| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| On the other hand , IC 50 of this peptide on binding of FGF 5 to the FGFR 1 ( IIIc ) / Fc chimera was 483 microM . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| Epileptiform activity was induced by kainic acid injection , and in situ hybridization was used to assess the progress of changes in distribution and intensities of FGF receptor 1 ( FGFR 1 ) , FGF 5 , and FGF 2 mRNAs . ^^^ The distinctive pattern of the FGFR 1 mRNA response appears to indicate that FGFR 1 is a factor in the modulation of the cellular response for FGF 5 and FGF 2 . ^^^ These results demonstrate that brain activity exerts influences at the gene expression levels of FGFR 1 and its ligands FGF 5 and FGF 2 . . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| Competition binding studies show that the KD for FGF 5 FGFR 1 and FGF 5 FGFR 2 interactions are both between 0 . 5 and 1 . 5 10 10 ( 9 ) M . . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| At high concentrations , hFGF 5S protein partially antagonized FGF 5 activity , whereas by itself , hFGF 5S exerted very weak neurotrophic activity . hFGF 5S protein binds to FGF receptor ( FGFR ) 1 on PC 12 transfectants and partially inhibits hFGF 5 induced tyrosine phosphorylation of FGFR 1 and an FGFR substrate , but it also induces phosphorylation by itself . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We detected the expression of mRNAs for FGF 1 through FGF 5 , FGF 7 through FGF 10 , and FGFR 1 through FGFR 4 ( IIIb and IIIc splice variants ) in rat metanephroi from E 14 to E 21 . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| Given that FGF 5 receptor ( FGFR 1 ) is expressed in dermal papilla cells ( DPCs ) , which are known to stimulate outer root sheath cell ( ORSC ) proliferation , we hypothesized that FGF 5 attenuates DPC mediated ORSC proliferation . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGF 5 is a secreted FGF that is believed to preferentially act via the IIIc splice variant of FGFR 1 . ^^^ AIM : In this study we investigated the importance of FGFR 1 IIIc expression for FGF 5 mitogenic signaling in a pancreatic ductal cell line . ^^^ RESULTS : TAKA 1 cells secrete FGF 5 , but were found not to express FGFR 1 and to be unresponsive to exogenous FGF 5 . ^^^ In contrast , TAKA 1 clones expressing FGFR 1 IIIc were growth stimulated in the presence of FGF 5 and displayed enhanced mitogen activated protein kinase ( MAPK ) activity in the presence of FGF 5 . ^^^ CONCLUSION : Our data demonstrate that FGFR 1 IIIc can mediate FGF 5 induced mitogenesis via the MAPK pathway in pancreatic ductal cells , and suggest that expression of FGFR 1 IIIc in conjunction with FGF 5 may contribute to the pathobiology of human pancreatic cancer . . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| A cDNA encoding FGFR 1 IIIc was stably transfected into the well differentiated TAKA 1 pancreatic ductal cell line that is not responsive to FGF 5 and does not express FGFR 1 . ^^^ |
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| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12034 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|