| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| Since Bmp 4 heterozygote embryos have reduced numbers of PGCs , we used a genetic approach to generate double mutant embryos to study interactions of Bmp8b and Bmp 4 . ^^^ Embryos that are double heterozygotes for the Bmp8b and Bmp 4 mutations have similar defects in PGC number as Bmp 4 heterozygotes , indicating that the effects of the two BMPs are not additive . ^^^ These findings suggest that BMP 4 and BMP8B function as heterodimers and homodimers in PGC specification in the mouse . . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| Previous studies have demonstrated that extraembryonic ectoderm derived BMP 4 and BMP8B are both required for PGC generation . ^^^ Using a genetic approach , we further show that Bmp 2 and Bmp 4 , but not Bmp 2 and Bmp8b , have an additive effect on PGC generation . ^^^ These results suggest that PGC generation in the mouse embryo is regulated not only by extraembryonic ectoderm derived BMP 4 and BMP8B , but also by endoderm derived BMP2 . . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| Recent studies have shown that primordial germ cells ( PGCs ) are absent or greatly reduced in Bmp 4 or Bmp8b mutant mice . ^^^ We found ectopic PGC like cells in the amnion of some Smad 5 mutant mice , however , the total number of PGCs was greatly reduced or completely absent in Smad 5 mutant embryos , similar to Bmp 4 or Bmp8b mutant embryos . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| In contrast , BMP 3 , BMP 4 , BMP 7 , and BMP 8 showed a restricted period of expression from day 14 through day 21 , when the resorption of calcified cartilage and osteoblastic recruitment were most active . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| Both bone morphogenetic proteins 4 ( Bmp 4 ) and 8b ( Bmp8b ) are expressed in the extraembryonic ectoderm and are required for PGC formation . ^^^ Furthermore , BMP 4 or BMP8B alone are unable to induce PGCs from cultured epiblasts , while they can in combination , indicating they signal through separate receptor complexes . ^^^ In addition , Bmp 4 homozygous embryos can not be induced to form PGCs by the synergistic action of BMP 4 and BMP8B , suggesting that BMP 4 proteins produced by pregastrula embryos are required for epiblast cells to maintain pluripotency . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| RESULTS : With reverse transcription PCR the expression profile for normal palmar fascia fibroblasts versus Dupuytren ' s fibroblasts was found to show similar expression of BMP 1 and 11 ; qualitatively decreased expression of BMP 6 , BMP 8 , BMPR IA , BMPR IB , and BMPR 2 in Dupuytren ' s fibroblasts ; and no expression of BMP 4 in Dupuytren ' s fibroblasts . ^^^ In line with the messenger RNA expression pattern BMP 4 was detected in only the control fibroblasts and not in the Dupuytren ' s fibroblasts , whereas BMP 8 ( chosen for comparison purposes ) was detectable in both cell populations . ^^^ Immunostaining for BMP 8 and BMP 4 confirmed our findings with reverse transcription PCR and Western blot analysis . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| BMP 2 , BMP 3 , BMP 4 , BMP 5 , BMP 6 , BMP 7 , BMP8A , BMP8B , BMP 10 , BMP 15 , AMH , GDF 1 , GDF 2 , GDF 3 , GDF 5 , GDF 6 , GDF 7 , GDF 8 , GDF 9 , GDF 10 , GDF 11 , and GDF 15 are BMP / GDF family genes within the human genome ; however , transcriptional regulation of BMP / GDF family members by the canonical WNT signaling pathway remains unclear . ^^^ |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and P34820 |
Pubmed |
SVM Score :0.0 |
| NA |
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