| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| The results indicate an endogenous interaction between nephrin and CD2AP in M 1 cells and suggest that this interaction is mediated by the third Src homology 3 ( SH 3 ) domain of CD2AP . ^^^ |
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| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| Described are biochemical and mouse genetics experiments demonstrating that membrane associated Nephrin is tyrosine phosphorylated by the Src family kinase Fyn . ^^^ |
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| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| Clustering induced tyrosine phosphorylation of nephrin by Src family kinases . ^^^ A specific inhibitor and cotransfection experiments were used to investigate role of Src family kinases in nephrin phosphorylation . ^^^ Several members of Src family kinases were able to induce nephrin phosphorylation when cotransfected to HEK 293 cells with nephrin . ^^^ Moreover , the Src family kinase Fyn was consistently found to be coimmunoprecipitated with nephrin . ^^^ CONCLUSION : Nephrin is a signaling protein phosphorylated by Src family kinases . . ^^^ |
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| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| SRC family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin . ^^^ It was hypothesized that these tyrosine residues are phosphorylated by Src family kinases and that this phosphorylation modulates the function of nephrin . ^^^ When nephrin was co transfected with Src family kinases Fyn or Src in Cos 1 cells , nephrin was strongly tyrosine phosphorylated by Fyn and less so by Src . ^^^ |
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| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that nephrin selectively binds the Src homology 2 ( SH 2 ) / SH3 domain containing Nck adaptor proteins , which in turn control the podocyte cytoskeleton in vivo . ^^^ The cytoplasmic tail of nephrin has multiple YDxV sites that form preferred binding motifs for the Nck SH 2 domain once phosphorylated by Src family kinases . ^^^ |
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| Interacting proteins: O60500 and P12931 |
Pubmed |
SVM Score :0.0 |
| Nephrin ectodomain engagement results in Src kinase activation , nephrin phosphorylation , Nck recruitment , and actin polymerization . ^^^ |
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