| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone related protein in vivo . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone related protein and interleukin 6 mRNA expression in larynx and renal cell carcinomas from normocalcaemic and hypercalcaemic patients . ^^^ AIMS To determine the expression of parathyroid hormone related protein ( PTHrP ) and interleukin 6 ( IL 6 ) mRNAs and their possible relation in malignant tumours , derived from patients with and without hypercalcaemia , commonly associated with humoral hypercalcaemia of malignancy . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Moreover , activation of cAMP signal transduction by parathyroid hormone and parathyroid hormone related protein is necessary and sufficient to induce both interleukin 6 and leukemia inhibitory factor . ^^^ Taken together with our previous results , this study suggests that interleukin 6 is crucial for stimulation of bone resorption not only by parathyroid hormone , but also by parathyroid hormone related protein , vasoactive intestinal peptide , and beta adrenergic agonists , like isoproterenol . . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| A novel mature B cell line ( DOBIL 6 ) producing both parathyroid hormone related protein and interleukin 6 from a myeloma patient presenting with hypercalcaemia . ^^^ Interestingly , abundant interleukin 6 ( IL 6 ) and parathyroid hormone related protein ( PTHrP ) accumulated in the culture supernatant of DOBIL 6 cells . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone related protein ( 107 139 ) stimulates interleukin 6 expression in human osteoblastic cells . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| The hypercalcaemia was associated with high plasma concentrations of parathyroid hormone related protein , interleukin 6 and tumour necrosis factor . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Hypercalcemia in a patient with renal cell carcinoma producing parathyroid hormone related protein and interleukin 6 . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| OAFs implicated in myeloma bone disease include tumor necrosis factor beta ( TNFbeta ) , RANK ligand ( RANKL ) , interleukin 1 ( IL 1 ) , parathyroid hormone related protein ( PTHrP ) , hepatocyte growth factor ( HGH ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNFalpha ) , and macrophage inflammatory protein 1 alpha ( MIP 1alpha ) . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| We have developed three transgenic models in which growth factors ( hepatocyte growth factor [ HGF ] , placental lactogen , or parathyroid hormone related protein ) have been targeted to the beta cell using rat insulin promoter ( RIP ) . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| In vivo demonstration that parathyroid hormone and parathyroid hormone related protein stimulate expression by osteoblasts of interleukin 6 and leukemia inhibitory factor . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| He subsequently developed clouding of consciousness with remarkable hypercalcemia , a high parathyroid hormone related protein ( PTHrP ) level , and elevated plasma cytokine levels [ tumor necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) ] . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Mediators including lymphotoxin , interleukin 1beta , parathyroid hormone related protein ( PTHrP ) , and interleukin 6 , produced by the myeloma cells or by marrow stromal cells in response to myeloma cells , have been implicated as osteoclast activating factors ( OAF ) in multiple myeloma . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Both N and C terminal domains of parathyroid hormone related protein increase interleukin 6 by nuclear factor kappa B activation in osteoblastic cells . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Highly increased serum levels of Interleukin 6 ( IL 6 ) and a parathyroid hormone related protein ( PTHrP ) together with a high level of serum calcium observed at the time of fractures suggested their contribution to the formation of the bone lesions . . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| In addition to RANKL , parathyroid hormone related protein and interleukin 6 are produced by prostate cancer cells and can promote osteoclastogenesis . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Medroxyprogesterone acetate decreases secretion of interleukin 6 and parathyroid hormone related protein in a new anaplastic thyroid cancer cell line , KTC 2 . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| We established a new renal carcinoma cell line that produces parathyroid hormone related protein ( PTHrP ) and interleukin 6 in culture . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Parathyroid hormone related protein ( PTHrP ) and hepatocyte growth factor ( HGF ) have been shown to stimulate proliferation in proximal nephron derived cells . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| HGF and KGF act within a system involving other factors such as parathyroid hormone related protein ( PTHrP ) . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 / soluble interleukin 6 receptor system induces parathyroid hormone related protein in human osteoblastic cells . ^^^ In the present in vitro study , we tested the hypothesis that parathyroid hormone related protein ( PTHrP ) might be a mediator of interleukin 6 ( IL 6 ) and its soluble receptor ( IL 6sR ) in osteoblasts . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| The tumors were analyzed by RT PCR to determine the mRNA expression of interleukin 6 ( IL 6 ) , parathyroid hormone related protein ( PTHrP ) , tumor necrosis factor alpha ( TNF alpha ) , receptor activator of nuclear factor kappaB ( RANK ) , RANK ligand ( RANKL ) , and osteoprotegerin . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : We have shown in FG pancreatic cancer cells that alpha2beta1 integrin mediated type 1 collagen adhesion decreases parathyroid hormone related protein ( PTHrP ) , interleukin 6 ( IL 6 ) , and interleukin 8 ( IL 8 ) expression , decreases the localization of E cadherin and beta catenin in cell cell contacts , increases cell migration , and increases glycogen synthase kinase 3 ( GSK 3 ) and protein kinase B ( PKB / Akt ) phosphorylation states relative to alpha5beta1 integrin mediated fibronectin ( Fn ) adhesion . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Various products of bone and stromal cells , and of leukocytes , such as Interleukin 6 or Tumor necrosis factor alpha , as well as high extracellular calcium concentration enhance PTHrP production by cultured lung squamous cell carcinoma and Leydig tumor cells , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| The tumor released 1 ) significant amounts of human interleukin 6 ( IL 6 ) and 2 ) parathyroid hormone related peptide ( PTHrP ) into the circulation . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Circulating levels of parathormone related peptide ( PTHrP ) , tumor necrosis factor alpha ( TNF alpha ) , and interleukin 6 ( IL 6 ) were measured . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have demonstrated by reverse transcription polymerase chain reaction and Northern blot analysis that OCC tumor also overexpressed interleukin 6 ( IL 6 ) mRNA and that tumor bearing animals exhibited a marked increase in plasma IL 6 as well as PTHrP concentrations . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| In this review , factors regulating islet development including differentiation factors ( Shh , activin , follistatin , and TGF alpha ) , transcriptional factors ( PDX 1 , Isl 1 , Pax 4 , Pax 6 , Nkx2 . 2 , Nkx6 . 1 , BETA 2 , and HNF ) , growth factors ( the EGF family , HGF , IGF 1 , IGF 2 , Reg , INGAP , PDGF , FGF , VEGF , and NGF ) , hormones ( insulin , the GH family , PTHrP , TRH , and gastrin ) , and cell adhesion molecules ( N CAM and cadherins ) are described after a short introduction and an outline of pancreatic development . . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| His plasma concentrations of parathyroid hormone related peptide ( PTHrP ) and interleukin 6 ( IL 6 ) were elevated . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| PTHrP in SF was measured by enzyme linked immunosorbent assay ( ELISA ) , whereas tumor necrosis factor alpha ( TNF alpha ) , interleukin 1beta ( IL 1beta ) , interleukin 2 ( IL 2 ) , interleukin 4 ( IL 4 ) , interleukin 6 ( IL 6 ) and interleukin 8 ( IL 8 ) in SF were all measured by ELISA . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| These factors include : the homeobox gene Barx 1 ; the bone morphogenetic protein ( BMP ) family member GDF 5 ; the growth factors HGF and PTHrP ; and the transcription factor ERG . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Verapamil or nifedipine ( at 50 microM ) or 25 nM BIM , but not 25 microM adenosine 3 ' , 5 ' cyclic monophosphorothioate , Rp isomer , a PKA inhibitor , abolished the PTHrP ( 107 139 ) induced increase in interleukin 6 messenger RNA ( assessed by RT , followed by PCR ) in UMR 106 cells . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Both cell types secreted intact , C terminal PTHrP and interleukin 6 in the culture medium . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| He had leukocytosis , thrombocytosis and hypercalcemia with elevated serum levels of parathyroid hormone related peptide ( PTHrP ) and interleukin 6 ( IL 6 ) . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Expression of cachexia inducing proinflammatory cytokines ( interleukin 6 and leukemia inhibitory factor ) is stimulated by PTHrP . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| Then , whether rat peritoneal tissue damages induced by intraperitoneal administration of glucose based PD is ameliorated by PLP or HGF was examined . ^^^ Both PLP and HGF prevented the thickening of rat peritoneum induced by PD and ameliorated accumulation of AGE and expression of TGF beta 1 , vascular endothelial growth factor , and type 1 collagen and a number of blood vessels . ^^^ Furthermore , expression of HGF was significantly increased in the peritoneum of PLP treated rats compared with that of PD treated rats . ^^^ PLP and HGF prevented peritoneal thickening ; accumulation of AGE ; expression of TGF beta 1 , vascular endothelial growth factor , and type 1 collagen ; and neoangiogenesis in rat peritoneum induced by PD . . ^^^ |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12272 and P05231 |
Pubmed |
SVM Score :0.0 |
| NA |
|