| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.64071924 |
| We also show that PTP1B forms a complex with Src and p 130 ( Cas ) , and that the proline rich motif PPRPPK ( residues 309 314 ) in PTP1B is essential for the complex formation . 0.64071924^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| PTP1C , a protein tyrosine phosphatase ( protein tyrosine phosphate phosphohydrolase , EC 3 . 1 . 3 . 48 ) containing two src homology 2 domains , is poorly active when assayed with various protein substrates in vitro . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| A protein tyrosine phosphatase ( PTPase ; EC 3 . 1 . 3 . 48 ) containing two Src homology 2 ( SH 2 ) domains , SHPTP 1 , was previously identified in hematopoietic and epithelial cells . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| We discovered a phosphotyrosine phosphatase ( PTPase ; EC 3 . 1 . 3 . 48 ) activity which associates with specific subcellular pools of c Src in vivo and which preferentially binds the SH 2 ( Src homology 2 ) domain of c Src in vitro . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , two tyrosine phosphatases , protein tyrosine phosphatase 1B and src homology 2 protein tyrosine phosphatase 1 , dephosphorylated phosphotyrosine 537 of the hER in vitro . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Direct binding of the proline rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p 130 ( Cas ) . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Second , dephosphorylation of autophosphorylated Src by protein tyrosine phosphatase 1B allowed Src to be inactivated by Csk . ^^^ Third , protein tyrosine phosphatase 1B preferentially dephosphorylates the Src autophosphorylation site and allows for Src regulation by Csk . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Identification of protein tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c Src in several human breast cancer cell lines . c Src tyrosine kinase activity is elevated in several types of human cancer , and this has been attributed to elevated c Src expression levels , increased c Src specific activity , and activating mutations in c Src . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| The time course of cleavage is most consistent with late calpain mediated events such as pp 60 ( c src ) cleavage , but not early events such as protein tyrosine phosphatase 1B activation . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that protein tyrosine phosphatase 1B ( PTPIB ) activates Src , thereby initiating the activation of a Rac dependent pathway leading to cytoskeletal remodeling . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein levels of protein tyrosine phosphatase 1B , Src homology phosphatase 2 , and protein kinase C did not vary among groups . ^^^ The amount of protein tyrosine phosphatase 1B , Src homology phosphatase 2 , and protein kinase C associated with IRbeta in insulin stimulated muscle also did not differ among the four groups . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated alpha actinin and protein tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase 10 Src complex and promote cell migration . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Investigations have focused on the non catalytic phosphotyrosine recognising domains such as Src homology 2 ( SH 2 ) and phosphotyrosine binding ( PTB ) domains , as well as catalytic proteins such as protein tyrosine phosphatase 1B ( PTP1B ) . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase 1B ( PTP1B ) is implicated in a number of signaling pathways including those mediated by insulin , epidermal growth factor ( EGF ) , and the Src family kinases . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| The phosphotyrosyl phosphatase ( PTPase ) specificity of phosphotyrosyl phosphatase activator ( PTPA ) stimulated protein phosphatase ( PP ) 2A ( D ) ( rabbit muscle ) and a bona fide PTP 1B ( Xenopus laevis oocytes ) were examined in vitro using phosphotyrosine containing peptides , derived from the phosphorylation sites of p34cdc2 , p50 / HS1 protein , Abl , c Src and c Fgr , as well as the intact phosphoprotein p50 / HS1 and the Src related tyrosine kinases , Lyn and c Fgr . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that Raf 1 purified form Sf 9 cells coinfected with baculovirus Ras but not Src could be inactivated by protein tyrosine phosphatase PTP 1B . 14 3 3 and Hsp 90 proteins blocked both the tyrosine dephosphorylation and inactivation of Raf 1 , suggesting that Raf 1 activity is phosphotyrosine dependent . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| The activation of calpain in both spreading and aggregated platelets resulted in a substantial decrease in the level of tyrosine phosphorylation of multiple platelet proteins and was associated with a 50 80 % reduction in the amount of cytoskeletal associated talin , integrin alphaIIbbeta 3 , PI 3 kinase , FAK , pp 60 ( c ) src , and PTP 1B . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Time course studies revealed that pp 60 ( c ) src proteolysis lagged well behind that of PTP 1B and correlated closely with the generation of the fully proteolyzed form of mu calpain ( 76 kDa ) . ^^^ In vitro proteolysis experiments with purified mu calpain and immunoprecipitated PTP 1B or pp 60 ( c ) src confirmed selective proteolysis of pp 60 ( c ) src by the 76 kDa enzyme , whereas PTP 1B cleavage was mediated by both the 76 and 78 kDa forms of mu calpain . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| To explore the cellular mechanism whereby TNF alpha regulates phosphorylation of FAK in the liver , we measured c Src kinase activity and the abundance of 3 major protein tyrosine phosphatases ( PTPs ) ( PTP 1B , leukocyte antigen related tyrosine phosphatase [ LAR ] , and src homology 2 domain containing protein tyrosine phosphatase [ SHPTP 2 ] ) in liver homogenates from obese Zucker rats after TNF alpha blockade . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have examined the expression and activity of focal adhesion tyrosine phosphatases [ Src homology 2 domain phosphatase ( SHP 2 ) , protein tyrosine phosphatase ( PTP 1B ) , and PTP proline , glutamate , serine , and threonine sequences ( PEST ) ] during normal nephrogenesis and in cystic kidneys from bcl 2 / mice . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present study , we tested the following hypotheses : 1 ) rat carotid artery injury induces the expression of PTP 1B , Src homology 2 domain phosphatase ( SHP 2 ) , and PTP proline , glutamate , serine , and threonine sequence ( PEST ) protein ; and 2 ) polypeptide growth factors as well as ANG 2 increase the levels of tyrosine phosphatases in cultured rat aortic smooth muscle cells . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Fibrinogen binding to alphaIIbbeta 3 triggers PTP 1B recruitment to the alphaIIbbeta 3 c Src Csk complex in a manner that is dependent on c Src and specific tyrosine ( tyrosine 152 and 153 ) and proline ( proline 309 and 310 ) residues in PTP 1B . ^^^ Studies of PTP 1B deficient mouse platelets indicate that PTP 1B is required for fibrinogen dependent Csk dissociation from alphaIIbbeta 3 , dephosphorylation of c Src tyrosine 529 , and c Src activation . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| After binding to EGFR , PTP1B becomes tyrosine phosphorylated at Tyr 66 , a site that conforms to the consensus binding sequence for the Src homology 2 ( SH 2 ) domains of the adapter protein Grb 2 . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that WT , but not PA PTP1B , inhibits transformation of rat 3Y1 fibroblasts by 5 crk , src , and ras , but not by 5 raf . ^^^ Expression of WT PTP1B reduces formation of p130Cas Crk complexes and inhibits mitogen activated protein kinase activation by Src and Crk . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Additionally , in cells expressing the mutant PTP1B , tyrosine phosphorylation of Src is enhanced and activity is reduced . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| PTP1B appears to modulate integrin mediated adhesion through regulation of src activation and cadherin mediated adhesion through dephosphorylation of beta catenin . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that the amounts of leukocyte antigen related PTPase ( LAR ) , PTPase 1B ( PTP1B ) , and src homology 2 containing PTPase ( SH PTP 2 ) were increased in particulate fractions of visceral and epididymal fat of OLETF rats . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Co transfection with Src led to tyrosine phosphorylation of TRPV 6 which could be dephosphorylated by PTP1B . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Since the binding of p130cas and Src to PTP1B is dependent upon these proline residues , we assayed the regulation of PTP1B in mouse embryo fibroblasts deficient in these proteins . ^^^ We found that neither p130cas nor Src is required for the inhibition of PTP1B activity by adhesion to extracellular matrix proteins . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Deletion of the ER targeting sequence resulted in cytosolic localization and altered the distribution of PTP1B at cell matrix foci , whereas mutations disrupting interactions with Src homology 3 ( SH 3 ) domains , and the insulin and cadherin receptors had no effect . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , the c Abl , c Src , and c Met kinases are produced in high yields in Escherichia coli by using a bicistronic vector encoding the PTP1B tyrosine phosphatase . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Several candidate tumor suppressor genes lie outside the common deleted region including SRC , HCK , p 107 , PTPN 1 , and CEBP beta . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using in vitro protein tyrosine phosphatase ( PTPase ) assays , we found that sodium stibogluconate , a drug used in treatment of leishmaniasis , is a potent inhibitor of PTPases Src homology PTPase 1 ( SHP 1 ) , SHP 2 , and PTP1B but not the dual specificity phosphatase mitogen activated protein kinase phosphatase 1 . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that PTP1B mutants that are defective in Src homology 3 domain binding fully retain the ability to inhibit insulin signalling , whereas mutants defective in insulin receptor binding fully retain the ability to inhibit integrin signalling . ^^^ These data show that PTP1B can independently regulate insulin and integrin signals , and that Src might represent a convergence point for regulating signal transduction by this phosphatase . . ^^^ |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18031 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|