| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Northern blot analyses revealed that c myc , c src , c H ras , c abl , c sis , and p 53 genes were expressed . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Suppression of anoikis by 5 Src but not by activated c H ras in human gallbladder epithelial cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| No evidence was found for activation of the oncogenes Ha ras , Ki ras , src , or myc in the plaque associated tumors . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The analysis includes the oncogenes myc , sis , mos , erbB , erbA , Ha ras , Ki ras , src , fps , and abl . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis was performed with eight oncogene probes ( myc , fos , Ha ras , src , erbA , erbB , sis , myb ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found elevated transcripts for Ha ras , Ki ras , and the myc oncogenes , while the src oncogene was not increased . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Activated Src and p21ras were able to induce CD 69 expression . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Angiotensin 2 controls p21ras activity via pp60c src . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| These include PDGF stimulated activation of inositol trisphosphate formation , Erk1 / 2 , p21Ras , and Src . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| By contrast , activated H ras , which acts downstream of src , failed to induce resistance to either of these drugs . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The steady state mRNA levels of fos , K ras , abl , sis , and src oncogenes were similar in the C3H 10T1 / 2 and TU 2 cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Three different membrane targeting motifs from K Ras , Fyn , and Src proteins were fused to the N or C terminus of Raf 1 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The possible relation of the N ras gene to regulation of src gene activities in RSV SR transformed cells is discussed . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We selected specific cellular oncogenes ( c fos , c myc , c src , and c H ras ) , based on their normal expression in liver and gut tissues from untreated mice . ^^^ As early as 5 min following whole body exposure of BCF 1 mice to gamma rays we detected induction of mRNA specific for c src and c H ras in both liver and gut tissues . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Rat 6 ( R 6 ) embryo fibroblasts transformed by 5 myc , rc mos ( rearranged mouse c mos ) , 5 src and activated c H ras oncogenes displayed differential sensitivities to cDDP , and the IC 50 values of cDDP decreased by approximately 3 . 0 , 1 . 2 , 2 . 0 and 1 . 5 fold , respectively . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Treatment of human Raf 1 purified from insect Sf 9 cells co expressing c H Ras and Src ( Y527F ) ( in which phenylalanine replaces tyrosine at residue 527 ) with either serine threonine or tyrosine phosphatases resulted in enzymatic inactivation of Raf 1 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Direct tumorigenic conversion of human gallbladder carcinoma cells by 5 src but not by activated c H ras oncogene . ^^^ The roles of activated ras and src oncogene products in the acquisition of fully neoplastic phenotype by human gallbladder adenocarcinoma cells were investigated by co transfecting non tumorigenic HAG 1 human gallbladder carcinoma cells with the pSV2neo plasmid and a plasmid carrying either activated c H ras or 5 src oncogene . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Proliferation was estimated as the proliferative index by the enumeration of S phase cells in imprints of tumor tissue exposed to bromodeoxyuridine in vitro , and the gene expression of c myc , c fos , c src , c H ras , N myc , acidic and basic fibroblast growth factor , insulin like growth factors 1 and 2 , platelet derived growth factor alpha , and epidermal growth factor was quantified by messenger ribonucleic acid dot blot hybridization assay . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The amplification levels of the genes studied were assessed by dot blot hybridisation followed by densitometric scanning . c H ras and c src were amplified about 20 fold in the genomes of Namalwa and Wish , while c fos was amplified approximately 12 fold in the same cell lines . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We investigated the mechanistic role of Src and Ras , important oncoproteins implicated in the pathogenesis of many human cancers , in taxane induced apoptosis using 5 src or c H ras transfected HAG 1 human gallbladder epithelial cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| This effect is selective since ACV at the same concentration had no effect on the src and Ha ras transformation of NIH 3T3 cells or on the proliferation of hemopoietic cells transformed by those oncogenes . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The earliest detectable step was activation of Src tyrosine kinases , followed by activation of Ha Ras and Raf 1 . ^^^ The response to UV was blocked by tyrosine kinase inhibitors and dominant negative mutants of 5 src , Ha ras , and raf 1 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| A detailed analysis of the NIH 3T3 transformants generated from REC : myc : gamma 33 and gamma 41 DNA failed to detect Ha ras , Ki ras , raf , neu , trk , abl , fms , or src oncogenes of rat origin . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cells transformed by mutant p 53 and polyoma virus middle T expressed nearly the same amount of the c src encoded pp60c src protein as cells transformed by the same p 53 and cotransfected activated Ha ras oncogene . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of protooncogenes c myc , N myc , c fos , Ha ras 1 , Ki ras 2 , yes , abl , src , N ras , met and mos was studied in human gastric tumors and in rat gastric mucosal membrane during gastric carcinogenesis induced in rats by means of N methyl N ' nitro N nitroso guanidine ( MNNG ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| To determine whether the proliferative advantage of metastatic cells is due to an increased growth fraction of the cell population or to a deregulated expression of some growth regulated genes , the mRNA levels of the S phase specific H 3 histone gene were compared with that of some cell cycle related genes ( vimentin , calcyclin , c myc , and p 53 ) and oncogenes ( Ki ras , Ha ras , c sis , c src , c fes , and c erb ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Total RNA isolated from these tumors was probed with cDNA ' s for alpha fetoprotein ( AFP ) , albumin , tyrosine aminotransferase ( TAT ) , and the oncogenes Ha ras , Ki ras , myc and src . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The expression of a number of proto oncogenes ( myc , erb B , Ha ras , bas , rel , mos , sis , myb , ki ras , fms , src and fos ) was studied in developing rat liver . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Enhanced expression of c myc and decreased expression of c fos protooncogenes in chemically and radiation transformed C3H / 10T1 / 2 Cl 8 mouse embryo cell lines . c abl , c fos , c Ha ras , c myc , and c mos were expressed whereas c sis , c fms , c rel , c src , and c myb expression was not detectable in C3H / 10T1 / 2 Cl 8 ( 10T1 / 2 ) cells and in eight chemically and radiation transformed 10T1 / 2 cell lines . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Pertussis toxin ( PT ) , which blocks the activity of several G proteins , has been found to exert a marked inhibitory effect on the DNA synthesis induced in 3T3 cells by serum or growth factors . 3T3 cells transformed with human c ras oncogenes ( Ha ras , Ki ras , N ras ) or with src , an oncogene coding for a protein kinase , have lost sensitivity to growth control by PT , even though substrates for PT can still be ADP ribosylated in vivo . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Following in situ hybridization with 32P labeled 5 src and 5 Ha ras DNA probes , src and Ha ras related transcripts were identified in cell lines transfected with 5 src and Ha ras , respectively . ^^^ In both the 5 src and c Ha ras transfected cell lines , the number of silver grains over individual cells were significantly higher ( p less than 0 . 001 , t test ) than in a non transfected , non tumorigenic , rat esophageal epithelial cell line . ^^^ Significantly fewer silver grains were counted over cells that had been preincubated with either non labeled 5 src or 5 Ha ras DNA or that were pretreated with RNase A . ^^^ Filter hybridization analysis of the transfected and non transfected cell lines confirmed that the expression of src and Ha ras transcripts was higher in the transfected cell lines than in the non transfected cell line . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show here that K 18 is a direct target of the Ras signal transduction pathway , by demonstrating that activated Ha Ras , as well as activated Src , Lck , or Raf , stimulates the transcription of K 18 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In view of the potent mitogenic effect exerted by insulin in human colonic cells , we used Caco 2 cells transfected with an activated ( Val 12 ) human Ha ras gene or the polyoma middle T ( PyMT ) oncogene , a constitutive activator of pp60c src tyrosine kinase activity , to investigate the effect of oncogenic p21ras and PyMT / pp60c src on insulin mitogenic signaling . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that cellular transformation by the EJ Ha ras and 5 src oncogenes is associated with a marked increase in PTHrP gene expression . ^^^ Ha ras and 5 src transfected NRK 49F cells and ras transfected RCB 2 . 2 cell lines secreted increased amounts of immunoreactive PTHrP . ^^^ No significant change in the half life of PTHrP mRNA transcripts was detected in Ha ras and 5 src transformed cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We report here that the XD 4 src kinase activity in Rat 2 cells can be restored by co expression with the tyrosine kinase encoded by 5 fps , but not by co expression with activated Ha ras . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| To investigate the mechanism ( s ) whereby oncogenic p21ras and pp60c src contribute to malignant transformation of intestine , human colonic Caco 2 cells transfected with an activated ( Val 12 ) human Ha ras gene ( Caco 2 T cells ) or Py MT oncogene , a constitutive activator of pp60c src tyrosine kinase activity ( Caco 2 MT cells ) , were analyzed for tumorigenicity , protein kinase C ( PKC ) isoform expression , and PKC activity . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| To this end , we used Caco 2 cells made highly tumorigenic by transfection with an activated ( Val 12 ) human Ha ras gene or with the polyoma middle T ( Py MT ) oncogene , a constitutive activator of pp60c src tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We therefore examined hexose transporter expression and / or activity in Caco 2 cells transfected either with an activated human ( Val 12 ) Ha ras gene or with the polyoma middle T ( PyMT ) oncogene , a constitutive activator of pp60c src tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| To this end , we used Caco 2 cells made highly tumorigenic by transfection with an activated Val 12 human Ha ras gene or with the polyoma middle T ( PyMT ) oncogene , a constitutive activator of pp60c src tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| To this end , we used Caco 2 cells transfected with an activated ( Val 12 ) human Ha ras gene or the polyoma middle T ( Py MT ) oncogene , a constitutive activator of pp60c src tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present study , to clarify both the value of neuronal c srcN 2 expression as a prognostic indicator and the significance of the coexpression of these protooncogenes , we examined the expression of 3 alternatively spliced src , trk A and Ha ras in neuroblastoma tissues from 60 patients by competitive RNA polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| GEM in Neuro2a cells , separated as a low density membrane fraction , contains essentially all glycosphingolipids and sphingomyelin , together with five signal transducer molecules ( c Src , Lyn , Csk , Rho A , Ha Ras ) . ( 3 ) H Labeled Il ( 3 ) NeuAc LacCer ( GM 3 ) , Gb4Cer ( globoside ) , and Il ( 3 ) NeuAc Gg4Cer ( GM 1 ) added exogenously to cells were incorporated and concentrated in the low density GEM fraction . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Previous work has shown that microinjection into cells of antibodies against p21ras blocks transformation by src , suggesting that oncogenic transformation by pp60v src is dependent on p21ras . ^^^ This predicts that overexpression of GAP would inactivate p21ras and block transformation of cells by src . ^^^ These results support the suggestion that p21ras plays a central role in the signalling pathway used by pp60v src . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic proteins that regulate signal transduction or induce cellular transformation , including cytoplasmic protein tyrosine kinases , p21ras GTPase activating protein ( GAP ) , phospholipase C gamma , and the 5 crk oncoprotein , possess one or two copies of a conserved noncatalytic domain , Src homology region 2 ( SH 2 ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Association of GP IIb IIIa , pp60c src , pp62c yes , and the p21ras GTPase activating protein with the membrane skeleton . ^^^ In addition , this cell fraction contained the tyrosine kinases pp60c src and pp62c yes and the p21ras GTPase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor phosphorylates insulin receptor substrate 1 ( IRS 1 ) and Shc on tyrosine residues , both of which associate with the protein abundant Src homology / growth factor receptor bound protein 2 ( ASH / GRB2 ) leading to p21ras activation . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Increased levels of p21ras GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP associated proteins , p 190 and p 62 , in c src overexpressors . ^^^ However , analysis of GTP bound p21ras revealed higher basal and EGF stimulated levels in c src overexpressors than in control cells . ^^^ Taken together , these results suggest that one mechanism by which pp60c src may contribute to early events in the EGF induced mitogenic pathway in 10T1 / 2 fibroblasts is by increasing the level of GAP associated p 190 and p 62 tyrosyl phosphorylation , which in turn results in higher levels of p21ras GTP . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| By using the yeast two hybrid system , we identified p 62 , a tyrosine phosphorylated protein that associates with p21ras GTPase activating protein , as a src family kinase SH 3 domain binding protein . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated IRS 1 binds the 85K subunit of phosphatidylinositol 3 kinase which may be involved in the translocation of glucose transporters and the abundant src homology protein ( ASH ) / Grb2 which may be involved in activation of p21ras and MAP kinase cascade . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Taking advantage of the potent mitogenic effect exerted by insulin in human colonic cells , we used Caco 2 cells transfected with an activated ( Val 12 ) human Haras gene or the polyoma middle T ( PyMT ) oncogene , a constitutive activator of pp60c src tyrosine kinase activity , to investigate the effect of oncogenic p21ras and PyMT / pp60c src on insulin mitogenic signaling . ^^^ In conclusion , this is the first evidence that oncogenic p21ras and PyMT / pp60c src abolish insulin mitogenic signaling in human colonic cells through mechanisms involving ( 1 ) constitutive activation of MAP kinase and ( 2 ) marked decreases in both IR function and expression which are mediated by PKC dependent and PKC independent pathways , respectively . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ras mediates Src but not epidermal growth factor receptor tyrosine kinase signaling pathways in GH 4 neuroendocrine cells . p21Ras has been implicated as a critical signaling component in mediating the effects of many growth factor receptor / tyrosine kinases on cell growth and differentiation . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Activation of the p21ras and pp60c src oncoproteins occurred at high incidence in the early stage of human colorectal carcinogenesis . ^^^ CONCLUSIONS : These results suggest that the activation of the p21ras and Py MT / pp60c src oncogenic pathways are critical effectors at different stages of colorectal carcinogenesis and in Caco 2 cells interferes with the program of enterocyte differentiation . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The Src homology ( SH ) 2 / SH3 domain containing protein Grb 2 and the oncoprotein Shc have been implicated in a highly conserved mechanism that regulates p21ras activation . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated the effects of IL 6 on some recently identified signaling intermediates , Shc ( Src homology and collagen ) and Grb 2 ( growth factor receptor bound protein 2 ) , known to activate p21ras . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both Shc and p 190 are substrates of activated src and once phosphorylated , they interact with other proteins and upregulate p21ras . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Hypoxia and hypoxia / reoxygenation activate Src family tyrosine kinases and p21ras in cultured rat cardiac myocytes . ^^^ Because Src family tyrosine kinases are known to be cell surface associated kinases and upstream regulators of p21ras , these results strongly suggested that activation of Src family tyrosine kinases plays a key role in triggering intracellular signaling cascades in cardiac myocytes in response to hypoxia and hypoxia / reoxygenation . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| G protein coupled receptors control vascular smooth muscle cell proliferation via pp60c src and p21ras . ^^^ We previously showed that the cytosolic tyrosine kinase pp60c src is crucial for angiotensin 2 ( ANG 2 ) induced activation of the protooncogene p21ras . ^^^ Therefore , we investigated the role of pp60c src and p21ras in rat aortic smooth muscle cell proliferation induced by several G protein coupled receptors . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Fifth , cholesterol enrichment also reduced the membrane content of p21ras ( a low molecular weight G protein requiring farnesylation for membrane targeting ) but did not alter the membrane content of the two proteins that do not require isoprenylation for membrane association & sbd ; PDGF receptor or p 60 src . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We previously reported that both hypoxia and hypoxia followed by reoxygenation ( hypoxia / reoxygenation ) rapidly activate Src family tyrosine kinases and p21ras in cultured rat cardiac myocytes . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In HaCaT cells , stimulation of the Src kinase family mediated FVIIa dependent p21Ras activation . ^^^ CONCLUSIONS : p21Ras activation is instrumental in FVIIa signal transduction and the FVIIa dependent activation of p21Ras involves either PKC or Src dependent mechanisms , depending on the cell type investigated . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The PTPN 11 gene encodes SHP 2 ( Src homology 2 domain containing protein tyrosine Phosphatase ) , a nonreceptor tyrosine protein tyrosine phosphatase ( PTPase ) that relays signals from activated growth factor receptors to p21Ras ( Ras ) and other signaling molecules . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K . ^^^ LPS induced activation of p21Ras was inhibited in the presence of PP 2 , LY 294002 , or wortmannin , suggesting that it depends on the activity of one or more members of the Src kinase family and the subsequent activation of PI3K . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Maximal immediate early PAI 1 induction upon exposure to TGF beta 1 required EGFR , p21ras , MEK and pp 60 ( c src ) signaling as pharmacologic or dominant negative inhibition of any of the four intermediates ( EGFR , p21ras , MEK , pp 60 ( c src ) ) virtually eliminated TGF beta 1 augmented PAI 1 levels . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Steady state levels of K ras , H ras , N ras , abl , sis , src , and fos were unchanged in the 10 ray transformed cells compared with non transformed C3H 10T1 / 2 cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The activation of int 1 and int 2 genes did not clearly correlate with an increase in the expression of oncogenes examined ; H ras , K ras , N ras , myc , raf , fgr , fms , erB , mos , and src genes . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both the normal human epidermal keratinocytes and cancer cell lines expressed multiple proto oncogenes such as src , erb B 1 , abl , fos , raf , H ras , and myc , and the amount of expression of these oncogenes was notably higher in the cancer cell lines than in the normal keratinocytes . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Frequently multiple oncogenes were found expressed although expression levels were rather moderate . 25 30 % of the analyzed tumors showed significant expression of either erbB , src , raf 1 , lck or H ras . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Subsequently it was found that this line could be transformed neoplastically by a variety of retrovirus containing H ras , bas , fes , fms , erbB , and src oncogenes . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Probes utilized represent 11 known oncogenes ( erbB 1 , gli , neu , myc , L myc , N myc , H ras , K ras , N ras , sis , and src ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Subsequently , it was found that this line could be transformed neoplastically by a variety of retroviruses containing H ras , bas , fes , fms , erbB and src oncogenes . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Analysis of cellular oncogenes showed that myc and fps were amplified approximately tenfold and threefold , respectively , in this cell line , whereas N myc , L myc , N ras , K ras , H ras , abl , erbB 2 , Blym , src , raf 1 , myb , and sis were not changed significantly . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The putative onc sequences of S 13 do not hybridize to DNA probes representing src , erb A , erb B , myc , myb , fps , fms , H ras , B lym , abl , rel , and ets . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , enhancement of H ras mRNA accumulation was detected in some , though expression of other genes such as actin , N ras , myc , src , B lym , and 20 other genes was not found to be enhanced . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| This antigen was expressed on many pre B and B cell lymphomas , but not on A MuLV transformed fibroblasts , T cell lymphomas , or myelomonocytic leukemias , gp 160 ( 6C3 ) was expressed by most early B lineage spontaneous tumors , and early B tumors induced by replication defective MuLV containing oncogenes the products of which are associated with the cytoplasmic aspect of the plasma membrane , i . e . , fes , abl , H ras , bas , src , erbB , and Cas NS 1 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using various oncogenes ( DNA tumor virus oncogenes : adenovirus 12 E 1 and its transcriptional subunits , myc and SV 40 T antigens ; RNA tumor retrovirus oncogens : fos , src and H ras ) for the transfer , it was demonstrated that these genes invariably caused remarkable and characteristic changes of the cellular expression of gangliosides in the same recipient rat embryonic cell line , 3Y1 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Northern blot hybridization performed simultaneously demonstrated multiple expression of c onc genes . 4 choriocarcinoma cell lines ( HCCM , CHl , CCl , ENAMI ) expressed at least 11 c onc genes ( H ras , K ras , N ras , c myc , N myc , fos , fms , src , yes , erb B and raf ) ; though the degree of expression of H ras , C myc , erb B and fms in these cells was either similar or enhanced as compared with normal fibroblast , the expression of two c onc genes ( N myc and fos ) was extremely enhanced . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we have evaluated 21 gliomas for amplification of tumor related genes including NMYC , EGFR , TGFalpha , MET , CMYC , SRC , HRAS , NRAS , SEC , ROS 1 , JUN , and WNT 1 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| DNA probes for the NRAS , HRAS , KRAS 2 , LCK , RAF 1 , MET , MYCL 1 , MYCN , MYB , ERBB 2 , FOS , CSF1R , and SRC protooncogene loci ; the retinoblastoma gene locus ( RB 1 ) ; the tumor virus integration sites INT 2 , PVT 1 , and MLV 12 ; and the locus of the tumor specific antigen T1A were used to screen mouse genomic DNAs from RF / J , CAST / Ei , MOLF / Ei , Mus musculus musculus , M . m . poschiavinus , and M . spretus . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found no detectable transcripts of 9 proto oncogenes ( c sis , c met , c src , c lyn , c fgr , c ros , c pim , Blym and N myc ) , but detected transcripts of 12 other proto oncogenes ( int 2 , erbB , c abl , c raf 1 , c fyn , K ras , H ras , c mos , c myc , c myb , c fos , and c jun ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| The two glioblastomas with multiple chromosomal changes showed increased EGFr , Ki ras , myb , mos and myc , decreased H ras and N ras and unchanged levels of abl , src and sis . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Nine of these genes ( H ras , c myc , c fos , c jun , junB , N myc , c abl , c yes , and p 53 ) were expressed in epithelial cells , whereas two ( RB 1 and N ras ) were not . expression of four other genes ( c src , K ras , c raf , and c myb ) was observed , but the intensity of these bands was too low for densitometric analysis . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Previous studies have demonstrated that caveolin co purifies with lipid modified signaling molecules , including Galpha subunits , H Ras , c Src , and other related Src family tyrosine kinases . ^^^ Src tyrosine kinases , Galpha subunits , and H Ras share a common membrane anchored scaffolding protein , caveolin . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Marked expression of H ras and c myc mRNA , but not N myc , src , N ras , or p 53 mRNA , was found in the mycoplasma transformed C3H cells that exhibited characteristic malignant properties of morphological changes and uncontrolled cell growth . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| As many acylated proteins [ G protein subunits ( alpha and beta gamma ) ; c Src and Src family tyrosine kinases ; H Ras and Ras related GTPases ; endothelial nitric oxide synthase ] are known to be targeted to caveolae membranes , it has been suggested that acylation is required or greatly facilitates this targeting event . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Associated with DIGEM , many signal transducer molecules such as c Src , FAK , and the low molecular weight G proteins Rho A and H Ras were also found . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| A marked increase in the protein amount of H Ras and a significant increase in the activity of c Src kinase , PTK , and Erk 2 were found in cells from TCDD treated animals . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Whereas C terminal lipid modification derived from the H ras CaaX box restored oncogenic activity to non transforming truncated middle T antigen species , N terminal myristylation from pp60c src did not . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor genes ( p 53 , p 16 ) , oncogenes ( c erbB 2 , H ras , K ras , cyclin D 1 , src ) , and growth factor / receptor ( TGF alpha , EGFR ) seem to cause the malignant transformation of Barrett ' s esophagus . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| An S27N mutant of M Ras , like the analogous H Ras S17N mutant , was a dominant inhibitor of activation of the c fos promoter by constitutively active Src Y527F , suggesting that M Ras and p 21 Ras shared guanine nucleotide exchange factors and are likely to be activated in parallel . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Suppression of malignant growth potentials of 5 Src transformed human gallbladder epithelial cells by adenovirus mediated dominant negative H Ras . ^^^ In the present study , we analyzed the functional role of Ras , which acts downstream of Src in intracellular signaling , in the acquisition of fully neoplastic potentials by 5 Src transformed human gallbladder epithelial cells ( HAG / src3 1 ) by infecting these cells with replication defective adenovirus vector expressing dominant negative H Ras ( AdCARasY 57 ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Transfection of other plasmid DNAs or oncogenes such as pUC 8 , pSV2neo , src , sis , and H ras had little or no effects on the phenotype of GM730pt cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have shown that 4 amino 5 ( 4 methylphenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine ( PP 1 ) , a selective inhibitor of the Src family of non receptor tyrosine kinases , interferes with the activation of 70 and 85 kDa S6K gene products ( p70S6K1 and p85S6K1 ) by insulin , insulin like growth factor 1 , sodium orthovanadate and activated alleles of phosphoinositide 3 kinase and H Ras . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| H Ras modulates N methyl D aspartate receptor function via inhibition of Src tyrosine kinase activity . ^^^ Here we investigated whether H Ras regulates phosphorylation and function of the NMDA receptor via Src family protein tyrosine kinases . ^^^ We identified Src as a novel H Ras binding partner . ^^^ H Ras bound to Src but not Fyn both in vitro and in brain via the Src kinase domain . ^^^ Cotransfection of H Ras and Src inhibited Src activity and decreased NR2A tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Exogenous hyaluronan promotes a rapid recruitment of Src to lamellae of mutant active H ras transformed fibroblasts and an Src and RHAMM ( CD 168 ) dependent increase in random motility . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that H Ras , N Ras , K Ras , EGFR and ErbB 2 but not 5 Src suppress RhoB promoter transcriptional activity in NIH3T3 cells and human cancer cell lines derived from lung ( A 549 ) , pancreatic ( Panc 1 ) and cervical ( C33A ) tumors . ^^^ Ectopic expression of RhoB , but not the closely related family member RhoA , antagonizes the ability of EGFR , ErbB 2 , H Ras , N Ras and K Ras but not 5 Src to transform NIH3T3 cells . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| In H RAS V 12 cells , membrane associated PDK 1 was phosphorylated at Y373 / 376 , which was abolished by the Src family kinase inhibitor PP 2 . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We further observed that ethanol exposure results in NR2A endocytosis through the activation of H Ras and the inhibition of the tyrosine kinase Src . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Compared with bovine cerebrum ( control ) , the oncogenes abl , erbA , fms , fos , K ras , mil , mos , myb , rel , sis , src and yes were expressed equally in both bovine cerebrum and the gliomas . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , NIH3T3 cells transformed by N ras , K ras , src , mos or polyoma middle T antigen exhibited a decreased level of phosphorylation of the 80K protein . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| A function of ts mutant src and k ras viral oncogenes , still expressed at the restrictive temperature , can sensitize non responsive cells , without there being any specificity towards the TGF producer cells . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cell membrane association by several important peripheral proteins , such as Src , MARCKS , HIV 1 Gag , and K Ras , requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have explored this signalling in transformed cells . 5 Src and K Ras activate PI3K and PLC , as demonstrated by in situ production of the corresponding lipid products . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Signaling events downstream of R Ras differed from integrins and K Ras , since pharmacological inhibition of Src or disruption of actin inhibited integrin mediated FAK and p 130 ( Cas ) phosphorylation , focal adhesion formation , and migration in control and K Ras ( 12V ) expressing cells but had minimal effect in cells expressing R Ras ( 38V ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Candidate drugs for several of these targets are currently being evaluated ; for example , the prenylation inhibitor AZD 3409 , a mimetic of the CAAX box of K Ras , inhibits protein farnesyl and geranylgeranyl tranferases and a novel , selective , orally active Src kinase inhibitor AZD 0530 have entered Phase 1 clinical trials and may have utility in breast cancer therapy . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Signaling molecules such as K Ras , Rac 1 , and c Src that are targeted to the membrane by electrostatic interactions were rapidly released from membrane subdomains where the surface charge was altered by lipid remodeling during phagocytosis . . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| CNE 323 transferred moderate transforming activity when introduced into JB 6 P+ cells and showed no homology to Ha , Ki , or N ras genes ; human promotion sensitivity genes ; src , myb , jun , myc , fos , raf , or int 2 oncogenes ; or epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| This location demonstrates that Dsi 1 is different from 16 of the known proto oncogenes ( c abl , c erbA c erbB , c ets 1 , c ets 2 , c fes , c fos , c myb , c myc , c raf , A raf , c Ha ras , c Ki ras , N ras , c sis , and c src ) and 12 cellular regions of tumor associated integrations in retrovirus induced tumors ( c erbB , Fis 1 , int 1 , int 2 , Mis 1 / pvt 1 , Mlvi 1 , Mlvi 2 , c mos , c myb , c myc , Pim 1 , and c Ha ras ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Sis and N ras were moderately hyperexpressed , raf , Blym , and erbA were slightly hyperexpressed , and abl , erbB , fes / fps , fgr , fos , mos , myb , myc , N myc , rasHarvey , rasKirsten , ros , src , and yes were not hyperexpressed in the tumor compared to the control tissue . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| RNA was extracted and analyzed for expression of cellular oncogenes coding for nuclear proteins ( c myc , c myb , c fos ) , the beta chain of platelet derived growth factor ( c sis ) , growth factor receptors or related proteins ( c src , c abl , c fes , c erbB ) , or putative intermediate transducers of mitogenic signals ( c Ha ras , c Ki ras , c N ras ) . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| NIH3T3 transformants from a tertiary round of transfection were analysed by Southern blot analysis for the presence of Ki ras , N ras , raf , trk , abl , fms , src , mos , fos , sis , fps , erbA , erbB or neu oncogenes of REC origin , and none were detected . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Modulation of pp60v src and pp60c src expression in Rous sarcoma virus transformed hamster fibroblasts transfected with activated N ras . ^^^ |
|
| Interacting proteins: P01112 and P12931 |
Pubmed |
SVM Score :0.0 |
| Two PAT activities are expressed by human cells : type 1 PATs that modify the farnesyl dependent palmitoylation motif found in H and N Ras , and type 2 PATs that modify the myristoyl dependent palmitoylation motif found in the Src family of tyrosine kinases . ^^^ |
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