| Interacting proteins: Q15418 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGFR 1 is a multifactorial protein whose N terminus interacts with CBP and C terminus with ribosomal S 6 kinase 1 ( RSK 1 ) . ^^^ |
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| Interacting proteins: Q15418 and P11362 |
Pubmed |
SVM Score :0.0 |
| Among the proteins detected with the intracellular FGFR 1 domain was a 90 kDa ribosomal S 6 kinase ( RSK 1 ) , a regulator of CREB , CBP , and histone phosphorylation . ^^^ FGFR 1 bound to the N terminal region of RSK 1 . ^^^ In TE 671 cells , transfected FGFR 1 colocalized and coimmunoprecipitated , almost exclusively , with nuclear RSK 1 . ^^^ Nuclear RSK 1 kinase activity and RSK 1 activation of CREB were enhanced by transfected FGFR 1 . ^^^ In contrast , kinase deleted FGFR 1 ( TK ) , which did not bind to RSK 1 failed to stimulate nuclear RSK 1 activity or RSK 1 activation of CREB . ^^^ |
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| Interacting proteins: Q15418 and P11362 |
Pubmed |
SVM Score :0.0 |
| RSK 1 increases the highly mobile cytosolic FGFR 1 population and its overall diffusion rate leading to increased FGFR 1 nuclear accumulation , which coaccumulates with RSK 1 . ^^^ |
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