| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.7822207 |
| Interactions of CRP with a specific CRP receptor ( CRP R ) and with the high affinity receptor for IgG , Fc gamma RI , on monocytic cells have previously been demonstrated . 0.7822207^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.64003044 |
| The goal of this study was to elucidate amino acid residues important for the interaction of CRP with human FcgammaRI ( CD 64 ) and FcgammaRIIa ( CD 32 ) . 0.64003044^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| Although human rIFN gamma and PMA increased FcRI expression , these reagents had no affect on CRP receptor expression . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| We previously determined that CRP binds to the high affinity receptor for IgG , FcgammaRI ( CD 64 ) . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| Monomeric IgG , which binds specifically to Fc gamma RI , inhibited a maximum of 20 % of CRP binding to these cells . mAb 197 and mAb IV . 3 , which block IgG binding to Fc gamma RI and Fc gamma RII , respectively , failed to inhibit CRP binding to U 937 cells . ^^^ The identity of this protein with Fc gamma RI was confirmed by the ability of both IgG Sepharose and CRP Sepharose to preclear the protein from cell lysates and by inhibition of binding to both IgG Sepharose and CRP Sepharose by anti Fc gamma RI mAb 197 . . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| The present study utilized monoclonal antibodies ( MAb ) to determine whether the Agg CRP potentiation of oxidative metabolism could be linked to activation through Fc gamma RI , Fc gamma RII , or Fc gamma RIII . ^^^ Preincubation of monocytes with MAb 32 . 2 , which recognizes an Fc gamma RI epitope distinct from its IgG binding site , had only a minimal ( 20 % ) inhibitory effect on Agg IgG induced luminol chemiluminescence ( CL ) and exerted no significant effect on its enhancement by Agg CRP . ^^^ MAb 10 . 1 , which blocks IgG binding to Fc gamma RI , reduced Agg IgG induced monocyte CL by 40 % , but did not alter the Agg CRP mediated enhancement . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| A significant correlation between monocyte expression of CD 64 and C reactive protein ( CRP ) , and blood platelet count , respectively , was found in the group of patients with RA . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| We have recently determined that the high and low affinity receptors for CRP on human leukocytes are Fc gamma RIIa and Fc gamma RI , respectively . ^^^ Further analysis of CRP binding to macrophages , neutrophils , and lymphocytes provides direct evidence that Fc gamma RIIb 1 , Fc gamma RIIb 2 , and Fc gamma RI are the receptors for CRP on mouse leukocytes . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| C reactive protein ( CRP ) and expression of CD 64 on neutrophils were measured at 0 h ( at the time of sepsis evaluation ) and 24 h . ^^^ The sensitivity , specificity , positive predictive value , and negative predictive value ( NPV ) of CRP , CD 64 , and the combination of these two markers for predicting neonatal sepsis were determined . ^^^ CRP and CD 64 in infected infants were both significantly elevated at 0 and 24 h compared with noninfected infants ( p < 0 . 001 ) . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Before therapy , PAC 1 binding , expression of CD11b and CD 64 on monocytes and neutrophils , circulating levels of monocyte ( CD11b+ or CD64+ ) platelet complexes , monocyte PAC 1+ platelet complexes , CRP , ESR , IL 6 , TNF a , fibrinogen , D dimer and sP selectin were significantly higher in RA patients compared to controls . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| CRP ( 100 microg / mL ) significantly upregulated surface expression of Fcgamma receptors , CD 32 , as well as CD 64 on HAECs ( P < 0 . 01 ) . ^^^ Also , preincubation with anti CD 32 and CD 64 antibodies significantly inhibited maximal binding of CRP to HAECs 64 % and 30 % , respectively , whereas antibodies to CD 16 had no effect . ^^^ Also , binding and internalization of biotinylated CRP was confirmed by confocal microscopy and CRP colocalized with CD 32 and CD 64 . ^^^ Most importantly , the increase in interleukin 8 , intercellular adhesion molecule 1 , and vascular cell adhesion molecule 1 and the decrease in eNOS and prostacyclin induced by CRP was abrogated with antibodies to CD 32 and CD 64 . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| C reactive protein ( CRP ) , monocyte HLA DR and neutrophil CD 64 expressions were quantitatively measured at the time of sepsis evaluation ( 0 h ) and 24 h afterwards by flow cytometry and standard laboratory method . ^^^ The areas under the receiver operating characteristics ( ROC ) curves for HLA DR , CD 64 and CRP were 0 . 52 0 . 54 , 0 . 88 0 . 94 and 0 . 75 0 . 77 , respectively . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| When compared to C reactive protein ( CRP ) , high PMN CD 64 and MON CD 64 were always associated with an increased CRP concentration , but minor proportions of samples with normal PMN CD 64 ( 11 / 52 ) or normal MON CD 64 ( 11 / 65 ) could also have an increased CRP . ^^^ |
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| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| Preincubation with antibodies to CD 32 and CD 64 or transient transfection with small interference RNA to CD 32 attenuated CRP induced NF kappaB activity , ICAM , VCAM , and monocyte endothelial cell adhesion under static conditions . ^^^ Furthermore , CRP activated endothelial cells supported monocyte rolling , arrest , and transmigration in shear flow ( 2 dyn / cm2 ) , and this was also inhibited by preincubation with antibodies to CD 32 and CD 64 . ^^^ |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P12314 |
Pubmed |
SVM Score :0.0 |
| NA |
|