| Interacting proteins: P11362 and Q92793 |
Pubmed |
SVM Score :0.72387895 |
| The present study shows that FGFR 1 accumulates and interacts with the transcriptional co activator CREB binding protein ( CBP ) in nuclear speckle domains in the developing brain and in neural progenitor like cells in vitro , which accompanies differentiation and postmitotic growth . 0.72387895^^^ The interaction of FGFR 1 with CBP and RSK 1 allows activation of gene transcription and may play a role in cell differentiation . . 0.62758749^^^ |
|
| Interacting proteins: P11362 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The predicted fusion proteins that are putatively oncogenic FOP FGFR 1 , CEP 110 FGFR1 , and FIM FGFR 1 and MOZ CBP , MOZ p 300 , and MOZ TIF 2 lead to tumorigenesis through distinct pathways . ^^^ |
|
| Interacting proteins: P11362 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The known up regulated genes included human 10 kD protein , FGFR 1 oncogene partner , intercellular adhesion molecular 1 , FK 506 binding protein and rTS beta genes . ^^^ |
|
| Interacting proteins: P11362 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We show that nuclear fibroblast growth factor receptor 1 ( FGFR 1 ) mediates cAMP induced neuronal differentiation and regulates CREB and CREB binding protein ( CBP ) function in alpha internexin expressing human neuronal progenitor cells ( HNPC ) . ^^^ FGFR 1 ( SP / NLS ) transactivated CRE , up regulated phosphorylation and transcriptional activity of CREB and stimulated the activity of CBP several fold . ^^^ |
|
| Interacting proteins: P11362 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We propose that FGFR 1 is part of a universal `` feed forward and gate ' ' signaling module in which classical signaling cascades initiated by specific membrane receptors transmit signals to sequence specific transcription factors ( ssTFs ) , while INFS elicited by the same stimuli feeds the signal forward to the common coactivator , CREB binding protein ( CBP ) . ^^^ |
|
| Interacting proteins: P11362 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Nuclear FGFR 1 can transactivate CRE ( cAMP responsive element ) , activate CRE binding protein ( CREB ) binding protein ( CBP ) and gene activities causing cellular growth and differentiation . ^^^ Among the proteins detected with the intracellular FGFR 1 domain was a 90 kDa ribosomal S 6 kinase ( RSK 1 ) , a regulator of CREB , CBP , and histone phosphorylation . ^^^ |
|