| Interacting proteins: O94887 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O94887 and P12931 |
Pubmed |
SVM Score :0.50832721 |
| FRG , a GDP / GTP exchange factor specific for Cdc 42 , was then recruited there , tyrosine phosphorylated by c Src , and activated , causing an increase in the GTP bound active form of Cdc 42 . 0.50832721^^^ |
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| Interacting proteins: O94887 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src kinase directly phosphorylates and activates FRG , as Vav family GEFs . ^^^ |
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| Interacting proteins: O94887 and P12931 |
Pubmed |
SVM Score :0.0 |
| The trans interactions of nectins first recruit and activate c Src at the nectin based cell cell contact sites . c Src then phosphorylates and activates FRG , a Cdc 42 GDP / GTP exchange factor ( GEF ) for Cdc 42 . ^^^ The activation of both c Src and Cdc 42 by FRG is necessary for the activation of Rac , but the Rac GEF responsible for this activation of Rac remains unknown . ^^^ |
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| Interacting proteins: O94887 and P12931 |
Pubmed |
SVM Score :0.0 |
| Nectins recruit and activate c Src at the nectin based cell cell contact sites . c Src then activates Cdc 42 through FRG , a Cdc 42 GDP / GTP exchange factor . ^^^ The activation of either c Src or Rap 1 alone was insufficient for and the activation of both molecules was essential for the activation of FRG . ^^^ The activation of Rap 1 was not necessary for the c Src mediated phosphorylation or recruitment of FRG . ^^^ These results indicate that Rap 1 is activated by nectins through the c Src Crk C3G signaling and involved in the nectin induced , c Src and FRG mediated activation of Cdc 42 and formation of AJs . . ^^^ |
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| Interacting proteins: O94887 and P12931 |
Pubmed |
SVM Score :0.0 |
| The activation of Cdc 42 and Rac by the trans interaction of nectin and nectin is mediated by c Src , another small G protein , Rap 1 , a Cdc 42 GEF , FRG , and a Rac GEF , Vav 2 . ^^^ Similarly to the activation of Cdc 42 and Rac by the trans interaction of nectin and nectin , the trans interaction of Necl 5 and nectin 3 first recruits and activates c Src at the Necl 5 / nectin 3 based cell cell contact sites . c Src then phosphorylates FRG and Vav 2 , and the tyrosine phosphorylated FRG and Vav 2 are recruited to the Necl 5 / nectin 3 based cell cell contact sites . ^^^ These results indicate that the trans interactions of Necl 5 and nectin 3 and of nectin and nectin induce the activation of Cdc 42 and Rac through the common signaling molecules c Src , Rap 1 , FRG , and Vav2 . . ^^^ |
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