| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.76845631 |
| METHODS : The ability of PTHrP to act as a substrate was studied by incubating a synthetic polypeptide , consisting of 34 amino acid residues of the amino terminal domain of PTHrP , with purified PSA . 0.76845631^^^ |
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| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen cleaves parathyroid hormone related protein in the PTH like domain : inactivation of PTHrP stimulated cAMP accumulation in mouse osteoblasts . ^^^ PURPOSE : To determine whether parathyroid hormone related protein ( PTHrP ) is a substrate of prostate specific antigen ( PSA ) and how the biological activity of PTHrP may be altered by cleavage with PSA . ^^^ |
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| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| Growth factors and peptides that have differentiating activity , such as transforming growth factor beta ( TGF beta ) , parathyroid hormone related protein ( PTH rp ) , and the bone morphogenetic proteins ( BMPs ) , can shift local homeostasis to produce the characteristic blastic phenotype , via interaction with prostate secreted human kalikrein 2 ( hK 2 ) , and prostate specific antigen ( PSA ) . ^^^ |
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| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| We determined immunoreactive PTHrP concentrations in plasma samples from 48 healthy persons ( mean + / SD , 3 . 1 + / 1 . 0 pmol / liter ; range , less than 2 to 5 pmol / liter ) , 8 patients with primary hyperparathyroidism , 36 patients with hypercalcemia and a concurrent malignant lesion , and 9 normocalcemic patients with cancer and increased serum levels of carcinoembryonic antigen or prostate specific antigen . ^^^ |
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| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen is a protease , which can cleave PTHrP and thus change the balance of osteolytic versus osteoblastic responses to metastatic tumor cells . ^^^ |
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| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P07288 |
Pubmed |
SVM Score :0.0 |
| NA |
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