| Interacting proteins: P12314 and P08631 |
Pubmed |
SVM Score :0.0 |
| The Fc gamma RI receptor signals through the activation of hck and MAP kinase . ^^^ IFN induces the expression of the nonreceptor protein tyrosine kinase , hck , and cross linking the Fc gamma RI receptor in U937IF cells results in the activation of hck kinase as evidenced by the three to fivefold increased tyrosine phosphorylation of hck . ^^^ In vitro kinase assays demonstrate that the specific kinase activity of hck is increased 10 fold after Fc gamma RI stimulation . hck is observed to associate with two prominent tyrosine phosphorylated proteins , p 72 and p 95 , after Fc gamma RI activation . ^^^ The data suggest that hck , p 72 , p 95 , and MAP kinase are involved in signal transduction through the Fc gamma RI receptor . . ^^^ |
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| Interacting proteins: P12314 and P08631 |
Pubmed |
SVM Score :0.0 |
| Physical and functional association of the high affinity immunoglobulin G receptor ( Fc gamma RI ) with the kinases Hck and Lyn . ^^^ We now report that the src type kinases hck and lyn are physically and functionally associated with Fc gamma RI . ^^^ Hck and lyn coimmunoprecipitated with Fc gamma RI from detergent lysates of normal human monocytes and of the monocytic line THP 1 . ^^^ Hck and lyn showed rapidly increased phosphorylation and increased exogenous substrate kinase activity after cross linking of Fc gamma RI . ^^^ These results demonstrate both physical and functional association of the Fc gamma RI / Fc epsilon RI gamma receptor complex with hck and lyn , and suggest a potential signal transducing role for these kinases in monocyte / macrophage activation . . ^^^ |
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| Interacting proteins: P12314 and P08631 |
Pubmed |
SVM Score :0.0 |
| The association of Fc gamma RII with Src PTK was specific for Fc gamma RII activation of THP 1 cells , since activation of cells via the high affinity Fc gamma receptor , Fc gamma RI ( CD 64 ) , did not result in association of Fc gamma RII with Hck or Lyn . ^^^ |
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| Interacting proteins: P12314 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
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