| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Site directed mutagenesis was employed to map and characterize Ca ( 2+ ) binding sites in annexin 2 , a member of the annexin family of Ca ( 2+ ) and phospholipid binding proteins which serves as a major cellular substrate for the tyrosine kinase encoded by the src oncogene . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Annexin 2 , a major cytoplasmic substrate of the src tyrosine kinase , is a member of the annexin family of Ca2+ / phospholipid binding proteins . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Xenopus annexin 2 heavy chain lacks the highly conserved tyrosine at position 23 which is the site of src oncogene tyrosine kinase phosphorylation in the murine protein . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Alkylation of cysteine 82 of p 11 abolishes the complex formation with the tyrosine protein kinase substrate p 36 ( annexin 2 , calpactin 1 , lipocortin 2 ) . p 36 ( annexin 2 ) is the major cytoplasmic target of the src tyrosine kinase and forms in vitro and in vivo a stable tetrameric complex in which two p 36 polypeptides interact with a dimer of a unique p 11 polypeptide . p 11 belongs into the superfamily of EF hand proteins . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using site directed mutagenesis , we generated mutant proteins that show defects in the Ca ( 2+ ) binding sites in a particular member of this family , the src tyrosine kinase substrate annexin 2 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Glycoproteins distribute unevenly between the two subfractions and antigens involved in signal transduction [ e . g . , annexin 2 , protein kinase C alpha , the G alpha subunits of heterotrimeric G proteins ( alpha s , alpha q , alpha i 2 , alpha i 3 ) , small GTP binding proteins , endothelial nitric oxide synthase , and nonreceptor protein kinase c src ] are concentrated in the NB ( plasmalemma proper enriched ) subfraction rather than in the caveolae of the B subfraction . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Extraction of ECV 304 endothelial cells in 1 % Triton 10 100 at 4 degrees C resulted in a detergent insoluble pellet that contained 90 % of the caveolin , 78 % of the src family kinases and 99 % of the annexin 2 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of a few downstream signaling enzymes including phosphatidylinositol 3 kinase , pp60c Src , and protein kinase C had no effect on insulin induced annexin 2 secretion , suggesting a possible direct link between receptor activation and annexin 2 secretion . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , stimulation of cells with H2O2 induces tyrosine phosphorylation of annexin 2 on the Golgi apparatus in a manner that is dependent on the kinase activity of Src kinases , leading to the translocation of annexin 2 from the Golgi apparatus to the endoplasmic reticulum . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of p 36 ( the calpactin 1 heavy chain ) was drastically reduced in cells expressing SRX 5 src , suggesting that the phenotype of SRX 5 results from an alteration in substrate recognition by the src kinase . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| C src variants encoding proteins with the alteration of arg 95 to trp , glu , or lys , or containing the deletion of residues 92 95 , induced alterations in cell morphology and promoted growth in soft agar as well as changes in glucose transport and in vivo tyrosine phosphorylation of cellular proteins ( including calpactin 1 heavy chain , p 36 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| The peptides were based on the sites of phosphorylation of pp60v src , lipocortin 1 , and lipocortin 2 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Two clones were isolated , and one , designated SAKAP 1 ( for Src A box Nck associated protein 1 ) , contained the carboxyl terminal half of the cbl proto oncogene product . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| It was purified approximately 3000 fold with an overall yield of 0 . 54 % according to [ Val 5 ] angiotensin 2 phosphorylation activity and the specific activity of the final sample ( 30 nmol phosphate . min 1 . mg protein 1 ) was relatively lower than that of the 40 kDa kinase , a catalytic fragment of p72syk which lacks two src homology regions 2 domains . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| In chicken embryo and NIH 3T3 fibroblasts under similar conditions , 5 Src rapidly translocates from the perinuclear region to the focal adhesions upon activation of the tyrosine kinase , resulting in downstream activation of activator protein 1 and mitogen activated protein kinase , which are required for the mitogenic and transforming activity of the oncoprotein . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor binding sites of coactivators glucocorticoid receptor interacting protein 1 ( GRIP 1 ) and steroid receptor coactivator 1 ( SRC 1 ) : multiple motifs with different binding specificities . ^^^ The activity of the AF 2 transcriptional activation function of nuclear receptors ( NR ) is mediated by the partially homologous transcriptional coactivators , glucocorticoid receptor interacting protein 1 ( GRIP 1 ) / transcriptional intermediary factor 2 ( TIF 2 ) and steroid receptor coactivator 1 ( SRC 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Scanning surface mutagenesis on the human thyroid hormone receptor was performed to define the site that binds the coactivators , glucocorticoid receptor interacting protein 1 ( GRIP 1 ) and steroid receptor coactivator 1 ( SRC 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We find that the Src homology 3 domains of Grb 2 directly associate , in vitro and in vivo , with murine hemopoietic specific protein 1 ( HS 1 ) , a protein identical to Lck binding protein 1 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| As anticipated from its location , the L454S mutant interacts weakly with CoAs , such as SRC 1 and glucocorticoid receptor interacting protein 1 ( GRIP 1 ) in gel mobility shift assays and in mammalian two hybrid assays , even in the presence of the maximal dose of T 3 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that members of the p 160 family of nuclear receptor coactivators , ACTR ( activator of thyroid and retinoic acid receptors ) , GRIP 1 ( glucocorticoid receptor interacting protein 1 ) , and SRC 1 ( steroid receptor coactivator 1 ) , potentiate the transcriptional activity by hERR 1 and hERR 2 in mammalian cells , and that both orphan receptors bind the coactivators in a ligand independent manner . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Association of mouse actin binding protein 1 ( mAbp1 / SH3P7 ) , an Src kinase target , with dynamic regions of the cortical actin cytoskeleton in response to Rac 1 activation . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We also show that JAB 1 potentiates the activity of a variety of transcription factors known to associate with SRC 1 ( nuclear receptors , activator protein 1 , and nuclear factor kappaB ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have used yeast genetics and in vitro protein protein interaction experiments to explore the possibility that GCN 5 ( general control nonrepressed protein 5 ) and several other ADA ( alteration / deficiency in activation ) adaptor proteins of the multimeric SAGA complex can regulate T3 / GRIP1 ( glucocorticoid receptor interacting protein 1 ) and SRC 1 ( steroid receptor coactivator 1 ) coactivator dependent activation of transcription by the human T 3 receptor beta 1 ( hTRbeta 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Members of the p 160 coactivator family ( steroid receptor coactivator 1 ( SRC 1 ) , glucocorticoid receptor interacting protein 1 ( GRIP 1 ) , and activator of thyroid and retinoic acid receptors ( ACTR ) ) mediate transcriptional activation by nuclear receptors . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| To determine whether this enhanced activity is mediated through modulation of the dimerization process or through interaction with coactivators , we performed quantitative protein protein interaction assays with in vitro translated vitamin D receptor ( ivtVDR ) and fusion proteins containing glutathione S transferase ( GST ) and either the ligand binding domain of retinoid 10 receptor ( RXRalpha ) , or the nuclear receptor interacting domain of the steroid receptor coactivator 1 ( SRC 1 ) , or the glucocorticoid receptor interacting protein 1 ( GRIP 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src potentiates activation functions in CREB binding protein ( CBP ) and glucocorticoid receptor interacting protein 1 ( GRIP 1 ) , and we discuss the possibility that the Src / JNK pathway enhances the activity of these coactivators , which are known to mediate AF 1 action . . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have described a reconstituted avian sarcoma virus ( ASV ) concerted DNA integration system with specially designed mini donor DNA containing a supF transcription unit , a supercoiled plasmid acceptor , purified bacterially expressed ASV integrase ( IN ) , and human high mobility group protein 1 ( Y ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found that cross linking with the TCR and the activity of Src tyrosine kinase p 56 ( lck ) were required for phosphorylation of ILT 2 and subsequent recruitment of Src homology protein 1 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated low density lipoprotein receptor related protein 1 ( Lrp 1 ) associates with the adaptor protein SHC in SRC transformed cells . 5 Src transforms fibroblasts in vitro and causes tumor formation in the animal by tyrosine phosphorylation of critical cellular substrates . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor interacting protein 1 ( GRIP 1 ) is a member of the steroid receptor coactivator ( SRC ) family of transcriptional regulators . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Loss of expression of human spectrin src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma . ^^^ The gene encoding human spectrin Src homology domain binding protein 1 , or Hssh3bp1 , which is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis , co localizes to a YAC containing chromosome 10p sequences at loci D10S89 and D10S111 that are frequently deleted in prostate tumors . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| The role of c Src in growth signaling by angiotensin ( Ang ) 2 was investigated in vascular smooth muscle cells ( VSMCs ) from arteries of hypertensive patients . c Src and extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 ) activity , proto oncogene expression , activating protein 1 ( AP 1 ) DNA binding activity , and DNA and protein synthesis were studied in Ang 2 stimulated VSMCs derived from small peripheral resistance arteries of normotensive subjects ( NTs , n=5 ) and age matched untreated hypertensive patients ( HTs , n=10 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| This is functionally achieved by bridging coactivators such as CEBP binding protein / p300 and members of the p 160 subfamily such as steroid receptor coactivator protein 1 ( SRC 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found that actin binding and Src homology 3 ( SH 3 ) domain containing proteins cortactin , hematopoietic specific protein 1 ( HS 1 ) , and hematopoietic progenitor kinase 1 interacting protein of 55 kDa ( HIP 55 , also called SH3P7 and Abp 1 ) were degraded in a caspase dependent manner during apoptosis . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using a GST CEACAM 1 cytoplasmic tail fusion protein , it was shown that the cytoplasmic tail of CEACAM 1 bound the src homology domain containing phosphatase 1 and adaptor protein 1 complex in its phosphorylated and nonphosphorylated states , respectively . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| This novel APPL interacting protein 1 ( APLIP 1 ) contains a Src homology 3 domain and a phosphotyrosine interaction domain and is expressed abundantly in neural tissues . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| It has been possible to identify the gene defective in XLP and to demonstrate that , in normal individuals , it encodes the Src homology 2 domain containing protein 1 A ( SH2D1A ) that plays a crucial role in signaling via a number of surface molecules expressed by cells of the immune system . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Electrophoretic mobility shift assay showed that activator protein 1 ( AP 1 ) is activated by IL 18 through ERK and Src but not through PI 3 kinase . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src homology protein 1 ( SHP 1 ) plays an important role in B cell Ag receptor ( BCR ) differentiation , proliferation , survival , and apoptosis . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Adaptor protein 3BP2 , a c Abl Src homology 3 ( SH 3 ) domain binding protein , is known to play a regulatory role in T cell receptor mediated transcriptional activation of nuclear factor of activated T cell and activator protein 1 by interacting with Syk / ZAP 70 protein tyrosine kinase . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor related protein 1 . ^^^ We recently observed that the LDL receptor related protein 1 ( LRP 1 ) is tyrosine phosphorylated in 5 Src transformed cells . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Human and mouse CABYR conserve potential functional motifs including a domain homologous to the dimerization interface of cyclic adenosine monophosphate dependent PKA RII alpha , 14 PXXP motifs , and regions of homology with extensins and src homology 3 binding protein 1 . mCABYR is arranged into six exons spanning about 14 kb of DNA . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| By contrast , mutations in the myristoylation site and in signaling sites of Nef , ie , sites important for interaction with phosphofurin acidic cluster sorting protein 1 ( PACS 1 ) , Src homology domain 3 ( SH 3 ) domains , and p 21 activated kinase 2 ( PAK 2 ) , were found to be critical for its effect on T cell development . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Research in past years has identified several htt interacting proteins such as htt interacting protein 1 , Src homology region 3 containing Grb 2 like protein 3 , protein kinase C and casein kinase substrate in neurons 1 , htt associated protein 1 , postsynaptic density 95 , FIP 2 ( for 14 . 7K interacting protein ) , specificity protein 1 and nuclear receptor co repressor . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that the GPCR kinase interacting protein 1 ( GIT 1 ) is a substrate for c Src that undergoes tyrosine phosphorylation in response to angiotensin 2 ( AngII ) and EGF in vascular smooth muscle and 293 cells . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| While double strand break repair protein rad 21 homologue , eukaryotic translation initiation factor 3 subunit 5 , mixed lineage leukemia septin like fusion protein B and heat shock protein 75 were increased ; beta amyloid precursor like protein 1 , tropomyosin 4 anaplastic lymphoma kinase fusion oncoprotein type 2 , Nck adaptor protein 2 , Src homology domain growth factor receptor bound 2 like endophilin B 2 , beta tubulin , septin 7 and hematopoietic stem / progenitor cells 140 were decreased . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that the GPCR kinase interacting protein 1 ( GIT 1 ) is a substrate for c Src that associates with MEK 1 in vascular smooth muscle cells and human embryonic kidney 293 cells . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Affinity purification experiments demonstrate that the interactions are mediated by the Abp 1 ( actin binding protein 1 ) SH 3 ( Src homology 3 ) domain , which associates with a proline rich motif that is conserved within the C terminal parts of ProSAP 1 ( proline rich synapse associated protein 1 ) / Shank2 and ProSAP2 / Shank3 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| The p 160 co activators , SRC 1 ( steroid receptor co activator 1 ) , GRIP 1 ( glucocorticoid receptor interacting protein 1 ) and ACTR ( activator for thyroid hormone and retinoid receptors ) , have two ADs ( activation domains ) , AD 1 and AD 2 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| CHO K 1 cells transfected with ERalpha or ERbeta show ERE sequence dependent differences in the functional interaction of ERalpha and ERbeta with coactivators steroid receptor coactivator 1 ( SRC 1 ) , SRC 2 ( glucocorticoid receptor interacting protein 1 ( GRIP 1 ) ) , SRC 3 amplified in breast cancer 1 ( AIB 1 ) and ACTR , cyclic AMP binding protein ( CBP ) , and steroid receptor RNA activator ( SRA ) , corepressors nuclear receptor co repressor ( NCoR ) and silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) , and secondary coactivators coactivator associated arginine methyltransferase 1 ( CARM 1 ) and protein arginine methyltransferase 1 ( PRMT 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src kinase exhibited the additional function of potentiating the transcriptional activity of Gal steroid receptor coactivator 1 ( SRC 1 ) and Gal cAMP response element binding protein binding protein in endometrial cancer cells while having no effect on Gal p 300 associated factor and Gal fusions of the other p 160 coactivators glucocorticoid interacting protein 1 ( transcriptional intermediary factor 2 / nuclear coactivator 2 / SRC 2 ) and amplified in breast cancer 1 ( receptor associated coactivator 3 / activator of transcription of nuclear receptor / SRC 3 ) . ^^^ Src kinase exhibited the additional function of potentiating the transcriptional activity of Gal steroid receptor coactivator 1 ( SRC 1 ) and Gal cAMP response element binding protein binding protein in endometrial cancer cells while having no effect on Gal p 300 associated factor and Gal fusions of the other p 160 coactivators glucocorticoid interacting protein 1 ( transcriptional intermediary factor 2 / nuclear coactivator 2 / SRC 2 ) and amplified in breast cancer 1 ( receptor associated coactivator 3 / activator of transcription of nuclear receptor / SRC 3 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| This review covers recent advances in ( 1 ) metal induced generation of reactive oxygen species ; ( 2 ) the receptors , kinases , and nuclear transcription factors affected by metals and metal induced oxidative stress , including growth factor receptors , src kinase , ras signaling , mitogen activated protein kinases , the phosphoinositide 3 phosphate / Akt pathway , nuclear transcription factor kappaB , activator protein 1 , p 53 , nuclear factor of activated T cells , and hypoxia inducible factor 1 ; and ( 3 ) global cellular phenomena ( signal transduction , cell cycle regulation , and apoptosis ) associated with metal induced ROS production and gene expression . . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although RA receptor gamma and glucocorticoid receptor bind to the same response element repressing transcription of keratins K6 / K16 , RA receptor interacts with the components of the EGF enhanceosome ( co activators : glucocorticoid receptor interactive protein 1 ( GRIP 1 ) / steroid receptors coactivator 1 ( SRC 1 ) ) without breaking it . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our experiments also showed that one member of the p 160 family of steroid receptor coactivators , steroid receptor coactivator ( SRC ) 1 , but not glucocorticoid receptor interacting protein 1 ( GRIP 1 ) or amplified in breast cancer 1 ( AIB 1 ) , also functioned in gene transactivation in response to leptin treatment . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We previously found that EGF ( epidermal growth factor ) increases the EGFR ( EGF receptor ) kinase binding affinity towards the major tyrosine phosphorylation sites in downstream adaptor proteins such as Gab 1 ( Grb 2 associated binding protein 1 ) and Shc [ Src homology 2 ( SH 2 ) domain and collagen containing protein ] , but not that towards EGFR autophosphorylation sites [ Fan , Wong , Deb and Johnson ( 2004 ) J . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ang 2 induced AT1R activation via Gq / 11 stimulates phospholipases A 2 , C , and D , and activates inositol trisphosphate / Ca2+ signaling , protein kinase C isoforms , and MAPKs , as well as several tyrosine kinases ( Pyk 2 , Src , Tyk 2 , FAK ) , scaffold proteins ( G protein coupled receptor kinase interacting protein 1 , p130Cas , paxillin , vinculin ) , receptor tyrosine kinases , and the nuclear factor kappaB pathway . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Rosiglitazone inhibited ANG 2 enhanced phosphorylation of eukaryotic initiation factor 4E binding protein 1 ( 4E BP 1 ) , as well as Src homology ( SH ) 2 containing inositol phosphatase 2 ( SHIP 2 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Previous studies indicate that adenovirus type 19 ( Ad 19 ) infection of human corneal fibroblasts ( HCFs ) induces the expression of several proinflammatory mediators , including IL 8 and monocyte chemoattractant protein 1 ( MCP 1 ) , and that the tyrosine kinase c Src and its downstream target , the mitogen activated protein kinase ERK1 / 2 , mediate IL 8 expression . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Additionally , Y 228 in the YLSF sequence and Y 291 are IRK substrates ; the former sequence provides optimum recognition motif in the tyrosine phosphatase , SHP 1 , and for SHC ( Src homology 2 domain containing transfroming protein 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| The pro atherogenic cytokine interleukin 18 induces CXCL 16 expression in rat aortic smooth muscle cells via MyD 88 , interleukin 1 receptor associated kinase , tumor necrosis factor receptor associated factor 6 , c Src , phosphatidylinositol 3 kinase , Akt , c Jun N terminal kinase , and activator protein 1 signaling . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src homology 3 domain growth factor receptor bound 2 like ( endophilin ) interacting protein 1 , a novel neuronal protein that regulates energy balance . ^^^ We therefore named this transcript Src homology 3 domain growth factor receptor bound 2 like ( endophilin ) interacting protein 1 ( SGIP 1 ) . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| SRC tyrosine kinase and multidrug resistance protein 1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel resistant ovarian cancer cells . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| PELP 1 ( proline , glutamic acid , and leucine rich protein 1 ) ( also known as the modulator of nongenomic activity of estrogen receptor ) plays a role in genomic functions of the estrogen receptor via histone interactions and in nongenomic functions via its influence on the MAPK Src pathway . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| We report here that overexpression of steroid receptor coactivator 1 ( SRC 1 ) and GR interacting protein 1 ( GRIP 1 ) enhanced repression by liganded GR , and by a GR mutant defective in repression . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| CD 3 and CD 28 costimulation induced a complex response including decreased threonine phosphorylation in the ERK 1 and ERK 2 activation loops and increased phosphorylation of selected tyrosine sites on ERK1 / 2 , p 38 , phospholipase C gamma , Src homology 2 domain containing transforming protein 1 , Grap 2 , and Vav 1 , potentiating T cell activation . ^^^ Quantitative information in our study suggests quantitative and qualitative contribution by costimulation of CD 28 on CD 3 stimulated TCR signaling networks via enhanced phosphorylation of phospholipase C gamma / Src homology 2 domain containing transforming protein 1 / Grap2 / Vav 1 and their effects on downstream components including MAPKs . . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| An inhibitor of Src kinase , PP 2 , significantly blocked S100B induced activation of Src kinase , mitogen activated protein kinases , transcription factors NF kappaB and STAT 3 , superoxide production , tyrosine phosphorylation of Cav 1 , VSMC migration , and expression of the pro inflammatory genes monocyte chemotactic protein 1 and interleukin 6 . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| Nuclear magnetic resonance spectroscopy demonstrated the direct binding of androsterone to purified human FXR ( hFXR ) ligand binding domain ( LBD ) protein , resulting in the recruitment of steroid receptor coactivator protein 1 ( SRC 1 ) coactivator peptide . ^^^ |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07355 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|