| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.56073145 |
| BMP 4 binds to two different type 1 receptors , BMP receptors type IA ( BMPR IA ) and type IB ( BMPR IB ) , and a type 2 receptor , BMP receptor type 2 ( BMPR 2 ) . 0.56073145^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| The growth factor bone morphogenetic protein 4 ( BMP 4 ) and its receptor ( BMPR IB ) have been detected in ovaries , and a mutation in BMPR IB has been associated with abnormal ovulation rate . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| ALK 5 is a TGF beta type 1 receptor , ALK 2 and ALK 4 are activin type 1 receptors , and ALK 3 and ALK 6 are type 1 receptors for osteogenic protein 1 ( OP 1 ) / bone morphogenetic protein 7 ( BMP 7 ) and BMP 4 . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| OP 1 bound to ALK 2 and ALK 6 efficiently , and to ALK 3 less efficiently , whereas BMP 4 bound to ALK 3 and ALK 6 efficiently . ^^^ These results suggest that ALK 3 and ALK 6 are type 1 receptors for OP 1 and BMP 4 ; in addition , ALK 2 is a type 1 receptor shared by activin and OP 1 , but not by BMP 4 . . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| Type 1 receptors for bone morphogenetic proteins ( BMPs ) , i . e . , BMPR IA and BMPR IB , are transmembrane serine / threonine kinases , that bind osteogenic protein 1 ( OP 1 , also termed BMP 7 ) and BMP 4 . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| METHODS : Transcription of bone morphogenetic proteins ( BMP ) 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 ; growth differentiation factor ( GDF ) 5 ) , and BMP receptors ( BMPR ) types 1 ( BMPR IA , BMPR IB ) and 2 ( BMPR 2 ) was investigated by reverse transcription polymerase chain reaction ( RT PCR ) in ex vivo and cultured cells . ^^^ RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization , the expression patterns of bmp 4 and alk 6 receptor were established . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| In addition , Shh expression was unaffected in the developing limb buds of the transgenic mice in which a constitutively active Bmpr IB is ectopically expressed in the forelimb posterior mesenchyme and throughout the hindlimb mesenchyme , suggesting that the repression of Shh expression by BMP 4 may not be mediated by BMP receptor IB . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| In the normal mouse embryo , Bmp 4 is expressed in mesenchymal cells surrounding the Wolffian duct ( WD ) and ureter stalk , whereas bone morphogenetic protein ( BMP ) type 1 receptor genes are transcribed either ubiquitously ( Alk 3 ) or exclusively in the WD and ureter epithelium ( Alk 6 ) . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMP 4 mRNA was detected in the dorsal aorta at stage 17 , coincident with BMPR IB mRNA expression in the sympathetic ganglia . ^^^ In secondary cultures of neural crest cells , exogenous BMP 2 and BMP 4 increased the expression of BMPR IA but decreased the expression of BMPR IB . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| Infection of USC with retroviral vectors expressing constitutively active ( CA ) BMPRs showed that CA BMPR IB , like exogenous BMP 4 , induced both colX mRNA and elevated alkaline phosphatase ( AP ) , while CA BMPR IA was markedly less potent . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| In the early stage , BMP 4 derived mRNA was localized mainly in cells in the anterior margin of the cervical discs , together with ALK 6 and BMP RII mRNA . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMP 4 and GDF 5 , natural ligands of BMPR IB , strongly inhibit secretion of progesterone by ovine granulosa cells in vitro , but granulosa cells from FecB ( B ) / FecB ( B ) ewes are less responsive than those from FecB ( + ) / FecB ( + ) to the action of these peptides . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| To evaluate the consequences of the Booroola mutation on BMPR1B functions , the action of ligands of the transforming growth factor beta ( TGFbeta ) / BMP family that act through ( growth and differentiation factor 5 , BMP 4 ) or independently of ( activin A , TGFbeta 1 ) BMPR1B were studied on primary cultures of GCs from homozygous FecB ( + ) and FecB ( B ) ewes . ^^^ In transfection experiments with HEK 293 cells , co expression of FecB ( + ) BMPR1B and BMPR 2 resulted in a 2 . 6 fold ( P < 0 . 01 ) induction of the activity of a BMP specific luciferase reporter construct by BMP 4 . ^^^ Interestingly , no response to BMP 4 was observed when cells were transfected with the FecB ( B ) form of the BMPR1B receptor . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| RESULTS : With reverse transcription PCR the expression profile for normal palmar fascia fibroblasts versus Dupuytren ' s fibroblasts was found to show similar expression of BMP 1 and 11 ; qualitatively decreased expression of BMP 6 , BMP 8 , BMPR IA , BMPR IB , and BMPR 2 in Dupuytren ' s fibroblasts ; and no expression of BMP 4 in Dupuytren ' s fibroblasts . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| Based on the recently discovered role of bone morphogenetic proteins ( BMPs ) in ENS development , we examined the expression of the ligands , BMP 2 and BMP 4 , and their receptors , BMPRIA , BMPRIB , and BMPRII , during formation of the human ENS . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| Tissues were analyzed using immunohistochemistry for BMP ligand ( BMP 2 , BMP 4 , BMP 7 ) and receptor ( BMPRIA , BMPRIB , BMPRII ) expression . ^^^ |
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| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12644 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
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