LRP tyrosine phosphorylation but that PDGFR beta mediated activation of phosphatidylinositol 3 kinase , RasGAP , SHP 2 , phospholipase C gamma , and Src are not necessary for LRP tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| The phosphotyrosyl phosphatase ( PTPase ) specificity of phosphotyrosyl phosphatase activator ( PTPA ) stimulated protein phosphatase ( PP ) 2A ( D ) ( rabbit muscle ) and a bona fide PTP 1B ( Xenopus laevis oocytes ) were examined in vitro using phosphotyrosine containing peptides , derived from the phosphorylation sites of p34cdc2 , p50 / HS1 protein , Abl , c Src and c Fgr , as well as the intact phosphoprotein p50 / HS1 and the Src related tyrosine kinases , Lyn and c Fgr . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| In conjunction with our previous results on growth cones , these data suggest that integrin binding to laminin triggers the recruitment of PTPalpha ( and perhaps other protein tyrosine phosphatases ) to adhesion sites , resulting in de phosphorylation of Src ' s tyr 527 . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Elimination of PTPalpha by 85 % inhibited c Src activity by 80 % . ^^^ It is concluded that endogenous PTPalpha is a key regulator of c Src activity in 3T3 L 1 adipocytes and that PTPalpha is not required for the dephosphorylation of the insulin receptor or the insulin receptor substrate proteins or for the regulation of several downstream insulin signaling events in 3T3 L 1 adipocytes . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that PTPalpha , an RPTP that dephosphorylates and activates src family kinases , forms a novel membrane spanning complex with the neuronal GPI anchored receptor contactin . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Translocation reduces the ability of PTPalpha to act on membrane associated substrates , as it loses its ability to dephosphorylate Src at its C terminal regulatory site , and its ability to dephosphorylate the Kv2 . 1 voltage gated potassium channel is severely impaired . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this process , PTPalpha Ser 180 and Ser 204 phosphorylation is critical for the induction of phosphatase activity , which is required for dephosphorylation of pp 60 ( c src ) . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Thus , Src kinase , its activator ( PTPalpha ) and substrate ( NMDA receptors ) are linked by the same scaffold protein , PSD 95 . ^^^ Removal of PTPalpha does not affect the association of Src with NMDA receptors , but turns off the constitutive regulation of NMDA receptors by the kinase . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatases such as PTPalpha displace phosphotyrosine 527 from the Src SH 2 domain and mediate its dephosphorylation leading to Src kinase activation . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src and PTPalpha , which positively regulates Src , became activated as indicated by phosphorylation at Tyr 416 and Tyr 789 , respectively . ^^^ |
|
| Interacting proteins: P18433 and P12931 |
Pubmed |
SVM Score :0.0 |
| Reduced NMDA receptor tyrosine phosphorylation in PTPalpha deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk 2 : an upstream role for PTPalpha in NMDA receptor regulation . ^^^ The NMDAR is a substrate of src family tyrosine kinases , and reduced activity of src , fyn , yes and lck , but not lyn , was apparent in the absence of PTPalpha . ^^^ Together , these findings provide evidence that aberrant NMDAR associated functions in PTPalpha null mice are due to impaired NMDAR tyrosine phosphorylation resulting from the reduced activity of probably more than one of the src family kinases src , fyn , yes and lck . ^^^ |
|