| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NIH3T3 cells transformed by src and other tumor cell lines responded less prominently , if at all . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The analysis of Grb2 / c Cbl interaction demonstrated that , in both acute leukemia and CML blasts , c Cbl was stably complexed with the N terminal Src homology ( SH ) 3 domain of Grb 2 and , in blasts from ALL patients , with the Grb 2 SH2 domain . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Activation of ABL can occur by substitution of the ABL first exon with breakpoint cluster region ( BCR ) sequences or by deletion of the noncatalytic SH 3 ( src homology region 3 ) domain . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Src family protein tyrosine kinase Lyn associates physically with the BCR and has been suggested to play an important role in BCR mediated signaling . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Src family protein tyrosine kinases ( PTKs ) are known to be important for B cell antigen receptor ( BCR ) signaling . ^^^ To study the mechanism of action of Src PTK in BCR signaling , kinase deficient and Src homology 2 ( SH 2 ) mutants of Src PTK were transfected into Lyn deficient B cells and analyzed . ^^^ These results demonstrate that the BCR induced phosphorylation of Src PTK is independent of Syk and that the kinase activity of Src PTK is critical for BCR signaling . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The p 85 alpha subunit contains a NH 2 terminal src homology ( SH ) 3 domain , a region with homology to the product of the breakpoint cluster region ( bcr ) gene , and a COOH terminal portion of the molecule which contains two SH 2 domains , separated by a spacer region . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Several tyrosine kinases have been shown to be associated with the BCR , including the src family members Lyn , Fyn , Blk , and Lck and the non src kinase Syk . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| In B cells , two classes of protein tyrosine kinases ( PTKs ) , the Src family of PTKs ( Lyn , Fyn , Lck , and Blk ) and non Src family of PTKs ( Syk ) , are known to be involved in signal transduction induced by the stimulation of the B cell antigen receptor ( BCR ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| B cell antigen receptor ( BCR ) cross linking activates both Src family and Syk tyrosine kinases , resulting in increased cellular protein tyrosine phosphorylation and activation of several downstream signaling enzymes . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| B cell antigen receptors ( BCR ) are composed of an antigen binding subunit , the membrane Ig , and Ig alpha / Ig beta heterodimers , that contain a transducing motif named ITAM for `` immuno receptor tyrosine based activation motif . ' ' Ig alpha and Ig beta ITAMs only differ by four amino acids located before the second conserved tyrosine ( DCSM in Ig alpha and QTAT in Ig beta ) , which determine the in vitro association of Ig alpha with the src kinase fyn . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| In B cells , sIgM engagement has been shown to induce immediate ( within seconds ) activation of src family protein tyrosine kinases ( PTKs ) such as p53lyn / 56lyn , p55blk , p56lck and p59fyn which are associated with B cell antigen receptor ( BCR ) complex . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , two BCR associated kinases that are known to play critical roles in anti IgM induced B cell signaling , the src family kinase Lyn and the non src family kinase Syk , accumulate in the membrane skeleton shortly after BCR cross linking , when most of IgM and Ig alpha accumulate in this fraction . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Src family kinase Hck interacts with Bcr Abl by a kinase independent mechanism and phosphorylates the Grb 2 binding site of Bcr . bcr abl , the oncogene causing chronic myeloid leukemia , encodes a fusion protein with constitutively active tyrosine kinase and transforming capacity in hematopoietic cells . ^^^ Various intracellular signaling intermediates become activated and / or associate by / with Bcr Abl , including the Src family kinase Hck . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cross linking of either class 2 molecules or the BCR on CD 45 positive K 46 17micromlambda B lymphoma cells was observed to induce activation of the Src family protein tyrosine kinase Lyn , tyrosine phosphorylation of Syk and phospholipase Cgamma , and the production of inositol 1 , 4 , 5 trisphosphate leading to intracellular mobilization as well as extracellular influx of Ca2+ . ^^^ These results demonstrate that CD 45 regulates both Src family kinase activation and Ca2+ mobilization associated with class 2 and BCR mediated signal transduction . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : To elucidate the role of the Src family kinase Lyn in B cell receptor ( BCR ) signaling , we and others previously generated lyn / mice and analyzed their B cell responses . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src homology 2 domain containing inositol 5 ' phosphatase ( SHIP ) mediates inhibitory signals that attenuate intracellular Ca2+ mobilization in B cells upon B cell receptor ( BCR ) stimulation . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although Btk activity can be regulated by Src family and Syk tyrosine kinases , and perhaps by phosphatidylinositol 3 , 4 , 5 trisphosphate , BCR coupled signaling pathways leading to Btk activation are poorly understood . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Signal transducer and activator of transcription ( STAT ) 5 activation by BCR / ABL is dependent on intact Src homology ( SH ) 3 and SH 2 domains of BCR / ABL and is required for leukemogenesis . ^^^ We show here that BCR / ABL induces phosphorylation and activation of STAT 5 by a mechanism that requires the BCR / ABL Src homology ( SH ) 2 domain and the proline rich binding site of the SH 3 domain . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Previous work in our laboratory established that Bcr is a major transformation related substrate for the 5 Fps tyrosine kinase , and tyrosine phosphorylation of Bcr induces Bcr Grb 2 / SOS association in vivo through the Src homology 2 ( SH 2 ) domain of Grb 2 . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Mutation of the N terminal Src homology 2 domain [ SH 2 ( N ) ] resulted in the complete loss of inositol 1 , 4 , 5 trisphosphate generation upon BCR engagement . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Complementary experiments in BCR expressing AtT 20 endocrine cells confirmed that Src kinases are sufficient for BCR induced Akt phosphorylation , but that Syk is required for sustained phosphorylation of Akt on both serine 473 and threonine 308 . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src family kinases Fyn and Lyn associate with the B cell antigen receptor ( BCR ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of Shc in response to B cell Ag receptor ( BCR ) engagement creates binding sites for the Src homology 2 ( SH 2 ) domain of Grb 2 . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| In Ag specific Id positive B cells , the co cross linking of BCR and Fc gamma RIIB 1 by anti Id Ab resulted in the association of both Src homology 2 containing protein tyrosine phosphatase ( SHP 1 ) and Src homology 2 containing inositol phosphatase ( SHIP ) with the Fc gamma RIIB 1 ; however , only SHIP activity was detected . `` Superclustering ' ' of the BCR and Fc gamma RIIB 1 complex induced by stimulation with anti Id Ab plus polyvalent Ag synergistically activated SHP 1 . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that upon cross linking , the BCR rapidly translocates into ganglioside G ( M 1 ) enriched lipid rafts that contain the Src family kinase Lyn and exclude the phosphatase CD45R . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src homology 2 domain bearing tyrosine phosphatase SHP 1 and Src homology 2 domain bearing inositol 5 ' phosphatase SHIP usually participate in negative regulation of the BCR . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Coaggregation of Fc gamma RIIB 1 with B cell Ag receptors ( BCR ) leads to inhibition of BCR mediated signaling via recruitment of Src homology domain 2 ( SH 2 ) containing phosphatases . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| A possible explanation for the involvement of Cbl in PLC gamma 2 activation was provided by findings that Cbl interacts via its Src homology 2 ( SH 2 ) domain with B cell linker protein ( BLNK ) after BCR ligation . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Partitioning of the BCR into this fraction is unaffected by src family kinase inhibition . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although the Src homology 2 domain containing 5 ' inositol phosphatase ( SHIP ) is a well known mediator of inhibitory signals after B cell antigen receptor ( BCR ) coaggregation with the low affinity Fc receptor , it is not known whether SHIP functions to inhibit signals after stimulation through the BCR alone . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Several protein tyrosine kinases are activated rapidly following engagement of the BCR / preBCR complexes , including members of the Src family ( Lyn and Blk ) , the Syk / ZAP70 family ( Syk ) , and the Tec family ( Btk ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , BCR stimulation induced rapid and transient translocation of the Src homology 2 domain containing inositol phosphatase , SHIP , into lipid rafts . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| B cell linker protein ( BLNK ) and Src homology 2 domain containing leukocyte protein of 76 kD ( SLP 76 ) are adaptor proteins required for B cell receptor ( BCR ) and T cell receptor function , respectively . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| BCR signaling in mature B cells was shown to be initiated by the translocation of the BCR into cholesterol and sphingolipid enriched membrane microdomains that include the Src family kinase Lyn and exclude the phosphatase CD 45 . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Interestingly , deletion of the Src homology 3 domain complemented the deficiencies of the CC deleted Bcr Abl in inducing MPD in mice . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The cross linking of the B cell Ag receptor ( BCR ) is coupled to the stimulation of multiple intracellular signal transduction cascades via receptor associated , protein tyrosine kinases of both the Src and Syk families . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Functional analysis of various PTP deficient DT 40 B cell lines stably expressing wild type chimeric Fc gamma RIIB 1 PECAM 1 receptor indicated that cytoplasmic Src homology 2 domain containing phosphatases , SHP 1 and SHP 2 , were both necessary and sufficient to deliver inhibitory negative regulation upon coligation of BCR complex with inhibitory receptor . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The cross linking of the B cell Ag receptor ( BCR ) leads to the initiation of a signal transduction cascade in which the earliest events involve the phosphorylation of the immunoreceptor tyrosine based activation motifs of Ig alpha and Ig beta by the Src family kinase Lyn and association of the BCR with the actin cytoskeleton . ^^^ Translocation of the BCR into lipid rafts did not require the Ig alpha / Ig beta signaling complex , was not dependent on engagement of the FcR , and was not blocked by the Src family kinase inhibitor PP 2 or the actin depolymerizing agents cytochalasin D or latrunculin . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , some other tyrosine ( s ) , as well as the Src homology ( SH ) 2 domain and the two proline rich regions in MIST , is still required for full reconstitution of the BCR signaling , in cooperation with LAT . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The B cell adaptor containing src homology 2 domain ( BASH ; also termed BLNK or SLP 65 ) , is crucial for B cell antigen receptor ( BCR ) mediated activation , proliferation , and differentiation of B cells . ^^^ BCR mediated tyrosine phosphorylation of BASH creates binding sites for signaling effectors such as phospholipase Cgamma ( PLCgamma ) 2 and Vav , while the function of its COOH terminal src homology 2 domain is unknown . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| This tyrosine was phosphorylated and recruited src homology 2 domain containing tyrosine phosphatase 2 ( SHP 2 ) on coligation of PD 1 with BCR . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using Fcgamma type IIB receptor CD 5 chimeras encompassing the cytoplasmic domain of CD 5 , we previously showed that a particular region of the molecule containing two tyrosine residues , Y 429 and Y 441 , in an amino acid stretch similar to the Src autophosphorylation motif and a putative ITIM , respectively , antagonized early signaling events triggered through the B cell receptor ( BCR ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Syk , recruited to the clustered BCR , becomes phosphorylated on three tyrosines ( Tyr 317 , Tyr 342 , and Tyr 346 ) located within the linker region that separates the C terminal catalytic domain from the N terminal tandem Src homology 2 domains . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| In both B 1 and B 2 cells BCR cross linking induced a modest increase of CD 19 associated Lyn , a Src family protein tyrosine kinase ( PTK ) thought to be important for CD 19 phosphorylation . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| In contrast to published results , we found CD 19 phosphorylation after BCR ligation to be unaffected by the absence of Lyn , yet dependent on Src family protein tyrosine kinases as it was inhibited fully by PP 2 , an Src family specific inhibitor . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The interaction of the Bcr Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains . ^^^ We demonstrated recently that the Src kinase Hck interacts directly with Bcr Abl by a kinase independent mechanism . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src homology protein 1 ( SHP 1 ) plays an important role in B cell Ag receptor ( BCR ) differentiation , proliferation , survival , and apoptosis . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Like the Src family kinase , Raftlin is localized exclusively in lipid rafts by fatty acylation of N terminal Gly 2 and Cys 3 , and is co localized with BCR before and after BCR stimulation . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Upon BCR stimulation , Btk is transphosphorylated at position Y 551 , which promotes its catalytic activity and subsequently results in autophosphorylation at position Y 223 in the Src homology 3 domain . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Whereas all four sites were rapidly modified in response to BCR engagement in normal B cells , Btk deficient B cells exhibited a marked reduction in phosphorylation of the Src homology 2 ( SH 2 ) SH 3 linker region sites , Tyr ( 753 ) and Tyr ( 759 ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Engagement of the B cell antigen receptor ( BCR ) activates kinases of the Src and Syk families and signaling complexes assembled by adaptor proteins , which dictate B cell fate and function . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Regulation of BCR signal transduction in B 1 cells requires the expression of the Src family kinase Lck . ^^^ Here , we report that the src family kinase Lck is required to confer the BCR hyporesponsiveness typical of CD5+ B 1 cells and appears involved in the maintenance of their unique function . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| An inhibitor of Src family protein tyrosine kinases ( PTKs ) blocked both BCR induced tyrosine phosphorylation of Bam 32 and BCR internalization . ^^^ These data suggest that Bam 32 functions downstream of Src family PTKs to regulate BCR internalization . ^^^ Collectively , these findings indicate a novel role of Bam 32 in connecting Src family PTKs to BCR internalization by an actin dependent mechanism . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of the adaptor protein hematopoietic Src homology 2 ( HSH 2 ) was found to significantly decrease BCR mediated apoptosis in the murine WEHI 231 cell line . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| We find that while CR 2 enhanced BCR signaling causes intracellular Ca2+ mobilization and total pTyr phosphorylation of an intensity comparable to optimal BCR ligation using anti IgM Abs , it does so with limited activation of inhibitory effectors ( such as CD 22 , Src homology region 2 domain containing phosphatase 1 , and SHIP 1 ) and without substantial receptor cross linking . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recently , defective BCR signaling in B 1 cells has been attributed to elevated expression of the canonical T cell src kinase , Lck . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Thus , the initiation of BCR signaling is a very dynamic process accompanied by reversible conformational changes induced by Src family kinase activity . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Bcr by the tyrosine kinase pp 60 ( src ) can lead to dissociation of the transcriptionally inactive Bcr / Tcf1 complex . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Bruton ' s tyrosine kinase ( Btk ) and the adapter protein SLP 65 ( Src homology 2 domain containing leukocyte specific phosphoprotein of 65 kDa ) transmit precursor BCR ( pre BCR ) signals that are essential for efficient developmental progression of large cycling into small resting pre B cells . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| BCR cross linking resulted in decreased Src and Syk activation but paradoxically enhanced and prolonged BCR signaling , as measured by cellular tyrosine phosphorylation , Ca ( ++ ) flux , AKT , and ERK activation . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present work the activity of the c abl and c src oncogene encoded tyrosine kinase was investigated during phorbol diester ( TPA ) induced differentiation of the K 562 CML cells . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Normal and leukemic SCID repopulating cells ( SRC ) coexist in the bone marrow and peripheral blood from CML patients in chronic phase , whereas leukemic SRC are detected in blast crisis . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The effect of mutations in the Src homology 2 ( SH 2 ) domain of the BCR / ABL oncogene on leukemogenesis was tested in a quantitative murine bone marrow transduction / transplantation assay that accurately models human Philadelphia positive B lymphoid leukemia and chronic myeloid leukemia ( CML ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| These data implicate the Src kinase family in Stat 5 and Erk activation downstream of Bcr Abl , and identify myeloid specific Src kinases as potential drug targets in CML . . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we describe a p . o . active , dual Src / Abl kinase inhibitor with potent antiproliferative activity against CML cells in culture . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| BCR ABL 1 retrovirus transduced marrow from mice lacking all three Src kinases efficiently induced CML but not B ALL in recipients . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| AP 23464 , a potent adenosine 5 ' triphosphate ( ATP ) based inhibitor of Src and Abl kinases , displays antiproliferative activity against a human CML cell line and Bcr Abl transduced Ba / F3 cells ( IC ( 50 ) = 14 nM ; imatinib mesylate IC ( 50 ) = 350 nM ) . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The participation of Src kinases in the induction of BCR ABL induced B cell acute lymphoblastic leukaemia ( B ALL ) , but not chronic myeloid leukaemia ( CML ) , demonstrates cell type specific signalling in Philadelphia chromosome positive ( Ph+ ) leukaemias . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Several agents interfering with intracellular targets that are components of key oncogenic signaling pathways , such as RAF kinase , phosphatidylinositol 3 kinase ( PI3K ) / Akt or Src , are in preclinical and early clinical development . `` Addictive ' ' targets , such as the Bcr Abl fusion protein in chronic myeloid leukemia ( CML ) , are critical for maintaining the malignant phenotype and hence represent an Achilles ' heel for selective drugs . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| The challenge for the future is to improve current clinical results with kinase inhibitors in CML , developing strategies that can eradicate residual disease and overcome or prevent resistance . ' Dual ' Src and Abl kinase inhibitors are an attractive class of compounds , since ( a ) these molecules are able to bind Bcr Abl with less stringent conformational requirements with respect to imatinib , therefore allowing for efficient inhibition of several , resistance associated mutant forms of Bcr Abl ; ( b ) Src kinases have been shown to be involved in Bcr Abl mediated leukemogenesis as well as upregulated in some patients resistant to imatinib . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Dasatinib [ BMS 354825 ] is an orally active , small molecule , dual inhibitor of both SRC and ABL kinases that is under development with Bristol Myers Squibb for the treatment of patients with chronic myelogenous leukaemia ( CML ) and imatinib acquired resistance / intolerance . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| Dasatinib ( BMS 354825 ) , which inhibits Abl and Src family kinases , is another promising new clinical candidate for CML that has shown good efficacy in CML patients . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Treatment with dasatinib attenuated the levels of autophosphorylated Bcr Abl , p CrkL , phospho signal transducer and activator of transcription 5 ( p STAT 5 ) , p c Src , and p Lyn ; inhibited the activity of Lyn and c Src ; and induced apoptosis of the cultured CML cells . ^^^ |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|