| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| In contrast , OPGL enhanced both NF kappaB and JNK kinase activation and increased the expression of c src , but not bcl 2 and bcl 10 ( L ) mRNA . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| Enhanced osteoclastogenesis is associated with high expression of otherwise TNF and RANKL induced mediators , including c Src , TRAF 2 , TRAF 6 , and MEKK 1 , levels of which were notably reduced in TNFr 1 knockouts . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| Receptor activator of NF kappaB ( RANKL ) significantly increased the LBC levels of cathepsin K , TRAP , and c Src , whereas calcitonin decreased the LBC levels of cathepsin K , TRAP , and Rab 7 , indicating that the transformation of early to late endosomal elements and lysosomes in OCLs is also regulated by osteoclastogenesis regulatory factors . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the course of studying with pharmacologic agents known to inhibit protein tyrosine kinases of the Src family , we found that radicicol increased cell fusion during receptor activator of nuclear factor kappaB ligand ( RANKL ) driven differentiation of osteoclasts at concentrations far below the ones shown to inhibit its targets in previous studies . ^^^ |
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| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| By retroviral transduction of RAW264 . 7 cells with a dominant negative Src homology 2 domain containing phosphatase 1 ( SHP 1 ) ( C453S ) , we studied the role of tyrosine phosphatase SHP 1 in RANKL induced osteoclastogenesis . ^^^ |
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| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| Stimulation of bone resorption by RANKL and , surprisingly , Src activity and Pyk 2 phosphorylation are normal in PTPepsilon deficient osteoclasts , indicating that loss of PTPepsilon does not cause widespread disruption of these signaling pathways . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study we showed that significant numbers of mature osteoclasts were generated from protein tyrosine phosphatase Src homology 2 domain phosphatase 1 defective Hcph ( me 5 ) / Hcph ( me 5 ) ( me ( 5 ) / me ( 5 ) ) bone marrow cells in the presence of M CSF and LPS without addition of RANKL in culture . ^^^ These results indicate that a defect of Src homology 2 domain phosphatase 1 function not only accelerates physiological osteoclast development by RANKL / RANK , but also acquires a novel pathway for osteoclastogenesis by LPS . . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| SH SY5Y showed the lowest OPG to RANKL ratio and promoted osteoclastic differentiation of FLG29 . 1 and peripheral mononuclear cells , inducing expression of the osteoclast markers RANK , c src , c fos , cathepsin K and TRAP . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| Additionally , overall RANKL induced global gene expression was significantly blunted in IKK alpha ( / ) cells , including osteoclast specific genes such as TRAP , MMP 9 , and c Src . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| We studied the regulatory mechanism as well as the significance of c src induction in RANKL induced differentiation of mouse monocytic RAW 264 cells to TRAP positive multinucleated cells . ^^^ Mutational and biochemical analyses in the region 0 . 9 kb upstream of the transcription start site revealed that c Fos and JNK pathways , in addition to NF kappaB , participate in c src induction in response to RANKL . ^^^ |
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| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our findings indicated that SC 19220 inhibits RANKL induced osteoclastogenesis through the suppression of RANK , c Fms , c Src , and NFAT 2 , suggesting that this EP 1 specific antagonist inhibits osteoclast formation induced by RANKL from the early stage of osteoclastogenesis . . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , we found that LMW HA enhanced the levels of c Src protein and phosphorylation of ERKs and p 38 MAPK in RAW 264 . 7 cells stimulated with RANKL , whereas the p 38 MAPK inhibitor SB 203580 inhibited RANKL induced osteoclast differentiation . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| RESULTS AND CONCLUSIONS : RANKL induced osteoclast differentiation and bone resorption at a higher extent in the presence than in the absence of BSP in RAW264 . 7 cells and bone marrow derived monocytes / macrophages . c Src dependent c Cbl phosphorylation was 8 fold higher in RAW264 . 7 cells treated with BSP and RANKL than in those treated with RANKL alone . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| Treatment of osteoclasts with PTH , PGE 2 , 1 , 25 ( OH ) 2D3 , IL 1 , but not RANKL or IL 6 , significantly stimulated resorption activity , increased PTP oc mRNA and protein levels , and reduced c Src PY 527 level with corresponding activation of c Src protein tyrosine kinase activity . ^^^ |
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| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| TRANCE , a TNF family member , activates Akt / PKB through a signaling complex involving TRAF 6 and c Src . ^^^ Here , we demonstrate that TRANCE activates the antiapoptotic serine / threonine kinase Akt / PKB through a signaling complex involving c Src and TRAF 6 . ^^^ A deficiency in c Src or addition of Src family kinase inhibitors blocks TRANCE mediated PKB activation in osteoclasts . c Src and TRAF 6 interact with each other and with TRANCE R upon receptor engagement . ^^^ These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross talk between TRAF proteins and Src family kinases . . ^^^ |
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| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor ( TRANCE R ) / RANK , TRAF 6 , and c Src . ^^^ |
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| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| TNF related activation induced cytokine ( TRANCE ) induces angiogenesis through the activation of Src and phospholipase C ( PLC ) in human endothelial cells . ^^^ These results indicate that the angiogenic activity of TRANCE is mediated through the Src PLC Ca ( 2+ ) signaling cascade upon receptor engagement in endothelial cells , suggesting the role of TRANCE in neovessel formation under physiological and pathological conditions . . ^^^ |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14788 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|