| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation of c kit receptor on tyrosine creates binding sites for cellular src homology 2 ( SH 2 ) containing signaling molecules . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Dominant proto oncogenes that have been found to be amplified or overexpressed in SCLC include the myc family , c myb , c kit , c jun , and c src . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| The coaggregation of c kit with Fc gamma RIIB did not affect ligand induced c kit phosphorylation and induced the tyrosyl phosphorylation of Fc gamma RIIB , which selectively recruited the Src homology 2 domain bearing inositol 5 phosphatase SHIP . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| We cloned a novel adaptor protein , APS ( adaptor molecule containing Pleckstrin homology ( PH ) and Src Homology 2 ( SH 2 ) domains ) , which was tyrosine phosphorylated in response to c kit or B cell receptor stimulation . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recently we found that the Src family member Lyn is highly expressed in SCF responsive cells , associates with c Kit and is activated within minutes of the addition of SCF . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Signaling via Src family kinases is required for normal internalization of the receptor c Kit . ^^^ We investigated whether signal transduction via Src family kinases is required for normal c Kit trafficking . ^^^ Treatment of the SCF responsive human hematopoietic cell line MO7e with the inhibitor of Src family kinases PP 1 blocked SCF induced capping of c Kit and internalization of c Kit . c Kit was able to associate with clathrin in the presence of PP 1 , suggesting that entry of c Kit into clathrin coated pits occurs independently of Src family kinases . ^^^ These results indicate that Src family kinases play a role in ligand induced trafficking of c Kit . . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Downstream of c Kit , multiple signal transduction components are activated , including phosphatidylinositol 3 kinase , Src family members , the JAK / STAT pathway and the Ras Raf MAP kinase cascade . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| By screening with c kit as bait , we cloned a novel cDNA , designed STAP 1 , encoding an adaptor protein with a Pleckstrin homology domain , the Src homology 2 ( SH 2 ) domain , and a number of tyrosine phosphorylation sites . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 3 kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok 1 in c Kit signaling . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Critical roles of c Kit tyrosine residues 567 and 719 in stem cell factor induced chemotaxis : contribution of src family kinase and PI 3 kinase on calcium mobilization and cell migration . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using the induction of vesicular structures as a sign of efficient internalization of the receptor analysis of mutant c kit constructs deficient either in activation of PI 3 Kinase or Src revealed that internalization of c kit is dependent on recruitment of Src but not PI 3 Kinase . . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Src selective kinase inhibitor PP 1 also inhibits Kit and Bcr Abl tyrosine kinases . 4 amino 5 ( 4 methylphenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine ( PP 1 ) was identified as an Src selective tyrosine kinase inhibitor and has been used extensively to investigate signaling pathways involving Src kinases , including events downstream of the stem cell factor ( SCF ) receptor c Kit . ^^^ SCF induced c Kit phosphorylation was also inhibited by the related inhibitor 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine ( PP 2 ) and by STI 571 but not by the Src inhibitor SU 6656 . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src family kinases are involved in the differential signaling from two splice forms of c Kit . ^^^ The kinetics of phosphorylation of Shc , previously demonstrated to be phosphorylated by Src downstream of c Kit , was stronger and more rapid in the GNNK form , whereas it showed slower kinetics in the GNNK+ form . ^^^ Inhibition of Src family kinases with the specific Src family kinase inhibitor SU 6656 altered the kinetics of activation of the GNNK form of c Kit so that it resembled that of the GNNK+ form . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Identification of Tyr 900 in the kinase domain of c Kit as a Src dependent phosphorylation site mediating interaction with c Crk . ^^^ We have previously demonstrated that ligand stimulation of c Kit induces phosphorylation of Tyr 568 and Tyr 570 in the juxtamembrane region of the receptor , leading to recruitment , phosphorylation and activation of members of the Src family of tyrosine kinases . ^^^ In this paper , we demonstrate that members of the Src family of tyrosine kinases are able to phosphorylate c Kit selectively on one particular tyrosine residue , Tyr 900 , located in the second part of the tyrosine kinase domain . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Restoring the Src family kinase ( SFK ) binding sites in the mutated c Kit receptor restored cellular survival and migration but only partially rescued proliferation and was associated with the rescue of the Ras / mitogen activated protein kinase , Rac / JNK kinase , and phosphatidylinositol 3 kinase ( PI 3 kinase ) / Akt pathways . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Biochemical studies revealed that TKI 28 potently inhibited the activities of tyrosine kinases such as ErbB 2 , EGFR , KDR , PDGFRbeta , c kit and c Src , but had little effect on Flt 1 in cell free system . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Binding of SCF to c Kit leads to activation of multiple pathways , including phosphatidyl inositol 3 ( PI 3 ) kinase , phospholipase C ( PLC ) gamma , Src kinase , Janus kinase ( JAK ) / Signal Transducers and Activators of Transcription ( STAT ) and mitogen activated protein ( MAP ) kinase pathways . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we present results showing that Cbl is activated by the SFKs ( Src family kinases ) and recruited to c Kit in order to trigger receptor ubiquitination . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| In biochemical assays , SU 10944 exhibits potent inhibitory activity against VEGFR 1 ; weak activity against other related subgroup members , including stem cell factor receptor ( SCFR ) , platelet derived growth factor receptor beta ( PDGFRbeta ) , and fibroblast growth factor receptor 1 ( FGFR 1 ) ; and no detectable activity against other protein tyrosine kinases such as epidermal growth factor receptor ( EGFR ) , Src , and hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Conservation in subclass 3 RTKs and the identification of the corresponding residue in beta PDGF R , Y 579 , as a binding site for src family tyrosine kinases suggests an important role for Y 568 in kit signal regulation and the definition of its oncogenic potential . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| The interaction of Kit with SLF leads to receptor dimerization , kinase activation , and tyrosine phosphorylation of cytoplasmic proteins that contain Src homology 2 motifs . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Transcripts coding for transcription factors ( RB , P 53 , FOS , MYC , MYB , ERBA , REL ) , growth factors ( FGF 1 , FGF 2 , INT 2 , TGFA , TGFB , PDGF , IGF 1 , IGF 2 ) , interleukins , ( IL 1 , IL 2 , IL 3 , IL 4 , IL 6 , TNF ) , growth factor receptors or cytosolic protein kinases ( RAF , PIM , FES , MET , SRC , ROS , TRK , KIT , CSFR , IGFR , PDGFR , EGFR , NEU ) were quantified in cultured human mammary fibroblasts from normal tissues , benign tumours , carcinomas and post radiation fibrosis lesions by slot blot autoradiography and image analysis . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| The 65 kDa protein was identified as the src homology domain 2 ( SH 2 ) containing protein tyrosine phosphatase SHP 1 , a negative regulator of signaling by Kit and other hematopoietic receptors , and the protein product of the murine motheaten locus . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Lck associates with and is activated by Kit in a small cell lung cancer cell line : inhibition of SCF mediated growth by the Src family kinase inhibitor PP 1 . ^^^ In an effort to define the signal transduction pathways activated by Kit in SCLC , we focused on Src family kinases and , in particular , Lck , a Src related tyrosine kinase that is expressed in hemopoietic cells and certain tumors , including SCLC . ^^^ These data demonstrate that , in the H 526 SCLC cell line , Lck and , possibly , Yes are downstream of Kit in a signal transduction pathway ; the inhibition by PP 1 of SCF mediated proliferation and inhibition of apoptosis suggests that Src family kinases are intermediates in the signaling pathways that regulate these processes . . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Kit signaling through PI 3 kinase and Src kinase pathways : an essential role for Rac 1 and JNK activation in mast cell proliferation . ^^^ We have investigated the role of phosphatidylinositol 3 ' kinase ( PI 3 kinase ) and Src kinases in Kit mediated cell proliferation and suppression of apoptosis induced both by factor deprivation and irradiation in bone marrow derived mast cells ( BMMC ) . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show that the expression of Socs 1 mRNA is rapidly increased in primary bone marrow derived mast cells following exposure to Steel factor , and Socs 1 inducibly binds to the Kit receptor tyrosine kinase via its Src homology 2 ( SH 2 ) domain . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src family kinase activity is required for Kit mediated mitogen activated protein ( MAP ) kinase activation , however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells . ^^^ Small cell lung cancer ( SCLC ) is characterized by multiple genetic alterations that include inactivation of the retinoblastoma protein ( Rb ) , the establishment of several autocrine loops including that induced by coexpression of stem cell factor ( SCF ) and Kit , and the ectopic expression and activation of Src family kinases . ^^^ In the present study , we have demonstrated that PP 1 , a pharmacological inhibitor of Src kinases , blocked SCF mediated activation of mitogen activated protein ( MAP ) kinase , but it also inhibited Kit activation . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| We used as experimental models wild type mast cells , which constitutively express the stem cell factor receptor Kit and FcgammaRIIB , FcgammaRIIB deficient mast cells reconstituted with wild type or mutated FcgammaRIIB , and Src homology 2 domain containing inositol polyphosphate 5 phosphatase 1 ( SHIP 1 ) deficient mast cells . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Role for Src kinase pathway in Kit induced cooperation with erythropoietin receptor . ^^^ Stimulation of Kit by its ligand , stem cell factor activates several distinct early signaling pathways , including phospholipase C gamma , phosphatidylinositol 3 kinase , Src kinase , Grb 2 , and Grb 7 . ^^^ Combined stimulation with Epo also resulted in impaired cooperation between Src defective Kit mutant and Epo R and , to a lesser extent , with Kit mutants defective in the activation of phosphatidylinositol 3 kinase or Grb 2 . ^^^ The impaired cooperation between the Src defective Kit mutant and Epo R was associated with reduced transphosphorylation of Epo R and expression of c Myc . ^^^ Remarkably , restoration of only the Src pathway in a Kit receptor defective in the activation of all early signaling pathways demonstrated a 50 % correction in proliferation in response to Kit stimulation and completely restored the cooperation with Epo R . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Despite specific connection of EE T Y 343 to Stat 5 , the contributions of Kit to EpoR dependent proliferation did not involve Kit effects on Stat 5 activation ( but was limited by the mutation of Kit Tyr ( P ) 567 and Tyr ( P ) 569 Src kinase recruitment sites ) . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Fc epsilon RI and SCF mediated NTAL phosphorylation appear to be differentially regulated by Src kinases and / or Kit kinase , respectively . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Critical role for Kit mediated Src kinase but not PI 3 kinase signaling in pro T and pro B cell development . ^^^ To investigate the roles of different Kit signaling pathways in vivo , we have generated knock in mice in which docking sites for PI 3 kinase ( KitY 719 ) or Src kinase ( KitY 567 ) have been mutated . ^^^ Thus , the Src family kinase , but not the PI 3 kinase docking site in Kit , mediates a critical signal for lymphocyte development . ^^^ Therefore , Kit mediated PI 3 kinase signaling and Src kinase family signaling is highly specific for different cellular contexts in vivo . . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| SCF induces autophosphorylation of Kit and activates a variety of signaling components including Jnks , Erks , PI 3 Kinase , the JAK Stat pathway and members of the Src family . ^^^ In this study , we used Lyn deficient bone marrow mast cells ( BMMC ) to examine the contribution of this Src family member to tyrosine phosphorylation of Kit and SCF induced activation of Jnks , Akt , Stat 3 and Erks . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| We examined expression of SIRPalpha , SIRPalpha ligand CD 47 , and Src homology 2 domain containing protein tyrosine phosphatase 1 ( SHP 1 ) , a tyrosine phosphatase type , negative regulator of KIT dependent signaling , in normal human lung mast cells ( HLMC ) and neoplastic MC obtained from nine patients with SM . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Kit modulated phosphorylation dependent interactions with pathways controlling focal adhesion ( paxillin , leupaxin , p130CAS , FAK 1 , the Src family kinase Lyn , Wasp , Fhl 3 , G25K , Ack 1 , Nap 1 , SH3P12 / ponsin ) and septin actin complexes ( NEDD 5 , cdc 11 , actin ) . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Kit activates Akt , Src family kinases , phosphatidylinositol 3 kinase , phospholipase Cgamma , and Ras / mitogen activated protein kinases . ^^^ |
|
| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Dasatinib ( BMS 354825 ) , a dual SRC / ABL kinase inhibitor , inhibits the kinase activity of wild type , juxtamembrane , and activation loop mutant KIT isoforms associated with human malignancies . ^^^ Some small molecule SRC / ABL inhibitors also have potency against WT KIT kinase . ^^^ |
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| Interacting proteins: P10721 and P12931 |
Pubmed |
SVM Score :0.0 |
| Second , we found that neither basolateral 250 nM nor basolateral 2 microM PP 2 , a high affinity inhibitor for the Src family that also inhibits the Bcr Abl sTK as well as the Kit RTK , reduces the CO ( 2 ) stimulated increase in J ( HCO ( 3 ) ) . ^^^ |
|