| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Pyk 2 and Src dependent tyrosine phosphorylation of PDK 1 regulates focal adhesions . 3 Phosphoinositide dependent protein kinase 1 ( PDK 1 ) is a signal integrator that activates the AGC superfamily of serine / threonine kinases . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| In vitro , PDK 1 could be tyrosine phosphorylated by both the c Src and Abl tyrosine kinases . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| An inhibitor of Src kinase ( PP 2 ) decreased the peroxovanadate induced PDK 1 tyrosine phosphorylation and overexpression of 5 Src stimulated this phosphorylation . ^^^ Mutation of tyrosine 373 of PDK 1 abolished the 5 Src induced PDK 1 tyrosine phosphorylation and partially reduced the effect of peroxovanadate . ^^^ Our findings suggest that PDK 1 could be a substrate for tyrosine kinases and identify Src kinase as one of the tyrosine kinases able to phosphorylate PDK1 . . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both of these residues can be phosphorylated by 5 Src tyrosine kinase in vitro , and co expression of 5 Src leads to tyrosine phosphorylation and activation of PDK 1 . ^^^ Thus , these data suggest that PDK 1 activity is regulated by reversible phosphorylation , possibly by a member of the Src kinase family . . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Moreover , Y 9 phosphorylation of PDK 1 by RET / PTC does not require phosphatidylinositol 3 kinase or Src activity . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Exposure of bovine aortic endothelial cells ( BAEC ) to chemically synthesized ONOO acutely and significantly increased phosphorylation of c Src , PDK 1 , AMPK , and its downstream target , acetyl CoA carboxylase ( ACC ) , without affecting cellular AMP . ^^^ Furthermore , dominant negative mutants of c Src or kinase defective PDK 1 also blocked H / R induced AMPK activation indicating that , as with addition of exogenous ONOO , both c Src and PI 3 kinase are upstream of AMPK . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| New insights into downstream signalling mechanisms , including the activation of STAT 3 , PDK 1 and Akt , further corroborate the importance of Src family kinases in tumorigenesis and chemoresistance . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the Src and Rac effector p 21 activated protein kinase ( PAK ) 1 on Thr 423 ( the phosphoinositide dependent kinase 1 [ PDK 1 ] site ) was attenuated by ROS inhibition , and infection of VSMCs with dominant negative PAK 1 adenovirus attenuated migration . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tumors exhibited increased association of Egfr with clathrin heavy chain ( CHC ) , Gab 1 , and p85alpha , the regulatory subunit of phosphoinositide 3 kinase ( PI3K ) , and tumors also overexpressed c Src , PDK 1 , and Akt . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| In H RAS V 12 cells , membrane associated PDK 1 was phosphorylated at Y373 / 376 , which was abolished by the Src family kinase inhibitor PP 2 . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| Similarly , a mutant phosphoinositide dependent kinase 1 ( PDK 1 ) that can not associate with Src abolished IRS 1 phosphorylation and degradation induced by angiotensin 2 . ^^^ CONCLUSIONS : Thus , angiotensin 2 decreases IRS 1 protein levels in VSMCs via Src , PDK 1 , and reactive oxygen species mediated phosphorylation of IRS 1 on Ser 307 and subsequent proteasome dependent degradation . ^^^ |
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| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15530 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|