| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.68795326 |
| While FGFR 1 interacts with FRS 2 constitutively , independent of ligand stimulation and tyrosine phosphorylation , NGF receptor ( TrkA ) binding to FRS 2 is strongly dependent on receptor activation . 0.68795326^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.51888205 |
| We showed the alternatively spliced VT motif , at the juxtamembrane domain of Fgfr 1 is required for FRS 2 interaction with Fgfr 1 . 0.51888205^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGFR 1 expressing clones exhibited ligand induced tyrosine phosphorylation of fibroblast growth factor receptor substrate 2 ( FRS 2 ) , a 90 kDa adaptor protein that links FGFR 1 activation to the MAPK cascade . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Finally , XLPTP 1 physically associates only with an activated FGFR 1 , and this interaction requires the presence of SNT1 / FRS 2 ( FGFR substrate 2 ) . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| In vitro , TAKA 1 cells stably transfected with FGFR 1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of FGFR substrate 2 ( FRS 2 ) , Shc , and phospholipase Cgamma ; and increased activation of mitogen activated protein kinase ( MAPK ) . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation by ectopic FGFR 1 that promotes malignancy was much more intense and yielded a phosphorylated 85 kDa SNT 1 . ^^^ The amount of the 85 kDa SNT 1 increased by 20 fold during proliferative aging of FGFR 1 expressing cell populations that is required for FGFR 1 stimulated mitogenesis and the malignant phenotype . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| The truncated CT 63 FGFR 1 mutant failed to mediate chemotaxis , but was in response to ligand stimulation capable of mediating proliferation of the cells , stimulation of MAP kinase activity and tyrosine phosphorylation of FRS 2 , an FGFR 1 specific signaling molecule . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Analysis of proteins implicated in FGFR 1 signalling indicates that upon stimulation , a tyrosine phosphorylated protein designated FRS 2 associates with SOS , Grb 2 and the receptor . ^^^ These results support the view that FRS 2 is the dominant FGFR 1 signalling entity in PC 12 cells . . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| The activated FGFR 1 couples to Ras through two adaptor proteins , FRS 2 and Shc . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| These results indicate that FGFR 1 , 3 , and 4 ( 1 ) are capable of signaling in a similar fashion ; ( 2 ) primarily use FRS 2 and , perhaps , PLCgamma ; and ( 3 ) do not utilize Shc . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| The Shb adaptor protein binds to tyrosine 766 in the FGFR 1 and regulates the Ras / MEK / MAPK pathway via FRS 2 phosphorylation in endothelial cells . ^^^ Overexpression of an SH 2 domain mutant Shb caused a dramatic reduction in FGFR 1 mediated FRS 2 phosphorylation with concomitant perturbment of the Ras / MEK / MAPK pathway . ^^^ We conclude , that Shb binds to tyrosine 766 in the FGFR 1 and regulates FGF mediated mitogenicity via FRS 2 phosphorylation and the subsequent activation of the Ras / MEK / MAPK pathway . . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Overexpression of mSef in NIH3T3 cells results in a decrease in FGF induced cell proliferation associated with a decrease in Tyr phosphorylation of FGFR 1 and FRS 2 . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Activated fibroblast growth factor receptor 1 ( FGFR 1 ) propagates FGF signals through multiple intracellular pathways via intermediates FRS 2 , PLCgamma , and Ras . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Similarly , T 3 enhanced FGF 2 activated autophosphorylation of FGFR 1 , but did not modify FGF 2 induced phosphorylation of the docking protein FRS 2 . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| A Cbl TKB domain mutant , G306E , disrupted the phosphorylation of the FGFR 1 but not that of FRS 2 . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Context specific requirements for Fgfr 1 signaling through Frs 2 and Frs 3 during mouse development . ^^^ Biochemical studies have implicated Fgf receptor specific substrates ( Frs 2 , Frs 3 ) as the principal mediators of Fgfr 1 signal transduction to the MAPK and PI3K pathways . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| Using the yeast two hybrid protein protein interaction assay , we show that FRS2 / SNT 1 and a newly isolated SNT 2 protein directly bind to FGF receptor 1 ( FGFR 1 ) . ^^^ A juxtamembrane segment of FGFR 1 and the phosphotyrosine binding domain of SNTs are both necessary and sufficient for interaction in yeast and in vitro , and FGFR mediated SNT tyrosine phosphorylation in vivo requires these segments of receptor and SNT . ^^^ The SNT binding motif of FGFR 1 is distinct from previously described phosphotyrosine binding domain recognition motifs , lacking both tyrosine and asparagine residues . . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| H , 13C and 15N resonance assignments of the SNT PTB domain in complex with FGFR 1 peptide . ^^^ |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|