| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.60686217 |
| The crystal structure of the complete signaling complex formed between bone morphogenetic protein 2 ( BMP 2 ) and the extracellular domains ( ECDs ) of its type 1 receptor [ bone morphogenetic protein receptor type Ia ( BMPR Ia ) ECD ] and its type 2 receptor [ activin receptor type 2 ( ActRII ) ECD ] shows two fundamental structural constraints for receptor assembly . 0.60686217^^^ |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| However , endoglin binds BMP 2 by interacting with the ligand binding type 1 receptors , ALK 3 and ALK 6 . ^^^ |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| In addition , BMP 6 weakly bound to BMPR IA ( ALK 3 ) , to which BMP 2 also bound . ^^^ |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Addition of a soluble form of bone morphogenetic protein receptor type IA to the culture markedly inhibited not only osteoclast formation induced by RANKL and bone morphogenetic protein 2 , but also the basal osteoclast formation supported by RANKL alone . ^^^ Both bone marrow macrophages and mature osteoclasts expressed bone morphogenetic protein 2 and bone morphogenetic protein receptor type IA mRNAs . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Using the complex structure of bone morphogenetic protein 2 bound to its type 1 receptor ( ALK 3 ) as a guide , we introduced extracellular domain mutations in the context of the truncated ALK 4 ( ALK 4 trunc ) construct and assessed the ability of the mutants to inhibit activin function . ^^^ Our results indicate that there is only a partial overlap of the binding sites on ALK 4 and ALK 3 for activin A and bone morphogenetic protein 2 , respectively . ^^^ |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| In response to 1 mM of 5 aza , P 19 cells expressed bone morphogenetic protein 2 ( BMP 2 ) , BMP 4 , Bmpr1a and Smad 1 at day 6 or 9 , and also cardiac markers such as GATA 4 , Nkx2 . 5 , cardiac troponin 1 , and desmin were up regulated in a time dependent manner after induction of BMP signaling molecules . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Bmpr , also known as ALK 3 and Brk 1 , encodes a type 1 transforming growth factor beta ( TGF beta ) family receptor for BMP 2 and BMP 4 . ^^^ |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Here , the RNA of human adult dental pulp and pulp cells in culture was examined by reverse transcription ( RT ) polymerase chain reaction ( PCR ) for evidence of mRNA for BMPs . mRNAs for BMP 2 , 4 , osteogenic protein 1 , ActR 1 ( activin like kinase receptor ) , BMPR IA , IB and 2 were detected by RT PCR . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Two type 1 receptors ( BMPR IA and BMPR IB ) have been identified for BMP 2 . ^^^ In the present study , we examined the involvement of functional BMP 2 type 1 receptors in signal transduction in C2C12 cells , which expressed mRNA for BMPR IA , but not for BMPR IB in Northern blotting . ^^^ Subclonal cell lines of C2C12 that stably expressed a kinase domain truncated BMPR IA ( DeltaBMPR IA ) differentiated into myosin heavy chain expressing myotubes but not into alkaline phosphatase ( ALP ) positive cells , even in the presence of BMP 2 . ^^^ When wild type BMPR IA was transiently transfected into the DeltaBMPR IA transfected C2C12 cells , a number of ALP positive cells appeared in the presence of BMP 2 . ^^^ These results suggest that the BMP 2 induced signals , which inhibit myogenic differentiation and induce osteoblast differentiation , are transduced via BMPR IA in C2C12 myoblasts . . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Two type 1 receptors for BMP 2 ( BMPR IA and BMPR IB ) have been cloned , but the role of the respective receptors in signal transduction is not clear . ^^^ In the present study , we examined the signal transduction of BMP 2 in C2C12 cells using constitutively activated mutant BMPR IA and BMPR IB . ^^^ When mutated BMPR IA and BMPR IB were transiently transfected into C2C12 cells , both BMPR IA and BMPR IB similarly induced ALP activity in the absence of BMP 2 . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| These observations showed that the amounts of BMPR IB , but not those of BMPR IA , were regulated by androgen and further suggest that BMPR IA and BMPR IB differentially modulate prostate cancer cell growth in response to BMP under different hormonal conditions ; BMPR IA elicits growth stimulation , and BMPR IB conveys a negative regulatory signal in response to BMP 2 . . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that the osteoinductive effects of BMP 2 in C2C12 cells are mediated by bone morphogenetic protein receptor type IA in combination with both activin receptor type 2 and bone morphogenetic protein receptor type 2 . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular basis for these effects , we demonstrated that BMP 2 is bound to mIMCD 3 cells by the type 1 serine / threonine kinase receptor , ALK 3 , and that OP 1 bound to an approximately 80 kDa protein using ligand receptor affinity assays . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis demonstrated that cells expressing either BMP 2 / 4 or their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) preferentially appeared in nodules . ^^^ |
|
| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| During tubule formation , HGF rescued the inhibitory effects of BMP 2 and of a constitutive active form of the BMP 2 receptor , ALK 3 , stably expressed in mIMCD 3 cells . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| We report here expression of the extracellular domain of the human type IA receptor for BMP 2 ( BMPR IA ) in Escherichia coli . ^^^ This soluble form of BMPR IA ( sBMPR IA ) was purified employing a BMP 2 affinity column . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| In secondary cultures of neural crest cells , exogenous BMP 2 and BMP 4 increased the expression of BMPR IA but decreased the expression of BMPR IB . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| The binding epitopes of BMP 2 for BMPR IA ( type 1 ) and BMPR 2 or ActR 2 ( type 2 ) were characterized using BMP 2 mutant proteins for analysis of interactions with receptor ectodomains . ^^^ A large epitope 1 for high affinity BMPR IA binding was detected spanning the interface of the BMP 2 dimer . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Messenger RNAs for BMP 2 , 4 , 7 , the BMP type 1 receptors Act R 1 ( alk 2 , activin like kinase receptor ) , BMPR IA ( alk 3 ) , IB ( alk 6 ) , and the type 2 receptor BMPR 2 were detected . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Activin receptor like kinase ( ALK ) 1 , ALK 2 , ALK 3 , and ALK 6 were able to reproduce the hypertrophic maturation of chondrocytes induced by BMP 2 . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Stereology and histology were used to analyse kidneys from mice heterozygous for mutations in either BMP 2 , BMPR IA or ActR IA . ^^^ By qualitative histology , kidneys from BMP 2 , BMPR IA and ActR IA heterozygous null mutant mice were found to be the same as those from wild type mice . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| The BRE containing promoter activity was stimulated by BMP 2 or by constitutively active BMP receptors ( BMPR IA and BMPR IB ) . ^^^ CONCLUSION : Signalling of BMP 2 to stimulate the expression of Id 1 would be transduced by BMPR IA and mediated by Smad 1 and Smad 4 , both of which form a complex on the 29 bp GC rich element . . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) demonstrated the presence of various BMPs ( BMP 2 , 3 , 4 , 6 , 7 , and 8A and 8B ) , BMP type 1 and 2 receptors ( ALK 2 , ALK 3 , ALK 4 , BMPR 2 , and ActR IIA and IIB ) , BMP antagonists ( DAN , gremlin , chordin , cerberus , noggin , and tsg ) , and Smads 1 8 . mRNA expression of these genes did not change during differentiation , except for BMP 3 , BMP 8a , and noggin . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Here we have performed a detailed in situ hybridization analysis of the spatial and temporal expression patterns of the BMP ligands ( BMP 2 , 3 , 3b , 4 , 6 , 7 , 15 ) , receptors ( BMPR IA , IB , 2 ) , and BMP antagonist , follistatin , in rat ovaries over the normal estrous cycle . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| The expression of the mRNA for BMP 2 , 4 , 6 , 7 , and BMPR IA , IB , and 2 was determined and quantified by a semiquantitative RT PCR . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Heparin dose dependently suppressed the accumulation of BMP 2 from the culture media into the cell layer or BMPR IA , and retained a large amount of BMP 2 in the culture media . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| We performed immunohistochemistry on the callus , using antibodies for BMP ( BMP 2 , 3 , 4 , 7 ) , their receptors ( BMPR IA , IB , 2 ) , and phosphorylated BMP receptor regulated Smads ( pBMP R Smads ) . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Consistent with the higher endogenous expression rate of BMPR IA in comparison with BMPR IB , BMPR IA plays the dominant role in BMP 2 mediated osteo / chondrogenic development . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Molecular analyses included sequencing of BMPR1B , linkage analysis for STS markers flanking GDF 5 , sequencing of GDF 5 , confirmation of the mutation by a restriction enzyme assay , and localisation of the mutation inferred from the very recently reported GDF 5 crystal structure , and by superimposing the GDF 5 protein sequence onto the crystal structure of BMP 2 bound to Bmpr1a . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Biosensor interaction analyses revealed loss of binding to BMPR1A and BMPR1B ectodomains for the L441P mutant , whereas the R438L mutant showed normal binding to BMPR1B but increased binding to BMPR1A , the receptor normally activated by BMP 2 . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| A BMP 2 inhibition ELISA was developed to measure the in vitro release kinetics of bioactive human BMP 2 from immersed solid implant materials by using Escherichia coli expressed and biotinylated recombinant human BMP 2 receptor IA extracellular domain ( ALK 3 ECD ) . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| BMP type 1 receptors , including activin receptor like kinase 2 ( ALK 2 ) ( also referred to as ActRIA ) and ALK 3 ( BMPRIA ) , both type 2 receptors , ActRII and BMPRII , as well as the ligands BMP 2 , 4 , and 7 and inhibin / activin subunits were expressed in PC 12 cells . ^^^ |
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| Interacting proteins: P12643 and P36894 |
Pubmed |
SVM Score :0.0 |
| Here , we show the existence of mRNA for BMP 2 and for the BMP receptors BMPR1A , BMPR1B , BMPRII , ACVR1A , ACVR 2 , and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes . ^^^ |
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