| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.53609347 |
| Furthermore , Paip 2 competes with Paip 1 for PABP binding . 0.53609347^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.51324878 |
| Here we report on the existence of an alternative mechanism by which Paip 2 inhibits translation by competing with eIF4G for binding to PABP . 0.51324878^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.58547334 |
| In contrast , Paip 2 strongly inhibits translation by promoting dissociation of PABP from poly ( A ) and by competing with eIF4G for binding to PABP . . 0.58547334^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| Recently , a human PABP interacting protein , Paip 2 , which disrupts the PABP poly ( A ) interaction and consequently inhibits translation , was described . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| Greater than 98 % of PABP can be depleted from extracts by preincubation with either of the PABP interacting proteins ( Paip 2 or Paip 1 ) coupled to beads , and these depleted extracts fail to support efficient translation of poly ( A ) + mRNAs . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| The activity of PCI 6 , therefore , is reminiscent of that of human PABP interacting protein 2 ( Paip 2 ) . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| Moreover , the poly ( A ) tail stimulates IRES mediated translation even in the presence of PAIP 2 or following effective depletion of the poly ( A ) binding protein ( PABP ) from HeLa cell extracts . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| The PABC domain from human PABP interacts with the proteins PAIP 1 , PAIP 2 and RF 3 via its PAM 2 motifs . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| By using peptides derived from PABP interacting protein ( Paip ) 1 , Paip 2 , and eRF 3 , we show that PABC functions as a peptide binding domain . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| In addition , translation in extracts in which elF4G is cleaved is resistant to inhibition by the PABP binding protein 2 ( Paip 2 ) . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| We conclude that the post transcriptional regulation of GLUT 5 by fructose involves increases in mRNA stability mediated by the cAMP pathway and Paip 2 ( PABP interacting protein 2 ) binding . . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| We have determined the solution structure of the human PABC domain in complex with two peptides from PABP interacting protein 1 ( Paip 1 ) and Paip 2 . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| This was confirmed by experiments where PABP was inactivated with poly ( rA ) or Paip 2 , and the effect of both treatments was reversed by addition of recombinant PABP . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| Poly ( A ) binding protein ( PABP ) homeostasis is mediated by the stability of its inhibitor , Paip 2 . ^^^ PABP activity is tightly controlled by the PABP interacting protein 2 ( Paip 2 ) , which inhibits translation by displacing PABP from the mRNA . ^^^ Here , we describe a close interplay between PABP and Paip 2 protein levels in the cell . ^^^ PABP depletion by RNA interference ( RNAi ) causes co depletion of Paip 2 protein without affecting Paip 2 mRNA levels . ^^^ Upon PABP knockdown , Paip 2 interacts with EDD , which leads to Paip 2 ubiquitination . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| Paip 2 ( PABP interacting protein 2 ) binds PABP and inhibits translation both in vitro and in vivo by decreasing the affinity of PABP for polyadenylated RNA . ^^^ A full length brain cDNA of Paip2B encodes a protein that shares 59 % identity and 80 % similarity with Paip 2 ( Paip2A ) , with the highest conservation in the two PABP binding domains . ^^^ Paip 2 protein degradation may constitute a primary mechanism by which cells regulate PABP activity in translation . . ^^^ Paip2B acts in a manner similar to Paip2A to inhibit translation of capped and polyadenylated mRNAs both in vitro and in vivo by displacing PABP from the poly ( A ) tail . ^^^ |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BPZ3 and P11940 |
Pubmed |
SVM Score :0.0 |
| NA |
|