| Interacting proteins: P11413 and O95336 |
Pubmed |
SVM Score :0.0 |
| Hemolytic anemia occurred in an individual who had inherited both the gene for 6 phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose 6 phosphate dehydrogenase ( EC 1 . 1 . 1 . 49 ) . ^^^ |
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| Interacting proteins: P11413 and O95336 |
Pubmed |
SVM Score :0.0 |
| Plasmodium berghei glucose 6 phosphate dehydrogenase 6 phosphogluconolactonase ( G6PD 6PGL ) is a bifunctional enzyme with significant sequence similarity in both the 6PGL and G6PD domains to the Plasmodium falciparum enzyme . ^^^ A recombinant form of the P . berghei enzyme was found to have both G6PD and 6PGL activities , and therefore catalyses the first two steps in the pentose phosphate pathway . ^^^ Excision of the insertion sequence in the P . berghei protein renders the G6PD domain inactive , although the 6PGL activity is unaffected . ^^^ Replacing the insertion sequence in P . berghei with the insertion sequence from P . falciparum restores some of the G6PD activity and also enhances 6PGL activity . ^^^ |
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