| Toll like receptor 3 associates with c Src tyrosine kinase on endosomes to initiate antiviral signaling . ^^^ Here we show that c Src tyrosine kinase is activated by dsRNA in human monocyte derived dendritic cells , and is recruited to TLR 3 in a dsRNA dependent manner . ^^^ We also provide evidence that TLR 3 is localized in the endoplasmic reticulum of unstimulated cells , moves to dsRNA containing endosomes in response to dsRNA , and colocalizes with c Src on endosomes containing dsRNA in the lumen . ^^^ |