| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.52726989 |
| BMPR 2 binds BMP 2 and 7 on its own , but binding is enhanced by coexpression of type 1 BMP receptors . 0.52726989^^^ |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Disruption of Bmpr 2 leads to diminished signaling by BMP 2 and BMP 4 and augmented signaling by BMP 6 and BMP 7 . ^^^ |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that the osteoinductive effects of BMP 2 in C2C12 cells are mediated by bone morphogenetic protein receptor type IA in combination with both activin receptor type 2 and bone morphogenetic protein receptor type 2 . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis demonstrated that cells expressing either BMP 2 / 4 or their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) preferentially appeared in nodules . ^^^ |
|
| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Compared with the normal pancreas , pancreatic cancers showed a 12 . 5 fold ( P < 0 . 01 ) , 2 fold ( P < 0 . 01 ) , and 8 fold ( P < 0 . 01 ) increase of BMP 2 , BMP receptor ( R ) IA , and BMPR 2 messenger RNA levels , respectively . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA for BMP 2 , 4 , 7 ( OP 1 ) , the BMP type 1 receptors Act RI , BMPR 1A and 1B , the type 2 receptor BMPR 2 , and type 1 collagen were detected by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMP 2 antagonists emerge from alterations in the low affinity binding epitope for receptor BMPR 2 . ^^^ The binding epitopes of BMP 2 for BMPR IA ( type 1 ) and BMPR 2 or ActR 2 ( type 2 ) were characterized using BMP 2 mutant proteins for analysis of interactions with receptor ectodomains . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Messenger RNAs for BMP 2 , 4 , 7 , the BMP type 1 receptors Act R 1 ( alk 2 , activin like kinase receptor ) , BMPR IA ( alk 3 ) , IB ( alk 6 ) , and the type 2 receptor BMPR 2 were detected . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMP 2 and BMP 4 are produced by the thymic stroma and the requisite BMP receptor molecules ( BMPR 1A , BMPR 1B , BMPR 2 ) , and signal transduction molecules ( Smad 1 , 5 , 8 , and 4 ) are expressed by DN thymocytes . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) demonstrated the presence of various BMPs ( BMP 2 , 3 , 4 , 6 , 7 , and 8A and 8B ) , BMP type 1 and 2 receptors ( ALK 2 , ALK 3 , ALK 4 , BMPR 2 , and ActR IIA and IIB ) , BMP antagonists ( DAN , gremlin , chordin , cerberus , noggin , and tsg ) , and Smads 1 8 . mRNA expression of these genes did not change during differentiation , except for BMP 3 , BMP 8a , and noggin . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMP 2 , BMPRIa , BMPRIb , BMPRII , phosphorylated Smad 1 , and Smad 4 are expressed predominantly in mature colonocytes at the epithelial surface in normal adult human and mouse colon . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| To determine the role of bone morphogenetic protein ( BMP ) signaling in ENS development , we first examined the expression of bmp 2 , bmp 4 , and bmprII during hindgut development and find these strongly expressed in the ENS . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| BMP type 1 receptors , including activin receptor like kinase 2 ( ALK 2 ) ( also referred to as ActRIA ) and ALK 3 ( BMPRIA ) , both type 2 receptors , ActRII and BMPRII , as well as the ligands BMP 2 , 4 , and 7 and inhibin / activin subunits were expressed in PC 12 cells . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Here , we show that bone morphogenetic protein type 2 receptor ( BMPR 2 ) which has a serine / threonine kinase domain , and stem cell factor receptor ( c kit ) which contains a tyrosine kinase domain form a complex in vitro and in vivo ; the interaction is induced upon treatment of cells with BMP 2 and SCF . ^^^ Abrogation of the c kit / SCF dependent phosphorylation of BMPR 2 at the Ser 757 interfered with the cooperative effect of BMP 2 and SCF . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Based on the recently discovered role of bone morphogenetic proteins ( BMPs ) in ENS development , we examined the expression of the ligands , BMP 2 and BMP 4 , and their receptors , BMPRIA , BMPRIB , and BMPRII , during formation of the human ENS . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Plasma glucose levels were measured before and after treatment and vascular gene expression of BMP 2 , BMP 7 , and BMP type 2 receptor was determined in the aorta by quantitative real time polymerase chain reaction analysis . ^^^ After 6 weeks gene expression of vascular BMP 2 , BMP 7 and BMP type 2 receptor was almost doubled in NOD mice compared with non diabetic controls ( p < 0 . 05 ) . ^^^ In conclusion , vascular BMP 2 , BMP 7 , and BMP type 2 receptor expression is upregulated in early stages of autoimmune diabetes mellitus . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| To clarify the possible involvement of BMP and BMPR 2 in the development of hypoxic PH , the expression of BMP 2 , BMPR 2 , and their downstream signals were investigated in rat lung under normal and hypoxic conditions by RT PCR , immunoblot , and immunohistochemical methods . ^^^ In rats under normal conditions , BMP 2 is localized in the endothelium of the pulmonary artery , whereas BMPR 2 is abundantly expressed in the endothelium , smooth muscle cells , and adventitial fibroblasts . ^^^ Because BMP 2 is known to inhibit proliferation of vascular smooth muscle cells and promote cellular apoptosis , disruption of BMP signaling pathway through downregulation of BMPR 2 in chronic hypoxia may result in pulmonary vascular remodeling due to the failure of critical antiproliferative / differentiation programs in the pulmonary vasculature . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Tooth germs , ameloblastomas , adenomatoid odontogenic tumors , and malignant ameloblastomas were examined by RT PCR and immunohistochemistry for detection of BMP 2 , 4 , 7 , BMP receptors 1 and 2 ( BMPR 1 , BMPR 2 ) , core binding factor alpha 1 ( CBFA 1 ) , and osterix . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| AC cells were found to : ( 1 ) express mRNA for multiple BMPs ( BMP 2 , 3 , 4 , 6 , 8a ) , growth / differentiation factors ( GDF 1 , 3 , 5 , 9 ) , Lefty A and B , and the inhibin alpha , beta ( A ) and beta ( B ) subunits ( 2 ) secrete inhibin A and inhibin B and ( 3 ) express mRNA encoding the inhibin co receptor , betaglycan , along with activin and BMP type 1 ( ALK 2 7 ) and type 2 ( ActRII , ActRIIB , BMPRII ) receptors , and binding proteins ( follistatin , BAMBI , gremlin ) . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Here , we show the existence of mRNA for BMP 2 and for the BMP receptors BMPR1A , BMPR1B , BMPRII , ACVR1A , ACVR 2 , and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes . ^^^ |
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| Interacting proteins: P12643 and Q13873 |
Pubmed |
SVM Score :0.0 |
| Tissues were analyzed using immunohistochemistry for BMP ligand ( BMP 2 , BMP 4 , BMP 7 ) and receptor ( BMPRIA , BMPRIB , BMPRII ) expression . ^^^ |
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