| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| We further demonstrate that modulation of Krox 20 and follistatin expression is not dependent on Bmp 4 , indicating the existence of multiple pathways of interaction between adjacent rhombomeres . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Several secreted molecules are able to induce or repress cement gland formation : these include noggin , follistatin , hedgehog , chordin , retinoic acid , embryonic fibroblast growth factor ( eFGF ) , Bone Morphogenetic Protein 4 ( BMP 4 ) , and Xwnt 8 . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| The neural inducing activity of Xnr 3 can be inhibited by overexpression of BMP 4 , as has been observed with the neural inducers noggin , chordin and follistatin . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| The dorsalizing and neural inducing gene follistatin is an antagonist of BMP 4 . ^^^ BMP 4 specifies ventral mesoderm differentiation and inhibits neural induction in Xenopus , whereas three molecules secreted from the organizer , noggin , follistatin and chordin dorsalize mesoderm and promote neural induction . ^^^ Here we report that follistatin antagonizes the activities of BMP 4 in frog embryos and mouse teratocarcinoma cells . ^^^ In Xenopus embryos follistatin blocks the ventralizing effect of BMP 4 . ^^^ BMP 4 antagonizes the action of follistatin and prevents neural differentiation . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Regulation of BMP 4 signaling is known to occur extracellularly by direct binding with chordin , noggin , and follistatin , and intracellularly through the antagonistic signal interaction with dorsalizing TGF beta family member activin . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| The dorsolateral extent of this expression domain is regulated by Bmp2b , Chordino , and Follistatin itself . ^^^ Comparison of the spatiotemporal expression pattern of follistatin and noggin with those of bmp2b and bmp 4 and overexpression studies suggest that Noggin and Follistatin may function as Bmp antagonists in later processes of zebrafish development , including late phases of D 5 patterning , to refine the early pattern set up by the interaction of Chordino and Bmp2 / 4 . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Ectopic application of recombinant human Follistatin , an antgaonist of certain TGFbeta super family proteins including Activin and Bmp 4 , results in the loss of tendon , implicating signalling by TGFbeta super family in the development of tendon during chick embryogenesis . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Two further examples show the contrast between BMP 4 and the proteins Noggin , Chordin , Follistatin and Gremlin . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| When the primitive streak has reached its full length , a later group of genes , including Ganf , Six 3 , Bmp 2 , Bmp 4 , Noggin , Follistatin , and Qin ( BF 1 ) , begins to be expressed . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Both TM and ONH cells and tissues expressed mRNAs for BMP 2 , BMP 4 , BMP 5 , BMP 7 , BMP RIA , BMP RIB , BMP RII , DRM ( gremlin ) , follistatin , chordin and NMA ( BAMBI ) . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Rapamycin induced BMP 4 and reduced follistatin expression in PC 3 cells . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Recent studies have indicated that BMP 4 upregulates the expression of the BMP antagonists noggin , gremlin , and follistatin , thereby establishing an autoregulatory feedback loop . ^^^ METHODS : Basal and BMP 4 induced expression of noggin , gremlin , follistatin , and chordin mRNA were investigated in control and fibrodysplasia ossificans progressiva lymphoblastoid cell lines with use of reverse transcriptase polymerase chain reaction and Northern analysis . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| In addition to activin , this review discusses the functions of other members of the TGF beta superfamily , for example growth differentiation factor 9 ( GDF 9 ) , bone morphogenetic protein 15 ( BMP 15 ) , BMP 6 , BMP 4 and BMP 7 , in the ovary , and the potential interactions between follistatin and these growth factors . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Interestingly , follistatin , noggin , and BMP 4 , 6 and 7 mRNAs were expressed in eosinophilic leukocytes , suggesting unexpected roles for eosinophil derived BMPs in uterine function . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Effects of follistatin and BMP 4 proteins on early dorso ventral patterning in chick . ^^^ We have grafted the gastrular organiser ( node ) into hosts , testing the effects of prior exposure of either grafted or host tissue to Follistatin ( a known antagonist of TGFbeta superfamily ligands including BMP 4 ) or to BMP 4 protein . ^^^ Early chick BMP 4 and BMP 7 expressions are consistent with the proposed roles , though Follistatin is probably an experimental tool only in the present study . . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Neither noggin , chordin , follistatin , nor Xnr 3 is induced by Xbra 3 to an extent different from their induction by Xbra nor is BMP 4 expression differentially affected . . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Third , the expression of BMP 4 , noggin , chordin , and follistatin , all of which are critical for neural induction , are at near normal levels . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Lateral line primordia and neuromasts also express bmp2b , 4 , follistatin , smad 1 , and smad 5 . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| To investigate the roles of follistatin during tooth development , we analyzed in detail the expression patterns of follistatin , activin beta A , as well as Bmp 2 , Bmp 4 , and Bmp 7 during tooth morphogenesis . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Conversely , BMP 2 and BMP 4 significantly stimulated expression of gremlin but down regulated that of follistatin . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Experiments on cultured tooth explants indicated that follistatin inhibits the ameloblast inducing activity of BMP 4 from the underlying mesenchymal odontoblasts and that follistatin expression is induced by activin from the surrounding dental follicle . ^^^ Hence , ameloblast differentiation is regulated by antagonistic actions of BMP 4 and activin A from two mesenchymal cell layers flanking the dental epithelium , and asymmetrically expressed follistatin regulates the labial lingual patterning of enamel formation . . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| Using a biological test based on progesterone production by ovine primary granulosa cells in culture , we show that follistatin was a strong antagonist of activin A , but not BMP 2 or BMP 4 actions . ^^^ |
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| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| At the basis of this effect , our data implicate the Bmp ( Bmp 7 , Bmp 4 ) / Bmp antagonist ( Follistatin ) signal : in the Dlx 5 ( / ) palate changes in the expression level of Bmp 7 and Follistatin counteract the reduced Bmp 4 expression . ^^^ |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19883 and P12644 |
Pubmed |
SVM Score :0.0 |
| NA |
|