Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Substitution of phenylalanine for tyrosine 905 ( Y905F ) that corresponds to tyrosine 416 of the Src protein abolished the transforming activity of Ret with the MEN2A mutation ( MEN2A Ret ) but not with the MEN2B mutation ( MEN2B Ret ) . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
The PKB Y 315 residue , which is known to be phosphorylated by Src tyrosine kinase , was also a major site of phosphorylation by RET / PTC . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Using the cytoplasmic domain of Ret as bait in a yeast two hybrid screen of a mouse embryonic library , it was discovered that the src homology 2 ( SH 2 ) domain containing protein Grb 10 bound Ret . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Direct association between the Ret receptor tyrosine kinase and the Src homology 2 containing adapter protein Grb 7 . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
But , none of these substrates have been identified and the ability of MEN 2B Ret phosphoprotein to interact with Src Homology 2 ( SH 2 ) domain containing molecules has been poorly investigated . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Recently , the Src homology 2 ( SH 2 ) domain containing protein Grb 10 has been shown to interact with RET in vitro and in vivo , early in development . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
To test the involvement of c Src in Ret mediated signaling , we measured the levels of c Src activity in NIH3T3 cells coexpressing Ret and the accessory GFR alpha 1 receptor or an epidermal growth factor receptor / Ret chimeric receptor when the cells were stimulated by glial cell line derived neurotrophic factor or epidermal growth factor , respectively . ^^^ Ret stimulation resulted in the activation of c Src . ^^^ Microinjection of a kinase inactive mutant of c Src blocked Ret mediated mitogenic effect . ^^^ These experiments demonstrate that activated Ret is able to bind and stimulate c Src kinase and that Src activation is essential for the mitogenic activity of Ret . . ^^^ Ret mediated mitogenesis requires Src kinase activity . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
GDNF triggers a novel ret independent Src kinase family coupled signaling via a GPI linked GDNF receptor alpha 1 . ^^^ Here we show that upon GDNF binding glycosyl phosphatidylinositol ( GPI ) linked GDNF receptor alpha 1 ( GFRalpha 1 ) activates cytoplasmic Src family tyrosine kinase ( s ) in Ret tyrosine kinase deficient cultured mouse dorsal root ganglion neurons and in two Ret negative cell lines . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
GDNF binding to GFRalpha 1 also recruits Ret to the lipid rafts and triggers association with Src , which is required for effective downstream signalling , leading to differentiation and neuronal survival . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Moreover , we have found that Ret interacts with members of the Src family kinases ( SFK ) only when it is localized to these microdomains . ^^^ These data confirm the importance of protein protein interactions between Ret and raft associated proteins in the signaling pathways elicited by GDNF , and the data implicate Src as one of the major signaling molecules involved in GDNF mediated bioactivity . . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Differently from oncogenes Src , Ras and Raf , RET / PTC1 caused actin filaments to form prominent stress fibers . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Repair by Src kinase of function impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH terminal kinase domain for phenylalanine . ^^^ A complex was shown to be formed between 5 Src and RET MEN2A through association of both with a cholesterol rich membrane microdomain known as `` a raft , ' ' possibly for efficient contact of submembranous domains of Src and RET to promote phosphorylation of Y 905 of the latter . ^^^ These results reveal a novel Src kinase mediated repair mechanism of otherwise function impaired mutant RET kinases . . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Activation of STAT 3 requires the intrinsic kinase activity of RET / PTC ; Janus tyrosine kinase and c Src kinase are not involved in the RET / PTC mediated activation of STAT 3 . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Tyrosine 981 , a novel ret autophosphorylation site , binds c Src to mediate neuronal survival . ^^^ Ligand induced translocation of Ret to lipid rafts , where it interacts with the nonreceptor tyrosine kinase Src , is a prerequisite for full biological activity of these neurotrophic factors . ^^^ Here we show by multiple approaches that Ret tyrosine 981 constitutes the major binding site of the Src homology 2 domain of Src and therefore the primary residue responsible for Src activation upon Ret engagement . ^^^ Other tyrosines such as 1015 and 1029 may contribute to the overall interaction between Ret and Src , as judged by overexpression experiments . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
Src homology 2 containing protein tyrosine phosphatase 1 ( SHP 1 ) , a cytoplasmic protein tyrosine phosphatase ( PTP ) , is activated by somatotropin release inhibiting factor and reduces mutated RET autophosphorylation in a heterologous system . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
RET familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src / JAK / STAT3 pathway , independent of glial cell line derived neurotrophic factor . ^^^ Furthermore , we show that STAT 3 activation is mediated by a signaling pathway involving Src , JAK 1 , and JAK 2 , differing from STAT 3 activation promoted by RET ( C634R ) which was previously found to be independent of Src and JAKs . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
We have previously shown that RET signals through focal adhesion kinase ( FAK ) in medullary thyroid cancer cells and that extracellular signal regulated kinase ( ERK ) activity can be blocked by pp 2 , an inhibitor of both Src and RET . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
To elucidate the molecular basis for signaling specificity of GDNF mediated RET signaling in kidney development , we characterized mice that exclusively express either the human RET 9 or RET 51 isoform , or express these isoforms with individual mutations in docking tyrosines for PTB and SH 2 domain containing adaptors Src ( Y 981 ) , PLCgamma ( Y 1015 ) , and Shc ( Y 1062 ) . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
By using RET / PTC3 molecules mutated in specific tyrosine autophosphorylation sites , we characterized Tyr ( 981 ) , a known binding site for c Src , as a major determinant of RET / PTC3 induced Erk 8 activation , although , surprisingly , the underlying mechanism did not strictly depend on the activity of Src . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
GDNF induced OECs migration was demonstrated depending on GFRalpha 1 and Ret receptor , and activation of JNK and Src signaling cascades . ^^^
Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P07949 and P12931	Pubmed	SVM Score :0.0
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