| Interacting proteins: Q9Y4J8 and P11532 |
Pubmed |
SVM Score :0.0 |
| We have recently cloned the gene for the murine 87 kDa postsynaptic protein dystrobrevin , a dystrophin associated protein . ^^^ Anti dystrobrevin antibodies stain the sarcolemma in normal skeletal muscle indicating that dystrobrevin co localises with dystrophin and the dystrophin associated protein complex . ^^^ By contrast , dystrobrevin membrane staining is severely reduced in muscles of Duchenne muscular dystrophy patients , consistent with dystrobrevin being a dystrophin associated protein . ^^^ Normal dystrobrevin staining is observed in patients with other forms of limb girdle muscular dystrophy where dystrophin and the rest of the dystrophin associated protein complex are normally expressed and in other neuromuscular disorders . ^^^ Our results show that dystrobrevin deficiency is a generic feature of dystrophies linked to dystrophin and the dystrophin associated proteins . ^^^ |
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| Interacting proteins: Q9Y4J8 and P11532 |
Pubmed |
SVM Score :0.0 |
| Dystrobrevin and dystrophin : an interaction through coiled coil motifs . ^^^ Dystrobrevin , a dystrophin related and associated protein , has been proposed to be important in the formation and maintenance of the neuromuscular junction . ^^^ Dystrobrevin coprecipitates with both the acetylcholine receptor complex as well as the dystrophin glycoprotein complex . ^^^ Although the nature of dystrobrevin ' s association with the dystrophin glycoprotein complex remains unclear , it is known that dystrobrevin binds directly to the syntrophins , a heterologous group of dystrophin associated proteins . ^^^ Using the yeast two hybrid system to identify protein protein interactions , we present evidence for the heterodimerization of dystrobrevin directly with dystrophin . ^^^ |
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| Interacting proteins: Q9Y4J8 and P11532 |
Pubmed |
SVM Score :0.0 |
| Dystrobrevin , a member of the dystrophin family of proteins , was initially identified as a major tyrosine phosphorylated synaptic protein in the electric organ of Torpedo californica . ^^^ |
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| Interacting proteins: Q9Y4J8 and P11532 |
Pubmed |
SVM Score :0.0 |
| We previously reported the identification and characterization of human dystrobrevin , a protein which is unique in being both homologous to dystrophin and a dystrophin associated protein . ^^^ A comparison between the genomic organization of dystrophin and human dystrobrevin shows that the two genes have significant similarities in their genomic structure , implying an ancestral or evolutionary relationship . ^^^ |
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| Interacting proteins: Q9Y4J8 and P11532 |
Pubmed |
SVM Score :0.0 |
| Immunostaining studies indicate that DTN B and DTN expression is absent in affected muscle fibers from DMD patients and carriers . . ^^^ Sequence analysis indicates that this gene , named DTN B , is highly homologous to the rabbit A 0 , the previously described dystrobrevin ( DTN ) , Torpedo 87 kDa and to the C terminus of dystrophin . ^^^ |
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