| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show that in HEK 293 cells , stimulation of mitogen activated protein ( MAP ) kinase by the beta 2 adrenergic receptor is mediated by the betagamma subunits of pertussis toxin sensitive G proteins through a pathway involving the non receptor tyrosine kinase c Src and the G protein Ras . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Try 350 / 354 creates a Src homology 2 ( SH 2 ) domain on the beta 2 adrenergic receptor and the binding of adaptor protein Grb 2 to this SH 2 domain of the beta adrenergic receptor takes place in an insulin dependent manner . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have previously identified c SRC as a molecule that is rapidly recruited to the beta 2 adrenergic receptor in a beta arrestin 1 dependent manner . ^^^ The SH 1 ( KD ) mutant did indeed block beta 2 adrenergic receptor internalization and receptor stimulated tyrosine phosphorylation of dynamin , actions previously shown to be c SRC dependent . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Ras dependent activation of ERK1 / 2 may involve the betaArrestin dependent recruitment of c Src to the beta 2 adrenergic receptor ( beta 2 AR ) . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| Truncation of the beta 2 adrenergic receptor C terminal cytoplasmic tail to a 15 amino acid motif harboring a potential Src homology 2 binding domain at Y 350 and an Akt phosphorylation site at S 345 , 346 was sufficient to enable receptor regulation by insulin . . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have developed a novel expressed substrate for PKA in live oocytes by constructing a fusion protein containing an N terminal myristylation sequence ( derived from the Src tyrosine kinase ) followed by an antigenic epitope tag and a substrate motif ( the C terminal cytoplasmic domain of beta 2 adrenergic receptor ) . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| Role of Src in hypersensitization to phosphodiesterase inhibitors in beta 2 adrenoceptor desensitized eosinophils . ^^^ The fenoterol induced beta 2 adrenoceptor desensitization was not affected by pretreatment with either genistein , a broad spectrum tyrosine kinase inhibitor , or PP 2 , a specific Src family tyrosine kinase inhibitor . ^^^ These findings suggested that Src family tyrosine kinases play important roles in the hypersensitization of PDE to PDE inhibitors in beta 2 adrenoceptor desensitized eosinophils . . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| SRC animals were trained for 10 days on a skilled reaching task while URC animals were trained on a simple bar pressing task . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| Finally , we observed that beta AR induced activation of MAP kinases is dependent on both Gs / cAMP / PKA and Gi / Src / Ras signaling pathways and that phosphorylation of beta AR is critical to the cross talk between these signaling pathways . . ^^^ |
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| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|