| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.54367343 |
| Recombinant BMP 2 binds to the Gla containing region of MGP in the presence of Ca2+ . 0.54367343^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Modulation of the binding of matrix Gla protein ( MGP ) to bone morphogenetic protein 2 ( BMP 2 ) . ^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Matrix GLA protein , a regulatory protein for bone morphogenetic protein 2 . ^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Activin betaA transgenic mice demonstrated retardation of catagen entry , down regulation of BMP 2 , and up regulation of expression of its antagonist matrix GLA protein . ^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Matrix GLA protein and BMP 2 regulate osteoinduction in calcifying vascular cells . ^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| BMP 2 also stimulated significantly Dlx 5 expression on days 3 9 , Msx 2 and matrix Gla protein expressions on days 3 and 6 , Runx 2 , alkaline phosphatase and osteocalcin expressions on days 6 and 9 in the culture . ^^^ |
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| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Additionally , BMP 2 may be related to loss of regulation of the matrix Gla protein . ^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Northern blotting demonstrated the expression of osteopontin ( OPN ) , matrix Gla protein ( MGP ) , osteonectin ( ON ) and BMP 4 mRNA but not bone sialoprotein , osteocalcin and BMP 2 mRNA . ^^^ |
|
| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Expression of the matrix Gla protein ( MGP ) gene , another marker of cartilage , was also reduced in the presence of 100 ng / ml BMP 2 or 4 , while it remained stable in the presence of BMP 12 or 13 at the same concentration . ^^^ |
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| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Matrix GLA protein function in human trabecular meshwork cells : inhibition of BMP 2 induced calcification process . ^^^ |
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| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Genes studied were : core binding factor alpha 1 ( Cbfa1 / Runx2 ) , a pivotal transcriptional regulator of osteogenesis ; bone morphogenetic protein 2 ( BMP 2 ) , an inducer of cartilage and bone ; and matrix gla protein ( MGP ) , a potent inhibitor of calcification , which exerts its action by blocking BMP 2 . ^^^ HCAECs were treated with oxidized low density lipoprotein ( ox LDL , 80 microg / mL ) or tumor necrosis factor alpha ( TNFalpha , 10 ng / mL ) , and the expression of Cbfa 1 , BMP 2 , and MGP was quantified by real time PCR . ^^^ The expression of BMP 2 and MGP increased early after exposure to ox LDL or TNFalpha ( at 2 8 h ) , and the increase was not evident at 24 h . ^^^ Ox LDL exerted a stronger effect on MGP than on BMP 2 expression . ^^^ The effects of ox LDL , but not TNFalpha , on MGP and BMP 2 expression were inhibited by pretreatment of cells with an antibody directed at LOX 1 , a lectin like receptor for ox LDL ( 10 microg / mL ) . ^^^ |
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| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Since MGP is an insoluble matrix protein , this work has focused on intracellular processing and transport of MGP to become an extracellular binding protein for bone morphogenetic protein 2 . ^^^ |
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| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| Alternatively , vitronectin bound MGP may have altered function for modulating BMP 2 or TGF beta activity . ^^^ |
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| Interacting proteins: P08493 and P12643 |
Pubmed |
SVM Score :0.0 |
| MGP is an extracellular matrix protein that acts as a calcification inhibitor by repressing bone morphogenetic protein 2 ( BMP 2 ) . ^^^ |
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