| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| However , endoglin binds BMP 2 by interacting with the ligand binding type 1 receptors , ALK 3 and ALK 6 . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMPR 2 is a transmembrane serine / threonine kinase that binds BMP 2 and BMP 7 in association with multiple type 1 receptors , including BMPR IA / Brk1 , BMPR IB , and ActR 1 , which is also an activin type 1 receptor . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Two type 1 receptors ( BMPR IA and BMPR IB ) have been identified for BMP 2 . ^^^ In the present study , we examined the involvement of functional BMP 2 type 1 receptors in signal transduction in C2C12 cells , which expressed mRNA for BMPR IA , but not for BMPR IB in Northern blotting . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Two type 1 receptors for BMP 2 ( BMPR IA and BMPR IB ) have been cloned , but the role of the respective receptors in signal transduction is not clear . ^^^ In the present study , we examined the signal transduction of BMP 2 in C2C12 cells using constitutively activated mutant BMPR IA and BMPR IB . ^^^ When mutated BMPR IA and BMPR IB were transiently transfected into C2C12 cells , both BMPR IA and BMPR IB similarly induced ALP activity in the absence of BMP 2 . ^^^ When the mutated BMPR IB transfected cells were cultured in medium with low serum ( differentiation medium ) without BMP 2 , the cells differentiated into ALP positive mononuclear cells and not into myosin heavy chain positive myotubes . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| These observations showed that the amounts of BMPR IB , but not those of BMPR IA , were regulated by androgen and further suggest that BMPR IA and BMPR IB differentially modulate prostate cancer cell growth in response to BMP under different hormonal conditions ; BMPR IA elicits growth stimulation , and BMPR IB conveys a negative regulatory signal in response to BMP 2 . . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis demonstrated that cells expressing either BMP 2 / 4 or their receptors ( BMPR IA , BMPR IB , and BMPR 2 ) preferentially appeared in nodules . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMP 2 induced ALP activity could be rescued by transfection of wild type ( wt ) BMPR IB into 2T3 clones containing trBMPR IB . ^^^ Expression of a constitutively active BMPR IB ( caBMPR IB ) induced formation of mineralized bone matrix by 2T3 cells without addition of BMP 2 . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Transcription of BMP 2 , BMP 3 , BMP 4 , BMP 5 , and BMP 7 and receptors of BMPR IA , BMPR IB and BMPR 2 was detected in ex vivo and cultured epithelium and stroma . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| In secondary cultures of neural crest cells , exogenous BMP 2 and BMP 4 increased the expression of BMPR IA but decreased the expression of BMPR IB . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Messenger RNAs for BMP 2 , 4 , 7 , the BMP type 1 receptors Act R 1 ( alk 2 , activin like kinase receptor ) , BMPR IA ( alk 3 ) , IB ( alk 6 ) , and the type 2 receptor BMPR 2 were detected . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Activin receptor like kinase ( ALK ) 1 , ALK 2 , ALK 3 , and ALK 6 were able to reproduce the hypertrophic maturation of chondrocytes induced by BMP 2 . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| The BRE containing promoter activity was stimulated by BMP 2 or by constitutively active BMP receptors ( BMPR IA and BMPR IB ) . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| With use of immunohistochemical analysis , we studied the localization of BMP 2 , BMP 4 , and BMP 7 and their receptors BMPR IA , BMPR IB , and BMPR 2 as well as pSmad 1 . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| BMP 2 , BMPRIa , BMPRIb , BMPRII , phosphorylated Smad 1 , and Smad 4 are expressed predominantly in mature colonocytes at the epithelial surface in normal adult human and mouse colon . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Gene silencing of ALK 6 using small interfering RNA also reduced DNA synthesis as well as Id 1 transcription in pphPASMCs regardless of BMP 2 stimulation . ^^^ Although Id 1 response was not stimulated by BMP 2 in control PASMCs , the gene delivery of wild type ALK 6 caused significant increase in the Id 1 transcripts in response to BMP 2 . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Consistent with the higher endogenous expression rate of BMPR IA in comparison with BMPR IB , BMPR IA plays the dominant role in BMP 2 mediated osteo / chondrogenic development . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction studies with antral follicles showed the expression of BMPR IA , BMPR IB , ActR IA , ActR IIB , BMPR 2 and BMP 4 mRNA in all follicular compartments , while BMP 2 mRNA was generally restricted to theca and cumulus tissue . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| The mRNAs encoding BMP 2 , BMP 4 , BMP 7 and the oocyte derived growth factor , growth differentiation factor ( GDF ) 9 were detected in the pituitaries of cyclic ewes by reverse transcriptase PCR , as well as the mRNAs encoding the BMP type 1 receptors , BMPR IA ( activin receptor like kinase ( ALK ) 3 ) and BMPR IB ( ALK 6 ) , and type 2 receptors ( BMPR 2 ) . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Molecular analyses included sequencing of BMPR1B , linkage analysis for STS markers flanking GDF 5 , sequencing of GDF 5 , confirmation of the mutation by a restriction enzyme assay , and localisation of the mutation inferred from the very recently reported GDF 5 crystal structure , and by superimposing the GDF 5 protein sequence onto the crystal structure of BMP 2 bound to Bmpr1a . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Biosensor interaction analyses revealed loss of binding to BMPR1A and BMPR1B ectodomains for the L441P mutant , whereas the R438L mutant showed normal binding to BMPR1B but increased binding to BMPR1A , the receptor normally activated by BMP 2 . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Based on the recently discovered role of bone morphogenetic proteins ( BMPs ) in ENS development , we examined the expression of the ligands , BMP 2 and BMP 4 , and their receptors , BMPRIA , BMPRIB , and BMPRII , during formation of the human ENS . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Here , we show the existence of mRNA for BMP 2 and for the BMP receptors BMPR1A , BMPR1B , BMPRII , ACVR1A , ACVR 2 , and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the TNF alpha induced loss of BMPR IB was found to ablate BMP 2 stimulated bone cell functions , including phosphorylation of Smad1 / 5 / 8 , alkaline phosphatase activity and osteocalcin expression . ^^^ In conclusion , our study has provided evidence , for the first time , that BMPR can be differentially modulated by TNF alpha at both the post transcriptional and post translational levels , with the TNF alpha induced shedding of the BMPR IB antigen associated with a significantly diminished response to BMP 2 in vitro . . ^^^ |
|
| Interacting proteins: P12643 and O00238 |
Pubmed |
SVM Score :0.0 |
| Tissues were analyzed using immunohistochemistry for BMP ligand ( BMP 2 , BMP 4 , BMP 7 ) and receptor ( BMPRIA , BMPRIB , BMPRII ) expression . ^^^ |
|