| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| Furthermore , GGF 2 can attenuate induction of the neurogenic transcription factor mammalian achaete scute homolog 1 , by low doses of BMP 2 . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| We , therefore , studied genes pertinent to early embryologic development of the ANS including mammalian achaete scute homolog 1 ( MASH 1 ) , bone morphogenic protein 2 ( BMP 2 ) , engrailed 1 ( EN 1 ) , TLX 3 , endothelin converting enzyme 1 ( ECE 1 ) , endothelin 1 ( EDN 1 ) , PHOX2a , and PHOX2b in 67 probands with CCHS , and gender and ethnicity matched controls . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| By contrast , robust activation of cAMP signaling opposes , even in the presence of BMP 2 , SA cell development and the expression of the SA lineage determining ASH 1 and Phox 2 genes . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that treatment of neural crest stem cells ( NCSCs ) with bone morphogenetic protein 2 ( BMP 2 ) leads to an induction of MASH 1 expression and consequent autonomic neuronal differentiation . ^^^ Constitutive expression of MASH 1 in NCSCs from a retroviral vector , in the absence of exogenous BMP 2 , induces expression of both Phox2a and c RET in a large fraction of infected colonies , and also promotes morphological neuronal differentiation and expression of pan neuronal markers . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| All autonomic progenitors express a common bHLH protein , MASH 1 , which appears to be induced by members of the BMP 2 subfamily secreted by the tissues to which these progenitors migrate . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| Moreover , BMP 2 fails to prevent expression of the sensory specific basic helix loop helix ( bHLH ) transcription factors neurogenin 1 , neurogenin 2 and neuroD , although it induces expression of the autonomic specific bHLH factor MASH 1 and the paired homeodomain factor Phox2a in other cells . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| In addition to regulating neuron number , BMP 2 promotes both panneuronal maturation and the acquisition of an enteric phenotype , as measured by lineage specific changes in the expression of tyrosine hydroxylase and MASH 1 . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| In telencephalic neuroepithelial cells , BMP 2 up regulated the expression of negative helix loop helix ( HLH ) factors Id 1 , Id 3 , and Hes 5 ( where Hes is homologue of hairy and Enhancer of Split ) that inhibited the transcriptional activity of neurogenic HLH transcription factors Mash 1 and neurogenin . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| At high concentrations of BMP 2 or in neural crest stem cells ( NCSCs ) , however , NGNs like MASH 1 promote only autonomic marker expression . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| We therefore studied genes pertinent to early embryologic development of the ANS , including MASH 1 , BMP 2 , PHOX2a , PHOX2b , RET , ECE 1 , EDN 1 , TLX 3 , and EN 1 in 92 probands with SIDS and 92 gender and ethnicity matched control subjects . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| Because the E box binds bHLH proteins like ASH 1 induced in NC cells by BMP 2 , we propose this novel 170 bp cis acting element is a composite site , mediating the synergistic regulation by BMP2+cAMP on Phox2a transcription . . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that bone morphogenic protein 2 ( BMP 2 ) induces the basic helix loop helix protein MASH 1 and neurogenesis in neural crest stem cells . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| MASH 1 maintains competence for BMP 2 induced neuronal differentiation in post migratory neural crest cells . ^^^ Expression of endogenous Mash 1 can be maintained by BMP 2 ; in turn , constitutive expression of Mash 1 from a retroviral vector maintains competence for neuronal differentiation in response to late addition of BMP 2 . ^^^ They also reveal an unexpected feedback interaction between BMP 2 and MASH 1 during neuronal differentiation . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| BMP 2 decreases Mash 1 stability by increasing Id 1 expression . ^^^ We report that exposure of neuroendocrine lung carcinoma cells to BMP 2 leads to a rapid decline in steady state levels of Mash 1 protein and some neuron specific markers . ^^^ BMP 2 induces a post transcriptional decrease in Mash 1 levels through enhanced degradation . ^^^ Transient induction of Id 1 by BMP 2 negatively correlates with Mash 1 levels . ^^^ Furthermore , an ectopic increase in Id 1 levels is sufficient to induce degradation of either ectopic or endogenous Mash 1 , whereas expression of Mash 1 in Id 1 deficient cells or overexpression of E 47 makes Mash 1 levels refractory to the addition of BMP 2 . ^^^ |
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| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50553 and P12643 |
Pubmed |
SVM Score :0.0 |
| NA |
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