| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| In addition , fibroblast growth factor receptor 1 ( FGFR 1 ) is identified as a receptor for AIGF . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| The findings that AIGF inhibited binding of [ 125I ] basic fibroblast growth factor ( bFGF ) and only FGF receptor ( FGFR ) 1 mRNA expressed in SC 3 cells suggested that AIGF acts through FGFR 1 . ^^^ When this variant FGFR 1 was expressed in FGFR negative myoblast L 6 cells , AIGF dependent inhibition of the differentiation to myocytes was observed suggesting that variant FGFR 1 is receptor of AIGF . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| Although two of the receptors which FGF 8 binds to ( FGFR 2 IIIc , FGFR 3 IIIc ) are not expressed in breast cancer cells , an autocrine activation loop is possible since expression of fibroblast growth factor receptor ( FGFR ) 4 and FGFR 1 are retained in malignant epithelial cells . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| Ectopic application of FGF 8 on the left side blocked NKX3 . 2 expression , whereas the FGF receptor 1 ( FGFR 1 ) antagonist SU 5402 , implanted on the right side , resulted in bilateral NKX3 . 2 expression in the LPM , suggesting that FGF 8 is an important negative determinant of asymmetric NKX3 . 2 expression . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGFR 1 bound well to FGF 2 but poorly to FGF 8 and FGF 9 . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| We show that these effects of FGF 8 are likely to be mediated via FGFR 1 and be modulated by the putative FGF antagonist , Sprouty 2 , identified using a differential display screen . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| First , we demonstrated that FGF receptor 1 ( Fgfr 1 ) and Fgfr 3 , expressed differentially in the developing brain , possess an equivalent potential to induce the regionally distinct Fgf 8 responsive genes , depending on the anterior posterior dimension of the brain . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| A similar phenotype is observed in Fgf 8 and Fgfr 1 mutant embryos and provides genetic evidence in support of a molecular link between the Fgf and Wnt signaling pathways in patterning nascent mesoderm . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| Zebrafish fgfr 1 is a member of the fgf 8 synexpression group and is required for fgf 8 signalling at the midbrain hindbrain boundary . ^^^ The expression patterns of fgfr 1 and fgf 8 are strikingly similar and knock down of fgfr 1 phenocopies many aspects observed in the fgf 8 mutant acerebellar , suggesting that Fgf 8 exerts its function mainly by binding to FgfR1 . . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| To address the role of FGF during external genitalia development , we have analyzed the expression of FGF genes ( Fgf 8 , 9 , 10 ) and receptor genes ( Fgfr 1 , r2IIIb , r2IIIc ) in GT of mice . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| The FGF 8 signal from the MHO , therefore , was believed to be transmitted by FGFR 1 exclusively . ^^^ However , incongruent results from conditional mutants of Fgf 8 and Fgfr 1 in the midbrain hindbrain ( MHB ) region contradict this hypothesis . ^^^ |
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| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| All cases of embryonal carcinoma ( 14 cases ) , yolk sac tumor ( 3 cases ) , and choriocarcinoma ( 3 cases ) showed positive immunostaining for FGF 8 , FGF 4 , and FGFR 1 . ^^^ In contrast , out of 13 cases of seminoma , immunostaining was negative for FGF 8 , FGF 4 , and FGFR 1 in 8 cases ( 61 . 5 % ) , 6 cases ( 46 . 1 % ) , and 7 cases ( 53 . 8 % ) , respectively . ^^^ In addition , the Ki 67 labeling index showed extremely high mitogenic activity in embryonal carcinoma , yolk sac tumor , and choriocarcinoma , which are precisely the carcinomas with the highest expressions of FGF 8 , FGF 4 , and FGFR 1 . ^^^ Taken together , these findings confirm the involvement of FGF 8 , FGF 4 , and FGFR 1 in highly proliferative conditions of nonseminomatous germ cell tumors . . ^^^ |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55075 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|