| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.5219288 |
| In this study , we searched for c Src binding proteins using a combination of pull down assays and mass spectrometric analysis , and identified the association of adhesion and degranulation promoting adaptor protein ( ADAP ) with c Src in RAW 264 cells and osteoclast precursors prepared from bone marrow cells . 0.5219288^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| FYB / SLAP has the hallmarks of an adaptor protein that binds to the SH 2 domains of the Src kinase FYN T and SLP 76 . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show that mAbp 1 binds the Fyb N terminal via its C terminally located src homology 3 domain . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| The molecular adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) , also known as Fyn binding protein ( FYB ) or Slp 76 associated protein of 130 kilodaltons ( SLAP 130 ) , interacts with a number of signaling intermediates including Slp 76 , the Src family tyrosine kinase Fyn , vasodilator stimulated phosphoprotein ( VASP ) , and the actin nucleating protein WASP . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| Platelet adhesion to dA1VWF induced Src kinase dependent tyrosine phosphorylation of the FcR gamma chain and the adapter molecule , ADAP , and triggered intracellular Ca ( 2+ ) oscillations and alpha IIb beta 3 activation . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| ADAP ( adhesion and degranulation promoting adaptor protein ) and SKAP 55 ( Src kinase associated phosphoprotein of 55 kDa ) are T cell adaptors that mediate inside out signaling from the T cell antigen receptor to integrins , giving rise to increased integrin affinity / avidity and formation of the immunological synapse between the T cell and the antigen presenting cell . ^^^ Inactivation of the Src homology 3 domain of SKAP 55 , which mediates the association between SKAP 55 with ADAP , blocks the protective effect of ADAP . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| The immune cell adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) and its binding to T cell adaptor Src kinase associated protein of 55 kDa ( SKAP 55 ) play a key role in the modulation of T cell adhesion . ^^^ Here , we show that the Src kinase p59fyn can induce the in vivo phosphorylation of the motif , and this event blocks ADAP SH3c domain binding to the peptide motif . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recently , the cDNA sequence of a novel Src and Fyn binding protein called AFAP 110 , for Actin Filament Associated Protein 110 kDa , was reported . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| By co transfection of truncated mutants of SKAP 55 and SLAP 130 as well as by using the two hybrid selection system , we further demonstrate that the association between SLAP 130 and SKAP 55 is direct and involves the Src homology 3 domain of SKAP 55 and the proline rich sequence of SLAP 130 . . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| Stimulation of T cells via the alpha4beta1 integrin enhances the association of tyrosine phosphorylated SLAP 130 / FYB with the SH 2 domain of the src tyrosine kinase p59fyn . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition to binding the src kinase p 59 ( fyn ) , FYB binds specifically to the hematopoietic signaling protein SLP 76 , an interaction mediated by the SLP 76 SH 2 domain . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| Another lymphoid specific adaptor FYB / SLAP has also been identified as a predominant binding partner of SLP 76 and the Src kinase FYN T , although its role in the activation process has been unclear . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| SLP 76 ( Src homology ( SH ) 2 domain containing leukocyte protein of 76 kDa ) and FYB / SLAP ( FYN T binding protein / SLP 76 associated protein ) are two hemopoietic cell specific adaptor proteins downstream of TCR activated protein tyrosine kinases . ^^^ |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15117 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|