| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.79274872 |
| When expressed alone in COS cells , BRK 3 specifically binds BMP 4 , but cross linking of BMP 4 to BRK 3 is undetectable in the absence of either the BRK 1 or BRK 2 BMP type 1 receptors . 0.79274872^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.95406398 |
| BMP 4 binds to two different type 1 receptors , BMP receptors type IA ( BMPR IA ) and type IB ( BMPR IB ) , and a type 2 receptor , BMP receptor type 2 ( BMPR 2 ) . 0.95406398^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BRK 3 is a vertebrate type 2 receptor for BMP 4 distantly related to invertebrate type 2 receptors for BMP 2 / BMP 4 / dpp , such as daf 4 and punt . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| In transfected COS 1 cells , osteogenic protein ( OP ) 1 / BMP 7 , and less efficiently BMP 4 , bound to BMPR 2 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| In transfected COS cells , the binding of osteogenic protein ( OP ) 1 and BMP 4 to certain ALKs was observed in the absence of type 2 receptors , and their binding was increased after co transfection of a BMP type 2 receptor from Caenorhabditis elegans , DAF 4 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| METHODS : Transcription of bone morphogenetic proteins ( BMP ) 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 ; growth differentiation factor ( GDF ) 5 ) , and BMP receptors ( BMPR ) types 1 ( BMPR IA , BMPR IB ) and 2 ( BMPR 2 ) was investigated by reverse transcription polymerase chain reaction ( RT PCR ) in ex vivo and cultured cells . ^^^ RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| The BMP 4 transcripts were expressed in all stages of differentiation , as were transcripts for BMP type IA receptor ( ALK 3 ) and BMP type 2 receptor . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| After optic vesicle invagination , Bmp 4 is expressed in the prospective dorsal neural retina , where BmprIA , BmprII , and Smad 1 , components of the BMP 4 signal transduction pathway , are also expressed . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMP 2 and BMP 4 are produced by the thymic stroma and the requisite BMP receptor molecules ( BMPR 1A , BMPR 1B , BMPR 2 ) , and signal transduction molecules ( Smad 1 , 5 , 8 , and 4 ) are expressed by DN thymocytes . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| In transfection experiments with HEK 293 cells , co expression of FecB ( + ) BMPR1B and BMPR 2 resulted in a 2 . 6 fold ( P < 0 . 01 ) induction of the activity of a BMP specific luciferase reporter construct by BMP 4 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Further analysis revealed that the interaction between LIMK 1 and BMPR 2 inhibited LIMK 1 ' s ability to phosphorylate cofilin , which could then be alleviated by addition of BMP 4 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| RESULTS : With reverse transcription PCR the expression profile for normal palmar fascia fibroblasts versus Dupuytren ' s fibroblasts was found to show similar expression of BMP 1 and 11 ; qualitatively decreased expression of BMP 6 , BMP 8 , BMPR IA , BMPR IB , and BMPR 2 in Dupuytren ' s fibroblasts ; and no expression of BMP 4 in Dupuytren ' s fibroblasts . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Thus , to further understand the functional significance of BMPRII in the pulmonary vasculature , we examined the expression of TGF beta superfamily receptors in human fetal lung fibroblasts ( HFL ) and investigated the role of BMP 4 on cell cycle regulation , fibroblast proliferation , and differentiation . ^^^ HFL expressed BMPRI and BMPRII mRNA and demonstrated specific 1 ( 125 ) BMP 4 binding sites . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Disruption of Bmpr 2 leads to diminished signaling by BMP 2 and BMP 4 and augmented signaling by BMP 6 and BMP 7 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| To determine the role of bone morphogenetic protein ( BMP ) signaling in ENS development , we first examined the expression of bmp 2 , bmp 4 , and bmprII during hindgut development and find these strongly expressed in the ENS . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we confirmed that proximal PASMCs harboring kinase domain mutations in BMPR 2 are deficient in Smad signaling and are unresponsive to the growth suppressive effect of BMP 4 . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Based on the recently discovered role of bone morphogenetic proteins ( BMPs ) in ENS development , we examined the expression of the ligands , BMP 2 and BMP 4 , and their receptors , BMPRIA , BMPRIB , and BMPRII , during formation of the human ENS . ^^^ |
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| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Tissues were analyzed using immunohistochemistry for BMP ligand ( BMP 2 , BMP 4 , BMP 7 ) and receptor ( BMPRIA , BMPRIB , BMPRII ) expression . ^^^ |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
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