| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| The absence of dystrophin leads to a dramatic reduction of the dystrophin associated proteins ( 156DAG , 59DAP , 50DAG , 43DAG and 35DAG ) in the sarcolemma of patients with Duchenne muscular dystrophy and mdx mice . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Dystrophin associated glycoprotein complex is classified into two subcomplexes : the dystroglycan complex ( 156DAG and 43DAG ) and the sarcoglycan complex ( 50DAG , A3b , and 35DAG ) . ^^^ We examined muscles from five SCARMD patients and found that dystrophin and 43DAG were present in almost normal levels while 35DAG and the newly identified protein A3b in addition to 50DAG were absent or greatly reduced . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Selective defect in dystrophin associated glycoproteins 50DAG ( A 2 ) and 35DAG ( A 4 ) in the dystrophic hamster : an animal model for severe childhood autosomal recessive muscular dystrophy ( SCARMD ) . ^^^ Antibodies against dystrophin , utrophin and DAGs including 50DAG ( A 2 ) , 43DAG ( A3a ) and 35DAG ( A 4 ) were employed for the examination . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| A monoclonal antibody MA 4 2 against a dystrophin associated protein 35DAG ( A 4 ) was established and applied to examine the distribution of 35DAG in monkey tissue and its expression in DMD patients . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate the co localization of Dp 116 ( a 116 kDa protein product of the DMD gene ) , full size utrophin , alpha and beta dystroglycan , 59DAP and 35DAG in a thin rim surrounding the outermost layer of myelin sheath of peripheral nerve fibers . ^^^ Dystrophin associated proteins are comprised of an extracellular glycoprotein of 156 kDa ( 156DAG ) , transmembrane glycoproteins of 50 kDa ( 50DAG ) , 43 kDa ( 43DAG ) and 35 kDa ( 35DAG ) , and a cytoskeletal protein of 59 kDa ( 59DAP ) . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| The dystrophin associated proteins are classified into three groups : ( 1 ) alpha and beta dystroglycan , ( 2 ) adhalin , 35DAG and A3b , and ( 3 ) members of the syntrophin family . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| In the 4 cases adhalin was completely absent in muscle sections , whereas dystrophin and the other members of the dystrophin associated protein complex were normal , except for the 35 kDa dystrophin associated glycoprotein which was decreased as usually observed in SCARMD . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| The dystrophic hamster is a model of limb girdle muscular dystrophy with sarcoglycan deficiency in which one of the dystrophin associated glycoproteins , delta sarcoglycan , is defective . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The patients presented a severe muscular dystrophy with a dystrophic pattern in the muscle biopsy , normal immunolabeling for dystrophin , very weak for alpha , beta and delta sarcoglycan and absent for gamma sarcoglycan . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry revealed normal expression of the dystrophin glycoprotein complex ( DGC ) , including dystrophin , beta dystroglycan , alpha ( adhalin ) , beta , gamma , and delta sarcoglycan , laminin alpha 2 chain ( merosin ) and syntrophin . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| The delta sarcoglycan deficient cardiomyopathic hamster and mice deficient in both dystrophin and utrophin showed loss of the smooth muscle sarcoglycan complex , whereas the complex was unaffected in alpha sarcoglycan null mice in agreement with the finding that alpha sarcoglycan is not expressed in smooth muscle cells . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| To determine if delta sarcoglycan deficiency occurred in other world populations , to identify the range of mutations and clinical phenotypes , and to test for the biochemical consequences of delta sarcoglycan gene mutations , we studied Duchenne like and limb girdle muscular dystrophy patients who we had previously shown not to exhibit gene mutations of dystrophin , alpha , beta , or gamma sarcoglycan for delta sarcoglycan mutations ( n = 54 ) . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis of the dystrophin associated proteins revealed a reduction of beta sarcoglycan and delta sarcoglycan in the sarcolemma of cardiac muscle but not skeletal muscle tissue . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Desmin immunoreactivity ( IR ) was detected by 3 days in vitro ( DIV 3 ) , IR for developmental heavy chain myosin , vimentin , utrophin , and beta dystroglycan , as well as alpha , beta , and gamma sarcoglycan , a day later . delta Sarcoglycan was found by DIV 7 ; dystrophin could be detected only by DIV 11 . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Here we report the screening of the human delta sarcoglycan gene , a member of the dystrophin associated protein complex , by single stranded DNA conformation polymorphism analysis and by DNA sequencing in patients with DCM . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| The dystrophin associated glycoproteins alpha , beta , gamma , and delta sarcoglycan and beta dystroglycan were markedly decreased in the membrane fraction of infected cells in culture , and the typical sarcolemmal localization for each of these proteins was lost in coxsackievirus B 3 infected cardiomyocytes in vivo . ^^^ Furthermore , sucrose gradient ultracentrifugation demonstrated that delta sarcoglycan was physically dissociated from dystrophin within the membrane fraction . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| The distribution of dystrophin associated proteins ( beta dystroglycan , alpha , beta , gamma and delta sarcoglycan , alpha syntrophin and sarcospan ) were studied in obliquely striated muscle of the leech Pontobdella muricata . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| These proteins are expressed mainly in skeletal muscles while dystrophin , beta dystroglycan , delta sarcoglycan and merosin are in cardiac and smooth muscles . ^^^ Dystrophin , beta , delta sarcoglycan and beta dystroglycan are first expressed in the myotome at the 4th week of human embryogenesis , followed by gamma sarcoglycan and merosin at the 6th week of development ; alpha sarcoglycan appears only at the level of the muscular fibre at the end of the embryonic period . . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Here , we observed that the growth factor regulated channel ( GRC ) , which belongs to the transient receptor potential channel family , is elevated in the sarcolemma of skeletal and / or cardiac muscle in dystrophic human patients and animal models deficient in dystrophin or delta sarcoglycan . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Like other members of the dystrophin associated protein complex ( DAPC ) , delta sarcoglycan localizes to the sarcolemmal membrane of the myofiber in adult zebrafish , but is more apparent at the myosepta in developing embryos . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Results of immunostaining of dystrophin , emerin , laminA / C , alpha , beta , gamma , delta sarcoglycan or dysferlin were normal . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| It has genetic and clinical features in common with humans who carry the gene deletion or mutation of the delta sarcoglycan ( SG ) gene , a component in dystrophin related proteins ( DRP ) . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| Finally , we provide evidence that the beta / delta sarcoglycan core can associate with the C terminus of dystrophin . ^^^ |
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| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92629 and P11532 |
Pubmed |
SVM Score :0.0 |
| NA |
|