| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| In this report , we describe a randomly generated STS ( 323F4 ) from human chromosome 16 genomic DNA that has 90 . 0 % sequence identity to the type 1 human inosine 5 ' monophosphate dehydrogenase ( IMPDH 1 ) gene and 72 % identity to the type 2 human inosine 5 ' monophosphate dehydrogenase ( IMPDH 2 ) gene . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| A screen of retinal transcripts comparing retinas from normal mice to retinas from crx / crx knockout mice ( with poorly differentiated photoreceptors ) demonstrated a 6 fold reduction in one candidate , inosine monophosphate dehydrogenase 1 ( IMPDH 1 ; EC 1 . 1 . 1 . 205 ) . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of IMPDH 1 , IMPDH 2 and HPRT transcripts , encoding enzymes of the de novo and salvage pathways of guanine nucleotide biosynthesis , respectively , in retinal sections of mice , the data indicating that the bulk of GTP within photoreceptors is generated by IMPDH 1 . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the recent study demonstrates that feeding sheep with MPA contaminated silage did not induce IMPDH 1 mRNA expression in various tissues and blood , except in jejunum , but has suppressive effects on IMPDH 2 mRNA expression in WBC and ileum . . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Human IMP dehydrogenase ( IMPDH ; EC 1 . 1 . 1 . 205 ) was recently found to consist of two molecular species ( types 1 and 2 ) with high expression of type 2 isozyme in leukemic cells . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Cancer cells have an increased ability to synthesize GTP ( guanosine triphosphate ) because of increased activity of IMP DH ( inosine 5 ' phosphate dehydrogenase , EC 1 . 1 . 1 . 205 ) . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Inosine monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) inhibitors including mycophenolic acid ( MPA ) were reported to induce K 562 human leukemia cells to differentiate into erythroid cells . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Two distinct cDNAs encoding proteins with 84 % sequence identity have been isolated for human IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) ( Natsumeda , Y . , Ohno , S . , Kawasaki , H . , Konno , Y . , Weber , G . , and Suzuki , K . ( 1990 ) J . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| The discovery of isozymes ( types 1 and 2 ) of IMP dehydrogenase ( IMPDH ; EC 1 . 1 . 1 . 205 ) , the rate limiting enzyme of de novo GTP biosynthesis , has attracted attention as a possible novel approach to cancer diagnosis and selective tumor cell chemotherapy . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| The increased activity in cancer cells of inosine 5 ' monophosphate dehydrogenase ( IMP DH , EC 1 . 1 . 1 . 205 ) , the rate limiting enzyme of de novo GTP biosynthesis , was suggested as a sensitive target for chemotherapy . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Tiazofurin was demonstrated to be an effective inhibitor of the growth of human cultured blast cells , and the high specific activities of IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) were observed in all the cell extracts tested . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) , the rate limiting enzyme of de novo GTP biosynthesis , is a promising target in antileukemic chemotherapy . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Tiazofurin ( 2 beta D ribofuranosylthiazole 4 carboxamide ; NSC 286193 ) , an inhibitor of the activity of IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) , the rate limiting enzyme of GTP biosynthesis , resulted in a rapid drop ( less than 1 h ) to 50 % of control in the target enzyme activity in the hepatoma cells and in a subsequent marked decrease to 55 % in GTP concentration . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) , the first de novo step committed to guanosine nucleotide synthesis , was also tested . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Mouse wild type neuroblastoma cells ( NB cells ) were stepwise selected for 10 , 000 fold increased resistance to mycophenolic acid ( NB Myco cells ) , an inhibitor of IMP dehydrogenase ( IMP : NAD+ oxidoreductase , EC 1 . 1 . 1 . 205 ) . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| The metabolic effects of tiazofurin ( 25 microM ) upon mouse L 1210 leukemia cells growing in culture define a `` metabolic crossover point ' ' at the reaction catalyzed by IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) which confirms previous reports of inhibition of this enzyme . . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Mycophenolic acid ( MA ) was demonstrated to be an effective inhibitor of the growth of the intracellular parasitic protozoan Eimeria tenella in tissue culture and guanine was shown to reverse this inhibition as expected for an inhibitor of IMP dehydrogenase ( IMP : NAD+ oxidoreductase , EC 1 . 1 . 1 . 205 ) . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) , the rate limiting enzyme of de novo GTP biosynthesis and a promising target for cancer chemotherapy , was purified 4860 fold to homogeneity from rat hepatoma 3924A by a method including affinity chromatography in which IMP is bound to epoxy activated Sepharose 6B . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| The stereospecificity of IMP dehydrogenase ( IMP : NAD+ oxidoreductase , EC 1 . 1 . 1 . 205 ) from two different sources was determined . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Tiazofurin ( 2 beta D ribofuranosyl 4 thiazole carboxamide ; NSC 286193 ) , an antitumor carbon linked nucleoside that inhibits IMP dehydrogenase ( IMP : NAD+ oxidoreductase ; EC 1 . 1 . 1 . 205 ) and depletes guanylate levels , can activate the erythroid differentiation program of K 562 human leukemia cells . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Two phage lambda clones that contain the 5 ' portion of the human type 1 inosine 5 ' monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) gene were isolated . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| EICAR causes a rapid and marked inhibition of inosinate ( IMP ) dehydrogenase ( EC 1 . 1 . 1 . 205 ) activity in intact L 1210 and CEM cells reflected by a concentration dependent accumulation of IMP and depletion of GTP and dGTP levels . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Cloning , sequencing , and structural analysis of the DNA encoding inosine monophosphate dehydrogenase ( EC 1 . 1 . 1 . 205 ) from Tritrichomonas foetus . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| The ability of human type 2 inosine monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) to catalyze the formation of xanthosine 5 ' monophosphate ( XMP ) from C 2 halogen substituted analogs of IMP has been investigated . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Mouse neuroblastoma cells ( NB ) selected for 10 , 000 fold increased resistance to mycophenolic acid ( NB Myco ) showed a 200 500 fold increase in IMP dehydrogenase protein , and the enzyme ( IMP : NAD+ oxidoreductase , EC 1 . 1 . 1 . 205 ) also exhibited a 2400 fold increased ki for mycophenolic acid and reduced catalytic efficiency ( Hodges , S . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Human type 2 inosine 5 ' monophosphate dehydrogenase ( EC 1 . 1 . 1 . 205 ) is the rate limiting enzyme in de novo guanine nucleotide biosynthesis . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| We determined the chromosomal localization and structure of the gene encoding human type 2 inosine 5 ' monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) , an enzyme associated with cellular proliferation , malignant transformation , and differentiation . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) from porcine thymus glands has been purified to homogeneity . 2 . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Therefore the present data indicate that nuclear inositol lipid cycle as a target of tiazofurin in addition to its inhibition of IMP dehydrogenase ( EC 1 . 1 . 1 . 205 ) activity . . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Mycophenolic acid , a specific inhibitor of IMP dehydrogenase ( IMPDH ; EC 1 . 1 . 1 . 205 ) , is a potent inhibitor of Pneumocystis carinii growth in culture , suggesting that IMPDH may be a sensitive target for chemotherapy in this organism . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Tiazofurin ( 2 beta D ribofuranosylthiazole 4 carboxamide , NSC 286193 ) , an oncolytic drug , inhibits IMP DH ( inosine 5 ' monophosphate dehydrogenase , EC 1 . 1 . 1 . 205 ) , reduces signal transduction activity and IP 3 ( inositol 1 , 4 , 5 trisphosphate ) concentration and arrests the cell cycle chiefly in S phase . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Inosine 5 ' monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) catalyzes the dehydrogenation of IMP to XMP utilizing NAD as the proton acceptor . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of inosine 5 ' monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) are effective immunosuppressive drugs that may also have additional potential applications as antitumour and antimicrobial agents . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Ribavirin inhibits IMP DH ( EC 1 . 1 . 1 . 205 ) activity and reduces cellular GTP concentration . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| These are , first , the inhibition of inosine 5 ' monophosphate dehydrogenase ( IMPDH , EC 1 . 1 . 1 . 205 ) , a rate limiting enzyme for GTP and dGTP synthesis that plays a major role in DNA synthesis , cell proliferation and regulation ; and second , the induction of apoptosis . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| Inosine 5 ' monophosphate dehydrogenase ( IMPDH ; EC 1 . 1 . 1 . 205 ) isolated from Escherichia coli B 3 cells was strongly inhibited by 2 [ 2 ( Z ) fluorovinyl ] inosine 5 ' monophosphate ( 2 FVIMP ) . ^^^ |
|
| Interacting proteins: P20839 and P12268 |
Pubmed |
SVM Score :0.0 |
| It is not yet known if similar differences exist in the inosine 5 ' monophosphate dehydrogenase ( IMPDH ; EC 1 . 1 . 1 . 205 ) , the rate limiting enzyme of the thiopurine synthesis . ^^^ |
|