| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.97801296 |
| Unlike agonist bound PR that interacts only with coactivators such as steroid receptor coactivator 1 ( SRC 1 ) , RU 486 bound PR binds to both coactivator SRC 1 and corepressor silencing mediator for retinoid and thyroid hormone receptor ( SMRT ) in vitro . 0.97801296^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.62403559 |
| To investigate the functional interactions between PR and steroid receptor coactivators ( SRCs ) required for regulation of gene transcription in vivo , we crossed PR activity indicator ( PRAI ) mice with SRC 1 ( + / ) and SRC 3 ( + / ) mice to generate bigenic mice , PRAI SRC 1 ( / ) and PRAI SRC 3 ( / ) . 0.62403559^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.72891743 |
| Upon ligand treatment , progesterone receptor ( PR ) interacted preferentially with SRC 1 , which recruited CBP and significantly enhanced acetylation at K 5 of histone H 4 . 0.72891743^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| To define the regions within the amino terminal portion of pp60src that influence morphological transformation , a series of overlapping deletion mutations in the src gene of Prague A RSV ( Pr A RSV ) were constructed and their biological and biochemical properties were analyzed . ^^^ These studies suggest that the region of the Pr A RSV src protein delineated by amino acid residues 142 to 169 is essential for initiation and maintenance of morphological transformation of chicken cells in culture . . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| PR 39 , a proline rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p 47 phox . ^^^ We show here that an endogenous proline arginine ( PR ) rich antibacterial peptide , PR 39 , inhibits NADPH oxidase activity by blocking assembly of this enzyme through interactions with Src homology 3 domains of a cytosolic component . ^^^ Its effects involve both a polybasic amino terminal segment and a proline rich core region of PR 39 that binds to the p47phox Src homology 3 domains and , thereby , inhibits interaction with the small subunit of cytochrome b 558 , p22phox . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Coexpression of CBP and SRC 1 stimulated ER and PR transcriptional activity in a synergistic manner and indicated that these two coactivators are not functional homologues . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PR transactivation was repressed by recruiting HD 1 into the PR DNA complex by fusing HD 1 to a PR ligand binding domain interacting portion of SRC 1 . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| CBP and SRC 1 interact and synergistically enhance transcriptional activation by the ER and PR . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate that liganded PR is present in stable complexes containing SRC 1 and transcription intermediary factor 2 ( TIF 2 ) in vivo . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Steroid receptor coactivator 1 ( SRC 1 ) family members interact with steroid receptors , including estrogen receptor alpha ( ERalpha ) and progesterone receptor ( PR ) , to enhance ligand dependent transcription . ^^^ Treatment of animals with estrogen induced PR expression in the ERalpha expressing mammary epithelial cells in the absence of detectable SRC 1 and did not affect the segregated pattern of SRC 1 and ERalpha expression . ^^^ PR was neither expressed nor induced by estrogen treatment in stroma , despite the coexpression of ERalpha and SRC 1 . ^^^ These results suggest that SRC 1 is not necessary for ERalpha mediated induction of PR in mammary epithelial cells and is also not sufficient for PR induction in stromal cells expressing both ERalpha and SRC 1 . ^^^ Furthermore , the expression of SRC 1 in a subpopulation of mammary epithelial cells distinct from those expressing ERalpha or PR raises the possibility that SRC 1 has cell type specific functions other than simply to act as coactivator for ERalpha or PR in the mammary epithelium . . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| The transcriptional activity of PR requires the involvement of coactivators such as steroid receptor coactivator 1 ( SRC 1 ) . ^^^ To dissect the role of SRC 1 in PR transactivation , we established an in vitro transcription system with chromatin templates , in which PR induced transcription in a ligand dependent and PRE dependent manner . ^^^ With this system , the ability of purified SRC 1 to act as a coactivator of PR was examined . ^^^ SRC 1 potentiated transcription by ligand activated PR , whereas it had no effect on transcription in the absence of ligands . ^^^ As SRC 1 possesses intrinsic histone acetyltransferase activity , we tested the role of acetylation in PR mediated transcription by using a histone deacetylase inhibitor , trichostatin A ( TSA ) . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we provide evidence that the hormone occupied PR forms a multisubunit receptor coactivator complex containing two previously described coactivators , CREB binding protein ( CBP ) and steroid receptor coactivator 1 ( SRC 1 , a member of the p 160 family of coactivators ) , in nuclear extracts of human breast tumor T47D cells . ^^^ Furthermore , depletion of SRC 1 / p160 by immunoprecipitation from these transcriptional extracts also significantly impaired PR mediated RNA synthesis from a naked PRE linked DNA template . ^^^ Most importantly , we noted that binding of E1A to CBP prevented the assembly of a coactivation complex containing PR , CBP , and SRC 1 / p160 , presumably by disrupting the interaction between CBP and SRC 1 / p160 . ^^^ Collectively , our results support the hypothesis that the assembly of a multisubunit coactivation complex containing PR , CBP , and SRC 1 / p160 is a critical regulatory step during hormone dependent gene activation by PR and that the fully assembled complex has the ability to control transcription through mechanisms that are independent of the histone modifying activities of its component coactivators . . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show here , by yeast and mammalian two hybrid analyses and by pull down experiments , that JAB 1 also interacts with both the progesterone receptor ( PR ) and the steroid receptor coactivator 1 ( SRC 1 ) and that it stabilizes PR SRC 1 complexes . ^^^ This occurs without any modification of PR or SRC 1 concentration . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| The cDNA predicts a 72 kDa protein containing an NH ( 2 ) terminal kinase , a Src Homology 3 ( SH 3 ) domain , and a proline rich ( PR ) tail . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have identified a specific polyproline motif in the amino terminal domain of conventional progesterone receptor ( PR ) that mediates direct progestin dependent interaction of PR with SH 3 domains of various cytoplasmic signaling molecules , including c Src tyrosine kinases . ^^^ Through this interaction , PR is a potent activator of Src kinases working by an SH 3 domain displacement mechanism . ^^^ By mutagenesis , we also show that rapid progestin induced activation of Src and downstream MAP kinase in mammalian cells is dependent on PR SH 3 domain interaction , but not on the transcriptional activity of PR . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Employing a cell free chromatin transcription system that recapitulates progesterone receptor ( PR ) mediated transcription in vivo , we have investigated further the coactivator functions of steroid receptor coactivator 1 ( SRC 1 ) in terms of its functional domains as well as cooperation with other coactivators in PR transactivation . ^^^ By analyzing wild type and mutant SRC 1 with liganded PR in the chromatin transcription system in vitro , the basic helix loop helix / Per Arnt Sim domain , the p 300 binding domain , and the carboxyl terminal region ( containing the PR binding site ) of SRC 1 were shown to be important for PR transactivation . ^^^ Although in context of a synthetic promoter its histone acetyltransferase activity was nonessential for PR mediated transcription , SRC 1 was observed to act synergistically with p 300 to enhance PR transactivation from chromatin . ^^^ Further analysis of synergism between SRC 1 and p 300 revealed an obligatory `` sequential ' ' recruitment of SRC 1 and p 300 to liganded PR . ^^^ In addition , functional analysis of SRC 2 and SRC 3 coactivators indicated that the SRC family modulated PR transactivation from chromatin by a similar mechanism . . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| This activity is comparable with that of the coactivator SRC 1 , but , in contrast , the interaction between EDD and PR does not appear to involve an LXXLL receptor binding motif . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Sumoylation was shown to increase PR SRC 1 interaction and to prolong SRC 1 retention in the nucleus . ^^^ Overexpression of SUMO 1 enhanced PR mediated gene transcription even in the presence of non sumoylated mutants of SRC 1 . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| To examine the sex steroid dependent growth mechanisms of the human endometrium , the expression of steroid receptor coactivators [ steroid receptor coactivator 1 ( SRC 1 ) and p300 / CREB binding protein ( p300 / CBP ) ] and corepressors ( nuclear receptor corepressor and silencing mediator for retinoid and thyroid hormone receptors ) was examined by immunohistochemistry , using 50 samples of normal endometria , and was compared with that of estrogen receptors ( ER ) , progesterone receptors ( PR ) , and proliferation marker Ki 67 . ^^^ Such change in the expression pattern of SRC 1 resembled that of ER , PR , and Ki 67 . ^^^ Complex formation between p300 / CBP and PR was noted in the secretory endometrium , whereas that between SRC 1 and PR was not apparent . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| The deleted transcript was characterized by an out of frame deletion of 437 bp , corresponding to the complete loss of exons 4 and 6 ( PR delta4+6 ASV ) . ^^^ PR delta4+6 ASV will result in a partial defect in the region of the ligand binding domain of hormone receptors , suggesting that the conserved residues are missing from the core of the protein . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| We also discovered that PR contains an SH 3 domain interaction motif in the N terminus that mediates interaction with Src tyrosine kinases and other signaling molecules . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found a novel alternatively spliced variant ( ASV ) of the PR mRNA in breast cancer tissues . ^^^ The deleted transcript was characterized by an out of frame deletion of 52 bp in exon 6 ( PR delta6 / 2 ASV ) . ^^^ The PR delta6 / 2 ASV mRNA results in a partial defect in the region of the ligand binding domain of the hormone receptor , where conserved residues are missing from the core of the protein . ^^^ To clarify the clinical significance of the PR delta6 / 2 ASV , we investigated the expression of this ASV in noncancerous and cancerous tissues from patients with breast cancer using RT PCR . ^^^ PR delta6 / 2 ASV mRNA was expressed more frequently in breast cancer tissues than in noncancerous tissues ( p < 0 . 0001 ) , which suggests a possible relationship between the expression of PR delta6 / 2 and breast cancer . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| We also show that the ligand dependent activities of ERalpha and progesterone receptor ( PR ) in yeast cells were strongly enhanced by the human p 160 protein steroid receptor coactivator ( SRC 1 ) , but not by CREB Binding Protein ( CBP ) or the p300 / CBP associated factor ( P / CAF ) . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| METHODS : Gene expression of SRC 1 , SRC 2 , SRC 3 , N CoR , SMRT , ERalpha , and PR was measured in 26 samples of normal endometrium and 30 primary endometrial carcinomas using real time RT PCR . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| MCF 7 cells stably expressing a mutant PR unable to bind c Src and activate MAPK failed to support progestin induced proliferation . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Cdk 2 activity abolishes progesterone dependent activation of PR target genes in part through inhibition of PR dependent recruitment of steroid receptor coactivator 1 ( SRC 1 ) and subsequent histone H 4 acetylation at the target promoter . ^^^ In vitro studies revealed that the interaction between SRC 1 and PR is dependent upon phosphorylation of SRC 1 . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| DtxR contains an N terminal metal and DNA binding domain that is connected by a proline rich flexible peptide segment ( Pr ) to a C terminal src homology 3 ( SH 3 ) like domain . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although PR is recruited to the MMTV promoter equivalently in the G 1 and S phases , recruitment of SRC 1 , SRC 3 , and , consequently , CBP is reduced in G 1 phase despite comparable expression levels of SRC 1 and SRC 3 . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Bigenic PRAI SRC 1 ( / ) mice revealed that SRC 1 modulates PR activity in the uterus in a cell specific fashion and is involved in PR gene activation in stroma and myometrium of the uterus in response to estrogen and progesterone . ^^^ In contrast , SRC 1 was involved in the down regulation of PR target gene expression in the luminal and glandular epithelial compartments of the uterus after chronic progesterone treatment . ^^^ Finally , we dissected the means by which SRC 1 dynamically regulates PR activity in each uterine cell compartment and demonstrated that it involves the differential ability of SRC 1 to modulate expression levels of distinct coactivators , corepressors , and PR in a cell specific fashion . . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present study , to assess the impact of these agents on brain sexual differentiation , region specific mRNA expression of estrogen receptors ( ER ) alpha and beta , the progesterone receptor ( PR ) , gonadotrophin releasing hormone , steroid receptor coactivators ( SRC ) 1 and 2 , and calbindin D in microdissected hypothalamic medial preoptic areas ( MPOAs ) at postnatal day 10 was first analyzed in rats exposed to 0 . 5 ppm EE from gestational day 15 by real time RT PCR . ^^^ Sexually dimorphic expression of ER alpha and PR was noted with predominance in females and males , respectively , EE up regulating SRC 1 in males and ER beta and PR in females . ^^^ Next , we similarly examined expression changes of ER alpha and beta , PR , and SRC 1 in animals exposed to MXC at 24 , 240 , and 1200 ppm , DINP at 4000 and 20 , 000 ppm , and GEN at 1000 ppm . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using small interfering RNA , we determined that induction is dependent on the presence of PR , estrogen receptor and SRC 1 . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this work we have determined the role of the 26S proteasome in the regulation of the content of progesterone receptors ( PR A and PR B ) , estrogen receptors ( ER alpha and ER beta ) , the coactivator SRC 1 and the corepressor SMRT in the rat brain during the estrous cycle . ^^^ The 26S proteasome inhibitor MG 132 was injected once into the lateral ventricle on proestrous day ; and 24h later , on estrous day we evaluated the content of PR and ER isoforms , SRC 1 and SMRT in the hypothalamus , the preoptic area and the hippocampus by Western blot . ^^^ A significant increase in the content of both PR isoforms , ER beta and SRC 1 was observed after the administration of MG 132 in the three studied cerebral regions . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Conversely , the MYST acetylase domain specifically enhanced SRC 1 coupling with PR NTD , through a hormone dependent mechanism . ^^^ Importantly , real time RT PCR analysis also revealed that HBO 1 enhanced SRC 1 coactivation of PR dependent transcription of human endogenous genes such as alpha 6 integrin and 11beta hydroxydehydrogenase 2 but not that of amphiregulin . ^^^ Immunofluorescence and confocal microscopy of human embryonic kidney PRB cells demonstrated that the hormone induces the colocalization of HBO 1 with PR SRC 1 complex into nuclear speckles characteristic of PR mediated chromatin remodeling . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Previously , our lab has shown that SRC 1 and CBP modulate estrogen receptor ( ER ) mediated induction of progestin receptor ( PR ) gene expression in the ventromedial nucleus of the hypothalamus ( VMN ) and hormone dependent sexual receptivity in female rats . ^^^ In the present experiments , the function of SRC 1 and CBP in distinct ER ( Exp . 1 ) and PR ( Exp . 2 ) dependent aspects of female sexual behavior was investigated . ^^^ In Exp . 2 , antisense to SRC 1 and CBP mRNA around the time of P administration reduced PR dependent ear wiggling and hopping and darting . ^^^ Taken together , these data suggest that SRC 1 and CBP modulate ER and PR action in brain and influence distinct aspects of hormone dependent sexual behaviors . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| To further dissect the roles of members of the steroid receptor coactivator ( SRC ) / p160 family in PR mediated reproductive processes in vivo , state of the art cre loxP engineering strategies were employed to generate a mouse model ( PR ( Cre / + ) SRC 2 ( flox / flox ) ) in which SRC 2 function was abrogated only in cell lineages that express the PR . ^^^ Fertility tests revealed that while ovarian activity was normal , PR ( Cre / + ) SRC 2 ( flox / flox ) mouse uterine function was severely compromised . ^^^ Absence of SRC 2 in PR positive uterine cells was shown to contribute to an early block in embryo implantation , a phenotype not shared by SRC 1 or 3 knockout mice . ^^^ In addition , histological and molecular analyses revealed an inability of the PR ( Cre / + ) SRC 2 ( flox / flox ) mouse uterus to undergo the necessary cellular and molecular changes that precede complete P induced decidual progression . ^^^ Moreover , removal of SRC 1 in the PR ( Cre / + ) SRC 2 ( flox / flox ) mouse uterus resulted in the absence of a decidual response , confirming that uterine SRC 2 and 1 cooperate in P initiated transcriptional programs which lead to full decidualization . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| In contrast , SRC 1 , a coactivator for the progesterone receptor , inhibited both AR mediated transactivation and interaction between the N and C termini . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| One leptomeningeal specimen was positive for AIB 1 , SRC 1 , and progesterone receptor . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Bromo cyclic AMP induces phosphorylation of two sites in SRC 1 that facilitate ligand independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC 1 and CREB binding protein . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Unlike the steroid hormone receptor coactivator 1 ( SRC 1 ) , beta catenin showed a strong interaction with AR but not with other steroid hormone receptors such as estrogen receptor alpha , progesterone receptor beta , and glucocorticoid receptor . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , mutation of the two cAMP inducible SRC 1 phosphorylation sites important for cAMP activation of chicken progesterone receptor or all seven known SRC 1 phosphorylation sites did not specifically impair cAMP activation of ER alpha . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c Src / Erk pathway in mammalian cells . ^^^ Progestins have been reported to activate also this pathway either via an interaction of the progesterone receptor isoform B ( PRB ) with ERalpha , which itself activates c Src , or by direct interaction of PRB with the SH 3 domain of c Src . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Treatment of cultured human uterine smooth muscle cells ( UtSMC ) with TNF alpha significantly reduced mRNA for the coactivators , SRC 1 ( 42 % , P < 0 . 01 ) and 2 ( 47 % , P < 0 . 03 ) , and diminished the respective protein levels , but did not significantly alter the mRNAs encoding SRC 3 , CBP and the corepressors , NCoR and SMRT ; or progesterone receptor protein levels . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| These pathways could be mediated by 1 ) the PGR localizing at or near the plasma membrane and activating SRC family kinases , 2 ) a membrane progestin receptor that responds to P 4 by lowering intracellular cAMP and increasing MAPK 3 / 1 activity , and 3 ) a membrane receptor complex composed of serpine 1 mRNA binding protein ( also known as PAIRBP 1 or RDA 288 ) and progesterone receptor membrane component 1 . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Binding of pIgA to pIgR stimulates transcytosis of the pIgA pIgR complex via a signal transduction pathway that is dependent on a protein tyrosine kinase ( PTK ) of the SRC family . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| The tumoral ER alpha protein expression was significantly correlated with that of PgR ( r = 0 . 61 , p = 0 . 001 ) and NCoR ( r = 0 . 4 , p = 0 . 043 ) , whereas ER beta expression was associated with SRC 1 ( r = 0 . 68 , p < or = . 001 ) , TIF 2 ( r = 0 . 64 , p = 0 . 001 ) and NCoR ( r = 0 . 48 , p = 0 . 014 ) protein levels in malignant specimens . ^^^ |
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| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| PIR B bears immunoreceptor tyrosine based inhibitory motif ( ITIM ) sequences in its cytoplasmic domain that recruit Src homology ( SH ) 2 domain containing tyrosine phosphatases SHP 1 and SHP 2 , leading to inhibition of B and mast cell activation . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the two hybrid system , two domains of rGrb 14 can mediate the interaction with insulin receptors : the Src homology 2 ( SH 2 ) domain and a region between the PH and SH 2 domains that we named PIR ( for phosphorylated insulin receptor interacting region ) . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the phosphorylated insulin receptor interacting region ( PIR ) and Src 2 homology domains ( SH 2 ) of Grb 7 and Grb 14 were differently implicated in the inhibition of FGFR signalling . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Grb 14 has been shown to bind to these activated RTKs through its Src homology 2 ( SH 2 ) domain , with the exception of the insulin receptor , where the primary binding interaction is via a small domain adjacent to the SH 2 domain ( the BPS or PIR domain ) . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Between the PH ( pleckstrin homology ) and SH 2 ( Src homology 2 ) domains is a new binding domain implicated in the interaction with receptor tyrosine kinases called PIR ( phosphorylated insulin receptor interaction region ) . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| Deletion mutagenesis on Grb 14 indicated a phosphorylated insulin receptor interacting ( PIR ) domain between the PH ( pleckstrin homology ) and SH 2 ( Src homology ) domains that binds to IRbeta . ^^^ |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06401 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|