| Interacting proteins: O75534 and P11940 |
Pubmed |
SVM Score :0.0 |
| Five mCRD associated proteins were identified : Unr , a purine rich RNA binding protein ; PABP , a poly ( A ) binding protein ; PAIP 1 , a poly ( A ) binding protein interacting protein ; hnRNP D , an AU rich element binding protein ; and NSAP 1 , an hnRNP R like protein . ^^^ |
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| Interacting proteins: O75534 and P11940 |
Pubmed |
SVM Score :0.0 |
| Among the five mCRD associated proteins identified previously , UNR was found to be an mCRD binding protein and also a PABP interacting protein . ^^^ Interaction between UNR and PABP is necessary for the full destabilization function of the mCRD . ^^^ |
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| Interacting proteins: O75534 and P11940 |
Pubmed |
SVM Score :0.0 |
| The 63 and 105 kDa polypeptides were identified , as IMP 1 , an ortholog of chicken zip code binding polypeptide , and UNR , a PABP binding polypeptide , respectively , by mass spectrometry of the ARS RNA affinity purified samples . ^^^ Although both IMP 1 and UNR could bind independently to the ARS RNA in vitro , their RNA binding ability was stimulated by PABP . ^^^ The ability of mutant ARS RNAs to form the PABP , IMP 1 and UNR containing RNP complex correlates well with the translational repressor activity of the ARS . ^^^ We show here that the ARS can not efficiently form a trimeric complex with PABP ; therefore , additional interactions with IMP 1 and UNR to form a heteromeric RNP complex may be required for maximal repression of PABP mRNA translation under physiological conditions . . ^^^ |
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